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Protein

Sperm-associated antigen 7

Gene

SPAG7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Recommended name:
Sperm-associated antigen 7
Gene namesi
Name:SPAG7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000091640.7
HGNCiHGNC:11216 SPAG7
MIMi610056 gene
neXtProtiNX_O75391

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000091640
PharmGKBiPA36052

Polymorphism and mutation databases

BioMutaiSPAG7

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000720972 – 227Sperm-associated antigen 7Add BLAST226

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei114PhosphoserineCombined sources1
Modified residuei158PhosphoserineCombined sources1
Modified residuei202PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiO75391
MaxQBiO75391
PaxDbiO75391
PeptideAtlasiO75391
PRIDEiO75391
ProteomicsDBi49964

PTM databases

iPTMnetiO75391
PhosphoSitePlusiO75391

Expressioni

Tissue specificityi

Detected in fetal brain.1 Publication

Gene expression databases

BgeeiENSG00000091640 Expressed in 232 organ(s), highest expression level in muscle of leg
CleanExiHS_SPAG7
ExpressionAtlasiO75391 baseline and differential
GenevisibleiO75391 HS

Organism-specific databases

HPAiHPA024032
HPA052394

Interactioni

Protein-protein interaction databases

BioGridi114924, 10 interactors
IntActiO75391, 4 interactors
STRINGi9606.ENSP00000206020

Structurei

Secondary structure

1227
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliO75391
SMRiO75391
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO75391

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini46 – 109R3HPROSITE-ProRule annotationAdd BLAST64

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi35 – 51Nuclear localization signalSequence analysisAdd BLAST17
Motifi122 – 139Nuclear localization signalSequence analysisAdd BLAST18

Phylogenomic databases

eggNOGiENOG410IG7F Eukaryota
ENOG4111H0W LUCA
GeneTreeiENSGT00390000001520
HOGENOMiHOG000234363
HOVERGENiHBG066267
InParanoidiO75391
OMAiHRSVIHE
OrthoDBiEOG091G0QPO
PhylomeDBiO75391
TreeFamiTF323631

Family and domain databases

CDDicd02636 R3H_sperm-antigen, 1 hit
Gene3Di3.30.1370.50, 1 hit
InterProiView protein in InterPro
IPR001374 R3H_dom
IPR036867 R3H_dom_sf
IPR034068 R3H_sperm-antigen
IPR017330 SPAG7
PANTHERiPTHR13498 PTHR13498, 1 hit
PfamiView protein in Pfam
PF01424 R3H, 1 hit
PIRSFiPIRSF037943 Sperm-assoc_antigen_PAG7, 1 hit
SMARTiView protein in SMART
SM00393 R3H, 1 hit
SUPFAMiSSF82708 SSF82708, 1 hit
PROSITEiView protein in PROSITE
PS51061 R3H, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

O75391-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MADLLGSILS SMEKPPSLGD QETRRKAREQ AARLKKLQEQ EKQQKVEFRK
60 70 80 90 100
RMEKEVSDFI QDSGQIKKKF QPMNKIERSI LHDVVEVAGL TSFSFGEDDD
110 120 130 140 150
CRYVMIFKKE FAPSDEELDS YRRGEEWDPQ KAEEKRKLKE LAQRQEEEAA
160 170 180 190 200
QQGPVVVSPA SDYKDKYSHL IGKGAAKDAA HMLQANKTYG CVPVANKRDT
210 220
RSIEEAMNEI RAKKRLRQSG EELPPTS
Length:227
Mass (Da):26,034
Last modified:March 29, 2005 - v2
Checksum:i429566BE9B276EE4
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
I3L0X5I3L0X5_HUMAN
Sperm-associated antigen 7
SPAG7
176Annotation score:
I3L4C3I3L4C3_HUMAN
Sperm-associated antigen 7
SPAG7
194Annotation score:
I3L0Q5I3L0Q5_HUMAN
Sperm-associated antigen 7
SPAG7
87Annotation score:

Sequence cautioni

The sequence AAC39888 differs from that shown. Reason: Frameshift at position 227.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF047437 mRNA Translation: AAC39888.1 Frameshift.
BC011934 mRNA Translation: AAH11934.1
CCDSiCCDS42240.1
RefSeqiNP_004881.2, NM_004890.2
UniGeneiHs.90436

Genome annotation databases

EnsembliENST00000206020; ENSP00000206020; ENSG00000091640
GeneIDi9552
KEGGihsa:9552
UCSCiuc002gae.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF047437 mRNA Translation: AAC39888.1 Frameshift.
BC011934 mRNA Translation: AAH11934.1
CCDSiCCDS42240.1
RefSeqiNP_004881.2, NM_004890.2
UniGeneiHs.90436

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2CPMNMR-A44-124[»]
ProteinModelPortaliO75391
SMRiO75391
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114924, 10 interactors
IntActiO75391, 4 interactors
STRINGi9606.ENSP00000206020

PTM databases

iPTMnetiO75391
PhosphoSitePlusiO75391

Polymorphism and mutation databases

BioMutaiSPAG7

Proteomic databases

EPDiO75391
MaxQBiO75391
PaxDbiO75391
PeptideAtlasiO75391
PRIDEiO75391
ProteomicsDBi49964

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000206020; ENSP00000206020; ENSG00000091640
GeneIDi9552
KEGGihsa:9552
UCSCiuc002gae.4 human

Organism-specific databases

CTDi9552
EuPathDBiHostDB:ENSG00000091640.7
GeneCardsiSPAG7
HGNCiHGNC:11216 SPAG7
HPAiHPA024032
HPA052394
MIMi610056 gene
neXtProtiNX_O75391
OpenTargetsiENSG00000091640
PharmGKBiPA36052
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IG7F Eukaryota
ENOG4111H0W LUCA
GeneTreeiENSGT00390000001520
HOGENOMiHOG000234363
HOVERGENiHBG066267
InParanoidiO75391
OMAiHRSVIHE
OrthoDBiEOG091G0QPO
PhylomeDBiO75391
TreeFamiTF323631

Miscellaneous databases

ChiTaRSiSPAG7 human
EvolutionaryTraceiO75391
GeneWikiiSPAG7
GenomeRNAii9552
PROiPR:O75391
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000091640 Expressed in 232 organ(s), highest expression level in muscle of leg
CleanExiHS_SPAG7
ExpressionAtlasiO75391 baseline and differential
GenevisibleiO75391 HS

Family and domain databases

CDDicd02636 R3H_sperm-antigen, 1 hit
Gene3Di3.30.1370.50, 1 hit
InterProiView protein in InterPro
IPR001374 R3H_dom
IPR036867 R3H_dom_sf
IPR034068 R3H_sperm-antigen
IPR017330 SPAG7
PANTHERiPTHR13498 PTHR13498, 1 hit
PfamiView protein in Pfam
PF01424 R3H, 1 hit
PIRSFiPIRSF037943 Sperm-assoc_antigen_PAG7, 1 hit
SMARTiView protein in SMART
SM00393 R3H, 1 hit
SUPFAMiSSF82708 SSF82708, 1 hit
PROSITEiView protein in PROSITE
PS51061 R3H, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSPAG7_HUMAN
AccessioniPrimary (citable) accession number: O75391
Secondary accession number(s): Q96EU5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: March 29, 2005
Last modified: November 7, 2018
This is version 139 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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