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UniProtKB - O75437 (ZN254_HUMAN)

Entry version 191 (23 Feb 2022)
Sequence version 3 (25 Nov 2008)
Previous versions | rss
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Protein

Zinc finger protein 254

Gene

ZNF254

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri210 – 232C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri238 – 260C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri266 – 288C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri294 – 316C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri322 – 344C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri350 – 372C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri378 – 400C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri406 – 428C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri434 – 456C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri462 – 484C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri490 – 512C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri518 – 540C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri546 – 568C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri574 – 596C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri602 – 624C2H2-type 15PROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		O75437

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-212436, Generic Transcription Pathway

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		O75437

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein 254
Alternative name(s):
Bone marrow zinc finger 5
Short name:
BMZF-5
Hematopoietic cell-derived zinc finger protein 1
Short name:
HD-ZNF1
Zinc finger protein 539
Zinc finger protein 91-like
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZNF254
Synonyms:BMZF5, ZNF539, ZNF91L
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:13047, ZNF254

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		604768, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_O75437

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000213096

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		9534

Open Targets

More...OpenTargetsi		ENSG00000213096

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA37625

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		O75437, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ZNF254

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000474871 – 659Zinc finger protein 254Add BLAST659

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		O75437

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		O75437

MaxQB - The MaxQuant DataBase

More...MaxQBi		O75437

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O75437

PeptideAtlas

More...PeptideAtlasi		O75437

PRoteomics IDEntifications database

More...PRIDEi		O75437

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		50003 [O75437-1]
50004 [O75437-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		O75437

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		O75437

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000213096, Expressed in kidney and 210 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		O75437, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		O75437, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000213096, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		114910, 9 interactors

Protein interaction database and analysis system

More...IntActi		O75437, 7 interactors

Molecular INTeraction database

More...MINTi		O75437

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000349494

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		O75437, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		O75437

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini13 – 84KRABPROSITE-ProRule annotationAdd BLAST72

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the krueppel C2H2-type zinc-finger protein family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri210 – 232C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri238 – 260C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri266 – 288C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri294 – 316C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri322 – 344C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri350 – 372C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri378 – 400C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri406 – 428C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri434 – 456C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri462 – 484C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri490 – 512C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri518 – 540C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri546 – 568C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri574 – 596C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri602 – 624C2H2-type 15PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1721, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000153236

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_002678_44_5_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O75437

Identification of Orthologs from Complete Genome Data

More...OMAi		DRITHWR

Database of Orthologous Groups

More...OrthoDBi		1318335at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		O75437

TreeFam database of animal gene trees

More...TreeFami		TF342117

Family and domain databases

Conserved Domains Database

More...CDDi		cd07765, KRAB_A-box, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001909, KRAB
IPR036051, KRAB_dom_sf
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01352, KRAB, 1 hit
PF00096, zf-C2H2, 14 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00349, KRAB, 1 hit
SM00355, ZnF_C2H2, 15 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF109640, SSF109640, 1 hit
SSF57667, SSF57667, 10 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50805, KRAB, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 13 hits
PS50157, ZINC_FINGER_C2H2_2, 15 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O75437-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPGPPRSLEM GLLTFRDVAI EFSLEEWQHL DIAQQNLYRN VMLENYRNLA 
        60         70         80         90        100
FLGIAVSKPD LITCLEQGKE PWNMKRHEMV DEPPGMCPHF AQDLWPEQGM 
       110        120        130        140        150
EDSFQKAILR RYGKYGHENL QLRKGCKSVD EYKVNKEGYN GLNQCFTTAQ 
       160        170        180        190        200
SKVFQCDKYL KVFYKFLNSN RPKIRHTEKK SFKCKKRVKL FCMLSHKTQH 
       210        220        230        240        250
KSIYHREKSY KCKECGKTFN WSSTLTNHRK IYTEEKPYKC EEYNKSPKQL 
       260        270        280        290        300
STLTTHEIIH AGEKLYKCEE CGEAFNRSSN LTTHKIIHTG EKPYKCEECG 
       310        320        330        340        350
KAFIWSSTLT EHKKIHTRKK PYKCEECGKA FIWSSTLTRH KRMHTGEKPY 
       360        370        380        390        400
KCEECGKAFS QSSTLTTHKI IHTGEKRYKC LECGKAFKQL STLTTHKIIH 
       410        420        430        440        450
VGEKLYKCEE CGKGFNRSSN LTTHKIIHTG EKPYKCEECG KAFIWSSTLT 
       460        470        480        490        500
KHKRIHTREK PYKCEECGKA FIWSSTLTRH KRMHTGEKPY KCEECGKSFS 
       510        520        530        540        550
QSSTLTTHKI IHTGEKPYKC EECGKAFNWS STLTKHKIIH TEEKPYKCEK 
       560        570        580        590        600
CGKAFKQSSI LTNHKRIHTG EKPYKCEECG KSFNRSSTFT KHKVIHTGVK 
       610        620        630        640        650
PYKCEECGKA FFWSSTLTKH KRIHTGEQPY KWEKFGKAFN RSSHLTTDKI 

THWREILQV
Length:659
Mass (Da):77,160
Last modified:November 25, 2008 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i82E89E6715D96394
GO
Isoform 2 (identifier: O75437-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     280-587: Missing.

Show »
Length:351
Mass (Da):41,538
Checksum:iDAD54AF67576BBCF
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WZJ7A0A087WZJ7_HUMAN
Zinc finger protein 254
ZNF254
618Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q7Z2R1Q7Z2R1_HUMAN
HCG19985, isoform CRA_b
ZNF254 hCG_19985
91Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QZY2M0QZY2_HUMAN
Zinc finger protein 254
ZNF254
53Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H2M4F5H2M4_HUMAN
Zinc finger protein 254
ZNF254
574Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087X0A2A0A087X0A2_HUMAN
Zinc finger protein 254
ZNF254
586Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R2X5M0R2X5_HUMAN
Zinc finger protein 254
ZNF254
75Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti273E → K in AAC39913 (PubMed:9653160).Curated1
Sequence conflicti653 – 659WREILQV → TGEKSYKYE in AAC39913 (PubMed:9653160).Curated7

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04746193D → G1 PublicationCorresponds to variant dbSNP:rs17854260Ensembl.1
Natural variantiVAR_047462386A → T. Corresponds to variant dbSNP:rs403356Ensembl.1
Natural variantiVAR_047463457T → A. Corresponds to variant dbSNP:rs2925930Ensembl.1
Natural variantiVAR_059906537K → N1 PublicationCorresponds to variant dbSNP:rs12611425Ensembl.1
Natural variantiVAR_047464594V → I. Corresponds to variant dbSNP:rs2446056Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_022010280 – 587Missing in isoform 2. 1 PublicationAdd BLAST308

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF054180 mRNA Translation: AAC39913.1
CH471106 Genomic DNA Translation: EAW84960.1
BC043147 mRNA Translation: AAH43147.2
BC139749 mRNA Translation: AAI39750.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS32983.1 [O75437-1]

NCBI Reference Sequences

More...RefSeqi		NP_975011.3, NM_203282.3 [O75437-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000357002; ENSP00000349494; ENSG00000213096

Database of genes from NCBI RefSeq genomes

More...GeneIDi		9534

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:9534

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000357002.5; ENSP00000349494.3; NM_203282.4; NP_975011.3

UCSC genome browser

More...UCSCi		uc002nru.5, human [O75437-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF054180 mRNA Translation: AAC39913.1
CH471106 Genomic DNA Translation: EAW84960.1
BC043147 mRNA Translation: AAH43147.2
BC139749 mRNA Translation: AAI39750.1
CCDSiCCDS32983.1 [O75437-1]
RefSeqiNP_975011.3, NM_203282.3 [O75437-1]

3D structure databases

SMRiO75437
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi114910, 9 interactors
IntActiO75437, 7 interactors
MINTiO75437
STRINGi9606.ENSP00000349494

PTM databases

iPTMnetiO75437
PhosphoSitePlusiO75437

Genetic variation databases

BioMutaiZNF254

Proteomic databases

jPOSTiO75437
MassIVEiO75437
MaxQBiO75437
PaxDbiO75437
PeptideAtlasiO75437
PRIDEiO75437
ProteomicsDBi50003 [O75437-1]
50004 [O75437-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		28793, 39 antibodies from 11 providers

The DNASU plasmid repository

More...DNASUi		9534

Genome annotation databases

EnsembliENST00000357002; ENSP00000349494; ENSG00000213096
GeneIDi9534
KEGGihsa:9534
MANE-SelectiENST00000357002.5; ENSP00000349494.3; NM_203282.4; NP_975011.3
UCSCiuc002nru.5, human [O75437-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		9534
DisGeNETi9534

GeneCards: human genes, protein and diseases

More...GeneCardsi		ZNF254
HGNCiHGNC:13047, ZNF254
HPAiENSG00000213096, Low tissue specificity
MIMi604768, gene
neXtProtiNX_O75437
OpenTargetsiENSG00000213096
PharmGKBiPA37625
VEuPathDBiHostDB:ENSG00000213096

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1721, Eukaryota
GeneTreeiENSGT00940000153236
HOGENOMiCLU_002678_44_5_1
InParanoidiO75437
OMAiDRITHWR
OrthoDBi1318335at2759
PhylomeDBiO75437
TreeFamiTF342117

Enzyme and pathway databases

PathwayCommonsiO75437
ReactomeiR-HSA-212436, Generic Transcription Pathway
SignaLinkiO75437

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		9534, 272 hits in 1002 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ZNF254, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		9534
PharosiO75437, Tdark

Protein Ontology

More...PROi		PR:O75437
RNActiO75437, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000213096, Expressed in kidney and 210 other tissues
ExpressionAtlasiO75437, baseline and differential
GenevisibleiO75437, HS

Family and domain databases

CDDicd07765, KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909, KRAB
IPR036051, KRAB_dom_sf
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type
PfamiView protein in Pfam
PF01352, KRAB, 1 hit
PF00096, zf-C2H2, 14 hits
SMARTiView protein in SMART
SM00349, KRAB, 1 hit
SM00355, ZnF_C2H2, 15 hits
SUPFAMiSSF109640, SSF109640, 1 hit
SSF57667, SSF57667, 10 hits
PROSITEiView protein in PROSITE
PS50805, KRAB, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 13 hits
PS50157, ZINC_FINGER_C2H2_2, 15 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZN254_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O75437
Secondary accession number(s): A4QPC0, Q86XL7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: November 25, 2008
Last modified: February 23, 2022
This is version 191 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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