UniProtKB - O75419 (CDC45_HUMAN)

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History
Entry version 161 (18 Jul 2018)
Sequence version 1 (01 Nov 1998)
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Protein

Cell division control protein 45 homolog

Gene

CDC45

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Required for initiation of chromosomal DNA replication.

GO - Molecular functionⁱ

3'-5' DNA helicase activity Source: GO_Central
chromatin binding Source: GO_Central
DNA replication origin binding Source: GO_Central
single-stranded DNA binding Source: GO_Central

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

DNA replication Source: Reactome
DNA replication checkpoint
Source: ProtInc
Traceable author statementⁱ
- 9660782
DNA replication initiation Source: GO_Central
double-strand break repair via break-induced replication Source: GO_Central
G1/S transition of mitotic cell cycle Source: Reactome
mitotic DNA replication preinitiation complex assembly Source: GO_Central
positive regulation of G1/S transition of mitotic cell cycle Source: GO_Central
pre-replicative complex assembly involved in nuclear cell cycle DNA replication Source: GO_Central
regulation of chromatin silencing at telomere Source: GO_Central
regulation of transcription involved in G1/S transition of mitotic cell cycle Source: Reactome

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Cell cycle, DNA replication

Biological process

Cell cycle, DNA replication

Enzyme and pathway databases

Reactomeⁱ	R-HSA-176187 Activation of ATR in response to replication stress R-HSA-176974 Unwinding of DNA R-HSA-539107 Activation of E2F1 target genes at G1/S R-HSA-68962 Activation of the pre-replicative complex

Reactomeⁱ

R-HSA-176187 Activation of ATR in response to replication stress
R-HSA-176974 Unwinding of DNA
R-HSA-539107 Activation of E2F1 target genes at G1/S
R-HSA-68962 Activation of the pre-replicative complex

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Cell division control protein 45 homolog Alternative name(s): PORC-PI-1
Gene namesⁱ	Name:CDC45 Synonyms:CDC45L, CDC45L2 ORF Names:UNQ374/PRO710
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 22

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000093009.9
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:1739 CDC45
MIMⁱ	603465 gene
neXtProtⁱ	NX_O75419

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	8318
MalaCards human disease database More...MalaCardsⁱ	CDC45
Open Targets More...OpenTargetsⁱ	ENSG00000093009
PharmGKBⁱ	PA371

Chemistry databases

ChEMBLⁱ	CHEMBL3040

ChEMBLⁱ

CHEMBL3040

Polymorphism and mutation databases

BioMutaⁱ	CDC45

BioMutaⁱ

CDC45

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000192815	1 – 566	Cell division control protein 45 homologAdd BLAST		566

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	130	PhosphotyrosineCombined sources	1
Modified residueⁱ	144	PhosphoserineCombined sources	1
Modified residueⁱ	148	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	O75419
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	O75419
PeptideAtlas More...PeptideAtlasⁱ	O75419
PRIDEⁱ	O75419
ProteomicsDBⁱ	49990 49991 [O75419-2]

PTM databases

iPTMnetⁱ	O75419
PhosphoSitePlusⁱ	O75419

Expressionⁱ

Tissue specificityⁱ

Widely expressed, highest levels are found in adult testis and thymus and in fetal liver.

Developmental stageⁱ

Transcript peaks at G1-S transition, but total protein remains constant throughout the cell cycle. Expressed in multiple tissues during embryogenesis, including neural crest-derived structures.

Gene expression databases

Bgeeⁱ	ENSG00000093009
CleanExⁱ	HS_CDC45L
ExpressionAtlasⁱ	O75419 baseline and differential
Genevisibleⁱ	O75419 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB009459 HPA000614

HPAⁱ

CAB009459
HPA000614

Interactionⁱ

Subunit structureⁱ

Associated with ORC2. Interacts with HELB (PubMed:25933514).1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
CDKN1A	P38936	2	EBI-374969,EBI-375077
CEP55	Q53EZ4	5	EBI-374969,EBI-747776
CLSPN	Q9HAW4	4	EBI-374969,EBI-1369377
MCM2	P49736	2	EBI-374969,EBI-374819
RPA2	P15927	4	EBI-374969,EBI-621404
TOPBP1	Q92547	6	EBI-374969,EBI-308302

Show more details

Protein-protein interaction databases

BioGridⁱ	113915, 45 interactors
Database of interacting proteins More...DIPⁱ	DIP-31725N
IntActⁱ	O75419, 35 interactors
Molecular INTeraction database More...MINTⁱ	O75419

Chemistry databases

BindingDBⁱ	O75419

BindingDBⁱ

O75419

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Show more details

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	6 – 10	Combined sources	5
Helixⁱ	11 – 14	Combined sources	4
Beta strandⁱ	17 – 26	Combined sources	10
Helixⁱ	27 – 42	Combined sources	16
Beta strandⁱ	46 – 54	Combined sources	9
Helixⁱ	55 – 65	Combined sources	11
Turnⁱ	66 – 68	Combined sources	3
Beta strandⁱ	70 – 78	Combined sources	9
Helixⁱ	83 – 87	Combined sources	5
Beta strandⁱ	94 – 98	Combined sources	5
Beta strandⁱ	101 – 103	Combined sources	3
Helixⁱ	106 – 110	Combined sources	5
Beta strandⁱ	113 – 117	Combined sources	5
Helixⁱ	130 – 133	Combined sources	4
Helixⁱ	165 – 189	Combined sources	25
Beta strandⁱ	192 – 194	Combined sources	3
Helixⁱ	198 – 208	Combined sources	11
Helixⁱ	214 – 229	Combined sources	16
Helixⁱ	235 – 255	Combined sources	21
Beta strandⁱ	269 – 277	Combined sources	9
Helixⁱ	281 – 283	Combined sources	3
Helixⁱ	286 – 292	Combined sources	7
Helixⁱ	294 – 299	Combined sources	6
Turnⁱ	300 – 303	Combined sources	4
Helixⁱ	305 – 318	Combined sources	14
Helixⁱ	322 – 326	Combined sources	5
Helixⁱ	329 – 331	Combined sources	3
Helixⁱ	334 – 350	Combined sources	17
Beta strandⁱ	356 – 366	Combined sources	11
Beta strandⁱ	369 – 372	Combined sources	4
Helixⁱ	373 – 384	Combined sources	12
Beta strandⁱ	389 – 391	Combined sources	3
Helixⁱ	393 – 403	Combined sources	11
Helixⁱ	410 – 435	Combined sources	26
Beta strandⁱ	443 – 449	Combined sources	7
Helixⁱ	457 – 459	Combined sources	3
Helixⁱ	463 – 480	Combined sources	18
Helixⁱ	486 – 488	Combined sources	3
Beta strandⁱ	491 – 498	Combined sources	8
Turnⁱ	499 – 502	Combined sources	4
Beta strandⁱ	503 – 509	Combined sources	7
Helixⁱ	522 – 531	Combined sources	10
Turnⁱ	532 – 534	Combined sources	3
Beta strandⁱ	541 – 543	Combined sources	3
Beta strandⁱ	546 – 550	Combined sources	5
Helixⁱ	551 – 553	Combined sources	3
Helixⁱ	554 – 565	Combined sources	12

3D structure databases

ProteinModelPortalⁱ	O75419
SMRⁱ	O75419
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the CDC45 family.Curated

Phylogenomic databases

Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000009662
HOGENOMⁱ	HOG000253949
HOVERGENⁱ	HBG050819
InParanoidⁱ	O75419
KEGG Orthology (KO) More...KOⁱ	K06628
OMAⁱ	PHKIQPV
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G05EU
PhylomeDBⁱ	O75419
TreeFamⁱ	TF101062

Family and domain databases

InterProⁱ	View protein in InterPro IPR003874 CDC45
PANTHERⁱ	PTHR10507 PTHR10507, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02724 CDC45, 1 hit

Sequences (3)ⁱ

Sequence statusⁱ: Complete.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket Added to basket

Isoform 1 (identifier: O75419-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFVSDFRKEF YEVVQSQRVL LFVASDVDAL CACKILQALF QCDHVQYTLV 
        60         70         80         90        100
PVSGWQELET AFLEHKEQFH YFILINCGAN VDLLDILQPD EDTIFFVCDT 
       110        120        130        140        150
HRPVNVVNVY NDTQIKLLIK QDDDLEVPAY EDIFRDEEED EEHSGNDSDG 
       160        170        180        190        200
SEPSEKRTRL EEEIVEQTMR RRQRREWEAR RRDILFDYEQ YEYHGTSSAM 
       210        220        230        240        250
VMFELAWMLS KDLNDMLWWA IVGLTDQWVQ DKITQMKYVT DVGVLQRHVS 
       260        270        280        290        300
RHNHRNEDEE NTLSVDCTRI SFEYDLRLVL YQHWSLHDSL CNTSYTAARF 
       310        320        330        340        350
KLWSVHGQKR LQEFLADMGL PLKQVKQKFQ AMDISLKENL REMIEESANK 
       360        370        380        390        400
FGMKDMRVQT FSIHFGFKHK FLASDVVFAT MSLMESPEKD GSGTDHFIQA 
       410        420        430        440        450
LDSLSRSNLD KLYHGLELAK KQLRATQQTI ASCLCTNLVI SQGPFLYCSL 
       460        470        480        490        500
MEGTPDVMLF SRPASLSLLS KHLLKSFVCS TKNRRCKLLP LVMAAPLSME 
       510        520        530        540        550
HGTVTVVGIP PETDSSDRKN FFGRAFEKAA ESTSSRMLHN HFDLSVIELK 
       560 
AEDRSKFLDA LISLLS

Length:566

Mass (Da):65,569

Last modified:November 1, 1998 - v1

Checksum:ⁱAE1BE2C8C8E5F867

Isoform 2 (identifier: O75419-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
68-113: Missing.

« Hide

        10         20         30         40         50
MFVSDFRKEF YEVVQSQRVL LFVASDVDAL CACKILQALF QCDHVQYTLV 
        60         70         80         90        100
PVSGWQELET AFLEHKEQIK LLIKQDDDLE VPAYEDIFRD EEEDEEHSGN 
       110        120        130        140        150
DSDGSEPSEK RTRLEEEIVE QTMRRRQRRE WEARRRDILF DYEQYEYHGT 
       160        170        180        190        200
SSAMVMFELA WMLSKDLNDM LWWAIVGLTD QWVQDKITQM KYVTDVGVLQ 
       210        220        230        240        250
RHVSRHNHRN EDEENTLSVD CTRISFEYDL RLVLYQHWSL HDSLCNTSYT 
       260        270        280        290        300
AARFKLWSVH GQKRLQEFLA DMGLPLKQVK QKFQAMDISL KENLREMIEE 
       310        320        330        340        350
SANKFGMKDM RVQTFSIHFG FKHKFLASDV VFATMSLMES PEKDGSGTDH 
       360        370        380        390        400
FIQALDSLSR SNLDKLYHGL ELAKKQLRAT QQTIASCLCT NLVISQGPFL 
       410        420        430        440        450
YCSLMEGTPD VMLFSRPASL SLLSKHLLKS FVCSTKNRRC KLLPLVMAAP 
       460        470        480        490        500
LSMEHGTVTV VGIPPETDSS DRKNFFGRAF EKAAESTSSR MLHNHFDLSV 
       510        520
IELKAEDRSK FLDALISLLS

Note: No experimental confirmation available.

Show »

Length:520

Mass (Da):60,245

Checksum:ⁱBE5CE1F95079C2E6

Isoform 3 (identifier: O75419-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
180-180: R → RSGSGSEPVAAALEKSSRLFAGPMSDRTAPRSP

« Hide

        10         20         30         40         50
MFVSDFRKEF YEVVQSQRVL LFVASDVDAL CACKILQALF QCDHVQYTLV 
        60         70         80         90        100
PVSGWQELET AFLEHKEQFH YFILINCGAN VDLLDILQPD EDTIFFVCDT 
       110        120        130        140        150
HRPVNVVNVY NDTQIKLLIK QDDDLEVPAY EDIFRDEEED EEHSGNDSDG 
       160        170        180        190        200
SEPSEKRTRL EEEIVEQTMR RRQRREWEAR SGSGSEPVAA ALEKSSRLFA 
       210        220        230        240        250
GPMSDRTAPR SPRRDILFDY EQYEYHGTSS AMVMFELAWM LSKDLNDMLW 
       260        270        280        290        300
WAIVGLTDQW VQDKITQMKY VTDVGVLQRH VSRHNHRNED EENTLSVDCT 
       310        320        330        340        350
RISFEYDLRL VLYQHWSLHD SLCNTSYTAA RFKLWSVHGQ KRLQEFLADM 
       360        370        380        390        400
GLPLKQVKQK FQAMDISLKE NLREMIEESA NKFGMKDMRV QTFSIHFGFK 
       410        420        430        440        450
HKFLASDVVF ATMSLMESPE KDGSGTDHFI QALDSLSRSN LDKLYHGLEL 
       460        470        480        490        500
AKKQLRATQQ TIASCLCTNL VISQGPFLYC SLMEGTPDVM LFSRPASLSL 
       510        520        530        540        550
LSKHLLKSFV CSTKNRRCKL LPLVMAAPLS MEHGTVTVVG IPPETDSSDR 
       560        570        580        590 
KNFFGRAFEK AAESTSSRML HNHFDLSVIE LKAEDRSKFL DALISLLS

Note: No experimental confirmation available.

Show »

Length:598

Mass (Da):68,768

Checksum:ⁱ2625590397EB6E6B

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	100	T → S in AAQ89330 (PubMed:12975309).Curated	1
Sequence conflictⁱ	115	I → V in CAA11530 (PubMed:9724329).Curated	1
Sequence conflictⁱ	346	E → Q in AAC67521 (PubMed:9755170).Curated	1
Sequence conflictⁱ	509	I → F in BAG56854 (PubMed:14702039).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_019286	81	V → I1 PublicationCorresponds to variant dbSNP:rs13447203Ensembl.	1
Natural variantⁱVAR_053026	356	M → R. Corresponds to variant dbSNP:rs17209274Ensembl.	1
Natural variantⁱVAR_019287	376	V → M1 PublicationCorresponds to variant dbSNP:rs13447263Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_043129	68 – 113	Missing in isoform 2. 1 PublicationAdd BLAST		46
Alternative sequenceⁱVSP_045411	180	R → RSGSGSEPVAAALEKSSRLF AGPMSDRTAPRSP in isoform 3. 1 Publication		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF062495 mRNA Translation: AAC67521.1 AF053074 mRNA Translation: AAC27289.1 AJ223728 mRNA Translation: CAA11530.1 AF081535 mRNA Translation: AAD08998.1 AY358971 mRNA Translation: AAQ89330.1 AK293123 mRNA Translation: BAG56675.1 AK293338 mRNA Translation: BAG56854.1 BT006792 mRNA Translation: AAP35438.1 AY572790 Genomic DNA Translation: AAS66985.1 CT841513 mRNA Translation: CAJ86443.1 AC000082 Genomic DNA No translation available. AC000087 Genomic DNA No translation available. AC000088 Genomic DNA No translation available. CH471176 Genomic DNA Translation: EAX03036.1 BC006232 mRNA Translation: AAH06232.1 BC010022 mRNA Translation: AAH10022.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS13762.1 [O75419-1] CCDS54499.1 [O75419-3] CCDS54500.1 [O75419-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_001171481.1, NM_001178010.2 [O75419-3] NP_001171482.1, NM_001178011.2 [O75419-2] NP_003495.1, NM_003504.4 [O75419-1] XP_005261342.1, XM_005261285.2 [O75419-3] XP_011528717.1, XM_011530415.1 [O75419-1] XP_011528720.1, XM_011530418.2 [O75419-2]
UniGeneⁱ	Hs.474217 Hs.742418

Genome annotation databases

Ensemblⁱ	ENST00000263201; ENSP00000263201; ENSG00000093009 [O75419-1] ENST00000404724; ENSP00000384978; ENSG00000093009 [O75419-2] ENST00000407835; ENSP00000385240; ENSG00000093009 [O75419-1] ENST00000437685; ENSP00000405726; ENSG00000093009 [O75419-3]
GeneIDⁱ	8318
KEGGⁱ	hsa:8318
UCSC genome browser More...UCSCⁱ	uc002zpr.5 human [O75419-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length
O75419	UPI000696475B		CHILA		594
CDC45-related protein		HETGA		583
UPI0004F0071A		PANPA		582
UPI0004F3F06E		PONAB		582
UPI000512535B		PANTR		582
+114
O75419-2	UPI0004F46A07		PONAB		536
UPI0006C9723A		PANPA		536
UPI00063FC15C		PROCO		525
Cell division cycle 45		CANLF		523
UPI000D185735		DESRO		523
+40
O75419-3	Cell division cycle 45		AILME		602
Cell division cycle 45		MACFA		598
Cell division cycle 45		MACMU		598
Cell division cycle 45		MACNE		598
Cell division cycle 45		COLAP		598
+21

Protein	Similar proteins		Species	Score	Length
O75419	UPI000696475B		CHILA		594
CDC45-related protein		HETGA		583
UPI000512535B		PANTR		582
UPI00053FEA9F		FUKDA		582
UPI0004F3F06E		PONAB		582
+444

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
5DGO	X-ray	2.10	A	1-566	[»]
ProteinModelPortalⁱ	O75419
SMRⁱ	O75419
ModBaseⁱ	Search...
MobiDBⁱ	Search...

BindingDBⁱ	O75419
ChEMBLⁱ	CHEMBL3040

BioMutaⁱ	CDC45

The DNASU plasmid repository More...DNASUⁱ	8318
Structural Biology Knowledgebase	Search...

CTDⁱ	8318
DisGeNET More...DisGeNETⁱ	8318
EuPathDBⁱ	HostDB:ENSG00000093009.9
GeneCardsⁱ	CDC45
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:1739 CDC45
Human Protein Atlas More...HPAⁱ	CAB009459 HPA000614
MalaCards human disease database More...MalaCardsⁱ	CDC45
MIMⁱ	603465 gene
neXtProtⁱ	NX_O75419
Open Targets More...OpenTargetsⁱ	ENSG00000093009
PharmGKBⁱ	PA371
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Reactomeⁱ	R-HSA-176187 Activation of ATR in response to replication stress R-HSA-176974 Unwinding of DNA R-HSA-539107 Activation of E2F1 target genes at G1/S R-HSA-68962 Activation of the pre-replicative complex

GeneWikiⁱ	CDC45-related_protein
GenomeRNAiⁱ	8318
Protein Ontology More...PROⁱ	PR:O75419
SOURCEⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CDC45_HUMAN
Accessionⁱ	O75419Primary (citable) accession number: O75419 Secondary accession number(s): B4DDB4 Q9UP68
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
	Last sequence update:	November 1, 1998
	Last modified:	July 18, 2018
	This is version 161 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

Human chromosome 22
Human chromosome 22: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
SIMILARITY comments
Index of protein domains and families

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UniRef

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Supporting data

UniProtKB - O75419 (CDC45_HUMAN)

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Cell division control protein 45 homolog

CDC45

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

Cytoskeleton

Nucleus

Other locations

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

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<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ