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UniProtKB - O75400 (PR40A_HUMAN)

Entry version 204 (23 Feb 2022)
Sequence version 2 (22 Aug 2003)
Previous versions | rss
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Protein

Pre-mRNA-processing factor 40 homolog A

Gene

PRPF40A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Binds to WASL/N-WASP and suppresses its translocation from the nucleus to the cytoplasm, thereby inhibiting its cytoplasmic function (By similarity).

Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. May play a role in cytokinesis. May be involved in pre-mRNA splicing.

By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell cycle, Cell division, mRNA processing, mRNA splicing

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		O75400

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-72163, mRNA Splicing - Major Pathway

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		O75400

Protein family/group databases

MoonDB Database of extreme multifunctional and moonlighting proteins

More...MoonDBi		O75400, Predicted

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Pre-mRNA-processing factor 40 homolog A
Alternative name(s):
Fas ligand-associated factor 1
Formin-binding protein 11
Formin-binding protein 3
Huntingtin yeast partner A
Huntingtin-interacting protein 10
Short name:
HIP-10
Huntingtin-interacting protein A
Renal carcinoma antigen NY-REN-6
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PRPF40A
Synonyms:FBP11, FLAF1, FNBP3, HIP10, HYPA
ORF Names:HSPC225
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:16463, PRPF40A

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		612941, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_O75400

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		55660

Open Targets

More...OpenTargetsi		ENSG00000196504

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA28195

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		O75400, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		PRPF40A

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000760851 – 957Pre-mRNA-processing factor 40 homolog AAdd BLAST957

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei9Omega-N-methylarginineBy similarity1
Modified residuei34PhosphoserineCombined sources1
Modified residuei151PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki191Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei196N6-acetyllysineCombined sources1
Cross-linki241Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei345PhosphothreonineCombined sources1
Modified residuei373PhosphothreonineCombined sources1
Cross-linki375Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki376Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei723PhosphoserineCombined sources1
Modified residuei787PhosphoserineCombined sources1
Modified residuei883PhosphoserineCombined sources1
Modified residuei885PhosphoserineCombined sources1
Modified residuei888PhosphoserineCombined sources1
Modified residuei932PhosphothreonineCombined sources1
Modified residuei933PhosphoserineCombined sources1
Modified residuei935PhosphoserineCombined sources1
Modified residuei938PhosphoserineCombined sources1
Isoform 2 (identifier: O75400-2)
Modified residuei17Omega-N-methylarginineCombined sources1
Modified residuei24Omega-N-methylarginineCombined sources1
Modified residuei47Omega-N-methylarginineCombined sources1
Isoform 5 (identifier: O75400-5)
Modified residuei17Omega-N-methylarginineCombined sources1
Modified residuei24Omega-N-methylarginineCombined sources1
Modified residuei47Omega-N-methylarginineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		O75400

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		O75400

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		O75400

MaxQB - The MaxQuant DataBase

More...MaxQBi		O75400

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O75400

PeptideAtlas

More...PeptideAtlasi		O75400

PRoteomics IDEntifications database

More...PRIDEi		O75400

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		49972 [O75400-1]
49973 [O75400-2]
49974 [O75400-3]
49975 [O75400-5]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		O75400, 1 site, 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		O75400

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		O75400

SwissPalm database of S-palmitoylation events

More...SwissPalmi		O75400

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the brain cortex (at protein level). Widely expressed.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000196504, Expressed in secondary oocyte and 255 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		O75400, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000196504, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with the N-terminus of HTT.

Interacts with the phosphorylated C-terminal domain of POLR2A.

Interacts with AKAP8L, SF1, SRPK1, ENAH, ATBF1 and MECP2 (By similarity).

Interacts through the WW domains with formin proline-rich regions and with WASL/N-WASP (By similarity).

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

O75400
With#Exp.IntAct
CHD3 [Q12873]2EBI-473291,EBI-523590
HTT [P42858]15EBI-473291,EBI-466029
NKAP [Q8N5F7]2EBI-473291,EBI-721539
SF1 [Q15637]3EBI-473291,EBI-744603
SF3A1 [Q15459]2EBI-473291,EBI-1054743
Isoform 2 [O75400-2]
With#Exp.IntAct
ABCG1 - isoform 6 [P45844-6]3EBI-5280197,EBI-25873349
ADAL - isoform 2 [Q6DHV7-2]3EBI-5280197,EBI-18899653
AKR1C8P [Q5T2L2]3EBI-5280197,EBI-22006248
ALKBH3 - isoform 2 [Q96Q83-2]3EBI-5280197,EBI-9089544
ANKEF1 [Q9NU02]3EBI-5280197,EBI-8464238
ANXA4 [Q6LES2]3EBI-5280197,EBI-10250835
ARFIP2 [P53365]3EBI-5280197,EBI-638194
ARL6IP4 - isoform 4 [Q66PJ3-4]3EBI-5280197,EBI-5280499
ATF4 [P18848]3EBI-5280197,EBI-492498
ATG10 [Q9H0Y0]3EBI-5280197,EBI-1048913
BAAT [Q14032]3EBI-5280197,EBI-8994378
BCAT1 - isoform 4 [P54687-4]3EBI-5280197,EBI-25834445
BCHE [P06276]3EBI-5280197,EBI-7936069
BEND7 - isoform 2 [Q8N7W2-2]3EBI-5280197,EBI-10181188
C12orf4 [Q9NQ89]3EBI-5280197,EBI-11090973
C3orf36 [Q3SXR2]3EBI-5280197,EBI-18036948
C4orf45 [Q96LM5]3EBI-5280197,EBI-12020542
CAPN2 [P17655]3EBI-5280197,EBI-1028956
CAPN3 - isoform IV [P20807-4]3EBI-5280197,EBI-11532021
CBX4 - isoform 2 [O00257-3]3EBI-5280197,EBI-4392727
CCNC [P24863]3EBI-5280197,EBI-395261
CCNL1 [Q9UK58]3EBI-5280197,EBI-2836773
CCNL1 - isoform 3 [Q9UK58-5]3EBI-5280197,EBI-25873837
CD209 - isoform 10 [Q9NNX6-10]3EBI-5280197,EBI-12300031
CDC23 [Q9UJX2]3EBI-5280197,EBI-396137
CDKN2C [P42773]3EBI-5280197,EBI-711290
CDS2 [O95674]3EBI-5280197,EBI-3913685
CFAP100 - isoform 2 [Q494V2-2]3EBI-5280197,EBI-11953200
CIAO2B [Q9Y3D0]3EBI-5280197,EBI-744045
CLTA - isoform Non-brain [P09496-2]3EBI-5280197,EBI-4401010
COA7 [Q96BR5]3EBI-5280197,EBI-6269632
COL2A1 - isoform 1 [P02458-1]3EBI-5280197,EBI-12375799
CRCT1 [Q9UGL9]3EBI-5280197,EBI-713677
CROT - isoform 2 [Q9UKG9-2]3EBI-5280197,EBI-25835363
CRYBB3 [P26998]3EBI-5280197,EBI-1965681
CSNK2A1 [P68400]2EBI-5280197,EBI-347804
CT45A1 [Q5HYN5]3EBI-5280197,EBI-12051833
CTNNB1 [P35222]3EBI-5280197,EBI-491549
CYBRD1 [Q53TN4]3EBI-5280197,EBI-8637742
CYP2C8 [P10632]3EBI-5280197,EBI-2951522
DDIT4L [Q96D03]3EBI-5280197,EBI-742054
DHRS1 [Q96LJ7]3EBI-5280197,EBI-746300
DLX3 [O60479]3EBI-5280197,EBI-3908248
DNAJA3 - isoform 3 [Q96EY1-3]3EBI-5280197,EBI-11526226
DOCK10 [Q96BY6]3EBI-5280197,EBI-748520
DPF1 - isoform 2 [Q92782-2]3EBI-5280197,EBI-23669343
DPYSL5 [Q9BPU6]3EBI-5280197,EBI-724653
DZIP1 [Q86YF9]3EBI-5280197,EBI-998108
DZIP1L [Q8IYY4]3EBI-5280197,EBI-10264440
EIF3F [O00303]3EBI-5280197,EBI-711990
ELL2 [O00472]3EBI-5280197,EBI-395274
FAM135B - isoform 4 [Q49AJ0-4]3EBI-5280197,EBI-25835236
FAM167A [Q96KS9]3EBI-5280197,EBI-10290462
FAM9A [Q8IZU1]3EBI-5280197,EBI-8468186
FGD5 [Q6ZNL6]3EBI-5280197,EBI-7962481
GLYR1 - isoform 4 [Q49A26-4]3EBI-5280197,EBI-12143817
GTF2H1 [P32780]3EBI-5280197,EBI-715539
HELLS - isoform 6 [Q9NRZ9-6]3EBI-5280197,EBI-12003732
HSPBAP1 - isoform 2 [Q96EW2-2]3EBI-5280197,EBI-25835621
HTT [P42858]9EBI-5280197,EBI-466029
JMJD7 [P0C870]3EBI-5280197,EBI-9090173
KCTD17 [Q8N5Z5]3EBI-5280197,EBI-743960
KLHDC4 - isoform 2 [Q8TBB5-2]3EBI-5280197,EBI-21838933
KLHL36 - isoform 2 [Q8N4N3-2]3EBI-5280197,EBI-10973851
KRBOX4 - isoform 3 [Q5JUW0-3]3EBI-5280197,EBI-12893625
LGALS9C [Q6DKI2]3EBI-5280197,EBI-9088829
LHX5 [Q9H2C1]3EBI-5280197,EBI-25835523
LONRF2 [Q1L5Z9]3EBI-5280197,EBI-2510853
MAOB [P27338]3EBI-5280197,EBI-3911344
MLST8 [A0A0A0MR05]3EBI-5280197,EBI-25835557
MPI - isoform 2 [P34949-2]3EBI-5280197,EBI-21823432
MRI1 [Q9BV20]3EBI-5280197,EBI-747381
MRM1 - isoform 2 [Q6IN84-2]3EBI-5280197,EBI-25835707
MYC [P01106]3EBI-5280197,EBI-447544
NAA60 [Q9H7X0]3EBI-5280197,EBI-12260336
NKAPD1 [Q6ZUT1]3EBI-5280197,EBI-3920396
NUP43 [Q8NFH3]3EBI-5280197,EBI-1059321
OGFOD2 - isoform 2 [Q6N063-2]3EBI-5280197,EBI-22006224
OTUD7B - isoform 2 [Q6GQQ9-2]3EBI-5280197,EBI-25830200
PCYT2 [Q99447]3EBI-5280197,EBI-750317
PDE4A - isoform 4 [P27815-4]3EBI-5280197,EBI-12080840
PER1 [O15534]3EBI-5280197,EBI-2557276
PICK1 [Q9NRD5]3EBI-5280197,EBI-79165
PITPNB [P48739]3EBI-5280197,EBI-1047143
PLIN3 [O60664]3EBI-5280197,EBI-725795
POLA2 [Q14181]3EBI-5280197,EBI-712752
POLR2I [P36954]3EBI-5280197,EBI-395202
PPBP [P02775]3EBI-5280197,EBI-718973
PPP1R21 - isoform 5 [Q6ZMI0-5]3EBI-5280197,EBI-25835994
PRKAG1 [P54619]3EBI-5280197,EBI-1181439
PRPH2 [P23942]3EBI-5280197,EBI-25836834
PTPN4 [P29074]3EBI-5280197,EBI-710431
RABGAP1L - isoform 9 [Q5R372-9]3EBI-5280197,EBI-10699389
RBM39 [Q14498]6EBI-5280197,EBI-395290
RELA [Q04206]3EBI-5280197,EBI-73886
RHEB [Q15382]3EBI-5280197,EBI-1055287
RNF10 [Q8N5U6]3EBI-5280197,EBI-714023
RSRC1 [Q96IZ7]3EBI-5280197,EBI-712189
SCAMP1 [O15126]3EBI-5280197,EBI-954338
SCP2 - isoform 3 [P22307-3]3EBI-5280197,EBI-25834804
SDCBP [O00560]3EBI-5280197,EBI-727004
SDCBP2 [Q9H190]6EBI-5280197,EBI-742426
SDF4 [Q9BRK5]3EBI-5280197,EBI-1389808
SEMA4G - isoform 3 [Q9NTN9-3]3EBI-5280197,EBI-9089805
SH3BP5L [Q7L8J4]3EBI-5280197,EBI-747389
SHCBP1L [Q9BZQ2]3EBI-5280197,EBI-10818532
SHOX2 - isoform 3 [O60902-3]3EBI-5280197,EBI-9092164
SLFN12 [Q8IYM2]3EBI-5280197,EBI-2822550
SMG6 [Q86US8]3EBI-5280197,EBI-3232100
SMIM12 [Q96EX1]3EBI-5280197,EBI-2874543
SNCA [P37840]3EBI-5280197,EBI-985879
SNF8 [Q96H20]3EBI-5280197,EBI-747719
SNW1 [Q13573]3EBI-5280197,EBI-632715
SPATS1 [Q496A3]3EBI-5280197,EBI-3923692
SPRY4 [Q9C004]3EBI-5280197,EBI-354861
SPRYD7 - isoform 2 [Q5W111-2]3EBI-5280197,EBI-12408727
SREK1 [Q8WXA9]3EBI-5280197,EBI-1044237
SREK1IP1 [Q8N9Q2]3EBI-5280197,EBI-10268630
SYMPK - isoform 2 [Q92797-2]3EBI-5280197,EBI-21560407
TCAP [O15273]3EBI-5280197,EBI-954089
TEN1 [Q86WV5]3EBI-5280197,EBI-2562799
TGM1 [P22735]3EBI-5280197,EBI-2562368
TGM5 [O43548]3EBI-5280197,EBI-12027348
TMEFF2 - isoform 2 [Q9UIK5-2]3EBI-5280197,EBI-25835153
TMEM171 - isoform 2 [Q8WVE6-2]3EBI-5280197,EBI-25874374
TP53BP1 [Q12888]3EBI-5280197,EBI-396540
TTYH1 - isoform 4 [Q9H313-4]3EBI-5280197,EBI-17671298
TUBA1C [Q9BQE3]3EBI-5280197,EBI-1103245
UBE2A [P49459]3EBI-5280197,EBI-2339348
UBE2G1 [P62253]3EBI-5280197,EBI-2340619
WBP1L [Q9NX94]3EBI-5280197,EBI-10316321
ZBTB14 [O43829]3EBI-5280197,EBI-10176632
ZBTB8OS - isoform 2 [Q8IWT0-2]3EBI-5280197,EBI-12956041
ZNF597 [Q96LX8]3EBI-5280197,EBI-9091553
ZNF829 - isoform 3 [Q3KNS6-3]3EBI-5280197,EBI-18036029
B7Z3E83EBI-5280197,EBI-25831617
Q86V283EBI-5280197,EBI-10259496

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		120792, 313 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		O75400

Protein interaction database and analysis system

More...IntActi		O75400, 244 interactors

Molecular INTeraction database

More...MINTi		O75400

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000386458

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		O75400, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1957
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Biological Magnetic Resonance Data Bank

More...BMRBi		O75400

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		O75400

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		O75400

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini140 – 173WW 1PROSITE-ProRule annotationAdd BLAST34
Domaini181 – 214WW 2PROSITE-ProRule annotationAdd BLAST34
Domaini393 – 447FF 1Add BLAST55
Domaini460 – 514FF 2Add BLAST55
Domaini527 – 587FF 3Add BLAST61
Domaini607 – 667FF 4Add BLAST61
Domaini672 – 727FF 5Add BLAST56
Domaini742 – 799FF 6Add BLAST58

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 36DisorderedSequence analysisAdd BLAST36
Regioni243 – 263DisorderedSequence analysisAdd BLAST21
Regioni337 – 386DisorderedSequence analysisAdd BLAST50
Regioni803 – 957DisorderedSequence analysisAdd BLAST155

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi249 – 263Polar residuesSequence analysisAdd BLAST15
Compositional biasi337 – 367Polar residuesSequence analysisAdd BLAST31
Compositional biasi368 – 386Basic and acidic residuesSequence analysisAdd BLAST19
Compositional biasi807 – 827Basic residuesSequence analysisAdd BLAST21
Compositional biasi828 – 866Basic and acidic residuesSequence analysisAdd BLAST39
Compositional biasi867 – 881Basic residuesSequence analysisAdd BLAST15
Compositional biasi882 – 927Basic and acidic residuesSequence analysisAdd BLAST46
Compositional biasi937 – 957Basic and acidic residuesSequence analysisAdd BLAST21

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The WW domains are essential for localization to nuclear speckles.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the PRPF40 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0152, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00930000150980

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_005825_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O75400

Database of Orthologous Groups

More...OrthoDBi		1112854at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		O75400

TreeFam database of animal gene trees

More...TreeFami		TF318732

Family and domain databases

Conserved Domains Database

More...CDDi		cd00201, WW, 2 hits

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.10.440, 5 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR002713, FF_domain
IPR036517, FF_domain_sf
IPR039726, Prp40-like
IPR001202, WW_dom
IPR036020, WW_dom_sf

The PANTHER Classification System

More...PANTHERi		PTHR11864, PTHR11864, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01846, FF, 5 hits
PF00397, WW, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00441, FF, 5 hits
SM00456, WW, 2 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF51045, SSF51045, 2 hits
SSF81698, SSF81698, 5 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51676, FF, 6 hits
PS01159, WW_DOMAIN_1, 2 hits
PS50020, WW_DOMAIN_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O75400-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRPGTGAERG GLMVSEMESH PPSQGPGDGE RRLSGSSLCS GSWVSADGFL 
        60         70         80         90        100
RRRPSMGHPG MHYAPMGMHP MGQRANMPPV PHGMMPQMMP PMGGPPMGQM 
       110        120        130        140        150
PGMMSSVMPG MMMSHMSQAS MQPALPPGVN SMDVAAGTAS GAKSMWTEHK 
       160        170        180        190        200
SPDGRTYYYN TETKQSTWEK PDDLKTPAEQ LLSKCPWKEY KSDSGKPYYY 
       210        220        230        240        250
NSQTKESRWA KPKELEDLEG YQNTIVAGSL ITKSNLHAMI KAEESSKQEE 
       260        270        280        290        300
CTTTSTAPVP TTEIPTTMST MAAAEAAAAV VAAAAAAAAA AAAANANAST 
       310        320        330        340        350
SASNTVSGTV PVVPEPEVTS IVATVVDNEN TVTISTEEQA QLTSTPAIQD 
       360        370        380        390        400
QSVEVSSNTG EETSKQETVA DFTPKKEEEE SQPAKKTYTW NTKEEAKQAF 
       410        420        430        440        450
KELLKEKRVP SNASWEQAMK MIINDPRYSA LAKLSEKKQA FNAYKVQTEK 
       460        470        480        490        500
EEKEEARSKY KEAKESFQRF LENHEKMTST TRYKKAEQMF GEMEVWNAIS 
       510        520        530        540        550
ERDRLEIYED VLFFLSKKEK EQAKQLRKRN WEALKNILDN MANVTYSTTW 
       560        570        580        590        600
SEAQQYLMDN PTFAEDEELQ NMDKEDALIC FEEHIRALEK EEEEEKQKSL 
       610        620        630        640        650
LRERRRQRKN RESFQIFLDE LHEHGQLHSM SSWMELYPTI SSDIRFTNML 
       660        670        680        690        700
GQPGSTALDL FKFYVEDLKA RYHDEKKIIK DILKDKGFVV EVNTTFEDFV 
       710        720        730        740        750
AIISSTKRST TLDAGNIKLA FNSLLEKAEA REREREKEEA RKMKRKESAF 
       760        770        780        790        800
KSMLKQAAPP IELDAVWEDI RERFVKEPAF EDITLESERK RIFKDFMHVL 
       810        820        830        840        850
EHECQHHHSK NKKHSKKSKK HHRKRSRSRS GSDSDDDDSH SKKKRQRSES 
       860        870        880        890        900
RSASEHSSSA ESERSYKKSK KHKKKSKKRR HKSDSPESDA EREKDKKEKD 
       910        920        930        940        950
RESEKDRTRQ RSESKHKSPK KKTGKDSGNW DTSGSELSEG ELEKRRRTLL 

EQLDDDQ
Length:957
Mass (Da):108,805
Last modified:August 22, 2003 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8874D0C1CE1FCDAF
GO
Isoform 2 (identifier: O75400-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MCSGSGRRRSSLSPTM
     14-55: Missing.

Show »
Length:930
Mass (Da):105,927
Checksum:i6AFC2E30F4FAEB47
GO
Isoform 3 (identifier: O75400-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     220-237: Missing.

Show »
Length:939
Mass (Da):106,907
Checksum:i05527BF2FC5C9449
GO
Isoform 5 (identifier: O75400-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MCSGSGRRRSSLSPTM
     14-55: Missing.
     127-128: PG → LN
     129-957: Missing.

Note: Probable target of nonsense-mediated mRNA decay.Curated
Show »
Length:101
Mass (Da):10,697
Checksum:i2C254F75EDA2059D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F5H578F5H578_HUMAN
Pre-mRNA-processing factor 40 homol...
PRPF40A
463Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YG38H0YG38_HUMAN
Pre-mRNA-processing factor 40 homol...
PRPF40A
367Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A7N4I394A0A7N4I394_HUMAN
Pre-mRNA-processing factor 40 homol...
PRPF40A
994Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C2N3H7C2N3_HUMAN
Pre-mRNA-processing factor 40 homol...
PRPF40A
157Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7BXZ7H7BXZ7_HUMAN
Pre-mRNA-processing factor 40 homol...
PRPF40A
109Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAC27501 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence AAC27502 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence AAC27506 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence AAD42862 differs from that shown. Reason: Frameshift.Curated
The sequence AAF36145 differs from that shown. Reason: Frameshift.Curated
The sequence AAH11788 differs from that shown. Contaminating sequence. Potential poly-A sequence starting in position 409.Curated
The sequence BAA91277 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAB15016 differs from that shown.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti372 – 373FT → LL in AAB93495 (Ref. 5) Curated2
Sequence conflicti433K → N in AAC27501 (PubMed:9700202).Curated1
Sequence conflicti433K → N in AAC27506 (PubMed:9700202).Curated1
Sequence conflicti787S → P in BAA91277 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0407811M → MCSGSGRRRSSLSPTM in isoform 2 and isoform 5. 3 Publications1
Alternative sequenceiVSP_00804714 – 55Missing in isoform 2 and isoform 5. 3 PublicationsAdd BLAST42
Alternative sequenceiVSP_040782127 – 128PG → LN in isoform 5. 1 Publication2
Alternative sequenceiVSP_040783129 – 957Missing in isoform 5. 1 PublicationAdd BLAST829
Alternative sequenceiVSP_008048220 – 237Missing in isoform 3. 1 PublicationAdd BLAST18

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AC012443 Genomic DNA No translation available.
AC079344 Genomic DNA No translation available.
AK000592 mRNA Translation: BAA91277.1 Different initiation.
AK024810 mRNA Translation: BAB15016.1 Sequence problems.
AF049523 mRNA Translation: AAC27501.1 Different initiation.
AF049524 mRNA Translation: AAC27502.1 Different initiation.
AF049528 mRNA Translation: AAC27506.1 Different initiation.
BC011788 mRNA Translation: AAH11788.1 Sequence problems.
BC027178 mRNA Translation: AAH27178.1
U70667 mRNA Translation: AAB93495.1
AF155096 mRNA Translation: AAD42862.1 Frameshift.
AF151059 mRNA Translation: AAF36145.1 Frameshift.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS46430.1 [O75400-2]

NCBI Reference Sequences

More...RefSeqi		NP_060362.3, NM_017892.3 [O75400-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000354363; ENSP00000346332; ENSG00000196504 [O75400-5]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		55660

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:55660

UCSC genome browser

More...UCSCi		uc002tyh.5, human [O75400-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC012443 Genomic DNA No translation available.
AC079344 Genomic DNA No translation available.
AK000592 mRNA Translation: BAA91277.1 Different initiation.
AK024810 mRNA Translation: BAB15016.1 Sequence problems.
AF049523 mRNA Translation: AAC27501.1 Different initiation.
AF049524 mRNA Translation: AAC27502.1 Different initiation.
AF049528 mRNA Translation: AAC27506.1 Different initiation.
BC011788 mRNA Translation: AAH11788.1 Sequence problems.
BC027178 mRNA Translation: AAH27178.1
U70667 mRNA Translation: AAB93495.1
AF155096 mRNA Translation: AAD42862.1 Frameshift.
AF151059 mRNA Translation: AAF36145.1 Frameshift.
CCDSiCCDS46430.1 [O75400-2]
RefSeqiNP_060362.3, NM_017892.3 [O75400-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1UZCNMR-A381-450[»]
1YWINMR-A142-173[»]
1YWJNMR-A142-173[»]
1ZR7NMR-A146-173[»]
2CQNNMR-A743-806[»]
2DYFNMR-A146-173[»]
2KZGNMR-A381-450[»]
2L5FNMR-A133-220[»]
2L9VNMR-A381-450[»]
2LKSNMR-A391-439[»]
BMRBiO75400
SMRiO75400
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi120792, 313 interactors
CORUMiO75400
IntActiO75400, 244 interactors
MINTiO75400
STRINGi9606.ENSP00000386458

Protein family/group databases

MoonDBiO75400, Predicted

PTM databases

GlyGeniO75400, 1 site, 1 O-linked glycan (1 site)
iPTMnetiO75400
PhosphoSitePlusiO75400
SwissPalmiO75400

Genetic variation databases

BioMutaiPRPF40A

Proteomic databases

EPDiO75400
jPOSTiO75400
MassIVEiO75400
MaxQBiO75400
PaxDbiO75400
PeptideAtlasiO75400
PRIDEiO75400
ProteomicsDBi49972 [O75400-1]
49973 [O75400-2]
49974 [O75400-3]
49975 [O75400-5]

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		55660

Genome annotation databases

EnsembliENST00000354363; ENSP00000346332; ENSG00000196504 [O75400-5]
GeneIDi55660
KEGGihsa:55660
UCSCiuc002tyh.5, human [O75400-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		55660
DisGeNETi55660

GeneCards: human genes, protein and diseases

More...GeneCardsi		PRPF40A
HGNCiHGNC:16463, PRPF40A
HPAiENSG00000196504, Low tissue specificity
MIMi612941, gene
neXtProtiNX_O75400
OpenTargetsiENSG00000196504
PharmGKBiPA28195

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0152, Eukaryota
GeneTreeiENSGT00930000150980
HOGENOMiCLU_005825_0_0_1
InParanoidiO75400
OrthoDBi1112854at2759
PhylomeDBiO75400
TreeFamiTF318732

Enzyme and pathway databases

PathwayCommonsiO75400
ReactomeiR-HSA-72163, mRNA Splicing - Major Pathway
SignaLinkiO75400

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		55660, 731 hits in 1053 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		PRPF40A, human
EvolutionaryTraceiO75400

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		PRPF40A

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		55660
PharosiO75400, Tbio

Protein Ontology

More...PROi		PR:O75400
RNActiO75400, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000196504, Expressed in secondary oocyte and 255 other tissues
GenevisibleiO75400, HS

Family and domain databases

CDDicd00201, WW, 2 hits
Gene3Di1.10.10.440, 5 hits
InterProiView protein in InterPro
IPR002713, FF_domain
IPR036517, FF_domain_sf
IPR039726, Prp40-like
IPR001202, WW_dom
IPR036020, WW_dom_sf
PANTHERiPTHR11864, PTHR11864, 1 hit
PfamiView protein in Pfam
PF01846, FF, 5 hits
PF00397, WW, 2 hits
SMARTiView protein in SMART
SM00441, FF, 5 hits
SM00456, WW, 2 hits
SUPFAMiSSF51045, SSF51045, 2 hits
SSF81698, SSF81698, 5 hits
PROSITEiView protein in PROSITE
PS51676, FF, 6 hits
PS01159, WW_DOMAIN_1, 2 hits
PS50020, WW_DOMAIN_2, 2 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPR40A_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O75400
Secondary accession number(s): O43856
, O75404, Q8TBQ1, Q9H782, Q9NWU9, Q9P0Q2, Q9Y5A8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 22, 2003
Last sequence update: August 22, 2003
Last modified: February 23, 2022
This is version 204 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
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