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Protein

Leucine-rich repeat and calponin homology domain-containing protein 4

Gene

LRCH4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Biological processi

  • nervous system development Source: ProtInc

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat and calponin homology domain-containing protein 4
Alternative name(s):
Leucine-rich repeat neuronal protein 4
Short name:
Leucine-rich neuronal protein
Gene namesi
Name:LRCH4
Synonyms:LRN, LRRN1, LRRN4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000077454.15
HGNCiHGNC:6691 LRCH4
neXtProtiNX_O75427

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000077454
PharmGKBiPA30467

Polymorphism and mutation databases

BioMutaiLRCH4

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000844801 – 683Leucine-rich repeat and calponin homology domain-containing protein 4Add BLAST683

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei279PhosphoserineBy similarity1
Modified residuei281PhosphoserineBy similarity1
Modified residuei304PhosphoserineCombined sources1
Modified residuei307PhosphoserineCombined sources1
Modified residuei309PhosphoserineCombined sources1
Modified residuei313PhosphoserineBy similarity1
Modified residuei432PhosphoserineCombined sources1
Modified residuei457PhosphoserineCombined sources1
Modified residuei511PhosphoserineCombined sources1
Modified residuei513PhosphoserineCombined sources1
Modified residuei517PhosphoserineCombined sources1
Modified residuei521PhosphoserineCombined sources1
Modified residuei589PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO75427
MaxQBiO75427
PaxDbiO75427
PeptideAtlasiO75427
PRIDEiO75427
ProteomicsDBi50000

PTM databases

iPTMnetiO75427
PhosphoSitePlusiO75427

Miscellaneous databases

PMAP-CutDBiO75427

Expressioni

Gene expression databases

BgeeiENSG00000077454 Expressed in 86 organ(s), highest expression level in left lobe of thyroid gland
CleanExiHS_LRCH4
HS_LRRN1
HS_LRRN4
ExpressionAtlasiO75427 baseline and differential
GenevisibleiO75427 HS

Organism-specific databases

HPAiHPA037667
HPA037668

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi110214, 16 interactors
IntActiO75427, 18 interactors
STRINGi9606.ENSP00000309689

Structurei

3D structure databases

ProteinModelPortaliO75427
SMRiO75427
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati43 – 64LRR 1Add BLAST22
Repeati69 – 90LRR 2Add BLAST22
Repeati92 – 114LRR 3Add BLAST23
Repeati115 – 136LRR 4Add BLAST22
Repeati137 – 158LRR 5Add BLAST22
Repeati160 – 182LRR 6Add BLAST23
Repeati183 – 205LRR 7Add BLAST23
Repeati206 – 226LRR 8Add BLAST21
Repeati228 – 249LRR 9Add BLAST22
Domaini534 – 647Calponin-homology (CH)PROSITE-ProRule annotationAdd BLAST114

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiKOG0532 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00930000150841
HOGENOMiHOG000049055
HOVERGENiHBG052350
InParanoidiO75427
OMAiVWGAPRK
OrthoDBiEOG091G05CB
PhylomeDBiO75427
TreeFamiTF318428

Family and domain databases

CDDicd00014 CH, 1 hit
Gene3Di1.10.418.10, 1 hit
3.80.10.10, 2 hits
InterProiView protein in InterPro
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
PfamiView protein in Pfam
PF00307 CH, 1 hit
PF13855 LRR_8, 2 hits
SMARTiView protein in SMART
SM00033 CH, 1 hit
SM00369 LRR_TYP, 5 hits
SUPFAMiSSF47576 SSF47576, 1 hit
PROSITEiView protein in PROSITE
PS50021 CH, 1 hit
PS51450 LRR, 7 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

O75427-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAAVAAPLA AGGEEAAATT SVPGSPGLPG RRSAERALEE AVATGTLNLS
60 70 80 90 100
NRRLKHFPRG AARSYDLSDI TQADLSRNRF PEVPEAACQL VSLEGLSLYH
110 120 130 140 150
NCLRCLNPAL GNLTALTYLN LSRNQLSLLP PYICQLPLRV LIVSNNKLGA
160 170 180 190 200
LPPDIGTLGS LRQLDVSSNE LQSLPSELCG LSSLRDLNVR RNQLSTLPEE
210 220 230 240 250
LGDLPLVRLD FSCNRVSRIP VSFCRLRHLQ VILLDSNPLQ SPPAQVCLKG
260 270 280 290 300
KLHIFKYLST EAGQRGSALG DLAPSRPPSF SPCPAEDLFP GHRYDGGLDS
310 320 330 340 350
GFHSVDSGSK RWSGNESTDE FSELSFRISE LAREPRGPRE RKEDGSADGD
360 370 380 390 400
PVQIDFIDSH VPGEDEERGT VEEQRPPELS PGAGDRERAP SSRREEPAGE
410 420 430 440 450
ERRRPDTLQL WQERERRQQQ QSGAWGAPRK DSLLKPGLRA VVGGAAAVST
460 470 480 490 500
QAMHNGSPKS SASQAGAAAG QGAPAPAPAS QEPLPIAGPA TAPAPRPLGS
510 520 530 540 550
IQRPNSFLFR SSSQSGSGPS SPDSVLRPRR YPQVPDEKDL MTQLRQVLES
560 570 580 590 600
RLQRPLPEDL AEALASGVIL CQLANQLRPR SVPFIHVPSP AVPKLSALKA
610 620 630 640 650
RKNVESFLEA CRKMGVPEAD LCSPSDLLQG TARGLRTALE AVKRVGGKAL
660 670 680
PPLWPPSGLG GFVVFYVVLM LLLYVTYTRL LGS
Length:683
Mass (Da):73,450
Last modified:June 21, 2004 - v2
Checksum:iAF297AA30E4DA353
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JYK0C9JYK0_HUMAN
Leucine-rich repeat and calponin ho...
LRCH4
231Annotation score:
A0A087X197A0A087X197_HUMAN
Leucine-rich repeat and calponin ho...
LRCH4
142Annotation score:
H7C5D9H7C5D9_HUMAN
Leucine-rich repeat and calponin ho...
LRCH4
177Annotation score:

Sequence cautioni

The sequence AAC78793 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti40E → D in AAC78793 (PubMed:9799793).Curated1
Sequence conflicti391S → N in AAC78793 (PubMed:9799793).Curated1
Sequence conflicti467 – 473AAAGQGA → GCSGAGS in AAC78793 (PubMed:9799793).Curated7
Sequence conflicti682 – 683GS → DP (PubMed:9799793).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_051135642V → M1 PublicationCorresponds to variant dbSNP:rs3197597Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF053356 Genomic DNA Translation: AAC78793.1 Sequence problems.
CH236956 Genomic DNA Translation: EAL23828.1
BC007634 mRNA Translation: AAH07634.1
BC018529 mRNA Translation: AAH18529.3
CCDSiCCDS34706.1
RefSeqiNP_001276863.1, NM_001289934.1
NP_002310.2, NM_002319.4
UniGeneiHs.125742

Genome annotation databases

EnsembliENST00000310300; ENSP00000309689; ENSG00000077454
GeneIDi4034
KEGGihsa:4034
UCSCiuc003uvj.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF053356 Genomic DNA Translation: AAC78793.1 Sequence problems.
CH236956 Genomic DNA Translation: EAL23828.1
BC007634 mRNA Translation: AAH07634.1
BC018529 mRNA Translation: AAH18529.3
CCDSiCCDS34706.1
RefSeqiNP_001276863.1, NM_001289934.1
NP_002310.2, NM_002319.4
UniGeneiHs.125742

3D structure databases

ProteinModelPortaliO75427
SMRiO75427
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110214, 16 interactors
IntActiO75427, 18 interactors
STRINGi9606.ENSP00000309689

PTM databases

iPTMnetiO75427
PhosphoSitePlusiO75427

Polymorphism and mutation databases

BioMutaiLRCH4

Proteomic databases

EPDiO75427
MaxQBiO75427
PaxDbiO75427
PeptideAtlasiO75427
PRIDEiO75427
ProteomicsDBi50000

Protocols and materials databases

DNASUi4034
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000310300; ENSP00000309689; ENSG00000077454
GeneIDi4034
KEGGihsa:4034
UCSCiuc003uvj.4 human

Organism-specific databases

CTDi4034
EuPathDBiHostDB:ENSG00000077454.15
GeneCardsiLRCH4
HGNCiHGNC:6691 LRCH4
HPAiHPA037667
HPA037668
neXtProtiNX_O75427
OpenTargetsiENSG00000077454
PharmGKBiPA30467
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0532 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00930000150841
HOGENOMiHOG000049055
HOVERGENiHBG052350
InParanoidiO75427
OMAiVWGAPRK
OrthoDBiEOG091G05CB
PhylomeDBiO75427
TreeFamiTF318428

Miscellaneous databases

ChiTaRSiLRCH4 human
GeneWikiiLRCH4
GenomeRNAii4034
PMAP-CutDBiO75427
PROiPR:O75427

Gene expression databases

BgeeiENSG00000077454 Expressed in 86 organ(s), highest expression level in left lobe of thyroid gland
CleanExiHS_LRCH4
HS_LRRN1
HS_LRRN4
ExpressionAtlasiO75427 baseline and differential
GenevisibleiO75427 HS

Family and domain databases

CDDicd00014 CH, 1 hit
Gene3Di1.10.418.10, 1 hit
3.80.10.10, 2 hits
InterProiView protein in InterPro
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
PfamiView protein in Pfam
PF00307 CH, 1 hit
PF13855 LRR_8, 2 hits
SMARTiView protein in SMART
SM00033 CH, 1 hit
SM00369 LRR_TYP, 5 hits
SUPFAMiSSF47576 SSF47576, 1 hit
PROSITEiView protein in PROSITE
PS50021 CH, 1 hit
PS51450 LRR, 7 hits
ProtoNetiSearch...

Entry informationi

Entry nameiLRCH4_HUMAN
AccessioniPrimary (citable) accession number: O75427
Secondary accession number(s): A4D2D5, Q8WV85, Q96ID0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 21, 2004
Last sequence update: June 21, 2004
Last modified: November 7, 2018
This is version 155 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
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