UniProtKB - O75417 (DPOLQ_HUMAN)
DNA polymerase theta
POLQ
Functioni
DNA polymerase that promotes microhomology-mediated end-joining (MMEJ), an alternative non-homologous end-joining (NHEJ) machinery triggered in response to double-strand breaks in DNA (PubMed:25642963, PubMed:25643323).
MMEJ is an error-prone repair pathway that produces deletions of sequences from the strand being repaired and promotes genomic rearrangements, such as telomere fusions, some of them leading to cellular transformation (PubMed:25642963, PubMed:25643323).
POLQ acts as an inhibitor of homology-recombination repair (HR) pathway by limiting RAD51 accumulation at resected ends (PubMed:25642963).
POLQ-mediated MMEJ may be required to promote the survival of cells with a compromised HR repair pathway, thereby preventing genomic havoc by resolving unrepaired lesions (By similarity).
The polymerase acts by binding directly the 2 ends of resected double-strand breaks, allowing microhomologous sequences in the overhangs to form base pairs. It then extends each strand from the base-paired region using the opposing overhang as a template. Requires partially resected DNA containing 2 to 6 base pairs of microhomology to perform MMEJ (PubMed:25643323).
The polymerase activity is highly promiscuous: unlike most polymerases, promotes extension of ssDNA and partial ssDNA (pssDNA) substrates (PubMed:18503084, PubMed:21050863, PubMed:22135286).
Also exhibits low-fidelity DNA synthesis, translesion synthesis and lyase activity, and it is implicated in interstrand-cross-link repair, base excision repair and DNA end-joining (PubMed:14576298, PubMed:18503084, PubMed:19188258, PubMed:24648516).
Involved in somatic hypermutation of immunoglobulin genes, a process that requires the activity of DNA polymerases to ultimately introduce mutations at both A/T and C/G base pairs (By similarity).
By similarity8 PublicationsCaution
Catalytic activityi
- EC:2.7.7.72 Publications
Kineticsi
- KM=1.095 µM for dATP:T1 Publication
- KM=0.622 µM for dATP: abasic site1 Publication
- KM=3.08 µM for dGTP: no template1 Publication
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 115 – 122 | ATPPROSITE-ProRule annotation | 8 |
GO - Molecular functioni
- 5'-deoxyribose-5-phosphate lyase activity Source: UniProtKB
- ATP binding Source: UniProtKB-KW
- chromatin binding Source: UniProtKB
- damaged DNA binding Source: ProtInc
- DNA-directed DNA polymerase activity Source: UniProtKB
- identical protein binding Source: IntAct
- single-stranded DNA helicase activity Source: UniProtKB
GO - Biological processi
- base-excision repair Source: UniProtKB
- cellular response to DNA damage stimulus Source: UniProtKB
- DNA-dependent DNA replication Source: InterPro
- DNA repair Source: ProtInc
- double-strand break repair Source: UniProtKB
- double-strand break repair via alternative nonhomologous end joining Source: UniProtKB
- negative regulation of double-strand break repair via homologous recombination Source: UniProtKB
- protein homooligomerization Source: UniProtKB
- somatic hypermutation of immunoglobulin genes Source: UniProtKB
Keywordsi
Molecular function | DNA-directed DNA polymerase, Nucleotidyltransferase, Transferase |
Biological process | DNA damage, DNA repair |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
PathwayCommonsi | O75417 |
Reactomei | R-HSA-5685939, HDR through MMEJ (alt-NHEJ) |
SABIO-RKi | O75417 |
SignaLinki | O75417 |
Names & Taxonomyi
Protein namesi | Recommended name: DNA polymerase theta2 PublicationsImported (EC:2.7.7.72 Publications)Alternative name(s): DNA polymerase eta1 Publication |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:9186, POLQ |
MIMi | 604419, gene |
neXtProti | NX_O75417 |
VEuPathDBi | HostDB:ENSG00000051341 |
Subcellular locationi
Nucleus
- Nucleus By similarity
Other locations
- Chromosome 1 Publication
Note: Enriched in chromatin in response to ultaviolet (UV) light (PubMed:25642963). Binds to chromatin during early G1 (PubMed:24989122).2 Publications
Cytosol
- cytosol Source: HPA
Golgi apparatus
- Golgi apparatus Source: HPA
Nucleus
- nucleoplasm Source: HPA
Other locations
- chromosome Source: UniProtKB-SubCell
Keywords - Cellular componenti
Chromosome, NucleusPathology & Biotechi
Involvement in diseasei
Breast cancer (BC)3 Publications
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 2540 – 2541 | DE → AA: Abolishes DNA polymerase activity. 2 Publications | 2 |
Organism-specific databases
DisGeNETi | 10721 |
MIMi | 114480, phenotype |
OpenTargetsi | ENSG00000051341 |
PharmGKBi | PA33506 |
Miscellaneous databases
Pharosi | O75417, Tbio |
Chemistry databases
ChEMBLi | CHEMBL6025 |
Genetic variation databases
BioMutai | POLQ |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000101279 | 1 – 2590 | DNA polymerase thetaAdd BLAST | 2590 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 990 | N6-acetyllysineCombined sources | 1 |
Keywords - PTMi
AcetylationProteomic databases
EPDi | O75417 |
jPOSTi | O75417 |
MassIVEi | O75417 |
MaxQBi | O75417 |
PaxDbi | O75417 |
PeptideAtlasi | O75417 |
PRIDEi | O75417 |
ProteomicsDBi | 49988 [O75417-1] 49989 [O75417-2] |
PTM databases
GlyGeni | O75417, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | O75417 |
PhosphoSitePlusi | O75417 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000051341, Expressed in secondary oocyte and 115 other tissues |
ExpressionAtlasi | O75417, baseline and differential |
Genevisiblei | O75417, HS |
Organism-specific databases
HPAi | ENSG00000051341, Tissue enhanced (bone marrow, lymphoid tissue) |
Interactioni
Subunit structurei
Binary interactionsi
POLQ - isoform 1 [O75417-1]
With | #Exp. | IntAct |
---|---|---|
itself | 5 | EBI-16141065,EBI-16141065 |
RAD51 [Q06609] | 3 | EBI-16141065,EBI-297202 |
GO - Molecular functioni
- identical protein binding Source: IntAct
Protein-protein interaction databases
BioGRIDi | 115946, 8 interactors |
DIPi | DIP-61500N |
IntActi | O75417, 3 interactors |
STRINGi | 9606.ENSP00000264233 |
Miscellaneous databases
RNActi | O75417, protein |
Structurei
Secondary structure
3D structure databases
SMRi | O75417 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 102 – 286 | Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST | 185 | |
Domaini | 321 – 554 | Helicase C-terminalPROSITE-ProRule annotationAdd BLAST | 234 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 33 | DisorderedSequence analysisAdd BLAST | 33 | |
Regioni | 847 – 894 | Interaction with RAD511 PublicationAdd BLAST | 48 | |
Regioni | 1034 – 1060 | DisorderedSequence analysisAdd BLAST | 27 | |
Regioni | 1594 – 1622 | DisorderedSequence analysisAdd BLAST | 29 | |
Regioni | 1777 – 1797 | DisorderedSequence analysisAdd BLAST | 21 | |
Regioni | 2142 – 2177 | Loop 11 PublicationAdd BLAST | 36 | |
Regioni | 2257 – 2322 | Loop 22 PublicationsAdd BLAST | 66 | |
Regioni | 2491 – 2535 | Loop 31 PublicationAdd BLAST | 45 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 1655 – 1716 | Sequence analysisAdd BLAST | 62 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 216 – 219 | DEAH box | 4 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 17 – 33 | Polar residuesSequence analysisAdd BLAST | 17 | |
Compositional biasi | 1594 – 1621 | Basic and acidic residuesSequence analysisAdd BLAST | 28 | |
Compositional biasi | 1782 – 1797 | Polar residuesSequence analysisAdd BLAST | 16 |
Domaini
Sequence similaritiesi
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | KOG0950, Eukaryota |
GeneTreei | ENSGT00940000158694 |
HOGENOMi | CLU_000818_0_1_1 |
InParanoidi | O75417 |
OrthoDBi | 179246at2759 |
PhylomeDBi | O75417 |
TreeFami | TF105018 |
Family and domain databases
Gene3Di | 3.30.420.10, 1 hit 3.40.50.300, 2 hits |
InterProi | View protein in InterPro IPR011545, DEAD/DEAH_box_helicase_dom IPR019760, DNA-dir_DNA_pol_A_CS IPR001098, DNA-dir_DNA_pol_A_palm_dom IPR043502, DNA/RNA_pol_sf IPR002298, DNA_polymerase_A IPR014001, Helicase_ATP-bd IPR001650, Helicase_C IPR027417, P-loop_NTPase IPR012337, RNaseH-like_sf IPR036397, RNaseH_sf |
PANTHERi | PTHR10133, PTHR10133, 1 hit |
Pfami | View protein in Pfam PF00270, DEAD, 1 hit PF00476, DNA_pol_A, 1 hit PF00271, Helicase_C, 1 hit |
PRINTSi | PR00868, DNAPOLI |
SMARTi | View protein in SMART SM00487, DEXDc, 1 hit SM00490, HELICc, 1 hit SM00482, POLAc, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit SSF53098, SSF53098, 1 hit SSF56672, SSF56672, 1 hit |
PROSITEi | View protein in PROSITE PS00447, DNA_POLYMERASE_A, 1 hit PS51192, HELICASE_ATP_BIND_1, 1 hit PS51194, HELICASE_CTER, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MNLLRRSGKR RRSESGSDSF SGSGGDSSAS PQFLSGSVLS PPPGLGRCLK
60 70 80 90 100
AAAAGECKPT VPDYERDKLL LANWGLPKAV LEKYHSFGVK KMFEWQAECL
110 120 130 140 150
LLGQVLEGKN LVYSAPTSAG KTLVAELLIL KRVLEMRKKA LFILPFVSVA
160 170 180 190 200
KEKKYYLQSL FQEVGIKVDG YMGSTSPSRH FSSLDIAVCT IERANGLINR
210 220 230 240 250
LIEENKMDLL GMVVVDELHM LGDSHRGYLL ELLLTKICYI TRKSASCQAD
260 270 280 290 300
LASSLSNAVQ IVGMSATLPN LELVASWLNA ELYHTDFRPV PLLESVKVGN
310 320 330 340 350
SIYDSSMKLV REFEPMLQVK GDEDHVVSLC YETICDNHSV LLFCPSKKWC
360 370 380 390 400
EKLADIIARE FYNLHHQAEG LVKPSECPPV ILEQKELLEV MDQLRRLPSG
410 420 430 440 450
LDSVLQKTVP WGVAFHHAGL TFEERDIIEG AFRQGLIRVL AATSTLSSGV
460 470 480 490 500
NLPARRVIIR TPIFGGRPLD ILTYKQMVGR AGRKGVDTVG ESILICKNSE
510 520 530 540 550
KSKGIALLQG SLKPVRSCLQ RREGEEVTGS MIRAILEIIV GGVASTSQDM
560 570 580 590 600
HTYAACTFLA ASMKEGKQGI QRNQESVQLG AIEACVMWLL ENEFIQSTEA
610 620 630 640 650
SDGTEGKVYH PTHLGSATLS SSLSPADTLD IFADLQRAMK GFVLENDLHI
660 670 680 690 700
LYLVTPMFED WTTIDWYRFF CLWEKLPTSM KRVAELVGVE EGFLARCVKG
710 720 730 740 750
KVVARTERQH RQMAIHKRFF TSLVLLDLIS EVPLREINQK YGCNRGQIQS
760 770 780 790 800
LQQSAAVYAG MITVFSNRLG WHNMELLLSQ FQKRLTFGIQ RELCDLVRVS
810 820 830 840 850
LLNAQRARVL YASGFHTVAD LARANIVEVE VILKNAVPFK SARKAVDEEE
860 870 880 890 900
EAVEERRNMR TIWVTGRKGL TEREAAALIV EEARMILQQD LVEMGVQWNP
910 920 930 940 950
CALLHSSTCS LTHSESEVKE HTFISQTKSS YKKLTSKNKS NTIFSDSYIK
960 970 980 990 1000
HSPNIVQDLN KSREHTSSFN CNFQNGNQEH QTCSIFRARK RASLDINKEK
1010 1020 1030 1040 1050
PGASQNEGKT SDKKVVQTFS QKTKKAPLNF NSEKMSRSFR SWKRRKHLKR
1060 1070 1080 1090 1100
SRDSSPLKDS GACRIHLQGQ TLSNPSLCED PFTLDEKKTE FRNSGPFAKN
1110 1120 1130 1140 1150
VSLSGKEKDN KTSFPLQIKQ NCSWNITLTN DNFVEHIVTG SQSKNVTCQA
1160 1170 1180 1190 1200
TSVVSEKGRG VAVEAEKINE VLIQNGSKNQ NVYMKHHDIH PINQYLRKQS
1210 1220 1230 1240 1250
HEQTSTITKQ KNIIERQMPC EAVSSYINRD SNVTINCERI KLNTEENKPS
1260 1270 1280 1290 1300
HFQALGDDIS RTVIPSEVLP SAGAFSKSEG QHENFLNISR LQEKTGTYTT
1310 1320 1330 1340 1350
NKTKNNHVSD LGLVLCDFED SFYLDTQSEK IIQQMATENA KLGAKDTNLA
1360 1370 1380 1390 1400
AGIMQKSLVQ QNSMNSFQKE CHIPFPAEQH PLGATKIDHL DLKTVGTMKQ
1410 1420 1430 1440 1450
SSDSHGVDIL TPESPIFHSP ILLEENGLFL KKNEVSVTDS QLNSFLQGYQ
1460 1470 1480 1490 1500
TQETVKPVIL LIPQKRTPTG VEGECLPVPE TSLNMSDSLL FDSFSDDYLV
1510 1520 1530 1540 1550
KEQLPDMQMK EPLPSEVTSN HFSDSLCLQE DLIKKSNVNE NQDTHQQLTC
1560 1570 1580 1590 1600
SNDESIIFSE MDSVQMVEAL DNVDIFPVQE KNHTVVSPRA LELSDPVLDE
1610 1620 1630 1640 1650
HHQGDQDGGD QDERAEKSKL TGTRQNHSFI WSGASFDLSP GLQRILDKVS
1660 1670 1680 1690 1700
SPLENEKLKS MTINFSSLNR KNTELNEEQE VISNLETKQV QGISFSSNNE
1710 1720 1730 1740 1750
VKSKIEMLEN NANHDETSSL LPRKESNIVD DNGLIPPTPI PTSASKLTFP
1760 1770 1780 1790 1800
GILETPVNPW KTNNVLQPGE SYLFGSPSDI KNHDLSPGSR NGFKDNSPIS
1810 1820 1830 1840 1850
DTSFSLQLSQ DGLQLTPASS SSESLSIIDV ASDQNLFQTF IKEWRCKKRF
1860 1870 1880 1890 1900
SISLACEKIR SLTSSKTATI GSRFKQASSP QEIPIRDDGF PIKGCDDTLV
1910 1920 1930 1940 1950
VGLAVCWGGR DAYYFSLQKE QKHSEISASL VPPSLDPSLT LKDRMWYLQS
1960 1970 1980 1990 2000
CLRKESDKEC SVVIYDFIQS YKILLLSCGI SLEQSYEDPK VACWLLDPDS
2010 2020 2030 2040 2050
QEPTLHSIVT SFLPHELPLL EGMETSQGIQ SLGLNAGSEH SGRYRASVES
2060 2070 2080 2090 2100
ILIFNSMNQL NSLLQKENLQ DVFRKVEMPS QYCLALLELN GIGFSTAECE
2110 2120 2130 2140 2150
SQKHIMQAKL DAIETQAYQL AGHSFSFTSS DDIAEVLFLE LKLPPNREMK
2160 2170 2180 2190 2200
NQGSKKTLGS TRRGIDNGRK LRLGRQFSTS KDVLNKLKAL HPLPGLILEW
2210 2220 2230 2240 2250
RRITNAITKV VFPLQREKCL NPFLGMERIY PVSQSHTATG RITFTEPNIQ
2260 2270 2280 2290 2300
NVPRDFEIKM PTLVGESPPS QAVGKGLLPM GRGKYKKGFS VNPRCQAQME
2310 2320 2330 2340 2350
ERAADRGMPF SISMRHAFVP FPGGSILAAD YSQLELRILA HLSHDRRLIQ
2360 2370 2380 2390 2400
VLNTGADVFR SIAAEWKMIE PESVGDDLRQ QAKQICYGII YGMGAKSLGE
2410 2420 2430 2440 2450
QMGIKENDAA CYIDSFKSRY TGINQFMTET VKNCKRDGFV QTILGRRRYL
2460 2470 2480 2490 2500
PGIKDNNPYR KAHAERQAIN TIVQGSAADI VKIATVNIQK QLETFHSTFK
2510 2520 2530 2540 2550
SHGHREGMLQ SDQTGLSRKR KLQGMFCPIR GGFFILQLHD ELLYEVAEED
2560 2570 2580 2590
VVQVAQIVKN EMESAVKLSV KLKVKVKIGA SWGELKDFDV
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A804HJJ9 | A0A804HJJ9_HUMAN | DNA polymerase theta | POLQ | 67 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 66 | R → I in AAR08421 (PubMed:14576298).Curated | 1 | |
Sequence conflicti | 982 | T → R in AAR08421 (PubMed:14576298).Curated | 1 | |
Sequence conflicti | 2013 | L → F in AAD05272 (Ref. 4) Curated | 1 | |
Sequence conflicti | 2513 | Q → R in AAC33565 (PubMed:10395804).Curated | 1 | |
Sequence conflicti | 2513 | Q → R in AAR08421 (PubMed:14576298).Curated | 1 | |
Sequence conflicti | 2547 | A → V in AAC33565 (PubMed:10395804).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_055707 | 1056 | P → L. Corresponds to variant dbSNP:rs34778629EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_040747 | 1 – 828 | Missing in isoform 2. 1 PublicationAdd BLAST | 828 | |
Alternative sequenceiVSP_040748 | 829 – 840 | VEVIL…AVPFK → MNSFLSFPISLC in isoform 2. 1 PublicationAdd BLAST | 12 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF052573 mRNA Translation: AAC33565.1 AY338826 mRNA Translation: AAR08421.2 AC069239 Genomic DNA No translation available. AC079841 Genomic DNA No translation available. AF043628 mRNA Translation: AAD05272.1 Frameshift. |
CCDSi | CCDS33833.1 [O75417-1] |
RefSeqi | NP_955452.3, NM_199420.3 [O75417-1] |
Genome annotation databases
Ensembli | ENST00000264233; ENSP00000264233; ENSG00000051341 |
GeneIDi | 10721 |
KEGGi | hsa:10721 |
MANE-Selecti | ENST00000264233.6; ENSP00000264233.5; NM_199420.4; NP_955452.3 |
UCSCi | uc003eee.5, human [O75417-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF052573 mRNA Translation: AAC33565.1 AY338826 mRNA Translation: AAR08421.2 AC069239 Genomic DNA No translation available. AC079841 Genomic DNA No translation available. AF043628 mRNA Translation: AAD05272.1 Frameshift. |
CCDSi | CCDS33833.1 [O75417-1] |
RefSeqi | NP_955452.3, NM_199420.3 [O75417-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4X0P | X-ray | 3.91 | A/B/C/D | 1792-2590 | [»] | |
4X0Q | X-ray | 3.90 | A/B | 1819-2590 | [»] | |
5A9F | X-ray | 3.20 | A | 67-894 | [»] | |
5A9J | X-ray | 3.55 | A/B/C/D | 1-894 | [»] | |
5AGA | X-ray | 2.90 | A | 67-894 | [»] | |
SMRi | O75417 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 115946, 8 interactors |
DIPi | DIP-61500N |
IntActi | O75417, 3 interactors |
STRINGi | 9606.ENSP00000264233 |
Chemistry databases
ChEMBLi | CHEMBL6025 |
PTM databases
GlyGeni | O75417, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | O75417 |
PhosphoSitePlusi | O75417 |
Genetic variation databases
BioMutai | POLQ |
Proteomic databases
EPDi | O75417 |
jPOSTi | O75417 |
MassIVEi | O75417 |
MaxQBi | O75417 |
PaxDbi | O75417 |
PeptideAtlasi | O75417 |
PRIDEi | O75417 |
ProteomicsDBi | 49988 [O75417-1] 49989 [O75417-2] |
Protocols and materials databases
Antibodypediai | 32825, 76 antibodies from 22 providers |
DNASUi | 10721 |
Genome annotation databases
Ensembli | ENST00000264233; ENSP00000264233; ENSG00000051341 |
GeneIDi | 10721 |
KEGGi | hsa:10721 |
MANE-Selecti | ENST00000264233.6; ENSP00000264233.5; NM_199420.4; NP_955452.3 |
UCSCi | uc003eee.5, human [O75417-1] |
Organism-specific databases
CTDi | 10721 |
DisGeNETi | 10721 |
GeneCardsi | POLQ |
HGNCi | HGNC:9186, POLQ |
HPAi | ENSG00000051341, Tissue enhanced (bone marrow, lymphoid tissue) |
MIMi | 114480, phenotype 604419, gene |
neXtProti | NX_O75417 |
OpenTargetsi | ENSG00000051341 |
PharmGKBi | PA33506 |
VEuPathDBi | HostDB:ENSG00000051341 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0950, Eukaryota |
GeneTreei | ENSGT00940000158694 |
HOGENOMi | CLU_000818_0_1_1 |
InParanoidi | O75417 |
OrthoDBi | 179246at2759 |
PhylomeDBi | O75417 |
TreeFami | TF105018 |
Enzyme and pathway databases
PathwayCommonsi | O75417 |
Reactomei | R-HSA-5685939, HDR through MMEJ (alt-NHEJ) |
SABIO-RKi | O75417 |
SignaLinki | O75417 |
Miscellaneous databases
BioGRID-ORCSi | 10721, 103 hits in 1050 CRISPR screens |
ChiTaRSi | POLQ, human |
GeneWikii | POLQ |
GenomeRNAii | 10721 |
Pharosi | O75417, Tbio |
PROi | PR:O75417 |
RNActi | O75417, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000051341, Expressed in secondary oocyte and 115 other tissues |
ExpressionAtlasi | O75417, baseline and differential |
Genevisiblei | O75417, HS |
Family and domain databases
Gene3Di | 3.30.420.10, 1 hit 3.40.50.300, 2 hits |
InterProi | View protein in InterPro IPR011545, DEAD/DEAH_box_helicase_dom IPR019760, DNA-dir_DNA_pol_A_CS IPR001098, DNA-dir_DNA_pol_A_palm_dom IPR043502, DNA/RNA_pol_sf IPR002298, DNA_polymerase_A IPR014001, Helicase_ATP-bd IPR001650, Helicase_C IPR027417, P-loop_NTPase IPR012337, RNaseH-like_sf IPR036397, RNaseH_sf |
PANTHERi | PTHR10133, PTHR10133, 1 hit |
Pfami | View protein in Pfam PF00270, DEAD, 1 hit PF00476, DNA_pol_A, 1 hit PF00271, Helicase_C, 1 hit |
PRINTSi | PR00868, DNAPOLI |
SMARTi | View protein in SMART SM00487, DEXDc, 1 hit SM00490, HELICc, 1 hit SM00482, POLAc, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit SSF53098, SSF53098, 1 hit SSF56672, SSF56672, 1 hit |
PROSITEi | View protein in PROSITE PS00447, DNA_POLYMERASE_A, 1 hit PS51192, HELICASE_ATP_BIND_1, 1 hit PS51194, HELICASE_CTER, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | DPOLQ_HUMAN | |
Accessioni | O75417Primary (citable) accession number: O75417 Secondary accession number(s): O95160, Q6VMB5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 30, 2000 |
Last sequence update: | March 8, 2011 | |
Last modified: | February 23, 2022 | |
This is version 158 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families