GPR32

Protein namesⁱ	Recommended name: Probable G-protein coupled receptor 32
Gene namesⁱ	Name:GPR32
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 19

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000142511.4
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:4487 GPR32
MIMⁱ	603195 gene
neXtProtⁱ	NX_O75388

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 44	ExtracellularSequence analysisAdd BLAST	44
Transmembraneⁱ	45 – 67	Helical; Name=1Sequence analysisAdd BLAST	23
Topological domainⁱ	68 – 78	CytoplasmicSequence analysisAdd BLAST	11
Transmembraneⁱ	79 – 100	Helical; Name=2Sequence analysisAdd BLAST	22
Topological domainⁱ	101 – 116	ExtracellularSequence analysisAdd BLAST	16
Transmembraneⁱ	117 – 137	Helical; Name=3Sequence analysisAdd BLAST	21
Topological domainⁱ	138 – 156	CytoplasmicSequence analysisAdd BLAST	19
Transmembraneⁱ	157 – 178	Helical; Name=4Sequence analysisAdd BLAST	22
Topological domainⁱ	179 – 220	ExtracellularSequence analysisAdd BLAST	42
Transmembraneⁱ	221 – 241	Helical; Name=5Sequence analysisAdd BLAST	21
Topological domainⁱ	242 – 257	CytoplasmicSequence analysisAdd BLAST	16
Transmembraneⁱ	258 – 280	Helical; Name=6Sequence analysisAdd BLAST	23
Topological domainⁱ	281 – 300	ExtracellularSequence analysisAdd BLAST	20
Transmembraneⁱ	301 – 320	Helical; Name=7Sequence analysisAdd BLAST	20
Topological domainⁱ	321 – 356	CytoplasmicSequence analysisAdd BLAST	36

Keywords - Cellular componentⁱ

Cell membrane, Membrane

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000142511
PharmGKBⁱ	PA28875

Chemistry databases

IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	99

GuidetoPHARMACOLOGYⁱ

99

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000069552	1 – 356	Probable G-protein coupled receptor 32Add BLAST		356

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	30	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	114 ↔ 191	PROSITE-ProRule annotation
Glycosylationⁱ	199	N-linked (GlcNAc...) asparagineSequence analysis	1

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbⁱ	O75388
PRIDEⁱ	O75388
ProteomicsDBⁱ	49962

PTM databases

iPTMnetⁱ	O75388
PhosphoSitePlusⁱ	O75388

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000142511 Expressed in 4 organ(s), highest expression level in adrenal tissue
CleanExⁱ	HS_GPR32
ExpressionAtlasⁱ	O75388 baseline and differential
Genevisibleⁱ	O75388 HS

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	9606.ENSP00000270590

STRINGⁱ

9606.ENSP00000270590

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	O75388
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410J9ZX Eukaryota ENOG4111EAW LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118990
HOGENOMⁱ	HOG000234122
HOVERGENⁱ	HBG107962
InParanoidⁱ	O75388
KEGG Orthology (KO) More...KOⁱ	K08381
OMAⁱ	QWLLGEW
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0L0L
PhylomeDBⁱ	O75388
TreeFamⁱ	TF341723

Family and domain databases

InterProⁱ	View protein in InterPro IPR000826 Formyl_rcpt-rel IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM
PANTHERⁱ	PTHR24225 PTHR24225, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00001 7tm_1, 1 hit
PRINTSⁱ	PR00237 GPCRRHODOPSN
PROSITEⁱ	View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

O75388-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MNGVSEGTRG CSDRQPGVLT RDRSCSRKMN SSGCLSEEVG SLRPLTVVIL 
        60         70         80         90        100
SASIVVGVLG NGLVLWMTVF RMARTVSTVC FFHLALADFM LSLSLPIAMY 
       110        120        130        140        150
YIVSRQWLLG EWACKLYITF VFLSYFASNC LLVFISVDRC ISVLYPVWAL 
       160        170        180        190        200
NHRTVQRASW LAFGVWLLAA ALCSAHLKFR TTRKWNGCTH CYLAFNSDNE 
       210        220        230        240        250
TAQIWIEGVV EGHIIGTIGH FLLGFLGPLA IIGTCAHLIR AKLLREGWVH 
       260        270        280        290        300
ANRPKRLLLV LVSAFFIFWS PFNVVLLVHL WRRVMLKEIY HPRMLLILQA 
       310        320        330        340        350
SFALGCVNSS LNPFLYVFVG RDFQEKFFQS LTSALARAFG EEEFLSSCPR 

GNAPRE

Length:356

Mass (Da):40,087

Last modified:November 1, 1998 - v1

Checksum:ⁱ0E00DCF4BD7F4C3A

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	167	L → P in AAH67453 (PubMed:15489334).Curated		1
Sequence conflictⁱ	186	N → D in AAH67453 (PubMed:15489334).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_011860	327	F → L. Corresponds to variant dbSNP:rs1864011Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF045764 Genomic DNA Translation: AAC39801.1 BC067453 mRNA Translation: AAH67453.1 BC067454 mRNA Translation: AAH67454.1 BC095544 mRNA Translation: AAH95544.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS12801.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001497.1, NM_001506.2
UniGeneⁱ	Hs.515555

Genome annotation databases

Ensemblⁱ	ENST00000270590; ENSP00000270590; ENSG00000142511
GeneIDⁱ	2854
KEGGⁱ	hsa:2854
UCSC genome browser More...UCSCⁱ	uc010ycf.3 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O75388	G protein-coupled receptor 32		HUMAN		356	UniRef100_O75388

Protein	Similar proteins		Species	Score	Length	Source
O75388	G protein-coupled receptor 32		HUMAN		356	UniRef90_O75388
GPR32 isoform 1		PONAB		370
G protein-coupled receptor 32		PANTR		356
Uncharacterized protein		PANPA		356
G protein-coupled receptor 32		GORGO		356
+1

Protein	Similar proteins		Species	Score	Length	Source
O75388	G protein-coupled receptor 32		HUMAN		356	UniRef50_O75388
GPR32 isoform 1		PONAB		370
Uncharacterized protein		PANPA		356
G protein-coupled receptor 32		GORGO		356
G protein-coupled receptor 32		PANTR		356
+36

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF045764 Genomic DNA Translation: AAC39801.1 BC067453 mRNA Translation: AAH67453.1 BC067454 mRNA Translation: AAH67454.1 BC095544 mRNA Translation: AAH95544.1
CCDSⁱ	CCDS12801.1
RefSeqⁱ	NP_001497.1, NM_001506.2
UniGeneⁱ	Hs.515555

3D structure databases

ProteinModelPortalⁱ	O75388
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	9606.ENSP00000270590

STRINGⁱ

9606.ENSP00000270590

Chemistry databases

GuidetoPHARMACOLOGYⁱ	99

GuidetoPHARMACOLOGYⁱ

99

Protein family/group databases

GPCRDBⁱ	Search...

GPCRDBⁱ

Search...

PTM databases

iPTMnetⁱ	O75388
PhosphoSitePlusⁱ	O75388

Proteomic databases

PaxDbⁱ	O75388
PRIDEⁱ	O75388
ProteomicsDBⁱ	49962

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	2854
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000270590; ENSP00000270590; ENSG00000142511
GeneIDⁱ	2854
KEGGⁱ	hsa:2854
UCSCⁱ	uc010ycf.3 human

Organism-specific databases

CTDⁱ	2854
EuPathDBⁱ	HostDB:ENSG00000142511.4
GeneCardsⁱ	GPR32
HGNCⁱ	HGNC:4487 GPR32
MIMⁱ	603195 gene
neXtProtⁱ	NX_O75388
OpenTargetsⁱ	ENSG00000142511
PharmGKBⁱ	PA28875
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410J9ZX Eukaryota ENOG4111EAW LUCA
GeneTreeⁱ	ENSGT00760000118990
HOGENOMⁱ	HOG000234122
HOVERGENⁱ	HBG107962
InParanoidⁱ	O75388
KOⁱ	K08381
OMAⁱ	QWLLGEW
OrthoDBⁱ	EOG091G0L0L
PhylomeDBⁱ	O75388
TreeFamⁱ	TF341723

Enzyme and pathway databases

Reactomeⁱ	R-HSA-418555 G alpha (s) signalling events

Reactomeⁱ

R-HSA-418555 G alpha (s) signalling events

Miscellaneous databases

GeneWikiⁱ	GPR32
GenomeRNAiⁱ	2854
Protein Ontology More...PROⁱ	PR:O75388
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000142511 Expressed in 4 organ(s), highest expression level in adrenal tissue
CleanExⁱ	HS_GPR32
ExpressionAtlasⁱ	O75388 baseline and differential
Genevisibleⁱ	O75388 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR000826 Formyl_rcpt-rel IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM
PANTHERⁱ	PTHR24225 PTHR24225, 1 hit
Pfamⁱ	View protein in Pfam PF00001 7tm_1, 1 hit
PRINTSⁱ	PR00237 GPCRRHODOPSN
PROSITEⁱ	View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	GPR32_HUMAN
Accessionⁱ	O75388Primary (citable) accession number: O75388 Secondary accession number(s): Q502U7, Q6NWS5
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
	Last sequence update:	November 1, 1998
	Last modified:	November 7, 2018
	This is version 140 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM
7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - O75388 (GPR32_HUMAN)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Probable G-protein coupled receptor 32

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Plasma Membrane

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Chemistry databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ