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Protein

Vesicle-trafficking protein SEC22b

Gene

SEC22B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

SNARE involved in targeting and fusion of ER-derived transport vesicles with the Golgi complex as well as Golgi-derived retrograde transport vesicles with the ER.1 Publication

Caution

The reference genome displays a polymorphic premature stop codon in position 39.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processER-Golgi transport, Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-1236974 ER-Phagosome pathway
R-HSA-204005 COPII-mediated vesicle transport
R-HSA-5694530 Cargo concentration in the ER
R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic

Names & Taxonomyi

Protein namesi
Recommended name:
Vesicle-trafficking protein SEC22b
Alternative name(s):
ER-Golgi SNARE of 24 kDa
Short name:
ERS-24
Short name:
ERS24
SEC22 vesicle-trafficking protein homolog B
SEC22 vesicle-trafficking protein-like 1
Gene namesi
Name:SEC22B
Synonyms:SEC22L1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000265808.3
HGNCiHGNC:10700 SEC22B
MIMi604029 gene
neXtProtiNX_O75396

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 194CytoplasmicSequence analysisAdd BLAST193
Transmembranei195 – 215Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35623

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources1 Publication
ChainiPRO_00002067702 – 215Vesicle-trafficking protein SEC22bAdd BLAST214

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei38N6-acetyllysineCombined sources1
Modified residuei137PhosphoserineCombined sources1
Modified residuei140PhosphothreonineCombined sources1
Modified residuei164PhosphoserineCombined sources1
Modified residuei168PhosphoserineCombined sources1
Modified residuei174PhosphoserineCombined sources1
Modified residuei177PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiO75396
MaxQBiO75396
PeptideAtlasiO75396
PRIDEiO75396
ProteomicsDBi49967
TopDownProteomicsiO75396

PTM databases

GlyConnecti1891
iPTMnetiO75396
PhosphoSitePlusiO75396
SwissPalmiO75396

Expressioni

Gene expression databases

BgeeiENSG00000265808 Expressed in 230 organ(s), highest expression level in chorionic villus
CleanExiHS_SEC22B
ExpressionAtlasiO75396 baseline and differential
GenevisibleiO75396 HS

Organism-specific databases

HPAiCAB079017

Interactioni

Subunit structurei

Interacts with STX17 (By similarity). Component of two distinct SNARE complexes consisting of STX5, GOSR2/BOS1, BET1 and SEC22B or STX18, USE1L, BNIP1/SEC20L and SEC22B. YKT6 can probably replace SEC22B in either complex. Interacts with the COPII Sec23/24 complex composed of SEC23A and SEC24A; recruits SEC22B into COPII-coated vesicles to allow its transport from the endoplasmic reticulum to the Golgi (PubMed:17499046, PubMed:18843296).By similarity3 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi114926, 98 interactors
DIPiDIP-50458N
IntActiO75396, 93 interactors
MINTiO75396

Structurei

Secondary structure

1215
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliO75396
SMRiO75396
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO75396

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 119LonginPROSITE-ProRule annotationAdd BLAST114
Domaini134 – 194v-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd BLAST61

Sequence similaritiesi

Belongs to the synaptobrevin family.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG052748
InParanoidiO75396
KOiK08517
OrthoDBiEOG091G0MPE
PhylomeDBiO75396

Family and domain databases

InterProiView protein in InterPro
IPR011012 Longin-like_dom_sf
IPR010908 Longin_dom
IPR001388 Synaptobrevin
PfamiView protein in Pfam
PF13774 Longin, 1 hit
PF00957 Synaptobrevin, 1 hit
PRINTSiPR00219 SYNAPTOBREVN
SMARTiView protein in SMART
SM01270 Longin, 1 hit
SUPFAMiSSF64356 SSF64356, 1 hit
PROSITEiView protein in PROSITE
PS50859 LONGIN, 1 hit
PS50892 V_SNARE, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

O75396-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVLLTMIARV ADGLPLAASM QEDEQSGRDL QQYQSQAKQL FRKLNEQSPT
60 70 80 90 100
RCTLEAGAMT FHYIIEQGVC DLVLCEAAFP KTLAFAYLED LHSEFDEQHG
110 120 130 140 150
KKVPTVSRPY SFIEFDTFIQ KTKKLYIDSC ARRNLGSINT ELQDVQRIMV
160 170 180 190 200
ANIEEVLQRG EALSALDSKA NNLSSLSKKY RQDAKYLNMH STYAKLAAVA
210
VFFIMLIVYV RFWWL
Length:215
Mass (Da):24,593
Last modified:January 11, 2011 - v4
Checksum:i9FA59C20F2D3F690
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087X1A9A0A087X1A9_HUMAN
Vesicle-trafficking protein SEC22b
SEC22B
79Annotation score:

Sequence cautioni

The sequence AL359758 differs from that shown. Reason: Erroneous termination at position 39. Translated as Gln.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06031171D → Y3 PublicationsCorresponds to variant dbSNP:rs2596331Ensembl.1
Natural variantiVAR_06031282T → K3 PublicationsCorresponds to variant dbSNP:rs2794053Ensembl.1
Natural variantiVAR_057343108R → Q. Corresponds to variant dbSNP:rs2655551Ensembl.1
Natural variantiVAR_060313130C → RCombined sources3 PublicationsCorresponds to variant dbSNP:rs2590131Ensembl.1
Natural variantiVAR_060314190H → R3 PublicationsCorresponds to variant dbSNP:rs2655557Ensembl.1
Natural variantiVAR_057344214W → C. Corresponds to variant dbSNP:rs7534444Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF047442 mRNA Translation: AAC39893.1
AK289875 mRNA Translation: BAF82564.1
AL359758 Genomic DNA No translation available.
BX537145 Genomic DNA No translation available.
BC001364 mRNA Translation: AAH01364.1
RefSeqiNP_004883.3, NM_004892.5
UniGeneiHs.632438
Hs.661819

Genome annotation databases

EnsembliENST00000578049; ENSP00000463393; ENSG00000265808
GeneIDi9554
KEGGihsa:9554
UCSCiuc031unv.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF047442 mRNA Translation: AAC39893.1
AK289875 mRNA Translation: BAF82564.1
AL359758 Genomic DNA No translation available.
BX537145 Genomic DNA No translation available.
BC001364 mRNA Translation: AAH01364.1
RefSeqiNP_004883.3, NM_004892.5
UniGeneiHs.632438
Hs.661819

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2NUPX-ray2.80C1-195[»]
2NUTX-ray2.30C1-195[»]
3EGDX-ray2.70C1-157[»]
3EGXX-ray3.30C1-157[»]
ProteinModelPortaliO75396
SMRiO75396
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114926, 98 interactors
DIPiDIP-50458N
IntActiO75396, 93 interactors
MINTiO75396

PTM databases

GlyConnecti1891
iPTMnetiO75396
PhosphoSitePlusiO75396
SwissPalmiO75396

Proteomic databases

EPDiO75396
MaxQBiO75396
PeptideAtlasiO75396
PRIDEiO75396
ProteomicsDBi49967
TopDownProteomicsiO75396

Protocols and materials databases

DNASUi9554
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000578049; ENSP00000463393; ENSG00000265808
GeneIDi9554
KEGGihsa:9554
UCSCiuc031unv.2 human

Organism-specific databases

CTDi9554
EuPathDBiHostDB:ENSG00000265808.3
GeneCardsiSEC22B
HGNCiHGNC:10700 SEC22B
HPAiCAB079017
MIMi604029 gene
neXtProtiNX_O75396
PharmGKBiPA35623
GenAtlasiSearch...

Phylogenomic databases

HOVERGENiHBG052748
InParanoidiO75396
KOiK08517
OrthoDBiEOG091G0MPE
PhylomeDBiO75396

Enzyme and pathway databases

ReactomeiR-HSA-1236974 ER-Phagosome pathway
R-HSA-204005 COPII-mediated vesicle transport
R-HSA-5694530 Cargo concentration in the ER
R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic

Miscellaneous databases

EvolutionaryTraceiO75396
GeneWikiiSEC22B
GenomeRNAii9554
PROiPR:O75396
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000265808 Expressed in 230 organ(s), highest expression level in chorionic villus
CleanExiHS_SEC22B
ExpressionAtlasiO75396 baseline and differential
GenevisibleiO75396 HS

Family and domain databases

InterProiView protein in InterPro
IPR011012 Longin-like_dom_sf
IPR010908 Longin_dom
IPR001388 Synaptobrevin
PfamiView protein in Pfam
PF13774 Longin, 1 hit
PF00957 Synaptobrevin, 1 hit
PRINTSiPR00219 SYNAPTOBREVN
SMARTiView protein in SMART
SM01270 Longin, 1 hit
SUPFAMiSSF64356 SSF64356, 1 hit
PROSITEiView protein in PROSITE
PS50859 LONGIN, 1 hit
PS50892 V_SNARE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSC22B_HUMAN
AccessioniPrimary (citable) accession number: O75396
Secondary accession number(s): A8K1G0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 29, 2004
Last sequence update: January 11, 2011
Last modified: October 10, 2018
This is version 171 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. SIMILARITY comments
    Index of protein domains and families
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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