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Protein

39S ribosomal protein L33, mitochondrial

Gene

MRPL33

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-5368286 Mitochondrial translation initiation
R-HSA-5389840 Mitochondrial translation elongation
R-HSA-5419276 Mitochondrial translation termination

Names & Taxonomyi

Protein namesi
Recommended name:
39S ribosomal protein L33, mitochondrial
Short name:
L33mt
Short name:
MRP-L33
Alternative name(s):
Mitochondrial large ribosomal subunit protein bL33m1 Publication
Gene namesi
Name:MRPL33
Synonyms:C2orf1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000243147.7
HGNCiHGNC:14487 MRPL33
MIMi610059 gene
neXtProtiNX_O75394

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

DisGeNETi9553
OpenTargetsiENSG00000243147
PharmGKBiPA30964

Polymorphism and mutation databases

BioMutaiMRPL33

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 8MitochondrionBy similarity8
ChainiPRO_00002386259 – 6539S ribosomal protein L33, mitochondrialAdd BLAST57

Proteomic databases

EPDiO75394
MaxQBiO75394
PaxDbiO75394
PeptideAtlasiO75394
PRIDEiO75394
ProteomicsDBi49965
49966 [O75394-2]
TopDownProteomicsiO75394-1 [O75394-1]

PTM databases

PhosphoSitePlusiO75394

Expressioni

Gene expression databases

BgeeiENSG00000243147 Expressed in 235 organ(s), highest expression level in right adrenal gland cortex
CleanExiHS_MRPL33
ExpressionAtlasiO75394 baseline and differential
GenevisibleiO75394 HS

Organism-specific databases

HPAiHPA066872

Interactioni

Subunit structurei

Component of the mitochondrial large ribosomal subunit (mt-LSU) (PubMed:28892042, PubMed:25838379, PubMed:25278503). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins.3 Publications

Protein-protein interaction databases

BioGridi114925, 37 interactors
CORUMiO75394
IntActiO75394, 9 interactors
STRINGi9606.ENSP00000296102

Structurei

Secondary structure

165
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliO75394
SMRiO75394
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG3505 Eukaryota
COG0267 LUCA
GeneTreeiENSGT00390000010130
HOGENOMiHOG000004840
HOVERGENiHBG053140
InParanoidiO75394
KOiK02913
OMAiAQTGFFY
OrthoDBiEOG091G1BUE
PhylomeDBiO75394
TreeFamiTF300279

Family and domain databases

Gene3Di2.20.28.120, 1 hit
InterProiView protein in InterPro
IPR038584 L33_sf
IPR001705 Ribosomal_L33
IPR011332 Ribosomal_zn-bd
PfamiView protein in Pfam
PF00471 Ribosomal_L33, 1 hit
SUPFAMiSSF57829 SSF57829, 1 hit
TIGRFAMsiTIGR01023 rpmG_bact, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: O75394-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MFLSAVFFAK SKSKNILVRM VSEAGTGFCF NTKRNRLREK LTLLHYDPVV
60
KQRVLFVEKK KIRSL
Length:65
Mass (Da):7,619
Last modified:November 1, 1998 - v1
Checksum:iF32C16A238A5D08A
GO
Isoform 2 (identifier: O75394-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     14-65: KNILVRMVSE...FVEKKKIRSL → NETKSPLRGK...EGGDTDSEIL

Note: No experimental confirmation available.
Show »
Length:54
Mass (Da):5,965
Checksum:i2BBEEFAA40BC171E
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8WF37F8WF37_HUMAN
39S ribosomal protein L33, mitochon...
MRPL33
69Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04282214 – 65KNILV…KIRSL → NETKSPLRGKEKNTLPLNGG LKMTLIYKEKTEGGDTDSEI L in isoform 2. 1 PublicationAdd BLAST52

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF047440 mRNA Translation: AAC39891.1
CR542117 mRNA Translation: CAG46914.1
CR456888 mRNA Translation: CAG33169.1
AC021171 Genomic DNA No translation available.
AC074091 Genomic DNA Translation: AAX93204.1
AC110084 Genomic DNA No translation available.
CH471053 Genomic DNA Translation: EAX00552.1
BC009475 mRNA Translation: AAH09475.1
BC020834 mRNA Translation: AAH20834.1
BC090047 mRNA Translation: AAH90047.1
AB051623 Genomic DNA Translation: BAB54951.1
CCDSiCCDS1761.1 [O75394-1]
CCDS33167.1 [O75394-2]
RefSeqiNP_004882.1, NM_004891.3 [O75394-1]
NP_663303.1, NM_145330.2 [O75394-2]
UniGeneiHs.515879

Genome annotation databases

EnsembliENST00000296102; ENSP00000296102; ENSG00000243147 [O75394-1]
ENST00000379666; ENSP00000368988; ENSG00000243147 [O75394-2]
GeneIDi9553
KEGGihsa:9553
UCSCiuc002rlm.1 human [O75394-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF047440 mRNA Translation: AAC39891.1
CR542117 mRNA Translation: CAG46914.1
CR456888 mRNA Translation: CAG33169.1
AC021171 Genomic DNA No translation available.
AC074091 Genomic DNA Translation: AAX93204.1
AC110084 Genomic DNA No translation available.
CH471053 Genomic DNA Translation: EAX00552.1
BC009475 mRNA Translation: AAH09475.1
BC020834 mRNA Translation: AAH20834.1
BC090047 mRNA Translation: AAH90047.1
AB051623 Genomic DNA Translation: BAB54951.1
CCDSiCCDS1761.1 [O75394-1]
CCDS33167.1 [O75394-2]
RefSeqiNP_004882.1, NM_004891.3 [O75394-1]
NP_663303.1, NM_145330.2 [O75394-2]
UniGeneiHs.515879

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J7Yelectron microscopy3.4011-65[»]
3J9Melectron microscopy3.5011-65[»]
5OOLelectron microscopy3.0611-65[»]
5OOMelectron microscopy3.0311-65[»]
ProteinModelPortaliO75394
SMRiO75394
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114925, 37 interactors
CORUMiO75394
IntActiO75394, 9 interactors
STRINGi9606.ENSP00000296102

PTM databases

PhosphoSitePlusiO75394

Polymorphism and mutation databases

BioMutaiMRPL33

Proteomic databases

EPDiO75394
MaxQBiO75394
PaxDbiO75394
PeptideAtlasiO75394
PRIDEiO75394
ProteomicsDBi49965
49966 [O75394-2]
TopDownProteomicsiO75394-1 [O75394-1]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000296102; ENSP00000296102; ENSG00000243147 [O75394-1]
ENST00000379666; ENSP00000368988; ENSG00000243147 [O75394-2]
GeneIDi9553
KEGGihsa:9553
UCSCiuc002rlm.1 human [O75394-1]

Organism-specific databases

CTDi9553
DisGeNETi9553
EuPathDBiHostDB:ENSG00000243147.7
GeneCardsiMRPL33
HGNCiHGNC:14487 MRPL33
HPAiHPA066872
MIMi610059 gene
neXtProtiNX_O75394
OpenTargetsiENSG00000243147
PharmGKBiPA30964
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3505 Eukaryota
COG0267 LUCA
GeneTreeiENSGT00390000010130
HOGENOMiHOG000004840
HOVERGENiHBG053140
InParanoidiO75394
KOiK02913
OMAiAQTGFFY
OrthoDBiEOG091G1BUE
PhylomeDBiO75394
TreeFamiTF300279

Enzyme and pathway databases

ReactomeiR-HSA-5368286 Mitochondrial translation initiation
R-HSA-5389840 Mitochondrial translation elongation
R-HSA-5419276 Mitochondrial translation termination

Miscellaneous databases

ChiTaRSiMRPL33 human
GeneWikiiMRPL33
GenomeRNAii9553
PROiPR:O75394
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000243147 Expressed in 235 organ(s), highest expression level in right adrenal gland cortex
CleanExiHS_MRPL33
ExpressionAtlasiO75394 baseline and differential
GenevisibleiO75394 HS

Family and domain databases

Gene3Di2.20.28.120, 1 hit
InterProiView protein in InterPro
IPR038584 L33_sf
IPR001705 Ribosomal_L33
IPR011332 Ribosomal_zn-bd
PfamiView protein in Pfam
PF00471 Ribosomal_L33, 1 hit
SUPFAMiSSF57829 SSF57829, 1 hit
TIGRFAMsiTIGR01023 rpmG_bact, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRM33_HUMAN
AccessioniPrimary (citable) accession number: O75394
Secondary accession number(s): Q53RZ6, Q5FVE3, Q96Q50
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: November 1, 1998
Last modified: October 10, 2018
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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