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Protein

Probable G-protein coupled receptor 32

Gene

GPR32

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Orphan receptor.

GO - Molecular functioni

  • G protein-coupled receptor activity Source: GO_Central
  • N-formyl peptide receptor activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-HSA-418555 G alpha (s) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Probable G-protein coupled receptor 32
Gene namesi
Name:GPR32
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000142511.4
HGNCiHGNC:4487 GPR32
MIMi603195 gene
neXtProtiNX_O75388

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 44ExtracellularSequence analysisAdd BLAST44
Transmembranei45 – 67Helical; Name=1Sequence analysisAdd BLAST23
Topological domaini68 – 78CytoplasmicSequence analysisAdd BLAST11
Transmembranei79 – 100Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini101 – 116ExtracellularSequence analysisAdd BLAST16
Transmembranei117 – 137Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini138 – 156CytoplasmicSequence analysisAdd BLAST19
Transmembranei157 – 178Helical; Name=4Sequence analysisAdd BLAST22
Topological domaini179 – 220ExtracellularSequence analysisAdd BLAST42
Transmembranei221 – 241Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini242 – 257CytoplasmicSequence analysisAdd BLAST16
Transmembranei258 – 280Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini281 – 300ExtracellularSequence analysisAdd BLAST20
Transmembranei301 – 320Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini321 – 356CytoplasmicSequence analysisAdd BLAST36

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000142511
PharmGKBiPA28875

Chemistry databases

GuidetoPHARMACOLOGYi99

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000695521 – 356Probable G-protein coupled receptor 32Add BLAST356

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi30N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi114 ↔ 191PROSITE-ProRule annotation
Glycosylationi199N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO75388
PRIDEiO75388
ProteomicsDBi49962

PTM databases

iPTMnetiO75388
PhosphoSitePlusiO75388

Expressioni

Gene expression databases

BgeeiENSG00000142511 Expressed in 4 organ(s), highest expression level in adrenal tissue
CleanExiHS_GPR32
ExpressionAtlasiO75388 baseline and differential
GenevisibleiO75388 HS

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000270590

Structurei

3D structure databases

ProteinModelPortaliO75388
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J9ZX Eukaryota
ENOG4111EAW LUCA
GeneTreeiENSGT00760000118990
HOGENOMiHOG000234122
HOVERGENiHBG107962
InParanoidiO75388
KOiK08381
OMAiQWLLGEW
OrthoDBiEOG091G0L0L
PhylomeDBiO75388
TreeFamiTF341723

Family and domain databases

InterProiView protein in InterPro
IPR000826 Formyl_rcpt-rel
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PANTHERiPTHR24225 PTHR24225, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

O75388-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNGVSEGTRG CSDRQPGVLT RDRSCSRKMN SSGCLSEEVG SLRPLTVVIL
60 70 80 90 100
SASIVVGVLG NGLVLWMTVF RMARTVSTVC FFHLALADFM LSLSLPIAMY
110 120 130 140 150
YIVSRQWLLG EWACKLYITF VFLSYFASNC LLVFISVDRC ISVLYPVWAL
160 170 180 190 200
NHRTVQRASW LAFGVWLLAA ALCSAHLKFR TTRKWNGCTH CYLAFNSDNE
210 220 230 240 250
TAQIWIEGVV EGHIIGTIGH FLLGFLGPLA IIGTCAHLIR AKLLREGWVH
260 270 280 290 300
ANRPKRLLLV LVSAFFIFWS PFNVVLLVHL WRRVMLKEIY HPRMLLILQA
310 320 330 340 350
SFALGCVNSS LNPFLYVFVG RDFQEKFFQS LTSALARAFG EEEFLSSCPR

GNAPRE
Length:356
Mass (Da):40,087
Last modified:November 1, 1998 - v1
Checksum:i0E00DCF4BD7F4C3A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti167L → P in AAH67453 (PubMed:15489334).Curated1
Sequence conflicti186N → D in AAH67453 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_011860327F → L. Corresponds to variant dbSNP:rs1864011Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF045764 Genomic DNA Translation: AAC39801.1
BC067453 mRNA Translation: AAH67453.1
BC067454 mRNA Translation: AAH67454.1
BC095544 mRNA Translation: AAH95544.1
CCDSiCCDS12801.1
RefSeqiNP_001497.1, NM_001506.2
UniGeneiHs.515555

Genome annotation databases

EnsembliENST00000270590; ENSP00000270590; ENSG00000142511
GeneIDi2854
KEGGihsa:2854
UCSCiuc010ycf.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF045764 Genomic DNA Translation: AAC39801.1
BC067453 mRNA Translation: AAH67453.1
BC067454 mRNA Translation: AAH67454.1
BC095544 mRNA Translation: AAH95544.1
CCDSiCCDS12801.1
RefSeqiNP_001497.1, NM_001506.2
UniGeneiHs.515555

3D structure databases

ProteinModelPortaliO75388
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000270590

Chemistry databases

GuidetoPHARMACOLOGYi99

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiO75388
PhosphoSitePlusiO75388

Proteomic databases

PaxDbiO75388
PRIDEiO75388
ProteomicsDBi49962

Protocols and materials databases

DNASUi2854
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000270590; ENSP00000270590; ENSG00000142511
GeneIDi2854
KEGGihsa:2854
UCSCiuc010ycf.3 human

Organism-specific databases

CTDi2854
EuPathDBiHostDB:ENSG00000142511.4
GeneCardsiGPR32
HGNCiHGNC:4487 GPR32
MIMi603195 gene
neXtProtiNX_O75388
OpenTargetsiENSG00000142511
PharmGKBiPA28875
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J9ZX Eukaryota
ENOG4111EAW LUCA
GeneTreeiENSGT00760000118990
HOGENOMiHOG000234122
HOVERGENiHBG107962
InParanoidiO75388
KOiK08381
OMAiQWLLGEW
OrthoDBiEOG091G0L0L
PhylomeDBiO75388
TreeFamiTF341723

Enzyme and pathway databases

ReactomeiR-HSA-418555 G alpha (s) signalling events

Miscellaneous databases

GeneWikiiGPR32
GenomeRNAii2854
PROiPR:O75388
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000142511 Expressed in 4 organ(s), highest expression level in adrenal tissue
CleanExiHS_GPR32
ExpressionAtlasiO75388 baseline and differential
GenevisibleiO75388 HS

Family and domain databases

InterProiView protein in InterPro
IPR000826 Formyl_rcpt-rel
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PANTHERiPTHR24225 PTHR24225, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGPR32_HUMAN
AccessioniPrimary (citable) accession number: O75388
Secondary accession number(s): Q502U7, Q6NWS5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1998
Last modified: November 7, 2018
This is version 140 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  6. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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