UniProtKB - O75391 (SPAG7_HUMAN)
Protein
Sperm-associated antigen 7
Gene
SPAG7
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- nucleic acid binding Source: InterPro
Enzyme and pathway databases
PathwayCommonsi | O75391 |
Names & Taxonomyi
Protein namesi | Recommended name: Sperm-associated antigen 7 |
Gene namesi | Name:SPAG7 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:11216, SPAG7 |
MIMi | 610056, gene |
neXtProti | NX_O75391 |
VEuPathDBi | HostDB:ENSG00000091640.7 |
Subcellular locationi
Nucleus
- Nucleus Curated
Nucleus
- nucleus Source: UniProtKB-SubCell
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 9552 |
OpenTargetsi | ENSG00000091640 |
PharmGKBi | PA36052 |
Miscellaneous databases
Pharosi | O75391, Tbio |
Genetic variation databases
BioMutai | SPAG7 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources | |||
ChainiPRO_0000072097 | 2 – 227 | Sperm-associated antigen 7Add BLAST | 226 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineCombined sources | 1 | |
Modified residuei | 114 | PhosphoserineCombined sources | 1 | |
Modified residuei | 158 | PhosphoserineCombined sources | 1 | |
Modified residuei | 202 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | O75391 |
jPOSTi | O75391 |
MassIVEi | O75391 |
MaxQBi | O75391 |
PaxDbi | O75391 |
PeptideAtlasi | O75391 |
PRIDEi | O75391 |
ProteomicsDBi | 49964 |
PTM databases
iPTMneti | O75391 |
MetOSitei | O75391 |
PhosphoSitePlusi | O75391 |
Expressioni
Tissue specificityi
Detected in fetal brain.1 Publication
Gene expression databases
Bgeei | ENSG00000091640, Expressed in muscle of leg and 244 other tissues |
ExpressionAtlasi | O75391, baseline and differential |
Genevisiblei | O75391, HS |
Organism-specific databases
HPAi | ENSG00000091640, Tissue enhanced (skeletal) |
Interactioni
Binary interactionsi
O75391
With | #Exp. | IntAct |
---|---|---|
LXN [Q9BS40] | 3 | EBI-348464,EBI-1044504 |
Protein-protein interaction databases
BioGRIDi | 114924, 16 interactors |
IntActi | O75391, 7 interactors |
STRINGi | 9606.ENSP00000206020 |
Miscellaneous databases
RNActi | O75391, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | O75391 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | O75391 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 46 – 109 | R3HPROSITE-ProRule annotationAdd BLAST | 64 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 35 – 51 | Nuclear localization signalSequence analysisAdd BLAST | 17 | |
Motifi | 122 – 139 | Nuclear localization signalSequence analysisAdd BLAST | 18 |
Phylogenomic databases
eggNOGi | ENOG502QW1E, Eukaryota |
GeneTreei | ENSGT00390000001520 |
HOGENOMi | CLU_091198_0_0_1 |
InParanoidi | O75391 |
OMAi | HRSVIHE |
OrthoDBi | 1416114at2759 |
PhylomeDBi | O75391 |
TreeFami | TF323631 |
Family and domain databases
CDDi | cd02636, R3H_sperm-antigen, 1 hit |
Gene3Di | 3.30.1370.50, 1 hit |
InterProi | View protein in InterPro IPR001374, R3H_dom IPR036867, R3H_dom_sf IPR034068, R3H_sperm-antigen IPR017330, SPAG7 |
PANTHERi | PTHR13498, PTHR13498, 1 hit |
Pfami | View protein in Pfam PF01424, R3H, 1 hit |
PIRSFi | PIRSF037943, Sperm-assoc_antigen_PAG7, 1 hit |
SMARTi | View protein in SMART SM00393, R3H, 1 hit |
SUPFAMi | SSF82708, SSF82708, 1 hit |
PROSITEi | View protein in PROSITE PS51061, R3H, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
O75391-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MADLLGSILS SMEKPPSLGD QETRRKAREQ AARLKKLQEQ EKQQKVEFRK
60 70 80 90 100
RMEKEVSDFI QDSGQIKKKF QPMNKIERSI LHDVVEVAGL TSFSFGEDDD
110 120 130 140 150
CRYVMIFKKE FAPSDEELDS YRRGEEWDPQ KAEEKRKLKE LAQRQEEEAA
160 170 180 190 200
QQGPVVVSPA SDYKDKYSHL IGKGAAKDAA HMLQANKTYG CVPVANKRDT
210 220
RSIEEAMNEI RAKKRLRQSG EELPPTS
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketI3L0X5 | I3L0X5_HUMAN | Sperm-associated antigen 7 | SPAG7 | 176 | Annotation score: | ||
I3L4C3 | I3L4C3_HUMAN | Sperm-associated antigen 7 | SPAG7 | 194 | Annotation score: | ||
I3L0Q5 | I3L0Q5_HUMAN | Sperm-associated antigen 7 | SPAG7 | 87 | Annotation score: |
Sequence cautioni
The sequence AAC39888 differs from that shown. Reason: Frameshift.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF047437 mRNA Translation: AAC39888.1 Frameshift. BC011934 mRNA Translation: AAH11934.1 |
CCDSi | CCDS42240.1 |
RefSeqi | NP_004881.2, NM_004890.2 |
Genome annotation databases
Ensembli | ENST00000206020; ENSP00000206020; ENSG00000091640 |
GeneIDi | 9552 |
KEGGi | hsa:9552 |
UCSCi | uc002gae.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF047437 mRNA Translation: AAC39888.1 Frameshift. BC011934 mRNA Translation: AAH11934.1 |
CCDSi | CCDS42240.1 |
RefSeqi | NP_004881.2, NM_004890.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2CPM | NMR | - | A | 44-124 | [»] | |
SMRi | O75391 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 114924, 16 interactors |
IntActi | O75391, 7 interactors |
STRINGi | 9606.ENSP00000206020 |
PTM databases
iPTMneti | O75391 |
MetOSitei | O75391 |
PhosphoSitePlusi | O75391 |
Genetic variation databases
BioMutai | SPAG7 |
Proteomic databases
EPDi | O75391 |
jPOSTi | O75391 |
MassIVEi | O75391 |
MaxQBi | O75391 |
PaxDbi | O75391 |
PeptideAtlasi | O75391 |
PRIDEi | O75391 |
ProteomicsDBi | 49964 |
Protocols and materials databases
Antibodypediai | 5775, 77 antibodies |
Genome annotation databases
Ensembli | ENST00000206020; ENSP00000206020; ENSG00000091640 |
GeneIDi | 9552 |
KEGGi | hsa:9552 |
UCSCi | uc002gae.4, human |
Organism-specific databases
CTDi | 9552 |
DisGeNETi | 9552 |
GeneCardsi | SPAG7 |
HGNCi | HGNC:11216, SPAG7 |
HPAi | ENSG00000091640, Tissue enhanced (skeletal) |
MIMi | 610056, gene |
neXtProti | NX_O75391 |
OpenTargetsi | ENSG00000091640 |
PharmGKBi | PA36052 |
VEuPathDBi | HostDB:ENSG00000091640.7 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QW1E, Eukaryota |
GeneTreei | ENSGT00390000001520 |
HOGENOMi | CLU_091198_0_0_1 |
InParanoidi | O75391 |
OMAi | HRSVIHE |
OrthoDBi | 1416114at2759 |
PhylomeDBi | O75391 |
TreeFami | TF323631 |
Enzyme and pathway databases
PathwayCommonsi | O75391 |
Miscellaneous databases
BioGRID-ORCSi | 9552, 21 hits in 1007 CRISPR screens |
ChiTaRSi | SPAG7, human |
EvolutionaryTracei | O75391 |
GeneWikii | SPAG7 |
GenomeRNAii | 9552 |
Pharosi | O75391, Tbio |
PROi | PR:O75391 |
RNActi | O75391, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000091640, Expressed in muscle of leg and 244 other tissues |
ExpressionAtlasi | O75391, baseline and differential |
Genevisiblei | O75391, HS |
Family and domain databases
CDDi | cd02636, R3H_sperm-antigen, 1 hit |
Gene3Di | 3.30.1370.50, 1 hit |
InterProi | View protein in InterPro IPR001374, R3H_dom IPR036867, R3H_dom_sf IPR034068, R3H_sperm-antigen IPR017330, SPAG7 |
PANTHERi | PTHR13498, PTHR13498, 1 hit |
Pfami | View protein in Pfam PF01424, R3H, 1 hit |
PIRSFi | PIRSF037943, Sperm-assoc_antigen_PAG7, 1 hit |
SMARTi | View protein in SMART SM00393, R3H, 1 hit |
SUPFAMi | SSF82708, SSF82708, 1 hit |
PROSITEi | View protein in PROSITE PS51061, R3H, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SPAG7_HUMAN | |
Accessioni | O75391Primary (citable) accession number: O75391 Secondary accession number(s): Q96EU5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 29, 2005 |
Last sequence update: | March 29, 2005 | |
Last modified: | April 7, 2021 | |
This is version 153 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references