Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 176 (08 May 2019)
Sequence version 2 (01 Feb 2005)
Previous versions | rss
Other tutorials and videosHelp videoFeedback
Protein

Transforming acidic coiled-coil-containing protein 1

Gene

TACC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Likely involved in the processes that promote cell division prior to the formation of differentiated tissues.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell cycle, Cell division

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transforming acidic coiled-coil-containing protein 1
Alternative name(s):
Gastric cancer antigen Ga55
Taxin-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TACC1
Synonyms:KIAA1103
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:11522 TACC1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
605301 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O75410

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Membrane, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi228S → A: Impairs phosphorylation by AURKC. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
6867

MalaCards human disease database

More...
MalaCardsi
TACC1

Open Targets

More...
OpenTargetsi
ENSG00000147526

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
251579 Giant cell glioblastoma
251576 Gliosarcoma

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA36299

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TACC1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001799862 – 805Transforming acidic coiled-coil-containing protein 1Add BLAST804
Isoform 5 (identifier: O75410-5)
Initiator methionineiRemoved1 Publication

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1
Modified residuei4PhosphoserineCombined sources1
Modified residuei10PhosphoserineCombined sources1
Modified residuei44PhosphoserineCombined sources1
Modified residuei147PhosphoserineCombined sources1
Modified residuei153PhosphoserineCombined sources1
Modified residuei228Phosphoserine; by AURKC1 Publication1
Modified residuei248PhosphoserineCombined sources1
Modified residuei276PhosphoserineCombined sources1
Modified residuei381PhosphoserineBy similarity1
Modified residuei406PhosphoserineBy similarity1
Modified residuei483PhosphoserineBy similarity1
Modified residuei533PhosphotyrosineCombined sources1
Modified residuei591PhosphoserineCombined sources1
Isoform 5 (identifier: O75410-5)
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi2N-myristoyl glycine1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Isoform 1 is heavily phosphorylated; isoform 6 is not.2 Publications

Keywords - PTMi

Acetylation, Lipoprotein, Myristate, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
O75410

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
O75410

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O75410

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O75410

PeptideAtlas

More...
PeptideAtlasi
O75410

PRoteomics IDEntifications database

More...
PRIDEi
O75410

ProteomicsDB human proteome resource

More...
ProteomicsDBi
49977
49978 [O75410-2]
49979 [O75410-3]
49980 [O75410-4]
49981 [O75410-5]
49982 [O75410-6]
49983 [O75410-7]
49984 [O75410-8]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O75410

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O75410

Miscellaneous databases

CutDB - Proteolytic event database

More...
PMAP-CutDBi
O75410

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform 1, isoform 3 and isoform 5 are ubiquitous. Isoform 2 is strongly expressed in the brain, weakly detectable in lung and colon, and overexpressed in gastric cancer. Isoform 4 is not detected in normal tissues, but strong expression was found in gastric cancer tissues. Down-regulated in a subset of cases of breast cancer.2 Publications

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed at high level during early embryogenesis.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000147526 Expressed in 246 organ(s), highest expression level in pigmented layer of retina

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
O75410 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O75410 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB017041
HPA024702

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with KIAA0097/CH-TOG and with the oncogenic transcription factor YEATS4. Interacts with AURKA, AURKB and AURKC. Interacts with LSM7, TDRD7 and SNRPG. Interacts with GCN5L2 and PCAF.6 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
112730, 40 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
O75410

Protein interaction database and analysis system

More...
IntActi
O75410, 40 interactors

Molecular INTeraction database

More...
MINTi
O75410

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000321703

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O75410

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini215 – 297SPAZ 1Add BLAST83
Domaini359 – 507SPAZ 2Add BLAST149

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni2 – 55Interaction with LSM7 and SNRPG1 PublicationAdd BLAST54
Regioni152 – 259Interaction with TDRD71 PublicationAdd BLAST108
Regioni206 – 427Interaction with YEATS41 PublicationAdd BLAST222
Regioni701 – 805Interaction with CH-TOGAdd BLAST105

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili610 – 805Add BLAST196

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi226 – 241Bipartite nuclear localization signal 1Sequence analysisAdd BLAST16
Motifi455 – 471Bipartite nuclear localization signal 2Sequence analysisAdd BLAST17

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TACC family.Curated

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IIVK Eukaryota
ENOG410YMFS LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156991

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O75410

KEGG Orthology (KO)

More...
KOi
K14281

Identification of Orthologs from Complete Genome Data

More...
OMAi
SEGHFDT

Database of Orthologous Groups

More...
OrthoDBi
669540at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O75410

TreeFam database of animal gene trees

More...
TreeFami
TF333149

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR039915 TACC
IPR007707 TACC_C

The PANTHER Classification System

More...
PANTHERi
PTHR13924 PTHR13924, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05010 TACC_C, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (8+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 8 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.

This entry has 8 described isoforms and 13 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O75410-1) [UniParc]FASTAAdd to basket
Also known as: A, Long

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAFSPWQILS PVQWAKWTWS AVRGGAAGED EAGGPEGDPE EEDSQAETKS
60 70 80 90 100
LSFSSDSEGN FETPEAETPI RSPFKESCDP SLGLAGPGAK SQESQEADEQ
110 120 130 140 150
LVAEVVEKCS SKTCSKPSEN EVPQQAIDSH SVKNFREEPE HDFSKISIVR
160 170 180 190 200
PFSIETKDST DISAVLGTKA AHGCVTAVSG KALPSSPPDA LQDEAMTEGS
210 220 230 240 250
MGVTLEASAE ADLKAGNSCP ELVPSRRSKL RKPKPVPLRK KAIGGEFSDT
260 270 280 290 300
NAAVEGTPLP KASYHFSPEE LDENTSPLLG DARFQKSPPD LKETPGTLSS
310 320 330 340 350
DTNDSGVELG EESRSSPLKL EFDFTEDTGN IEARKALPRK LGRKLGSTLT
360 370 380 390 400
PKIQKDGISK SAGLEQPTDP VARDGPLSQT SSKPDPSQWE SPSFNPFGSH
410 420 430 440 450
SVLQNSPPLS SEGSYHFDPD NFDESMDPFK PTTTLTSSDF CSPTGNHVNE
460 470 480 490 500
ILESPKKAKS RLITSGCKVK KHETQSLALD ACSRDEGAVI SQISDISNRD
510 520 530 540 550
GHATDEEKLA STSCGQKSAG AEVKGEPEED LEYFECSNVP VSTINHAFSS
560 570 580 590 600
SEAGIEKETC QKMEEDGSTV LGLLESSAEK APVSVSCGGE SPLDGICLSE
610 620 630 640 650
SDKTAVLTLI REEIITKEIE ANEWKKKYEE TRQEVLEMRK IVAEYEKTIA
660 670 680 690 700
QMIEDEQRTS MTSQKSFQQL TMEKEQALAD LNSVERSLSD LFRRYENLKG
710 720 730 740 750
VLEGFKKNEE ALKKCAQDYL ARVKQEEQRY QALKIHAEEK LDKANEEIAQ
760 770 780 790 800
VRTKAKAESA ALHAGLRKEQ MKVESLERAL QQKNQEIEEL TKICDELIAK

LGKTD
Length:805
Mass (Da):87,794
Last modified:February 1, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3A261EF58C165107
GO
Isoform 2 (identifier: O75410-2) [UniParc]FASTAAdd to basket
Also known as: F

The sequence of this isoform differs from the canonical sequence as follows:
     464-464: T → TTTEQVKFLCFLL

Show »
Length:817
Mass (Da):89,218
Checksum:iB9D4BDE7B742E813
GO
Isoform 3 (identifier: O75410-3) [UniParc]FASTAAdd to basket
Also known as: E

The sequence of this isoform differs from the canonical sequence as follows:
     1-195: Missing.

Show »
Length:610
Mass (Da):67,073
Checksum:i802527D4B613A881
GO
Isoform 4 (identifier: O75410-4) [UniParc]FASTAAdd to basket
Also known as: D

The sequence of this isoform differs from the canonical sequence as follows:
     1-426: Missing.
     427-464: DPFKPTTTLT...PKKAKSRLIT → MGGSHSQTPR...EQVKFLCFLL

Show »
Length:379
Mass (Da):42,326
Checksum:iA3CF1029DF65E860
GO
Isoform 5 (identifier: O75410-5) [UniParc]FASTAAdd to basket
Also known as: C

The sequence of this isoform differs from the canonical sequence as follows:
     1-438: Missing.
     439-464: DFCSPTGNHVNEILESPKKAKSRLIT → MGGSHSQTPRGREPAGERHPRPTETA

Show »
Length:367
Mass (Da):40,903
Checksum:iF1761EA28D5AB9A8
GO
Isoform 6 (identifier: O75410-6) [UniParc]FASTAAdd to basket
Also known as: Short

The sequence of this isoform differs from the canonical sequence as follows:
     54-54: S → R
     55-464: Missing.

Show »
Length:395
Mass (Da):43,984
Checksum:iB29F0EA1DCAAF8E1
GO
Isoform 7 (identifier: O75410-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-41: Missing.
     42-53: EDSQAETKSLSF → MNNILKLK
     525-553: Missing.

Show »
Length:731
Mass (Da):79,872
Checksum:i385263AECC0C7060
GO
Isoform 8 (identifier: O75410-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-651: Missing.

Show »
Length:154
Mass (Da):17,815
Checksum:iF7CF945C5A3E277D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 13 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7EVI4E7EVI4_HUMAN
Transforming acidic coiled-coil-con...
TACC1
581Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
R4GMT7R4GMT7_HUMAN
Transforming acidic coiled-coil-con...
TACC1
580Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7ET87E7ET87_HUMAN
Transforming acidic coiled-coil-con...
TACC1
609Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YBT8H0YBT8_HUMAN
Transforming acidic coiled-coil-con...
TACC1
454Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YAY0H0YAY0_HUMAN
Transforming acidic coiled-coil-con...
TACC1
562Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B4E3H6B4E3H6_HUMAN
Transforming acidic coiled-coil-con...
TACC1
242Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RJU4E5RJU4_HUMAN
Transforming acidic coiled-coil-con...
TACC1
138Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RJG6E5RJG6_HUMAN
Transforming acidic coiled-coil-con...
TACC1
129Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RFM9E5RFM9_HUMAN
Transforming acidic coiled-coil-con...
TACC1
557Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0C4DGD3A0A0C4DGD3_HUMAN
Transforming acidic coiled-coil-con...
TACC1
133Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti291L → I in AAC32327 (PubMed:10435627).Curated1
Sequence conflicti428P → H in AAH41391 (PubMed:15489334).Curated1
Sequence conflicti588G → V in BAA83055 (PubMed:10470851).Curated1
Sequence conflicti654Missing in BAA83055 (PubMed:10470851).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_053703187P → L. Corresponds to variant dbSNP:rs34235313Ensembl.1
Natural variantiVAR_053704243I → T. Corresponds to variant dbSNP:rs6980553Ensembl.1
Natural variantiVAR_053705255E → G. Corresponds to variant dbSNP:rs10107016Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0126401 – 651Missing in isoform 8. 1 PublicationAdd BLAST651
Alternative sequenceiVSP_0126391 – 438Missing in isoform 5. CuratedAdd BLAST438
Alternative sequenceiVSP_0126411 – 426Missing in isoform 4. CuratedAdd BLAST426
Alternative sequenceiVSP_0126381 – 195Missing in isoform 3. 1 PublicationAdd BLAST195
Alternative sequenceiVSP_0126371 – 41Missing in isoform 7. 1 PublicationAdd BLAST41
Alternative sequenceiVSP_01264342 – 53EDSQA…KSLSF → MNNILKLK in isoform 7. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_01264454S → R in isoform 6. 1 Publication1
Alternative sequenceiVSP_01264555 – 464Missing in isoform 6. 1 PublicationAdd BLAST410
Alternative sequenceiVSP_012642427 – 464DPFKP…SRLIT → MGGSHSQTPRGREPAGERHP RPTETATTEQVKFLCFLL in isoform 4. CuratedAdd BLAST38
Alternative sequenceiVSP_012646439 – 464DFCSP…SRLIT → MGGSHSQTPRGREPAGERHP RPTETA in isoform 5. CuratedAdd BLAST26
Alternative sequenceiVSP_012647464T → TTTEQVKFLCFLL in isoform 2. 2 Publications1
Alternative sequenceiVSP_012648525 – 553Missing in isoform 7. 1 PublicationAdd BLAST29

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF049910 mRNA Translation: AAC32327.1
AY177411 mRNA Translation: AAO53446.1
AY139007 mRNA Translation: AAN28955.1
AK314620 mRNA Translation: BAG37186.1
CH471080 Genomic DNA Translation: EAW63293.1
CH471080 Genomic DNA Translation: EAW63296.1
CH471080 Genomic DNA Translation: EAW63298.1
BC041391 mRNA Translation: AAH41391.1
AB029026 mRNA Translation: BAA83055.1
AY039239 mRNA Translation: AAK68658.1
AY072874 mRNA Translation: AAL62461.1
AY072875 mRNA Translation: AAL62462.1
AY072876 mRNA Translation: AAL62463.2

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS47845.1 [O75410-6]
CCDS55224.1 [O75410-3]
CCDS6109.1 [O75410-1]
CCDS87601.1 [O75410-7]

NCBI Reference Sequences

More...
RefSeqi
NP_001116296.1, NM_001122824.1 [O75410-6]
NP_001139688.1, NM_001146216.2 [O75410-3]
NP_006274.2, NM_006283.2 [O75410-1]
XP_005273682.1, XM_005273625.4 [O75410-2]
XP_011542933.1, XM_011544631.1
XP_011542934.1, XM_011544632.2 [O75410-2]
XP_011542938.1, XM_011544636.2 [O75410-5]
XP_016869261.1, XM_017013772.1
XP_016869262.1, XM_017013773.1
XP_016869263.1, XM_017013774.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000276520; ENSP00000276520; ENSG00000147526 [O75410-6]
ENST00000317827; ENSP00000321703; ENSG00000147526 [O75410-1]
ENST00000518415; ENSP00000428706; ENSG00000147526 [O75410-7]
ENST00000520615; ENSP00000428450; ENSG00000147526 [O75410-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
6867

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:6867

UCSC genome browser

More...
UCSCi
uc003xlz.4 human [O75410-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF049910 mRNA Translation: AAC32327.1
AY177411 mRNA Translation: AAO53446.1
AY139007 mRNA Translation: AAN28955.1
AK314620 mRNA Translation: BAG37186.1
CH471080 Genomic DNA Translation: EAW63293.1
CH471080 Genomic DNA Translation: EAW63296.1
CH471080 Genomic DNA Translation: EAW63298.1
BC041391 mRNA Translation: AAH41391.1
AB029026 mRNA Translation: BAA83055.1
AY039239 mRNA Translation: AAK68658.1
AY072874 mRNA Translation: AAL62461.1
AY072875 mRNA Translation: AAL62462.1
AY072876 mRNA Translation: AAL62463.2
CCDSiCCDS47845.1 [O75410-6]
CCDS55224.1 [O75410-3]
CCDS6109.1 [O75410-1]
CCDS87601.1 [O75410-7]
RefSeqiNP_001116296.1, NM_001122824.1 [O75410-6]
NP_001139688.1, NM_001146216.2 [O75410-3]
NP_006274.2, NM_006283.2 [O75410-1]
XP_005273682.1, XM_005273625.4 [O75410-2]
XP_011542933.1, XM_011544631.1
XP_011542934.1, XM_011544632.2 [O75410-2]
XP_011542938.1, XM_011544636.2 [O75410-5]
XP_016869261.1, XM_017013772.1
XP_016869262.1, XM_017013773.1
XP_016869263.1, XM_017013774.1

3D structure databases

SMRiO75410
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112730, 40 interactors
CORUMiO75410
IntActiO75410, 40 interactors
MINTiO75410
STRINGi9606.ENSP00000321703

PTM databases

iPTMnetiO75410
PhosphoSitePlusiO75410

Polymorphism and mutation databases

BioMutaiTACC1

Proteomic databases

EPDiO75410
jPOSTiO75410
MaxQBiO75410
PaxDbiO75410
PeptideAtlasiO75410
PRIDEiO75410
ProteomicsDBi49977
49978 [O75410-2]
49979 [O75410-3]
49980 [O75410-4]
49981 [O75410-5]
49982 [O75410-6]
49983 [O75410-7]
49984 [O75410-8]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
6867
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000276520; ENSP00000276520; ENSG00000147526 [O75410-6]
ENST00000317827; ENSP00000321703; ENSG00000147526 [O75410-1]
ENST00000518415; ENSP00000428706; ENSG00000147526 [O75410-7]
ENST00000520615; ENSP00000428450; ENSG00000147526 [O75410-3]
GeneIDi6867
KEGGihsa:6867
UCSCiuc003xlz.4 human [O75410-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
6867
DisGeNETi6867

GeneCards: human genes, protein and diseases

More...
GeneCardsi
TACC1

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0007462
HGNCiHGNC:11522 TACC1
HPAiCAB017041
HPA024702
MalaCardsiTACC1
MIMi605301 gene
neXtProtiNX_O75410
OpenTargetsiENSG00000147526
Orphaneti251579 Giant cell glioblastoma
251576 Gliosarcoma
PharmGKBiPA36299

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IIVK Eukaryota
ENOG410YMFS LUCA
GeneTreeiENSGT00940000156991
InParanoidiO75410
KOiK14281
OMAiSEGHFDT
OrthoDBi669540at2759
PhylomeDBiO75410
TreeFamiTF333149

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
TACC1 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
TACC1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
6867
PMAP-CutDBiO75410

Protein Ontology

More...
PROi
PR:O75410

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000147526 Expressed in 246 organ(s), highest expression level in pigmented layer of retina
ExpressionAtlasiO75410 baseline and differential
GenevisibleiO75410 HS

Family and domain databases

InterProiView protein in InterPro
IPR039915 TACC
IPR007707 TACC_C
PANTHERiPTHR13924 PTHR13924, 1 hit
PfamiView protein in Pfam
PF05010 TACC_C, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTACC1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O75410
Secondary accession number(s): B2RBD9
, D3DSX6, Q6Y687, Q86YG7, Q8IUJ2, Q8IUJ3, Q8IUJ4, Q8IZG2, Q8NEY7, Q9UPP9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: February 1, 2005
Last modified: May 8, 2019
This is version 176 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again