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Entry version 140 (13 Feb 2019)
Sequence version 2 (12 Dec 2006)
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Protein

GRB10-interacting GYF protein 1

Gene

GIGYF1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May act cooperatively with GRB10 to regulate tyrosine kinase receptor signaling. May increase IGF1 receptor phosphorylation under IGF1 stimulation as well as phosphorylation of IRS1 and SHC1 (By similarity).By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
GRB10-interacting GYF protein 1
Alternative name(s):
PERQ amino acid-rich with GYF domain-containing protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GIGYF1
Synonyms:CDS2, PERQ1
ORF Names:PP3360
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000146830.9

Human Gene Nomenclature Database

More...
HGNCi
HGNC:9126 GIGYF1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
612064 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O75420

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
64599

Open Targets

More...
OpenTargetsi
ENSG00000146830

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162389554

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
GIGYF1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000583141 – 1035GRB10-interacting GYF protein 1Add BLAST1035

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei24PhosphoserineCombined sources1
Modified residuei28PhosphoserineCombined sources1
Modified residuei137PhosphoserineCombined sources1
Modified residuei157PhosphoserineCombined sources1
Modified residuei230PhosphoserineCombined sources1
Modified residuei341PhosphoserineBy similarity1
Modified residuei406PhosphoserineCombined sources1
Modified residuei538PhosphoserineCombined sources1
Modified residuei638PhosphoserineCombined sources1
Modified residuei862PhosphoserineCombined sources1

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
O75420

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
O75420

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O75420

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O75420

PeptideAtlas

More...
PeptideAtlasi
O75420

PRoteomics IDEntifications database

More...
PRIDEi
O75420

ProteomicsDB human proteome resource

More...
ProteomicsDBi
49992

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O75420

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O75420

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000146830 Expressed in 195 organ(s), highest expression level in left lobe of thyroid gland

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O75420 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA020999
HPA023995

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with GRB10. This transient binding is increased under IGF1 stimulation and leads to recruitment of GIGYF1/GRB10 complex to IGF1 receptor (By similarity).By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
122218, 94 interactors

Protein interaction database and analysis system

More...
IntActi
O75420, 44 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000275732

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11035
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5NVKX-ray2.90B/D/F/H33-103[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
O75420

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O75420

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini474 – 522GYFPROSITE-ProRule annotationAdd BLAST49

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi203 – 210Poly-Glu8
Compositional biasi266 – 271Poly-Gly6
Compositional biasi335 – 339Poly-Glu5
Compositional biasi548 – 617Gln-richAdd BLAST70
Compositional biasi596 – 602Poly-Pro7
Compositional biasi603 – 608Poly-Gln6
Compositional biasi969 – 975Poly-Gln7

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The GYF domain interacts with GRB10.By similarity

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the GIGYF family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1862 Eukaryota
ENOG4111AQ6 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159845

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000290720

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG082121

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O75420

KEGG Orthology (KO)

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KOi
K18730

Identification of Orthologs from Complete Genome Data

More...
OMAi
PLWGANG

Database of Orthologous Groups

More...
OrthoDBi
412069at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O75420

TreeFam database of animal gene trees

More...
TreeFami
TF325513

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00072 GYF, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.1490.40, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003169 GYF
IPR035445 GYF-like_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02213 GYF, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00444 GYF, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF55277 SSF55277, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50829 GYF, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O75420-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAETLNFGP EWLRALSGGG SVASPPPSPA MPKYKLADYR YGREEMLALY
60 70 80 90 100
VKENKVPEEL QDKEFAAVLQ DEPLQPLALE PLTEEEQRNF SLSVNSVAVL
110 120 130 140 150
RLMGKGAGPP LAGTSRGRGS TRSRGRGRGD SCFYQRSIEE GDGAFGRSPR
160 170 180 190 200
EIQRSQSWDD RGERRFEKSA RRDGARCGFE EGGAGPRKEH ARSDSENWRS
210 220 230 240 250
LREEQEEEEE GSWRLGAGPR RDGDRWRSAS PDGGPRSAGW REHGERRRKF
260 270 280 290 300
EFDLRGDRGG CGEEEGRGGG GSSHLRRCRA PEGFEEDKDG LPEWCLDDED
310 320 330 340 350
EEMGTFDASG AFLPLKKGPK EPIPEEQELD FQGLEEEEEP SEGLEEEGPE
360 370 380 390 400
AGGKELTPLP PQEEKSSSPS PLPTLGPLWG TNGDGDETAE KEPPAAEDDI
410 420 430 440 450
RGIQLSPGVG SSAGPPGDLE DDEGLKHLQQ EAEKLVASLQ DSSLEEEQFT
460 470 480 490 500
AAMQTQGLRH SAAATALPLS HGAARKWFYK DPQGEIQGPF TTQEMAEWFQ
510 520 530 540 550
AGYFSMSLLV KRGCDEGFQP LGEVIKMWGR VPFAPGPSPP PLLGNMDQER
560 570 580 590 600
LKKQQELAAA ALYQQLQHQQ FLQLVSSRQL PQCALREKAA LGDLTPPPPP
610 620 630 640 650
PPQQQQQQLT AFLQQLQALK PPRGGDQNLL PTMSRSLSVP DSGRLWDVHT
660 670 680 690 700
SASSQSGGEA SLWDIPINSS TQGPILEQLQ LQHKFQERRE VELRAKREEE
710 720 730 740 750
ERKRREEKRR QQQQEEQKRR QEEEELFRRK HVRQQELLLK LLQQQQAVPV
760 770 780 790 800
PPAPSSPPPL WAGLAKQGLS MKTLLELQLE GERQLHKQPP PREPARAQAP
810 820 830 840 850
NHRVQLGGLG TAPLNQWVSE AGPLWGGPDK SGGGSSGLGL WEDTPKSGGS
860 870 880 890 900
LVRGLGLKNS RSSPSLSDSY SHLSGRPIRK KTEEEEKLLK LLQGIPRPQD
910 920 930 940 950
GFTQWCEQML HTLSATGSLD VPMAVAILKE VESPYDVHDY IRSCLGDTLE
960 970 980 990 1000
AKEFAKQFLE RRAKQKASQQ RQQQQEAWLS SASLQTAFQA NHSTKLGPGE
1010 1020 1030
GSKAKRRALM LHSDPSILGY SLHGSSGEIE SVDDY
Length:1,035
Mass (Da):114,601
Last modified:December 12, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7DACB6F80EBEA7D0
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAC78792 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence AAL55738 differs from that shown. Reason: Frameshift at positions 784 and 856.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti729 – 730RK → DE in AAL55738 (PubMed:15498874).Curated2
Sequence conflicti835S → T in AAL55738 (PubMed:15498874).Curated1
Sequence conflicti851L → V in AAL55738 (PubMed:15498874).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF053356 Genomic DNA Translation: AAC78792.1 Sequence problems.
AY176044 mRNA Translation: AAO46888.1
AF289554 mRNA Translation: AAL55738.1 Frameshift.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS34708.1

NCBI Reference Sequences

More...
RefSeqi
NP_072096.2, NM_022574.4
XP_005250589.1, XM_005250532.1

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.414396

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000275732; ENSP00000275732; ENSG00000146830
ENST00000646601; ENSP00000494292; ENSG00000146830

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
64599

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:64599

UCSC genome browser

More...
UCSCi
uc003uwg.2 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF053356 Genomic DNA Translation: AAC78792.1 Sequence problems.
AY176044 mRNA Translation: AAO46888.1
AF289554 mRNA Translation: AAL55738.1 Frameshift.
CCDSiCCDS34708.1
RefSeqiNP_072096.2, NM_022574.4
XP_005250589.1, XM_005250532.1
UniGeneiHs.414396

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5NVKX-ray2.90B/D/F/H33-103[»]
ProteinModelPortaliO75420
SMRiO75420
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122218, 94 interactors
IntActiO75420, 44 interactors
STRINGi9606.ENSP00000275732

PTM databases

iPTMnetiO75420
PhosphoSitePlusiO75420

Polymorphism and mutation databases

BioMutaiGIGYF1

Proteomic databases

EPDiO75420
jPOSTiO75420
MaxQBiO75420
PaxDbiO75420
PeptideAtlasiO75420
PRIDEiO75420
ProteomicsDBi49992

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
64599
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000275732; ENSP00000275732; ENSG00000146830
ENST00000646601; ENSP00000494292; ENSG00000146830
GeneIDi64599
KEGGihsa:64599
UCSCiuc003uwg.2 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
64599
DisGeNETi64599
EuPathDBiHostDB:ENSG00000146830.9

GeneCards: human genes, protein and diseases

More...
GeneCardsi
GIGYF1
HGNCiHGNC:9126 GIGYF1
HPAiHPA020999
HPA023995
MIMi612064 gene
neXtProtiNX_O75420
OpenTargetsiENSG00000146830
PharmGKBiPA162389554

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1862 Eukaryota
ENOG4111AQ6 LUCA
GeneTreeiENSGT00940000159845
HOGENOMiHOG000290720
HOVERGENiHBG082121
InParanoidiO75420
KOiK18730
OMAiPLWGANG
OrthoDBi412069at2759
PhylomeDBiO75420
TreeFamiTF325513

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
GIGYF1 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
64599

Protein Ontology

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PROi
PR:O75420

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000146830 Expressed in 195 organ(s), highest expression level in left lobe of thyroid gland
GenevisibleiO75420 HS

Family and domain databases

CDDicd00072 GYF, 1 hit
Gene3Di3.30.1490.40, 1 hit
InterProiView protein in InterPro
IPR003169 GYF
IPR035445 GYF-like_dom_sf
PfamiView protein in Pfam
PF02213 GYF, 1 hit
SMARTiView protein in SMART
SM00444 GYF, 1 hit
SUPFAMiSSF55277 SSF55277, 1 hit
PROSITEiView protein in PROSITE
PS50829 GYF, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGGYF1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O75420
Secondary accession number(s): Q6Y7W7, Q8WZ38
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: December 12, 2006
Last modified: February 13, 2019
This is version 140 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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