Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Transforming acidic coiled-coil-containing protein 1

Gene

TACC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Likely involved in the processes that promote cell division prior to the formation of differentiated tissues.

GO - Biological processi

Keywordsi

Biological processCell cycle, Cell division

Names & Taxonomyi

Protein namesi
Recommended name:
Transforming acidic coiled-coil-containing protein 1
Alternative name(s):
Gastric cancer antigen Ga55
Taxin-1
Gene namesi
Name:TACC1
Synonyms:KIAA1103
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000147526.19
HGNCiHGNC:11522 TACC1
MIMi605301 gene
neXtProtiNX_O75410

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Membrane, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi228S → A: Impairs phosphorylation by AURKC. 1 Publication1

Organism-specific databases

DisGeNETi6867
MalaCardsiTACC1
OpenTargetsiENSG00000147526
Orphaneti251579 Giant cell glioblastoma
251576 Gliosarcoma
PharmGKBiPA36299

Polymorphism and mutation databases

BioMutaiTACC1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00001799862 – 805Transforming acidic coiled-coil-containing protein 1Add BLAST804
Isoform 5 (identifier: O75410-5)
Initiator methionineiRemoved1 Publication

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei4PhosphoserineCombined sources1
Modified residuei10PhosphoserineCombined sources1
Modified residuei44PhosphoserineCombined sources1
Modified residuei147PhosphoserineCombined sources1
Modified residuei153PhosphoserineCombined sources1
Modified residuei228Phosphoserine; by AURKC1 Publication1
Modified residuei248PhosphoserineCombined sources1
Modified residuei276PhosphoserineCombined sources1
Modified residuei381PhosphoserineBy similarity1
Modified residuei406PhosphoserineBy similarity1
Modified residuei483PhosphoserineBy similarity1
Modified residuei533PhosphotyrosineCombined sources1
Modified residuei591PhosphoserineCombined sources1
Isoform 5 (identifier: O75410-5)
Lipidationi2N-myristoyl glycine1 Publication1

Post-translational modificationi

Isoform 1 is heavily phosphorylated; isoform 6 is not.2 Publications

Keywords - PTMi

Acetylation, Lipoprotein, Myristate, Phosphoprotein

Proteomic databases

EPDiO75410
MaxQBiO75410
PaxDbiO75410
PeptideAtlasiO75410
PRIDEiO75410
ProteomicsDBi49977
49978 [O75410-2]
49979 [O75410-3]
49980 [O75410-4]
49981 [O75410-5]
49982 [O75410-6]
49983 [O75410-7]
49984 [O75410-8]

PTM databases

iPTMnetiO75410
PhosphoSitePlusiO75410

Miscellaneous databases

PMAP-CutDBiO75410

Expressioni

Tissue specificityi

Isoform 1, isoform 3 and isoform 5 are ubiquitous. Isoform 2 is strongly expressed in the brain, weakly detectable in lung and colon, and overexpressed in gastric cancer. Isoform 4 is not detected in normal tissues, but strong expression was found in gastric cancer tissues. Down-regulated in a subset of cases of breast cancer.2 Publications

Developmental stagei

Expressed at high level during early embryogenesis.

Gene expression databases

BgeeiENSG00000147526 Expressed in 246 organ(s), highest expression level in pigmented layer of retina
ExpressionAtlasiO75410 baseline and differential
GenevisibleiO75410 HS

Organism-specific databases

HPAiCAB017041
HPA024702

Interactioni

Subunit structurei

Interacts with KIAA0097/CH-TOG and with the oncogenic transcription factor YEATS4. Interacts with AURKA, AURKB and AURKC. Interacts with LSM7, TDRD7 and SNRPG. Interacts with GCN5L2 and PCAF.6 Publications

Binary interactionsi

Protein-protein interaction databases

BioGridi112730, 39 interactors
CORUMiO75410
IntActiO75410, 40 interactors
MINTiO75410
STRINGi9606.ENSP00000321703

Structurei

3D structure databases

ProteinModelPortaliO75410
SMRiO75410
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini215 – 297SPAZ 1Add BLAST83
Domaini359 – 507SPAZ 2Add BLAST149

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni2 – 55Interaction with LSM7 and SNRPG1 PublicationAdd BLAST54
Regioni152 – 259Interaction with TDRD71 PublicationAdd BLAST108
Regioni206 – 427Interaction with YEATS41 PublicationAdd BLAST222
Regioni701 – 805Interaction with CH-TOGAdd BLAST105

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili610 – 805Add BLAST196

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi226 – 241Bipartite nuclear localization signal 1Sequence analysisAdd BLAST16
Motifi455 – 471Bipartite nuclear localization signal 2Sequence analysisAdd BLAST17

Sequence similaritiesi

Belongs to the TACC family.Curated

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiENOG410IIVK Eukaryota
ENOG410YMFS LUCA
GeneTreeiENSGT00530000063855
HOVERGENiHBG105967
InParanoidiO75410
KOiK14281
OMAiPLDGICL
OrthoDBiEOG091G072Z
PhylomeDBiO75410
TreeFamiTF333149

Family and domain databases

InterProiView protein in InterPro
IPR007707 TACC_C
PfamiView protein in Pfam
PF05010 TACC, 1 hit

Sequences (8+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 8 isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.

This entry has 8 described isoforms and 13 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O75410-1) [UniParc]FASTAAdd to basket
Also known as: A, Long

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAFSPWQILS PVQWAKWTWS AVRGGAAGED EAGGPEGDPE EEDSQAETKS
60 70 80 90 100
LSFSSDSEGN FETPEAETPI RSPFKESCDP SLGLAGPGAK SQESQEADEQ
110 120 130 140 150
LVAEVVEKCS SKTCSKPSEN EVPQQAIDSH SVKNFREEPE HDFSKISIVR
160 170 180 190 200
PFSIETKDST DISAVLGTKA AHGCVTAVSG KALPSSPPDA LQDEAMTEGS
210 220 230 240 250
MGVTLEASAE ADLKAGNSCP ELVPSRRSKL RKPKPVPLRK KAIGGEFSDT
260 270 280 290 300
NAAVEGTPLP KASYHFSPEE LDENTSPLLG DARFQKSPPD LKETPGTLSS
310 320 330 340 350
DTNDSGVELG EESRSSPLKL EFDFTEDTGN IEARKALPRK LGRKLGSTLT
360 370 380 390 400
PKIQKDGISK SAGLEQPTDP VARDGPLSQT SSKPDPSQWE SPSFNPFGSH
410 420 430 440 450
SVLQNSPPLS SEGSYHFDPD NFDESMDPFK PTTTLTSSDF CSPTGNHVNE
460 470 480 490 500
ILESPKKAKS RLITSGCKVK KHETQSLALD ACSRDEGAVI SQISDISNRD
510 520 530 540 550
GHATDEEKLA STSCGQKSAG AEVKGEPEED LEYFECSNVP VSTINHAFSS
560 570 580 590 600
SEAGIEKETC QKMEEDGSTV LGLLESSAEK APVSVSCGGE SPLDGICLSE
610 620 630 640 650
SDKTAVLTLI REEIITKEIE ANEWKKKYEE TRQEVLEMRK IVAEYEKTIA
660 670 680 690 700
QMIEDEQRTS MTSQKSFQQL TMEKEQALAD LNSVERSLSD LFRRYENLKG
710 720 730 740 750
VLEGFKKNEE ALKKCAQDYL ARVKQEEQRY QALKIHAEEK LDKANEEIAQ
760 770 780 790 800
VRTKAKAESA ALHAGLRKEQ MKVESLERAL QQKNQEIEEL TKICDELIAK

LGKTD
Length:805
Mass (Da):87,794
Last modified:February 1, 2005 - v2
Checksum:i3A261EF58C165107
GO
Isoform 2 (identifier: O75410-2) [UniParc]FASTAAdd to basket
Also known as: F

The sequence of this isoform differs from the canonical sequence as follows:
     464-464: T → TTTEQVKFLCFLL

Show »
Length:817
Mass (Da):89,218
Checksum:iB9D4BDE7B742E813
GO
Isoform 3 (identifier: O75410-3) [UniParc]FASTAAdd to basket
Also known as: E

The sequence of this isoform differs from the canonical sequence as follows:
     1-195: Missing.

Show »
Length:610
Mass (Da):67,073
Checksum:i802527D4B613A881
GO
Isoform 4 (identifier: O75410-4) [UniParc]FASTAAdd to basket
Also known as: D

The sequence of this isoform differs from the canonical sequence as follows:
     1-426: Missing.
     427-464: DPFKPTTTLT...PKKAKSRLIT → MGGSHSQTPR...EQVKFLCFLL

Show »
Length:379
Mass (Da):42,326
Checksum:iA3CF1029DF65E860
GO
Isoform 5 (identifier: O75410-5) [UniParc]FASTAAdd to basket
Also known as: C

The sequence of this isoform differs from the canonical sequence as follows:
     1-438: Missing.
     439-464: DFCSPTGNHVNEILESPKKAKSRLIT → MGGSHSQTPRGREPAGERHPRPTETA

Show »
Length:367
Mass (Da):40,903
Checksum:iF1761EA28D5AB9A8
GO
Isoform 6 (identifier: O75410-6) [UniParc]FASTAAdd to basket
Also known as: Short

The sequence of this isoform differs from the canonical sequence as follows:
     54-54: S → R
     55-464: Missing.

Show »
Length:395
Mass (Da):43,984
Checksum:iB29F0EA1DCAAF8E1
GO
Isoform 7 (identifier: O75410-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-41: Missing.
     42-53: EDSQAETKSLSF → MNNILKLK
     525-553: Missing.

Show »
Length:731
Mass (Da):79,872
Checksum:i385263AECC0C7060
GO
Isoform 8 (identifier: O75410-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-651: Missing.

Show »
Length:154
Mass (Da):17,815
Checksum:iF7CF945C5A3E277D
GO

Computationally mapped potential isoform sequencesi

There are 13 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7EVI4E7EVI4_HUMAN
Transforming acidic coiled-coil-con...
TACC1
581Annotation score:
B4E3H6B4E3H6_HUMAN
cDNA FLJ52297, highly similar to Tr...
TACC1
242Annotation score:
E7ET87E7ET87_HUMAN
Transforming acidic coiled-coil-con...
TACC1
609Annotation score:
H0YBT8H0YBT8_HUMAN
Transforming acidic coiled-coil-con...
TACC1
454Annotation score:
H0YAY0H0YAY0_HUMAN
Transforming acidic coiled-coil-con...
TACC1
562Annotation score:
R4GMT7R4GMT7_HUMAN
Transforming acidic coiled-coil-con...
TACC1
580Annotation score:
E5RJU4E5RJU4_HUMAN
Transforming acidic coiled-coil-con...
TACC1
138Annotation score:
E5RJG6E5RJG6_HUMAN
Transforming acidic coiled-coil-con...
TACC1
129Annotation score:
E5RIP3E5RIP3_HUMAN
Transforming acidic coiled-coil-con...
TACC1
60Annotation score:
E5RFM9E5RFM9_HUMAN
Transforming acidic coiled-coil-con...
TACC1
557Annotation score:
There are more potential isoformsShow all

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti291L → I in AAC32327 (PubMed:10435627).Curated1
Sequence conflicti428P → H in AAH41391 (PubMed:15489334).Curated1
Sequence conflicti588G → V in BAA83055 (PubMed:10470851).Curated1
Sequence conflicti654Missing in BAA83055 (PubMed:10470851).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_053703187P → L. Corresponds to variant dbSNP:rs34235313Ensembl.1
Natural variantiVAR_053704243I → T. Corresponds to variant dbSNP:rs6980553Ensembl.1
Natural variantiVAR_053705255E → G. Corresponds to variant dbSNP:rs10107016Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0126401 – 651Missing in isoform 8. 1 PublicationAdd BLAST651
Alternative sequenceiVSP_0126391 – 438Missing in isoform 5. CuratedAdd BLAST438
Alternative sequenceiVSP_0126411 – 426Missing in isoform 4. CuratedAdd BLAST426
Alternative sequenceiVSP_0126381 – 195Missing in isoform 3. 1 PublicationAdd BLAST195
Alternative sequenceiVSP_0126371 – 41Missing in isoform 7. 1 PublicationAdd BLAST41
Alternative sequenceiVSP_01264342 – 53EDSQA…KSLSF → MNNILKLK in isoform 7. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_01264454S → R in isoform 6. 1 Publication1
Alternative sequenceiVSP_01264555 – 464Missing in isoform 6. 1 PublicationAdd BLAST410
Alternative sequenceiVSP_012642427 – 464DPFKP…SRLIT → MGGSHSQTPRGREPAGERHP RPTETATTEQVKFLCFLL in isoform 4. CuratedAdd BLAST38
Alternative sequenceiVSP_012646439 – 464DFCSP…SRLIT → MGGSHSQTPRGREPAGERHP RPTETA in isoform 5. CuratedAdd BLAST26
Alternative sequenceiVSP_012647464T → TTTEQVKFLCFLL in isoform 2. 2 Publications1
Alternative sequenceiVSP_012648525 – 553Missing in isoform 7. 1 PublicationAdd BLAST29

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF049910 mRNA Translation: AAC32327.1
AY177411 mRNA Translation: AAO53446.1
AY139007 mRNA Translation: AAN28955.1
AK314620 mRNA Translation: BAG37186.1
CH471080 Genomic DNA Translation: EAW63293.1
CH471080 Genomic DNA Translation: EAW63296.1
CH471080 Genomic DNA Translation: EAW63298.1
BC041391 mRNA Translation: AAH41391.1
AB029026 mRNA Translation: BAA83055.1
AY039239 mRNA Translation: AAK68658.1
AY072874 mRNA Translation: AAL62461.1
AY072875 mRNA Translation: AAL62462.1
AY072876 mRNA Translation: AAL62463.2
CCDSiCCDS47845.1 [O75410-6]
CCDS55224.1 [O75410-3]
CCDS6109.1 [O75410-1]
CCDS87601.1 [O75410-7]
RefSeqiNP_001116296.1, NM_001122824.1 [O75410-6]
NP_001139688.1, NM_001146216.2 [O75410-3]
NP_006274.2, NM_006283.2 [O75410-1]
XP_005273682.1, XM_005273625.4 [O75410-2]
XP_011542933.1, XM_011544631.1
XP_011542934.1, XM_011544632.2 [O75410-2]
XP_011542938.1, XM_011544636.2 [O75410-5]
XP_016869261.1, XM_017013772.1
XP_016869262.1, XM_017013773.1
XP_016869263.1, XM_017013774.1
UniGeneiHs.279245

Genome annotation databases

EnsembliENST00000276520; ENSP00000276520; ENSG00000147526 [O75410-6]
ENST00000317827; ENSP00000321703; ENSG00000147526 [O75410-1]
ENST00000518415; ENSP00000428706; ENSG00000147526 [O75410-7]
ENST00000520615; ENSP00000428450; ENSG00000147526 [O75410-3]
GeneIDi6867
KEGGihsa:6867
UCSCiuc003xlz.4 human [O75410-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF049910 mRNA Translation: AAC32327.1
AY177411 mRNA Translation: AAO53446.1
AY139007 mRNA Translation: AAN28955.1
AK314620 mRNA Translation: BAG37186.1
CH471080 Genomic DNA Translation: EAW63293.1
CH471080 Genomic DNA Translation: EAW63296.1
CH471080 Genomic DNA Translation: EAW63298.1
BC041391 mRNA Translation: AAH41391.1
AB029026 mRNA Translation: BAA83055.1
AY039239 mRNA Translation: AAK68658.1
AY072874 mRNA Translation: AAL62461.1
AY072875 mRNA Translation: AAL62462.1
AY072876 mRNA Translation: AAL62463.2
CCDSiCCDS47845.1 [O75410-6]
CCDS55224.1 [O75410-3]
CCDS6109.1 [O75410-1]
CCDS87601.1 [O75410-7]
RefSeqiNP_001116296.1, NM_001122824.1 [O75410-6]
NP_001139688.1, NM_001146216.2 [O75410-3]
NP_006274.2, NM_006283.2 [O75410-1]
XP_005273682.1, XM_005273625.4 [O75410-2]
XP_011542933.1, XM_011544631.1
XP_011542934.1, XM_011544632.2 [O75410-2]
XP_011542938.1, XM_011544636.2 [O75410-5]
XP_016869261.1, XM_017013772.1
XP_016869262.1, XM_017013773.1
XP_016869263.1, XM_017013774.1
UniGeneiHs.279245

3D structure databases

ProteinModelPortaliO75410
SMRiO75410
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112730, 39 interactors
CORUMiO75410
IntActiO75410, 40 interactors
MINTiO75410
STRINGi9606.ENSP00000321703

PTM databases

iPTMnetiO75410
PhosphoSitePlusiO75410

Polymorphism and mutation databases

BioMutaiTACC1

Proteomic databases

EPDiO75410
MaxQBiO75410
PaxDbiO75410
PeptideAtlasiO75410
PRIDEiO75410
ProteomicsDBi49977
49978 [O75410-2]
49979 [O75410-3]
49980 [O75410-4]
49981 [O75410-5]
49982 [O75410-6]
49983 [O75410-7]
49984 [O75410-8]

Protocols and materials databases

DNASUi6867
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000276520; ENSP00000276520; ENSG00000147526 [O75410-6]
ENST00000317827; ENSP00000321703; ENSG00000147526 [O75410-1]
ENST00000518415; ENSP00000428706; ENSG00000147526 [O75410-7]
ENST00000520615; ENSP00000428450; ENSG00000147526 [O75410-3]
GeneIDi6867
KEGGihsa:6867
UCSCiuc003xlz.4 human [O75410-1]

Organism-specific databases

CTDi6867
DisGeNETi6867
EuPathDBiHostDB:ENSG00000147526.19
GeneCardsiTACC1
H-InvDBiHIX0007462
HGNCiHGNC:11522 TACC1
HPAiCAB017041
HPA024702
MalaCardsiTACC1
MIMi605301 gene
neXtProtiNX_O75410
OpenTargetsiENSG00000147526
Orphaneti251579 Giant cell glioblastoma
251576 Gliosarcoma
PharmGKBiPA36299
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IIVK Eukaryota
ENOG410YMFS LUCA
GeneTreeiENSGT00530000063855
HOVERGENiHBG105967
InParanoidiO75410
KOiK14281
OMAiPLDGICL
OrthoDBiEOG091G072Z
PhylomeDBiO75410
TreeFamiTF333149

Miscellaneous databases

ChiTaRSiTACC1 human
GeneWikiiTACC1
GenomeRNAii6867
PMAP-CutDBiO75410
PROiPR:O75410
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000147526 Expressed in 246 organ(s), highest expression level in pigmented layer of retina
ExpressionAtlasiO75410 baseline and differential
GenevisibleiO75410 HS

Family and domain databases

InterProiView protein in InterPro
IPR007707 TACC_C
PfamiView protein in Pfam
PF05010 TACC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTACC1_HUMAN
AccessioniPrimary (citable) accession number: O75410
Secondary accession number(s): B2RBD9
, D3DSX6, Q6Y687, Q86YG7, Q8IUJ2, Q8IUJ3, Q8IUJ4, Q8IZG2, Q8NEY7, Q9UPP9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: February 1, 2005
Last modified: September 12, 2018
This is version 171 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again