UniProtKB - O75426 (FBX24_HUMAN)
Protein
F-box only protein 24
Gene
FBXO24
Organism
Homo sapiens (Human)
Status
Functioni
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.By similarity
GO - Molecular functioni
- ubiquitin-protein transferase activity Source: UniProtKB
GO - Biological processi
- protein ubiquitination Source: UniProtKB
Keywordsi
Biological process | Ubl conjugation pathway |
Enzyme and pathway databases
PathwayCommonsi | O75426 |
Names & Taxonomyi
Protein namesi | Recommended name: F-box only protein 24 |
Gene namesi | Name:FBXO24 Synonyms:FBX24 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:13595, FBXO24 |
MIMi | 609097, gene |
neXtProti | NX_O75426 |
VEuPathDBi | HostDB:ENSG00000106336.12 |
Subcellular locationi
Other locations
- ubiquitin ligase complex Source: UniProtKB
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 26261 |
OpenTargetsi | ENSG00000106336 |
PharmGKBi | PA28037 |
Miscellaneous databases
Pharosi | O75426, Tdark |
Genetic variation databases
BioMutai | FBXO24 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000119909 | 1 – 580 | F-box only protein 24Add BLAST | 580 |
Proteomic databases
MassIVEi | O75426 |
PaxDbi | O75426 |
PeptideAtlasi | O75426 |
PRIDEi | O75426 |
ProteomicsDBi | 49996 [O75426-1] 49997 [O75426-2] 49998 [O75426-3] 49999 [O75426-4] |
PTM databases
iPTMneti | O75426 |
PhosphoSitePlusi | O75426 |
Expressioni
Gene expression databases
Bgeei | ENSG00000106336, Expressed in right testis and 144 other tissues |
ExpressionAtlasi | O75426, baseline and differential |
Genevisiblei | O75426, HS |
Organism-specific databases
HPAi | ENSG00000106336, Tissue enriched (testis) |
Interactioni
Subunit structurei
Directly interacts with SKP1 and CUL1.
By similarityBinary interactionsi
Hide detailsO75426
With | #Exp. | IntAct |
---|---|---|
HSP90AB1 [P08238] | 2 | EBI-6425658,EBI-352572 |
NUDCD2 [Q8WVJ2] | 2 | EBI-6425658,EBI-1052153 |
Protein-protein interaction databases
BioGRIDi | 117647, 8 interactors |
IntActi | O75426, 16 interactors |
STRINGi | 9606.ENSP00000416558 |
Miscellaneous databases
RNActi | O75426, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 36 – 82 | F-boxPROSITE-ProRule annotationAdd BLAST | 47 | |
Repeati | 376 – 425 | RCC1Add BLAST | 50 |
Phylogenomic databases
eggNOGi | KOG0274, Eukaryota |
GeneTreei | ENSGT00390000017455 |
HOGENOMi | CLU_032821_0_0_1 |
InParanoidi | O75426 |
OMAi | SCCLPHL |
OrthoDBi | 379673at2759 |
PhylomeDBi | O75426 |
TreeFami | TF328722 |
Family and domain databases
Gene3Di | 2.130.10.30, 1 hit |
InterProi | View protein in InterPro IPR036047, F-box-like_dom_sf IPR001810, F-box_dom IPR009091, RCC1/BLIP-II IPR000408, Reg_chr_condens |
Pfami | View protein in Pfam PF12937, F-box-like, 1 hit PF00415, RCC1, 1 hit |
SMARTi | View protein in SMART SM00256, FBOX, 1 hit |
SUPFAMi | SSF50985, SSF50985, 1 hit SSF81383, SSF81383, 1 hit |
PROSITEi | View protein in PROSITE PS50181, FBOX, 1 hit PS50012, RCC1_3, 1 hit |
s (4+)i Sequence
Sequence statusi: Complete.
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: O75426-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MGEKAVPLLR RRRVKRSCPS CGSELGVEEK RGKGNPISIQ LFPPELVEHI
60 70 80 90 100
ISFLPVRDLV ALGQTCRYFH EVCDGEGVWR RICRRLSPRL QDQGSGVRPW
110 120 130 140 150
KRAAILNYTK GLYFQAFGGR RRCLSKSVAP LLAHGYRRFL PTKDHVFILD
160 170 180 190 200
YVGTLFFLKN ALVSTLGQMQ WKRACRYVVL CRGAKDFASD PRCDTVYRKY
210 220 230 240 250
LYVLATREPQ EVVGTTSSRA CDCVEVYLQS SGQRVFKMTF HHSMTFKQIV
260 270 280 290 300
LVGQETQRAL LLLTEEGKIY SLVVNETQLD QPRSYTVQLA LRKVSHYLPH
310 320 330 340 350
LRVACMTSNQ SSTLYVTDQG GVYFEVHTPG VYRDLFGTLQ AFDPLDQQMP
360 370 380 390 400
LALSLPAKIL FCALGYNHLG LVDEFGRIFM QGNNRYGQLG TGDKMDRGEP
410 420 430 440 450
TQVCYLQRPI TLWCGLNHSL VLSQSSEFSK ELLGCGCGAG GRLPGWPKGS
460 470 480 490 500
ASFVKLQVKV PLCACALCAT RECLYILSSH DIEQHAPYRH LPASRVVGTP
510 520 530 540 550
EPSLGARAPQ DPGGMAQACE EYLSQIHSCQ TLQDRTEKMK EIVGWMPLMA
560 570 580
AQKDFFWEAL DMLQRAEGGG GGVGPPAPET
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketC9K0U2 | C9K0U2_HUMAN | F-box only protein 24 | FBXO24 | 130 | Annotation score: | ||
C9J4S8 | C9J4S8_HUMAN | F-box only protein 24 | FBXO24 | 187 | Annotation score: | ||
F8WC52 | F8WC52_HUMAN | F-box only protein 24 | FBXO24 | 37 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_049042 | 302 | R → H. Corresponds to variant dbSNP:rs7801492Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_043458 | 1 – 13 | MGEKA…LRRRR → M in isoform 4. 1 PublicationAdd BLAST | 13 | |
Alternative sequenceiVSP_043459 | 1 – 12 | MGEKA…LLRRR → MVWESQQERGGQGPRRQEGR SREGAIRMVRGSQRRKLQKF TRLCGREEGL in isoform 3. 1 PublicationAdd BLAST | 12 | |
Alternative sequenceiVSP_011351 | 94 – 108 | GSGVR…AILNY → D in isoform 2. 1 PublicationAdd BLAST | 15 | |
Alternative sequenceiVSP_011352 | 319 – 332 | QGGVY…TPGVY → PILCSWLQPPWPGG in isoform 2. 1 PublicationAdd BLAST | 14 | |
Alternative sequenceiVSP_011353 | 333 – 580 | Missing in isoform 2. 1 PublicationAdd BLAST | 248 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF174604 mRNA Translation: AAF04525.1 AF053356 Genomic DNA Translation: AAC78801.1 AL136811 mRNA Translation: CAB66745.1 AK301864 mRNA Translation: BAG63303.1 AK302252 mRNA Translation: BAG63604.1 AC069281 Genomic DNA Translation: AAP21862.1 AC069281 Genomic DNA Translation: AAP21863.1 CH236956 Genomic DNA Translation: EAL23827.1 CH471091 Genomic DNA Translation: EAW76517.1 BC067293 mRNA Translation: AAH67293.1 |
CCDSi | CCDS55138.1 [O75426-4] CCDS5698.1 [O75426-1] CCDS5699.2 [O75426-3] |
RefSeqi | NP_001156971.1, NM_001163499.1 [O75426-4] NP_036304.2, NM_012172.4 [O75426-3] NP_277041.1, NM_033506.2 [O75426-1] |
Genome annotation databases
Ensembli | ENST00000241071; ENSP00000241071; ENSG00000106336 [O75426-1] ENST00000427939; ENSP00000416558; ENSG00000106336 [O75426-3] ENST00000465843; ENSP00000419602; ENSG00000106336 [O75426-2] ENST00000468962; ENSP00000420239; ENSG00000106336 [O75426-4] |
GeneIDi | 26261 |
KEGGi | hsa:26261 |
UCSCi | uc003uvl.2, human [O75426-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF174604 mRNA Translation: AAF04525.1 AF053356 Genomic DNA Translation: AAC78801.1 AL136811 mRNA Translation: CAB66745.1 AK301864 mRNA Translation: BAG63303.1 AK302252 mRNA Translation: BAG63604.1 AC069281 Genomic DNA Translation: AAP21862.1 AC069281 Genomic DNA Translation: AAP21863.1 CH236956 Genomic DNA Translation: EAL23827.1 CH471091 Genomic DNA Translation: EAW76517.1 BC067293 mRNA Translation: AAH67293.1 |
CCDSi | CCDS55138.1 [O75426-4] CCDS5698.1 [O75426-1] CCDS5699.2 [O75426-3] |
RefSeqi | NP_001156971.1, NM_001163499.1 [O75426-4] NP_036304.2, NM_012172.4 [O75426-3] NP_277041.1, NM_033506.2 [O75426-1] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 117647, 8 interactors |
IntActi | O75426, 16 interactors |
STRINGi | 9606.ENSP00000416558 |
PTM databases
iPTMneti | O75426 |
PhosphoSitePlusi | O75426 |
Genetic variation databases
BioMutai | FBXO24 |
Proteomic databases
MassIVEi | O75426 |
PaxDbi | O75426 |
PeptideAtlasi | O75426 |
PRIDEi | O75426 |
ProteomicsDBi | 49996 [O75426-1] 49997 [O75426-2] 49998 [O75426-3] 49999 [O75426-4] |
Protocols and materials databases
Antibodypediai | 30754, 220 antibodies |
Genome annotation databases
Ensembli | ENST00000241071; ENSP00000241071; ENSG00000106336 [O75426-1] ENST00000427939; ENSP00000416558; ENSG00000106336 [O75426-3] ENST00000465843; ENSP00000419602; ENSG00000106336 [O75426-2] ENST00000468962; ENSP00000420239; ENSG00000106336 [O75426-4] |
GeneIDi | 26261 |
KEGGi | hsa:26261 |
UCSCi | uc003uvl.2, human [O75426-1] |
Organism-specific databases
CTDi | 26261 |
DisGeNETi | 26261 |
GeneCardsi | FBXO24 |
HGNCi | HGNC:13595, FBXO24 |
HPAi | ENSG00000106336, Tissue enriched (testis) |
MIMi | 609097, gene |
neXtProti | NX_O75426 |
OpenTargetsi | ENSG00000106336 |
PharmGKBi | PA28037 |
VEuPathDBi | HostDB:ENSG00000106336.12 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0274, Eukaryota |
GeneTreei | ENSGT00390000017455 |
HOGENOMi | CLU_032821_0_0_1 |
InParanoidi | O75426 |
OMAi | SCCLPHL |
OrthoDBi | 379673at2759 |
PhylomeDBi | O75426 |
TreeFami | TF328722 |
Enzyme and pathway databases
PathwayCommonsi | O75426 |
Miscellaneous databases
BioGRID-ORCSi | 26261, 6 hits in 875 CRISPR screens |
ChiTaRSi | FBXO24, human |
GenomeRNAii | 26261 |
Pharosi | O75426, Tdark |
PROi | PR:O75426 |
RNActi | O75426, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000106336, Expressed in right testis and 144 other tissues |
ExpressionAtlasi | O75426, baseline and differential |
Genevisiblei | O75426, HS |
Family and domain databases
Gene3Di | 2.130.10.30, 1 hit |
InterProi | View protein in InterPro IPR036047, F-box-like_dom_sf IPR001810, F-box_dom IPR009091, RCC1/BLIP-II IPR000408, Reg_chr_condens |
Pfami | View protein in Pfam PF12937, F-box-like, 1 hit PF00415, RCC1, 1 hit |
SMARTi | View protein in SMART SM00256, FBOX, 1 hit |
SUPFAMi | SSF50985, SSF50985, 1 hit SSF81383, SSF81383, 1 hit |
PROSITEi | View protein in PROSITE PS50181, FBOX, 1 hit PS50012, RCC1_3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | FBX24_HUMAN | |
Accessioni | O75426Primary (citable) accession number: O75426 Secondary accession number(s): A4D2D4 Q9H0G1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 21, 2001 |
Last sequence update: | August 16, 2004 | |
Last modified: | February 10, 2021 | |
This is version 160 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot