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Protein

Motile sperm domain-containing protein 3

Gene

MOSPD3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Motile sperm domain-containing protein 3
Gene namesi
Name:MOSPD3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000106330.11
HGNCiHGNC:25078 MOSPD3
MIMi609125 gene
neXtProtiNX_O75425

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei180 – 200HelicalSequence analysisAdd BLAST21
Transmembranei213 – 233HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi64598
OpenTargetsiENSG00000106330
PharmGKBiPA134865874

Polymorphism and mutation databases

BioMutaiMOSPD3

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002134651 – 235Motile sperm domain-containing protein 3Add BLAST235

Proteomic databases

MaxQBiO75425
PaxDbiO75425
PeptideAtlasiO75425
PRIDEiO75425
ProteomicsDBi49993
49994 [O75425-2]
49995 [O75425-3]

PTM databases

iPTMnetiO75425
PhosphoSitePlusiO75425

Expressioni

Gene expression databases

BgeeiENSG00000106330 Expressed in 219 organ(s), highest expression level in right testis
CleanExiHS_MOSPD3
ExpressionAtlasiO75425 baseline and differential
GenevisibleiO75425 HS

Organism-specific databases

HPAiHPA041137
HPA048240

Interactioni

Protein-protein interaction databases

IntActiO75425, 11 interactors
STRINGi9606.ENSP00000223054

Structurei

3D structure databases

ProteinModelPortaliO75425
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini33 – 145MSPPROSITE-ProRule annotationAdd BLAST113

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0439 Eukaryota
COG5066 LUCA
GeneTreeiENSGT00390000013613
HOGENOMiHOG000008144
HOVERGENiHBG053141
InParanoidiO75425
OMAiPENPHPQ
OrthoDBiEOG091G0YPX
PhylomeDBiO75425
TreeFamiTF319778

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR013783 Ig-like_fold
IPR000535 MSP_dom
IPR008962 PapD-like_sf
IPR016763 VAP
PANTHERiPTHR10809 PTHR10809, 1 hit
PfamiView protein in Pfam
PF00635 Motile_Sperm, 1 hit
SUPFAMiSSF49354 SSF49354, 1 hit
PROSITEiView protein in PROSITE
PS50202 MSP, 1 hit

Sequences (4+)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O75425-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRRGAPQDQE LVGPGPPGRG SRGAPPPLGP VVPVLVFPPD LVFRADQRSG
60 70 80 90 100
PRQLLTLYNP TGTALRFRVL CTAPAKYTVF DAEGYVKPQS CIDIVIRHVA
110 120 130 140 150
PIPSHYDVQD RFRIELSEEG AEGRVVGRKD ITSILRAPAY PLELQGQPDP
160 170 180 190 200
APRPGPPAGT PPPTARHFQE HPRQQLATSS FLLFLLTGIV SVAFLLLPLP
210 220 230
DELGSQLPQV LHVSLGQKLV AAYVLGLLTM VFLRT
Length:235
Mass (Da):25,519
Last modified:November 1, 1998 - v1
Checksum:i405D69B8309C4FAF
GO
Isoform 2 (identifier: O75425-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-23: MRRGAPQDQELVGPGPPGRGSRG → MSDRPEPAC

Note: Gene prediction confirmed by EST data.
Show »
Length:221
Mass (Da):24,148
Checksum:i3E09D222B8C831B1
GO
Isoform 3 (identifier: O75425-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-53: Missing.
     54-68: LLTLYNPTGTALRFR → MTHMAGLVCVCLYPP

Note: Gene prediction confirmed by EST data.
Show »
Length:182
Mass (Da):19,855
Checksum:i539793EA583AD1A3
GO
Isoform 4 (identifier: O75425-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     95-104: Missing.

Note: Gene prediction confirmed by EST data.
Show »
Length:225
Mass (Da):24,448
Checksum:i7752A894A9D387A1
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9J3M4C9J3M4_HUMAN
Motile sperm domain-containing prot...
MOSPD3
225Annotation score:
F8WF07F8WF07_HUMAN
Motile sperm domain-containing prot...
MOSPD3
69Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0140541 – 53Missing in isoform 3. CuratedAdd BLAST53
Alternative sequenceiVSP_0140531 – 23MRRGA…RGSRG → MSDRPEPAC in isoform 2. CuratedAdd BLAST23
Alternative sequenceiVSP_01405554 – 68LLTLY…ALRFR → MTHMAGLVCVCLYPP in isoform 3. CuratedAdd BLAST15
Alternative sequenceiVSP_04452295 – 104Missing in isoform 4. 1 Publication10

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF053356 Genomic DNA Translation: AAC78797.1
AF053356 Genomic DNA Translation: AAC78798.1
AF053356 Genomic DNA Translation: AAC78799.1
AC099394 Genomic DNA No translation available.
CH236956 Genomic DNA Translation: EAL23824.1
CH471091 Genomic DNA Translation: EAW76511.1
CH471091 Genomic DNA Translation: EAW76512.1
CH471091 Genomic DNA Translation: EAW76513.1
BC005042 mRNA Translation: AAH05042.1
BC011653 mRNA Translation: AAH11653.1
BC028475 mRNA No translation available.
CCDSiCCDS47662.1 [O75425-4]
CCDS5701.1 [O75425-1]
RefSeqiNP_001035186.1, NM_001040097.1 [O75425-1]
NP_001035187.1, NM_001040098.1 [O75425-1]
NP_001035188.1, NM_001040099.1 [O75425-4]
NP_076438.1, NM_023948.4 [O75425-1]
XP_005250586.1, XM_005250529.4
XP_005250588.1, XM_005250531.3
UniGeneiHs.521086

Genome annotation databases

EnsembliENST00000223054; ENSP00000223054; ENSG00000106330 [O75425-1]
ENST00000379527; ENSP00000368842; ENSG00000106330 [O75425-1]
ENST00000393950; ENSP00000377522; ENSG00000106330 [O75425-1]
ENST00000424091; ENSP00000404626; ENSG00000106330 [O75425-4]
GeneIDi64598
KEGGihsa:64598
UCSCiuc003uvq.4 human [O75425-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF053356 Genomic DNA Translation: AAC78797.1
AF053356 Genomic DNA Translation: AAC78798.1
AF053356 Genomic DNA Translation: AAC78799.1
AC099394 Genomic DNA No translation available.
CH236956 Genomic DNA Translation: EAL23824.1
CH471091 Genomic DNA Translation: EAW76511.1
CH471091 Genomic DNA Translation: EAW76512.1
CH471091 Genomic DNA Translation: EAW76513.1
BC005042 mRNA Translation: AAH05042.1
BC011653 mRNA Translation: AAH11653.1
BC028475 mRNA No translation available.
CCDSiCCDS47662.1 [O75425-4]
CCDS5701.1 [O75425-1]
RefSeqiNP_001035186.1, NM_001040097.1 [O75425-1]
NP_001035187.1, NM_001040098.1 [O75425-1]
NP_001035188.1, NM_001040099.1 [O75425-4]
NP_076438.1, NM_023948.4 [O75425-1]
XP_005250586.1, XM_005250529.4
XP_005250588.1, XM_005250531.3
UniGeneiHs.521086

3D structure databases

ProteinModelPortaliO75425
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO75425, 11 interactors
STRINGi9606.ENSP00000223054

PTM databases

iPTMnetiO75425
PhosphoSitePlusiO75425

Polymorphism and mutation databases

BioMutaiMOSPD3

Proteomic databases

MaxQBiO75425
PaxDbiO75425
PeptideAtlasiO75425
PRIDEiO75425
ProteomicsDBi49993
49994 [O75425-2]
49995 [O75425-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000223054; ENSP00000223054; ENSG00000106330 [O75425-1]
ENST00000379527; ENSP00000368842; ENSG00000106330 [O75425-1]
ENST00000393950; ENSP00000377522; ENSG00000106330 [O75425-1]
ENST00000424091; ENSP00000404626; ENSG00000106330 [O75425-4]
GeneIDi64598
KEGGihsa:64598
UCSCiuc003uvq.4 human [O75425-1]

Organism-specific databases

CTDi64598
DisGeNETi64598
EuPathDBiHostDB:ENSG00000106330.11
GeneCardsiMOSPD3
HGNCiHGNC:25078 MOSPD3
HPAiHPA041137
HPA048240
MIMi609125 gene
neXtProtiNX_O75425
OpenTargetsiENSG00000106330
PharmGKBiPA134865874
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0439 Eukaryota
COG5066 LUCA
GeneTreeiENSGT00390000013613
HOGENOMiHOG000008144
HOVERGENiHBG053141
InParanoidiO75425
OMAiPENPHPQ
OrthoDBiEOG091G0YPX
PhylomeDBiO75425
TreeFamiTF319778

Miscellaneous databases

ChiTaRSiMOSPD3 human
GenomeRNAii64598
PROiPR:O75425
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000106330 Expressed in 219 organ(s), highest expression level in right testis
CleanExiHS_MOSPD3
ExpressionAtlasiO75425 baseline and differential
GenevisibleiO75425 HS

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR013783 Ig-like_fold
IPR000535 MSP_dom
IPR008962 PapD-like_sf
IPR016763 VAP
PANTHERiPTHR10809 PTHR10809, 1 hit
PfamiView protein in Pfam
PF00635 Motile_Sperm, 1 hit
SUPFAMiSSF49354 SSF49354, 1 hit
PROSITEiView protein in PROSITE
PS50202 MSP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMSPD3_HUMAN
AccessioniPrimary (citable) accession number: O75425
Secondary accession number(s): A4D2D1
, A6NG17, C9JE89, D6W5W1, O75423, O75424
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: November 1, 1998
Last modified: November 7, 2018
This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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