Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Alpha-tectorin

Gene

TECTA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

One of the major non-collagenous components of the tectorial membrane (By similarity). The tectorial membrane is an extracellular matrix of the inner ear that covers the neuroepithelium of the cochlea and contacts the stereocilia bundles of specialized sensory hair cells. Sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia and leads to fluctuations in hair-cell membrane potential, transducing sound into electrical signals.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • cell-matrix adhesion Source: InterPro
  • sensory perception of sound Source: ProtInc

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processHearing

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-163125 Post-translational modification: synthesis of GPI-anchored proteins

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Alpha-tectorin
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TECTA
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000109927.9

Human Gene Nomenclature Database

More...
HGNCi
HGNC:11720 TECTA

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
602574 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O75443

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Extracellular matrix, Membrane, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Deafness, autosomal dominant, 12 (DFNA12)9 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.
See also OMIM:601543
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_066076197D → N in DFNA12. 1 Publication1
Natural variantiVAR_066077211F → S in DFNA12. 1 Publication1
Natural variantiVAR_066078317V → E in DFNA12. 1 Publication1
Natural variantiVAR_066079362S → C in DFNA12. 1 PublicationCorresponds to variant dbSNP:rs779123206Ensembl.1
Natural variantiVAR_066080465N → K in DFNA12. 1 Publication1
Natural variantiVAR_066081562T → M in DFNA12. 1 PublicationCorresponds to variant dbSNP:rs779401654EnsemblClinVar.1
Natural variantiVAR_066082815T → M in DFNA12. 1 PublicationCorresponds to variant dbSNP:rs111759871EnsemblClinVar.1
Natural variantiVAR_066083886N → S in DFNA12. 1 PublicationCorresponds to variant dbSNP:rs146175803EnsemblClinVar.1
Natural variantiVAR_0660841036C → Y in DFNA12. 1 PublicationCorresponds to variant dbSNP:rs772606235EnsemblClinVar.1
Natural variantiVAR_0189701057C → S in DFNA12; progressive deafness with late onset. 1 PublicationCorresponds to variant dbSNP:rs121909059EnsemblClinVar.1
Natural variantiVAR_0660851098A → V in DFNA12. 1 PublicationCorresponds to variant dbSNP:rs761524812Ensembl.1
Natural variantiVAR_0660861136D → H in DFNA12. 1 PublicationCorresponds to variant dbSNP:rs147890616EnsemblClinVar.1
Natural variantiVAR_0660871248P → L in DFNA12. 1 PublicationCorresponds to variant dbSNP:rs138768918EnsemblClinVar.1
Natural variantiVAR_0660881509C → G in DFNA12. 1 Publication1
Natural variantiVAR_0660891517C → R in DFNA12. 1 Publication1
Natural variantiVAR_0189711619C → S in DFNA12. 1 PublicationCorresponds to variant dbSNP:rs121909060EnsemblClinVar.1
Natural variantiVAR_0660901791P → R in DFNA12. 1 PublicationCorresponds to variant dbSNP:rs754213928Ensembl.1
Natural variantiVAR_0189731820L → F in DFNA12; prelingual and stable deafness. 1 PublicationCorresponds to variant dbSNP:rs281865415EnsemblClinVar.1
Natural variantiVAR_0189741824G → D in DFNA12; prelingual and stable deafness. 1 PublicationCorresponds to variant dbSNP:rs267607107EnsemblClinVar.1
Natural variantiVAR_0189751837C → G in DFNA12; postlingual and progressive. 2 PublicationsCorresponds to variant dbSNP:rs121909061EnsemblClinVar.1
Natural variantiVAR_0660911837C → R in DFNA12. 1 PublicationCorresponds to variant dbSNP:rs121909061EnsemblClinVar.1
Natural variantiVAR_0660921866T → M in DFNA12. 2 PublicationsCorresponds to variant dbSNP:rs140236996EnsemblClinVar.1
Natural variantiVAR_0660931867H → R in DFNA12. 1 Publication1
Natural variantiVAR_0189761870Y → C in DFNA12; prelingual and stable deafness. 1 PublicationCorresponds to variant dbSNP:rs121909058EnsemblClinVar.1
Natural variantiVAR_0660941890R → C in DFNA12. 2 PublicationsCorresponds to variant dbSNP:rs121909063EnsemblClinVar.1
Natural variantiVAR_0660951898C → R in DFNA12. 1 Publication1
Natural variantiVAR_0660961947R → C in DFNA12. 1 PublicationCorresponds to variant dbSNP:rs1428598791Ensembl.1
Natural variantiVAR_0660972009I → T in DFNA12. 1 Publication1
Natural variantiVAR_0189772021R → H in DFNA12; prelingual and stable deafness. 1 PublicationCorresponds to variant dbSNP:rs121909062EnsemblClinVar.1
Deafness, autosomal recessive, 21 (DFNB21)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.
See also OMIM:603629

Keywords - Diseasei

Deafness, Disease mutation, Non-syndromic deafness

Organism-specific databases

DisGeNET

More...
DisGeNETi
7007

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...
GeneReviewsi
TECTA

MalaCards human disease database

More...
MalaCardsi
TECTA
MIMi601543 phenotype
603629 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000109927

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
90635 Autosomal dominant non-syndromic sensorineural deafness type DFNA
90636 Autosomal recessive non-syndromic sensorineural deafness type DFNB

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TECTA

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 22Sequence analysisAdd BLAST22
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000004173523 – 2091Alpha-tectorinAdd BLAST2069
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_00000417362092 – 2155Removed in mature formSequence analysisAdd BLAST64

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi34N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi187N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi215N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi278N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi455N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi506N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi528N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi560N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi670N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi687N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi813N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi843N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi855N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi898N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi920N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi931N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi949N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1048N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1235N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1364N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1538N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1565N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi1717 ↔ 1775By similarity
Disulfide bondi1741 ↔ 1784By similarity
Glycosylationi1756N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1772N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1786 ↔ 1818By similarity
Glycosylationi1794N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1806 ↔ 1898By similarity
Disulfide bondi1837 ↔ 1857By similarity
Glycosylationi1851N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1864N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1880N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1920N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1939N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1980 ↔ 2040PROSITE-ProRule annotation
Disulfide bondi2001 ↔ 2056By similarity
Disulfide bondi2045 ↔ 2052By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi2091GPI-anchor amidated asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

The presence of a hydrophobic C-terminus preceded by a potential cleavage site strongly suggests that tectorins are synthesized as glycosylphosphatidylinositol-linked, membrane-bound precursors. Tectorins are targeted to the apical surface of the inner ear epithelia by the lipid and proteolytically released into the extracellular compartment.

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
O75443

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O75443

PeptideAtlas

More...
PeptideAtlasi
O75443

PRoteomics IDEntifications database

More...
PRIDEi
O75443

ProteomicsDB human proteome resource

More...
ProteomicsDBi
50008

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O75443

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O75443

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000109927 Expressed in 138 organ(s), highest expression level in oocyte

CleanEx database of gene expression profiles

More...
CleanExi
HS_TECTA

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O75443 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA018870

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

May form homomeric filament after self-association or heteromeric filament after association with beta-tectorin. Interacts with CEACAM16.1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
112866, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000264037

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
O75443

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O75443

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini98 – 252NIDOPROSITE-ProRule annotationAdd BLAST155
Domaini260 – 314VWFCAdd BLAST55
Domaini321 – 540VWFD 1PROSITE-ProRule annotationAdd BLAST220
Domaini597 – 650TIL 1Add BLAST54
Domaini712 – 929VWFD 2PROSITE-ProRule annotationAdd BLAST218
Domaini984 – 1036TIL 2Add BLAST53
Domaini1099 – 1317VWFD 3PROSITE-ProRule annotationAdd BLAST219
Domaini1372 – 1425TIL 3Add BLAST54
Domaini1486 – 1694VWFD 4PROSITE-ProRule annotationAdd BLAST209
Domaini1805 – 2059ZPPROSITE-ProRule annotationAdd BLAST255

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Zona pellucida domain may enable to form filaments.

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1216 Eukaryota
KOG4291 Eukaryota
ENOG410YR2E LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154874

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000168220

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG079244

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O75443

KEGG Orthology (KO)

More...
KOi
K18273

Identification of Orthologs from Complete Genome Data

More...
OMAi
SCNELQY

Database of Orthologous Groups

More...
OrthoDBi
22053at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O75443

TreeFam database of animal gene trees

More...
TreeFami
TF300299

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000742 EGF-like_dom
IPR003886 NIDO_dom
IPR036084 Ser_inhib-like_sf
IPR033026 TECTA
IPR002919 TIL_dom
IPR025615 TILa_dom
IPR014853 Unchr_dom_Cys-rich
IPR001007 VWF_dom
IPR001846 VWF_type-D
IPR001507 ZP_dom
IPR017977 ZP_dom_CS

The PANTHER Classification System

More...
PANTHERi
PTHR11339:SF235 PTHR11339:SF235, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08742 C8, 4 hits
PF06119 NIDO, 1 hit
PF01826 TIL, 3 hits
PF12714 TILa, 2 hits
PF00094 VWD, 4 hits
PF00100 Zona_pellucida, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00832 C8, 4 hits
SM00181 EGF, 3 hits
SM00539 NIDO, 1 hit
SM00215 VWC_out, 3 hits
SM00216 VWD, 4 hits
SM00241 ZP, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57567 SSF57567, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51220 NIDO, 1 hit
PS51233 VWFD, 4 hits
PS00682 ZP_1, 1 hit
PS51034 ZP_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

O75443-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNYSSFLRIW VSFIFALVQH QAQPRELMYP FWQNDTKTPK VDDGSSSEIK
60 70 80 90 100
LAIPVFFFGV PYRTVYVNNN GVVSFNVLVS QFTPESFPLT DGRAFVAPFW
110 120 130 140 150
ADVHNGIRGE IYYRETMEPA ILKRATKDIR KYFKDMATFS ATWVFIVTWE
160 170 180 190 200
EVTFYGGSST TPVNTFQAVL VSDGSYTFTL FNYYEINWTT GTASGGDPLT
210 220 230 240 250
GLGGVMAQAG FNGGNLTNFF SLPGSRTPEI VNIQETTNVN VPGRWAFKVD
260 270 280 290 300
GKEIDPANGC TSRGQFLRRG EVFWDDLNCT VKCRCLDFNN EIYCQEASCS
310 320 330 340 350
PYEVCEPKGK FFYCSAVETS TCVVFGEPHY HTFDGFLFHF QGSCAYLLAR
360 370 380 390 400
QCLQTSSLPF FSVEAKNEHR RGSAVSWVKE LSVEVNGYKI LIPKGSYGRV
410 420 430 440 450
KVNDLVTSLP VTLDLGTVKI YQSGISTAVE TDFGLLVTFD GQHYASISVP
460 470 480 490 500
GSYINSTCGL CGNYNKNPLD DFLRPDGRPA MSVLDLGESW RVYHADWKCD
510 520 530 540 550
SGCVDNCTQC DAATEALYFG SDYCGFLNKT DGPLWECGTV VDPTAFVHSC
560 570 580 590 600
VYDLCSVRDN GTLLCQAIQA YALVCQALGI PIGDWRTQTG CVSTVQCPSF
610 620 630 640 650
SHYSVCTSSC PDTCSDLTAS RNCATPCTEG CECNQGFVLS TSQCVPLHKC
660 670 680 690 700
GCDFDGHYYT MGEFFWATAN CTVQCLCEEG GDVYCFNKTC GSGEVCAVED
710 720 730 740 750
GYQGCFPKRE TVCLLSQNQV LHTFDGASYA FPSEFSYTLL KTCPERPEYL
760 770 780 790 800
EIDINKKKPD AGPAWLRGLR ILVADQEVKI GGIGASEVKL NGQEVELPFF
810 820 830 840 850
HPSGKLEIYR NKNSTTVESK GVVTVQYSDI GLLYIRLSTT YFNCTGGLCG
860 870 880 890 900
FYNANASDEF CLPNGKCTDN LAVFLESWTT FEEICNGECG DLLKACNNDS
910 920 930 940 950
ELLKFYRSRS RCGIINDPSN SSFLECHGVV NVTAYYRTCL FRLCQSGGNE
960 970 980 990 1000
SELCDSVARY ASACKNADVE VGPWRTYDFC PLECPENSHF EECITCTETC
1010 1020 1030 1040 1050
ETLTLGPICV DSCSEGCQCD EGYALLGSQC VTRSECGCNF EGHQLATNET
1060 1070 1080 1090 1100
FWVDLDCQIF CYCSGTDNRV HCETIPCKDD EYCMEEGGLY YCQARTDASC
1110 1120 1130 1140 1150
IVSGYGHYLT FDGFPFDFQT SCPLILCTTG SRPSSDSFPK FVVTAKNEDR
1160 1170 1180 1190 1200
DPSLALWVKQ VDVTVFGYSI VIHRAYKHTV LVNSERLYLP LKLGQGKINI
1210 1220 1230 1240 1250
FSFGFHVVVE TDFGLKVVYD WKTFLSITVP RSMQNSTYGL CGRYNGNPDD
1260 1270 1280 1290 1300
DLEMPMGLLA SSVNEFGQSW VKRDTFCQVG CGDRCPSCAK VEGFSKVQQL
1310 1320 1330 1340 1350
CSLIPNQNAA FSKCHSKVNP TFFYKNCLFD SCIDGGAVQT ACSWLQNYAS
1360 1370 1380 1390 1400
TCQTQGITVT GWRNYTSCTV TCPPNSHYES CVSVCQPRCA AIRLKSDCSH
1410 1420 1430 1440 1450
YCVEGCHCDA GYVLNGKSCI LPHSCGCYSD GKYYEPKQLF WNSDCTRRCR
1460 1470 1480 1490 1500
CFRRNVIQCD PRQCKSDEEC ALRNGVRGCF STKTSYCLAA GGGVFRTFDG
1510 1520 1530 1540 1550
AFLRFPANCA FVLSTICQKL PDISFQLIIN FDKWSAPNLT IISPVYFYIN
1560 1570 1580 1590 1600
EEQILINDRN TVKVNGTQVN VPFITGLATK IYSSEGFLVI DTSPDIQIYY
1610 1620 1630 1640 1650
NGFNVIKISI SERLQNKVCG LCGNFNGDLT DDYVTLRGKP VVSSVVLAQS
1660 1670 1680 1690 1700
WKTNGMQKRP LAPSCNELQF SQYAAMCDNV HIQKMQGDGY CLKLTDMKGF
1710 1720 1730 1740 1750
FQPCYGLLDP LPFYESCYLD GCYSHKKFQL CGSLAAYGEA CRSFGILSTE
1760 1770 1780 1790 1800
WIEKENCSGV VEDPCVGADC PNRTCELGNG RELCGCIEPP PYGNNSHDII
1810 1820 1830 1840 1850
DAEVTCKAAQ MEVSISKCKL FQLGFEREGV RINDRQCTGI EGEDFISFQI
1860 1870 1880 1890 1900
NNTKGNCGNI VQSNGTHIMY KNTLWIESAN NTGNIITRDR TINVEFSCAY
1910 1920 1930 1940 1950
ELDIKISLDS VVKPMLSVIN LTVPTQEGSF ITKMALYKNA SYKHPYRQGE
1960 1970 1980 1990 2000
VVLTTRDVLY VGVFVVGADA THLILTLNKC YATPTRDSND KLRYFIIEGG
2010 2020 2030 2040 2050
CQNLKDNTIG IEENAVSLTC RFHVTVFKFI GDYDEVHLHC AVSLCDSEKY
2060 2070 2080 2090 2100
SCKITCPHNS RIATDYTKEP KEQIISVGPI RRKRLDWCED NGGCEQICTS
2110 2120 2130 2140 2150
RVDGPLCSCV TGTLQEDGKS CRASNSSMEL QVWTLLLIMI QISLWHFVYK

SGTTS
Length:2,155
Mass (Da):239,527
Last modified:November 30, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA7CB1CD9E7C594C3
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2R8YDL0A0A2R8YDL0_HUMAN
Alpha-tectorin
TECTA
2,150Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8YGQ5A0A2R8YGQ5_HUMAN
Alpha-tectorin
TECTA
1,329Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05750019Q → R. Corresponds to variant dbSNP:rs35507522EnsemblClinVar.1
Natural variantiVAR_066076197D → N in DFNA12. 1 Publication1
Natural variantiVAR_066077211F → S in DFNA12. 1 Publication1
Natural variantiVAR_036423284R → H in a breast cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs886047837EnsemblClinVar.1
Natural variantiVAR_066078317V → E in DFNA12. 1 Publication1
Natural variantiVAR_066079362S → C in DFNA12. 1 PublicationCorresponds to variant dbSNP:rs779123206Ensembl.1
Natural variantiVAR_018968371R → G2 PublicationsCorresponds to variant dbSNP:rs612969EnsemblClinVar.1
Natural variantiVAR_066080465N → K in DFNA12. 1 Publication1
Natural variantiVAR_066081562T → M in DFNA12. 1 PublicationCorresponds to variant dbSNP:rs779401654EnsemblClinVar.1
Natural variantiVAR_036424771I → N in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_036425813N → T in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_066082815T → M in DFNA12. 1 PublicationCorresponds to variant dbSNP:rs111759871EnsemblClinVar.1
Natural variantiVAR_066083886N → S in DFNA12. 1 PublicationCorresponds to variant dbSNP:rs146175803EnsemblClinVar.1
Natural variantiVAR_018969932V → A2 PublicationsCorresponds to variant dbSNP:rs520805EnsemblClinVar.1
Natural variantiVAR_0660841036C → Y in DFNA12. 1 PublicationCorresponds to variant dbSNP:rs772606235EnsemblClinVar.1
Natural variantiVAR_0189701057C → S in DFNA12; progressive deafness with late onset. 1 PublicationCorresponds to variant dbSNP:rs121909059EnsemblClinVar.1
Natural variantiVAR_0660851098A → V in DFNA12. 1 PublicationCorresponds to variant dbSNP:rs761524812Ensembl.1
Natural variantiVAR_0660861136D → H in DFNA12. 1 PublicationCorresponds to variant dbSNP:rs147890616EnsemblClinVar.1
Natural variantiVAR_0660871248P → L in DFNA12. 1 PublicationCorresponds to variant dbSNP:rs138768918EnsemblClinVar.1
Natural variantiVAR_0660881509C → G in DFNA12. 1 Publication1
Natural variantiVAR_0660891517C → R in DFNA12. 1 Publication1
Natural variantiVAR_0575011584S → T. Corresponds to variant dbSNP:rs34963131EnsemblClinVar.1
Natural variantiVAR_0189711619C → S in DFNA12. 1 PublicationCorresponds to variant dbSNP:rs121909060EnsemblClinVar.1
Natural variantiVAR_0189721724S → N1 PublicationCorresponds to variant dbSNP:rs526433EnsemblClinVar.1
Natural variantiVAR_0660901791P → R in DFNA12. 1 PublicationCorresponds to variant dbSNP:rs754213928Ensembl.1
Natural variantiVAR_0189731820L → F in DFNA12; prelingual and stable deafness. 1 PublicationCorresponds to variant dbSNP:rs281865415EnsemblClinVar.1
Natural variantiVAR_0189741824G → D in DFNA12; prelingual and stable deafness. 1 PublicationCorresponds to variant dbSNP:rs267607107EnsemblClinVar.1
Natural variantiVAR_0189751837C → G in DFNA12; postlingual and progressive. 2 PublicationsCorresponds to variant dbSNP:rs121909061EnsemblClinVar.1
Natural variantiVAR_0660911837C → R in DFNA12. 1 PublicationCorresponds to variant dbSNP:rs121909061EnsemblClinVar.1
Natural variantiVAR_0660921866T → M in DFNA12. 2 PublicationsCorresponds to variant dbSNP:rs140236996EnsemblClinVar.1
Natural variantiVAR_0660931867H → R in DFNA12. 1 Publication1
Natural variantiVAR_0189761870Y → C in DFNA12; prelingual and stable deafness. 1 PublicationCorresponds to variant dbSNP:rs121909058EnsemblClinVar.1
Natural variantiVAR_0599651878S → R. Corresponds to variant dbSNP:rs202045605Ensembl.1
Natural variantiVAR_0660941890R → C in DFNA12. 2 PublicationsCorresponds to variant dbSNP:rs121909063EnsemblClinVar.1
Natural variantiVAR_0660951898C → R in DFNA12. 1 Publication1
Natural variantiVAR_0660961947R → C in DFNA12. 1 PublicationCorresponds to variant dbSNP:rs1428598791Ensembl.1
Natural variantiVAR_0660972009I → T in DFNA12. 1 Publication1
Natural variantiVAR_0189772021R → H in DFNA12; prelingual and stable deafness. 1 PublicationCorresponds to variant dbSNP:rs121909062EnsemblClinVar.1
Natural variantiVAR_0189782100S → T1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF055136
, AF055114, AF055115, AF055116, AF055117, AF055118, AF055119, AF055120, AF055121, AF055122, AF055123, AF055124, AF055125, AF055126, AF055127, AF055128, AF055129, AF055130, AF055131, AF055132, AF055133, AF055134, AF055135 Genomic DNA Translation: AAC26019.1
AP000646 Genomic DNA No translation available.
AP000826 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS8434.1

NCBI Reference Sequences

More...
RefSeqi
NP_005413.2, NM_005422.2

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.248162

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000264037; ENSP00000264037; ENSG00000109927
ENST00000392793; ENSP00000376543; ENSG00000109927

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
7007

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:7007

UCSC genome browser

More...
UCSCi
uc010rzo.2 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF055136
, AF055114, AF055115, AF055116, AF055117, AF055118, AF055119, AF055120, AF055121, AF055122, AF055123, AF055124, AF055125, AF055126, AF055127, AF055128, AF055129, AF055130, AF055131, AF055132, AF055133, AF055134, AF055135 Genomic DNA Translation: AAC26019.1
AP000646 Genomic DNA No translation available.
AP000826 Genomic DNA No translation available.
CCDSiCCDS8434.1
RefSeqiNP_005413.2, NM_005422.2
UniGeneiHs.248162

3D structure databases

ProteinModelPortaliO75443
SMRiO75443
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112866, 1 interactor
STRINGi9606.ENSP00000264037

PTM databases

iPTMnetiO75443
PhosphoSitePlusiO75443

Polymorphism and mutation databases

BioMutaiTECTA

Proteomic databases

jPOSTiO75443
PaxDbiO75443
PeptideAtlasiO75443
PRIDEiO75443
ProteomicsDBi50008

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
7007
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000264037; ENSP00000264037; ENSG00000109927
ENST00000392793; ENSP00000376543; ENSG00000109927
GeneIDi7007
KEGGihsa:7007
UCSCiuc010rzo.2 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
7007
DisGeNETi7007
EuPathDBiHostDB:ENSG00000109927.9

GeneCards: human genes, protein and diseases

More...
GeneCardsi
TECTA
GeneReviewsiTECTA
HGNCiHGNC:11720 TECTA
HPAiHPA018870
MalaCardsiTECTA
MIMi601543 phenotype
602574 gene
603629 phenotype
neXtProtiNX_O75443
OpenTargetsiENSG00000109927
Orphaneti90635 Autosomal dominant non-syndromic sensorineural deafness type DFNA
90636 Autosomal recessive non-syndromic sensorineural deafness type DFNB

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1216 Eukaryota
KOG4291 Eukaryota
ENOG410YR2E LUCA
GeneTreeiENSGT00940000154874
HOGENOMiHOG000168220
HOVERGENiHBG079244
InParanoidiO75443
KOiK18273
OMAiSCNELQY
OrthoDBi22053at2759
PhylomeDBiO75443
TreeFamiTF300299

Enzyme and pathway databases

ReactomeiR-HSA-163125 Post-translational modification: synthesis of GPI-anchored proteins

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
TECTA

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
7007

Protein Ontology

More...
PROi
PR:O75443

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000109927 Expressed in 138 organ(s), highest expression level in oocyte
CleanExiHS_TECTA
GenevisibleiO75443 HS

Family and domain databases

InterProiView protein in InterPro
IPR000742 EGF-like_dom
IPR003886 NIDO_dom
IPR036084 Ser_inhib-like_sf
IPR033026 TECTA
IPR002919 TIL_dom
IPR025615 TILa_dom
IPR014853 Unchr_dom_Cys-rich
IPR001007 VWF_dom
IPR001846 VWF_type-D
IPR001507 ZP_dom
IPR017977 ZP_dom_CS
PANTHERiPTHR11339:SF235 PTHR11339:SF235, 1 hit
PfamiView protein in Pfam
PF08742 C8, 4 hits
PF06119 NIDO, 1 hit
PF01826 TIL, 3 hits
PF12714 TILa, 2 hits
PF00094 VWD, 4 hits
PF00100 Zona_pellucida, 1 hit
SMARTiView protein in SMART
SM00832 C8, 4 hits
SM00181 EGF, 3 hits
SM00539 NIDO, 1 hit
SM00215 VWC_out, 3 hits
SM00216 VWD, 4 hits
SM00241 ZP, 1 hit
SUPFAMiSSF57567 SSF57567, 3 hits
PROSITEiView protein in PROSITE
PS51220 NIDO, 1 hit
PS51233 VWFD, 4 hits
PS00682 ZP_1, 1 hit
PS51034 ZP_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTECTA_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O75443
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: November 30, 2010
Last modified: January 16, 2019
This is version 164 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again