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UniProtKB - O75437 (ZN254_HUMAN)
Protein
Zinc finger protein 254
Gene
ZNF254
Organism
Homo sapiens (Human)
Status
Functioni
May be involved in transcriptional regulation.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 210 – 232 | C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 238 – 260 | C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 266 – 288 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 294 – 316 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 322 – 344 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 350 – 372 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 378 – 400 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 406 – 428 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 434 – 456 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 462 – 484 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 490 – 512 | C2H2-type 11PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 518 – 540 | C2H2-type 12PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 546 – 568 | C2H2-type 13PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 574 – 596 | C2H2-type 14PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 602 – 624 | C2H2-type 15PROSITE-ProRule annotationAdd BLAST | 23 |
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- negative regulation of transcription by RNA polymerase II Source: ProtInc
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | O75437 |
Reactomei | R-HSA-212436, Generic Transcription Pathway |
SignaLinki | O75437 |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger protein 254Alternative name(s): Bone marrow zinc finger 5 Short name: BMZF-5 Hematopoietic cell-derived zinc finger protein 1 Short name: HD-ZNF1 Zinc finger protein 539 Zinc finger protein 91-like |
Gene namesi | Name:ZNF254 Synonyms:BMZF5, ZNF539, ZNF91L |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:13047, ZNF254 |
MIMi | 604768, gene |
neXtProti | NX_O75437 |
VEuPathDBi | HostDB:ENSG00000213096 |
Subcellular locationi
Nucleus
- Nucleus Curated
Nucleus
- nucleus Source: GO_Central
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 9534 |
OpenTargetsi | ENSG00000213096 |
PharmGKBi | PA37625 |
Miscellaneous databases
Pharosi | O75437, Tdark |
Genetic variation databases
BioMutai | ZNF254 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000047487 | 1 – 659 | Zinc finger protein 254Add BLAST | 659 |
Proteomic databases
jPOSTi | O75437 |
MassIVEi | O75437 |
MaxQBi | O75437 |
PaxDbi | O75437 |
PeptideAtlasi | O75437 |
PRIDEi | O75437 |
ProteomicsDBi | 50003 [O75437-1] 50004 [O75437-2] |
PTM databases
iPTMneti | O75437 |
PhosphoSitePlusi | O75437 |
Expressioni
Gene expression databases
Bgeei | ENSG00000213096, Expressed in kidney and 210 other tissues |
ExpressionAtlasi | O75437, baseline and differential |
Genevisiblei | O75437, HS |
Organism-specific databases
HPAi | ENSG00000213096, Low tissue specificity |
Interactioni
Protein-protein interaction databases
BioGRIDi | 114910, 9 interactors |
IntActi | O75437, 7 interactors |
MINTi | O75437 |
STRINGi | 9606.ENSP00000349494 |
Miscellaneous databases
RNActi | O75437, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 13 – 84 | KRABPROSITE-ProRule annotationAdd BLAST | 72 |
Sequence similaritiesi
Belongs to the krueppel C2H2-type zinc-finger protein family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 210 – 232 | C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 238 – 260 | C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 266 – 288 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 294 – 316 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 322 – 344 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 350 – 372 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 378 – 400 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 406 – 428 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 434 – 456 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 462 – 484 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 490 – 512 | C2H2-type 11PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 518 – 540 | C2H2-type 12PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 546 – 568 | C2H2-type 13PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 574 – 596 | C2H2-type 14PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 602 – 624 | C2H2-type 15PROSITE-ProRule annotationAdd BLAST | 23 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000153236 |
HOGENOMi | CLU_002678_44_5_1 |
InParanoidi | O75437 |
OMAi | DRITHWR |
OrthoDBi | 1318335at2759 |
PhylomeDBi | O75437 |
TreeFami | TF342117 |
Family and domain databases
CDDi | cd07765, KRAB_A-box, 1 hit |
InterProi | View protein in InterPro IPR001909, KRAB IPR036051, KRAB_dom_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF01352, KRAB, 1 hit PF00096, zf-C2H2, 14 hits |
SMARTi | View protein in SMART SM00349, KRAB, 1 hit SM00355, ZnF_C2H2, 15 hits |
SUPFAMi | SSF109640, SSF109640, 1 hit SSF57667, SSF57667, 10 hits |
PROSITEi | View protein in PROSITE PS50805, KRAB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 13 hits PS50157, ZINC_FINGER_C2H2_2, 15 hits |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: O75437-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MPGPPRSLEM GLLTFRDVAI EFSLEEWQHL DIAQQNLYRN VMLENYRNLA
60 70 80 90 100
FLGIAVSKPD LITCLEQGKE PWNMKRHEMV DEPPGMCPHF AQDLWPEQGM
110 120 130 140 150
EDSFQKAILR RYGKYGHENL QLRKGCKSVD EYKVNKEGYN GLNQCFTTAQ
160 170 180 190 200
SKVFQCDKYL KVFYKFLNSN RPKIRHTEKK SFKCKKRVKL FCMLSHKTQH
210 220 230 240 250
KSIYHREKSY KCKECGKTFN WSSTLTNHRK IYTEEKPYKC EEYNKSPKQL
260 270 280 290 300
STLTTHEIIH AGEKLYKCEE CGEAFNRSSN LTTHKIIHTG EKPYKCEECG
310 320 330 340 350
KAFIWSSTLT EHKKIHTRKK PYKCEECGKA FIWSSTLTRH KRMHTGEKPY
360 370 380 390 400
KCEECGKAFS QSSTLTTHKI IHTGEKRYKC LECGKAFKQL STLTTHKIIH
410 420 430 440 450
VGEKLYKCEE CGKGFNRSSN LTTHKIIHTG EKPYKCEECG KAFIWSSTLT
460 470 480 490 500
KHKRIHTREK PYKCEECGKA FIWSSTLTRH KRMHTGEKPY KCEECGKSFS
510 520 530 540 550
QSSTLTTHKI IHTGEKPYKC EECGKAFNWS STLTKHKIIH TEEKPYKCEK
560 570 580 590 600
CGKAFKQSSI LTNHKRIHTG EKPYKCEECG KSFNRSSTFT KHKVIHTGVK
610 620 630 640 650
PYKCEECGKA FFWSSTLTKH KRIHTGEQPY KWEKFGKAFN RSSHLTTDKI
THWREILQV
Computationally mapped potential isoform sequencesi
There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A087WZJ7 | A0A087WZJ7_HUMAN | Zinc finger protein 254 | ZNF254 | 618 | Annotation score: | ||
Q7Z2R1 | Q7Z2R1_HUMAN | HCG19985, isoform CRA_b | ZNF254 hCG_19985 | 91 | Annotation score: | ||
M0QZY2 | M0QZY2_HUMAN | Zinc finger protein 254 | ZNF254 | 53 | Annotation score: | ||
F5H2M4 | F5H2M4_HUMAN | Zinc finger protein 254 | ZNF254 | 574 | Annotation score: | ||
A0A087X0A2 | A0A087X0A2_HUMAN | Zinc finger protein 254 | ZNF254 | 586 | Annotation score: | ||
M0R2X5 | M0R2X5_HUMAN | Zinc finger protein 254 | ZNF254 | 75 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 273 | E → K in AAC39913 (PubMed:9653160).Curated | 1 | |
Sequence conflicti | 653 – 659 | WREILQV → TGEKSYKYE in AAC39913 (PubMed:9653160).Curated | 7 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_047461 | 93 | D → G1 PublicationCorresponds to variant dbSNP:rs17854260Ensembl. | 1 | |
Natural variantiVAR_047462 | 386 | A → T. Corresponds to variant dbSNP:rs403356Ensembl. | 1 | |
Natural variantiVAR_047463 | 457 | T → A. Corresponds to variant dbSNP:rs2925930Ensembl. | 1 | |
Natural variantiVAR_059906 | 537 | K → N1 PublicationCorresponds to variant dbSNP:rs12611425Ensembl. | 1 | |
Natural variantiVAR_047464 | 594 | V → I. Corresponds to variant dbSNP:rs2446056Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_022010 | 280 – 587 | Missing in isoform 2. 1 PublicationAdd BLAST | 308 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF054180 mRNA Translation: AAC39913.1 CH471106 Genomic DNA Translation: EAW84960.1 BC043147 mRNA Translation: AAH43147.2 BC139749 mRNA Translation: AAI39750.1 |
CCDSi | CCDS32983.1 [O75437-1] |
RefSeqi | NP_975011.3, NM_203282.3 [O75437-1] |
Genome annotation databases
Ensembli | ENST00000357002; ENSP00000349494; ENSG00000213096 |
GeneIDi | 9534 |
KEGGi | hsa:9534 |
MANE-Selecti | ENST00000357002.5; ENSP00000349494.3; NM_203282.4; NP_975011.3 |
UCSCi | uc002nru.5, human [O75437-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF054180 mRNA Translation: AAC39913.1 CH471106 Genomic DNA Translation: EAW84960.1 BC043147 mRNA Translation: AAH43147.2 BC139749 mRNA Translation: AAI39750.1 |
CCDSi | CCDS32983.1 [O75437-1] |
RefSeqi | NP_975011.3, NM_203282.3 [O75437-1] |
3D structure databases
SMRi | O75437 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 114910, 9 interactors |
IntActi | O75437, 7 interactors |
MINTi | O75437 |
STRINGi | 9606.ENSP00000349494 |
PTM databases
iPTMneti | O75437 |
PhosphoSitePlusi | O75437 |
Genetic variation databases
BioMutai | ZNF254 |
Proteomic databases
jPOSTi | O75437 |
MassIVEi | O75437 |
MaxQBi | O75437 |
PaxDbi | O75437 |
PeptideAtlasi | O75437 |
PRIDEi | O75437 |
ProteomicsDBi | 50003 [O75437-1] 50004 [O75437-2] |
Protocols and materials databases
Antibodypediai | 28793, 39 antibodies from 11 providers |
DNASUi | 9534 |
Genome annotation databases
Ensembli | ENST00000357002; ENSP00000349494; ENSG00000213096 |
GeneIDi | 9534 |
KEGGi | hsa:9534 |
MANE-Selecti | ENST00000357002.5; ENSP00000349494.3; NM_203282.4; NP_975011.3 |
UCSCi | uc002nru.5, human [O75437-1] |
Organism-specific databases
CTDi | 9534 |
DisGeNETi | 9534 |
GeneCardsi | ZNF254 |
HGNCi | HGNC:13047, ZNF254 |
HPAi | ENSG00000213096, Low tissue specificity |
MIMi | 604768, gene |
neXtProti | NX_O75437 |
OpenTargetsi | ENSG00000213096 |
PharmGKBi | PA37625 |
VEuPathDBi | HostDB:ENSG00000213096 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000153236 |
HOGENOMi | CLU_002678_44_5_1 |
InParanoidi | O75437 |
OMAi | DRITHWR |
OrthoDBi | 1318335at2759 |
PhylomeDBi | O75437 |
TreeFami | TF342117 |
Enzyme and pathway databases
PathwayCommonsi | O75437 |
Reactomei | R-HSA-212436, Generic Transcription Pathway |
SignaLinki | O75437 |
Miscellaneous databases
BioGRID-ORCSi | 9534, 272 hits in 1002 CRISPR screens |
ChiTaRSi | ZNF254, human |
GenomeRNAii | 9534 |
Pharosi | O75437, Tdark |
PROi | PR:O75437 |
RNActi | O75437, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000213096, Expressed in kidney and 210 other tissues |
ExpressionAtlasi | O75437, baseline and differential |
Genevisiblei | O75437, HS |
Family and domain databases
CDDi | cd07765, KRAB_A-box, 1 hit |
InterProi | View protein in InterPro IPR001909, KRAB IPR036051, KRAB_dom_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF01352, KRAB, 1 hit PF00096, zf-C2H2, 14 hits |
SMARTi | View protein in SMART SM00349, KRAB, 1 hit SM00355, ZnF_C2H2, 15 hits |
SUPFAMi | SSF109640, SSF109640, 1 hit SSF57667, SSF57667, 10 hits |
PROSITEi | View protein in PROSITE PS50805, KRAB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 13 hits PS50157, ZINC_FINGER_C2H2_2, 15 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | ZN254_HUMAN | |
Accessioni | O75437Primary (citable) accession number: O75437 Secondary accession number(s): A4QPC0, Q86XL7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 24, 2001 |
Last sequence update: | November 25, 2008 | |
Last modified: | February 23, 2022 | |
This is version 191 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families