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Entry version 165 (08 May 2019)
Sequence version 3 (11 Jan 2001)
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Protein

Nucleoside diphosphate kinase 6

Gene

NME6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Inhibitor of p53-induced apoptosis.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei19ATPBy similarity1
Binding sitei68ATPBy similarity1
Binding sitei96ATPBy similarity1
Binding sitei102ATPBy similarity1
Binding sitei116ATPBy similarity1
Binding sitei126ATPBy similarity1
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei129Pros-phosphohistidine intermediatePROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Transferase
Biological processApoptosis, Nucleotide metabolism
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nucleoside diphosphate kinase 6 (EC:2.7.4.6)
Short name:
NDK 6
Short name:
NDP kinase 6
Alternative name(s):
Inhibitor of p53-induced apoptosis-alpha
Short name:
IPIA-alpha
nm23-H6
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NME6
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:20567 NME6

Online Mendelian Inheritance in Man (OMIM)

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MIMi
608294 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O75414

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
10201

Open Targets

More...
OpenTargetsi
ENSG00000172113

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134873104

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
NME6

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001371271 – 186Nucleoside diphosphate kinase 6Add BLAST186

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
O75414

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
O75414

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O75414

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O75414

PeptideAtlas

More...
PeptideAtlasi
O75414

PRoteomics IDEntifications database

More...
PRIDEi
O75414

ProteomicsDB human proteome resource

More...
ProteomicsDBi
49985
49986 [O75414-2]
49987 [O75414-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O75414

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O75414

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed at a moderately low level in many tissues. Most abundant in kidney, prostate, ovary, intestine, and spleen.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000172113 Expressed in 179 organ(s), highest expression level in placenta

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
O75414 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
O75414 HS

Organism-specific databases

Human Protein Atlas

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HPAi
HPA017909

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
RCC1LQ96I514EBI-3941531,EBI-2117080

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
115496, 15 interactors

Protein interaction database and analysis system

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IntActi
O75414, 4 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000416658

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
O75414

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NDK family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0888 Eukaryota
COG0105 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000160284

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000224565

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O75414

KEGG Orthology (KO)

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KOi
K00940

Database of Orthologous Groups

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OrthoDBi
1395365at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
O75414

TreeFam database of animal gene trees

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TreeFami
TF354225

Family and domain databases

Conserved Domains Database

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CDDi
cd04414 NDPk6, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.30.70.141, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR034907 NDK-like_dom
IPR036850 NDK-like_dom_sf
IPR037994 NDPk6
IPR001564 Nucleoside_diP_kinase
IPR023005 Nucleoside_diP_kinase_AS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00334 NDK, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR01243 NUCDPKINASE

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00562 NDK, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF54919 SSF54919, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00469 NDP_KINASES, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O75414-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MASILRSPQA LQLTLALIKP DAVAHPLILE AVHQQILSNK FLIVRMRELL
60 70 80 90 100
WRKEDCQRFY REHEGRFFYQ RLVEFMASGP IRAYILAHKD AIQLWRTLMG
110 120 130 140 150
PTRVFRARHV APDSIRGSFG LTDTRNTTHG SDSVVSASRE IAAFFPDFSE
160 170 180
QRWYEEEEPQ LRCGPVCYSP EGGVHYVAGT GGLGPA
Length:186
Mass (Da):21,142
Last modified:January 11, 2001 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDB8C5E046FACD143
GO
Isoform 2 (identifier: O75414-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     65-131: Missing.

Show »
Length:119
Mass (Da):13,510
Checksum:i57FB2BF44A5619F5
GO
Isoform 3 (identifier: O75414-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     65-186: GRFFYQRLVE...VAGTGGLGPA → AGQSEPTSLP...AIAQREVSTM

Show »
Length:163
Mass (Da):18,087
Checksum:iA27E767C901CC647
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JQB1C9JQB1_HUMAN
Nucleoside diphosphate kinase
NME6
141Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0C4DG91A0A0C4DG91_HUMAN
Nucleoside diphosphate kinase
NME6 hCG_1779448
194Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J9V6C9J9V6_HUMAN
Nucleoside diphosphate kinase
NME6
174Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8Y7V2A0A2R8Y7V2_HUMAN
Nucleoside diphosphate kinase
NME6
114Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8Y547A0A2R8Y547_HUMAN
Nucleoside diphosphate kinase
NME6
88Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J1J2C9J1J2_HUMAN
Nucleoside diphosphate kinase 6
NME6
111Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J867C9J867_HUMAN
Nucleoside diphosphate kinase 6
NME6
61Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F2Z2J2F2Z2J2_HUMAN
Nucleoside diphosphate kinase 6
NME6
82Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAC69439 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH01808 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH12828 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAD96275 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti182G → S in BAD96275 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_03688365 – 186GRFFY…GLGPA → AGQSEPTSLPTRMPSSSGGR SWDPPECSEHAMWPQILSVG VSASLTPATPPMVRTLWFQP AERLQPSSLTSVNSAGMRRK SPSCAVALCAIAQREVSTM in isoform 3. 1 PublicationAdd BLAST122
Alternative sequenceiVSP_03688265 – 131Missing in isoform 2. 1 PublicationAdd BLAST67

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF051941 mRNA Translation: AAC78463.1
U90449 mRNA Translation: AAC69439.1 Different initiation.
AK294809 mRNA Translation: BAG57928.1
AK297364 mRNA Translation: BAG59811.1
AK222555 mRNA Translation: BAD96275.1 Different initiation.
AC105267 Genomic DNA No translation available.
BC001808 mRNA Translation: AAH01808.1 Different initiation.
BC012828 mRNA Translation: AAH12828.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS77733.1 [O75414-3]
CCDS77734.1 [O75414-1]
CCDS82768.1 [O75414-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001295355.1, NM_001308426.1 [O75414-1]
NP_001295356.1, NM_001308427.1 [O75414-1]
NP_001295357.1, NM_001308428.1 [O75414-1]
NP_001295360.1, NM_001308431.1 [O75414-3]
NP_001295362.1, NM_001308433.1 [O75414-3]
NP_001295364.1, NM_001308435.1 [O75414-2]
NP_005784.1, NM_005793.4
XP_016861003.1, XM_017005514.1 [O75414-1]
XP_016861004.1, XM_017005515.1 [O75414-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000415053; ENSP00000399582; ENSG00000172113 [O75414-1]
ENST00000415644; ENSP00000394232; ENSG00000172113 [O75414-2]
ENST00000426689; ENSP00000440286; ENSG00000172113 [O75414-1]
ENST00000435684; ENSP00000393261; ENSG00000172113 [O75414-3]
ENST00000442597; ENSP00000406642; ENSG00000172113 [O75414-1]
ENST00000451657; ENSP00000407933; ENSG00000172113 [O75414-3]
ENST00000452211; ENSP00000392352; ENSG00000172113 [O75414-1]
ENST00000643457; ENSP00000495130; ENSG00000172113 [O75414-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
10201

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:10201

UCSC genome browser

More...
UCSCi
uc003cso.4 human [O75414-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF051941 mRNA Translation: AAC78463.1
U90449 mRNA Translation: AAC69439.1 Different initiation.
AK294809 mRNA Translation: BAG57928.1
AK297364 mRNA Translation: BAG59811.1
AK222555 mRNA Translation: BAD96275.1 Different initiation.
AC105267 Genomic DNA No translation available.
BC001808 mRNA Translation: AAH01808.1 Different initiation.
BC012828 mRNA Translation: AAH12828.1 Different initiation.
CCDSiCCDS77733.1 [O75414-3]
CCDS77734.1 [O75414-1]
CCDS82768.1 [O75414-2]
RefSeqiNP_001295355.1, NM_001308426.1 [O75414-1]
NP_001295356.1, NM_001308427.1 [O75414-1]
NP_001295357.1, NM_001308428.1 [O75414-1]
NP_001295360.1, NM_001308431.1 [O75414-3]
NP_001295362.1, NM_001308433.1 [O75414-3]
NP_001295364.1, NM_001308435.1 [O75414-2]
NP_005784.1, NM_005793.4
XP_016861003.1, XM_017005514.1 [O75414-1]
XP_016861004.1, XM_017005515.1 [O75414-3]

3D structure databases

SMRiO75414
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115496, 15 interactors
IntActiO75414, 4 interactors
STRINGi9606.ENSP00000416658

PTM databases

iPTMnetiO75414
PhosphoSitePlusiO75414

Polymorphism and mutation databases

BioMutaiNME6

Proteomic databases

EPDiO75414
jPOSTiO75414
MaxQBiO75414
PaxDbiO75414
PeptideAtlasiO75414
PRIDEiO75414
ProteomicsDBi49985
49986 [O75414-2]
49987 [O75414-3]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
10201
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000415053; ENSP00000399582; ENSG00000172113 [O75414-1]
ENST00000415644; ENSP00000394232; ENSG00000172113 [O75414-2]
ENST00000426689; ENSP00000440286; ENSG00000172113 [O75414-1]
ENST00000435684; ENSP00000393261; ENSG00000172113 [O75414-3]
ENST00000442597; ENSP00000406642; ENSG00000172113 [O75414-1]
ENST00000451657; ENSP00000407933; ENSG00000172113 [O75414-3]
ENST00000452211; ENSP00000392352; ENSG00000172113 [O75414-1]
ENST00000643457; ENSP00000495130; ENSG00000172113 [O75414-1]
GeneIDi10201
KEGGihsa:10201
UCSCiuc003cso.4 human [O75414-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
10201
DisGeNETi10201

GeneCards: human genes, protein and diseases

More...
GeneCardsi
NME6

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0019874
HGNCiHGNC:20567 NME6
HPAiHPA017909
MIMi608294 gene
neXtProtiNX_O75414
OpenTargetsiENSG00000172113
PharmGKBiPA134873104

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0888 Eukaryota
COG0105 LUCA
GeneTreeiENSGT00940000160284
HOGENOMiHOG000224565
InParanoidiO75414
KOiK00940
OrthoDBi1395365at2759
PhylomeDBiO75414
TreeFamiTF354225

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
NME6 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
10201

Protein Ontology

More...
PROi
PR:O75414

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000172113 Expressed in 179 organ(s), highest expression level in placenta
ExpressionAtlasiO75414 baseline and differential
GenevisibleiO75414 HS

Family and domain databases

CDDicd04414 NDPk6, 1 hit
Gene3Di3.30.70.141, 1 hit
InterProiView protein in InterPro
IPR034907 NDK-like_dom
IPR036850 NDK-like_dom_sf
IPR037994 NDPk6
IPR001564 Nucleoside_diP_kinase
IPR023005 Nucleoside_diP_kinase_AS
PfamiView protein in Pfam
PF00334 NDK, 1 hit
PRINTSiPR01243 NUCDPKINASE
SMARTiView protein in SMART
SM00562 NDK, 1 hit
SUPFAMiSSF54919 SSF54919, 1 hit
PROSITEiView protein in PROSITE
PS00469 NDP_KINASES, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNDK6_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O75414
Secondary accession number(s): B4DGW7
, B4DM99, Q53HM5, Q96E73, Q9BQ63
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: January 11, 2001
Last modified: May 8, 2019
This is version 165 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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