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Protein

Metaxin-2

Gene

MTX2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in transport of proteins into the mitochondrion.1 Publication

GO - Biological processi

  • mitochondrial transport Source: ProtInc
  • protein transport Source: UniProtKB-KW

Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-1268020 Mitochondrial protein import
R-HSA-8949613 Cristae formation

Names & Taxonomyi

Protein namesi
Recommended name:
Metaxin-2
Alternative name(s):
Mitochondrial outer membrane import complex protein 2
Gene namesi
Name:MTX2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000128654.13
HGNCiHGNC:7506 MTX2
MIMi608555 gene
neXtProtiNX_O75431

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi10651
OpenTargetsiENSG00000128654
PharmGKBiPA31308

Polymorphism and mutation databases

BioMutaiMTX2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002209952 – 263Metaxin-2Add BLAST262

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiO75431
MaxQBiO75431
PaxDbiO75431
PeptideAtlasiO75431
PRIDEiO75431
ProteomicsDBi50001
TopDownProteomicsiO75431-1 [O75431-1]

PTM databases

iPTMnetiO75431
PhosphoSitePlusiO75431
SwissPalmiO75431

Expressioni

Gene expression databases

BgeeiENSG00000128654 Expressed in 225 organ(s), highest expression level in C1 segment of cervical spinal cord
CleanExiHS_MTX2
ExpressionAtlasiO75431 baseline and differential
GenevisibleiO75431 HS

Organism-specific databases

HPAiHPA031550
HPA031551
HPA031552

Interactioni

Subunit structurei

Interacts with MTX1/metaxin-1. Associates with the mitochondrial contact site and cristae organizing system (MICOS) complex, composed of at least MINOS1/MIC10, CHCHD3/MIC19, CHCHD6/MIC25, APOOL/MIC27, IMMT/MIC60, APOO/MIC23/MIC26 and QIL1/MIC13. This complex was also known under the names MINOS or MitOS complex. The MICOS complex associates with mitochondrial outer membrane proteins SAMM50, MTX1 and MTX2 (together described as components of the mitochondrial outer membrane sorting assembly machinery (SAM) complex) and DNAJC11, mitochondrial inner membrane protein TMEM11 and with HSPA9. The MICOS and SAM complexes together with DNAJC11 are part of a large protein complex spanning both membranes termed the mitochondrial intermembrane space bridging (MIB) complex.3 Publications

Binary interactionsi

Protein-protein interaction databases

BioGridi115894, 29 interactors
CORUMiO75431
IntActiO75431, 28 interactors
MINTiO75431
STRINGi9606.ENSP00000249442

Structurei

3D structure databases

ProteinModelPortaliO75431
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the metaxin family.Curated

Phylogenomic databases

eggNOGiKOG3027 Eukaryota
ENOG410XY7W LUCA
GeneTreeiENSGT00530000063166
HOGENOMiHOG000231908
HOVERGENiHBG003471
InParanoidiO75431
KOiK17776
OMAiFTILTTQ
OrthoDBiEOG091G132X
PhylomeDBiO75431
TreeFamiTF313422

Family and domain databases

InterProiView protein in InterPro
IPR036282 Glutathione-S-Trfase_C_sf
IPR040079 Glutathione_S-Trfase
IPR033468 Metaxin_GST
IPR019564 Sam37/metaxin_N
PfamiView protein in Pfam
PF17171 GST_C_6, 1 hit
PF10568 Tom37, 1 hit
SFLDiSFLDS00019 Glutathione_Transferase_(cytos, 1 hit
SUPFAMiSSF47616 SSF47616, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O75431-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSLVAEAFVS QIAAAEPWPE NATLYQQLKG EQILLSDNAA SLAVQAFLQM
60 70 80 90 100
CNLPIKVVCR ANAEYMSPSG KVPFIHVGNQ VVSELGPIVQ FVKAKGHSLS
110 120 130 140 150
DGLEEVQKAE MKAYMELVNN MLLTAELYLQ WCDEATVGEI THARYGSPYP
160 170 180 190 200
WPLNHILAYQ KQWEVKRKMK AIGWGKKTLD QVLEDVDQCC QALSQRLGTQ
210 220 230 240 250
PYFFNKQPTE LDALVFGHLY TILTTQLTND ELSEKVKNYS NLLAFCRRIE
260
QHYFEDRGKG RLS
Length:263
Mass (Da):29,763
Last modified:November 1, 1998 - v1
Checksum:i3A2EF476F1C78465
GO
Isoform 2 (identifier: O75431-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-13: MSLVAEAFVSQIA → MYI

Show »
Length:253
Mass (Da):28,823
Checksum:iBEA40149AD239824
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JNK6C9JNK6_HUMAN
Metaxin-2
MTX2
207Annotation score:
C9JAZ1C9JAZ1_HUMAN
Metaxin-2
MTX2
229Annotation score:
F8WE26F8WE26_HUMAN
Metaxin-2
MTX2
45Annotation score:
F8WCW1F8WCW1_HUMAN
Metaxin-2
MTX2
37Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0544681 – 13MSLVA…VSQIA → MYI in isoform 2. 2 PublicationsAdd BLAST13

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF053551 mRNA Translation: AAC25105.1
AK289359 mRNA Translation: BAF82048.1
AK303564 mRNA Translation: BAG64587.1
AC016739 Genomic DNA Translation: AAY14795.1
AC073069 Genomic DNA Translation: AAX93188.1
CH471058 Genomic DNA Translation: EAX11076.1
CH471058 Genomic DNA Translation: EAX11078.1
BC017271 mRNA Translation: AAH17271.1
BC067831 mRNA Translation: AAH67831.1
BC088359 mRNA Translation: AAH88359.1
CCDSiCCDS2272.1 [O75431-1]
RefSeqiNP_001006636.1, NM_001006635.2 [O75431-2]
NP_001306026.1, NM_001319097.1
NP_001306027.1, NM_001319098.1
NP_006545.1, NM_006554.4 [O75431-1]
UniGeneiHs.470728

Genome annotation databases

EnsembliENST00000249442; ENSP00000249442; ENSG00000128654 [O75431-1]
GeneIDi10651
KEGGihsa:10651
UCSCiuc002ukx.4 human [O75431-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF053551 mRNA Translation: AAC25105.1
AK289359 mRNA Translation: BAF82048.1
AK303564 mRNA Translation: BAG64587.1
AC016739 Genomic DNA Translation: AAY14795.1
AC073069 Genomic DNA Translation: AAX93188.1
CH471058 Genomic DNA Translation: EAX11076.1
CH471058 Genomic DNA Translation: EAX11078.1
BC017271 mRNA Translation: AAH17271.1
BC067831 mRNA Translation: AAH67831.1
BC088359 mRNA Translation: AAH88359.1
CCDSiCCDS2272.1 [O75431-1]
RefSeqiNP_001006636.1, NM_001006635.2 [O75431-2]
NP_001306026.1, NM_001319097.1
NP_001306027.1, NM_001319098.1
NP_006545.1, NM_006554.4 [O75431-1]
UniGeneiHs.470728

3D structure databases

ProteinModelPortaliO75431
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115894, 29 interactors
CORUMiO75431
IntActiO75431, 28 interactors
MINTiO75431
STRINGi9606.ENSP00000249442

PTM databases

iPTMnetiO75431
PhosphoSitePlusiO75431
SwissPalmiO75431

Polymorphism and mutation databases

BioMutaiMTX2

Proteomic databases

EPDiO75431
MaxQBiO75431
PaxDbiO75431
PeptideAtlasiO75431
PRIDEiO75431
ProteomicsDBi50001
TopDownProteomicsiO75431-1 [O75431-1]

Protocols and materials databases

DNASUi10651
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000249442; ENSP00000249442; ENSG00000128654 [O75431-1]
GeneIDi10651
KEGGihsa:10651
UCSCiuc002ukx.4 human [O75431-1]

Organism-specific databases

CTDi10651
DisGeNETi10651
EuPathDBiHostDB:ENSG00000128654.13
GeneCardsiMTX2
H-InvDBiHIX0002618
HGNCiHGNC:7506 MTX2
HPAiHPA031550
HPA031551
HPA031552
MIMi608555 gene
neXtProtiNX_O75431
OpenTargetsiENSG00000128654
PharmGKBiPA31308
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3027 Eukaryota
ENOG410XY7W LUCA
GeneTreeiENSGT00530000063166
HOGENOMiHOG000231908
HOVERGENiHBG003471
InParanoidiO75431
KOiK17776
OMAiFTILTTQ
OrthoDBiEOG091G132X
PhylomeDBiO75431
TreeFamiTF313422

Enzyme and pathway databases

ReactomeiR-HSA-1268020 Mitochondrial protein import
R-HSA-8949613 Cristae formation

Miscellaneous databases

ChiTaRSiMTX2 human
GenomeRNAii10651
PROiPR:O75431
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000128654 Expressed in 225 organ(s), highest expression level in C1 segment of cervical spinal cord
CleanExiHS_MTX2
ExpressionAtlasiO75431 baseline and differential
GenevisibleiO75431 HS

Family and domain databases

InterProiView protein in InterPro
IPR036282 Glutathione-S-Trfase_C_sf
IPR040079 Glutathione_S-Trfase
IPR033468 Metaxin_GST
IPR019564 Sam37/metaxin_N
PfamiView protein in Pfam
PF17171 GST_C_6, 1 hit
PF10568 Tom37, 1 hit
SFLDiSFLDS00019 Glutathione_Transferase_(cytos, 1 hit
SUPFAMiSSF47616 SSF47616, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMTX2_HUMAN
AccessioniPrimary (citable) accession number: O75431
Secondary accession number(s): A8JZZ4
, Q53S50, Q53SQ2, Q5M7Z6, Q8IZ68
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: November 1, 1998
Last modified: November 7, 2018
This is version 155 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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