UniProtKB - O75388 (GPR32_HUMAN)
Protein
Probable G-protein coupled receptor 32
Gene
GPR32
Organism
Homo sapiens (Human)
Status
Functioni
Orphan receptor.
GO - Molecular functioni
- complement receptor activity Source: GO_Central
- G protein-coupled receptor activity Source: GO_Central
- N-formyl peptide receptor activity Source: GO_Central
GO - Biological processi
- complement receptor mediated signaling pathway Source: GO_Central
- G protein-coupled receptor signaling pathway Source: Reactome
- inflammatory response Source: GO_Central
- phospholipase C-activating G protein-coupled receptor signaling pathway Source: GO_Central
- positive regulation of cytosolic calcium ion concentration Source: GO_Central
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Enzyme and pathway databases
PathwayCommonsi | O75388 |
Reactomei | R-HSA-418555, G alpha (s) signalling events R-HSA-9660821, ADORA2B mediated anti-inflammatory cytokines production |
Names & Taxonomyi
Protein namesi | Recommended name: Probable G-protein coupled receptor 32 |
Gene namesi | Name:GPR32 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000142511.4 |
HGNCi | HGNC:4487, GPR32 |
MIMi | 603195, gene |
neXtProti | NX_O75388 |
Subcellular locationi
Plasma membrane
Plasma Membrane
- integral component of plasma membrane Source: ProtInc
- plasma membrane Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 44 | ExtracellularSequence analysisAdd BLAST | 44 | |
Transmembranei | 45 – 67 | Helical; Name=1Sequence analysisAdd BLAST | 23 | |
Topological domaini | 68 – 78 | CytoplasmicSequence analysisAdd BLAST | 11 | |
Transmembranei | 79 – 100 | Helical; Name=2Sequence analysisAdd BLAST | 22 | |
Topological domaini | 101 – 116 | ExtracellularSequence analysisAdd BLAST | 16 | |
Transmembranei | 117 – 137 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Topological domaini | 138 – 156 | CytoplasmicSequence analysisAdd BLAST | 19 | |
Transmembranei | 157 – 178 | Helical; Name=4Sequence analysisAdd BLAST | 22 | |
Topological domaini | 179 – 220 | ExtracellularSequence analysisAdd BLAST | 42 | |
Transmembranei | 221 – 241 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Topological domaini | 242 – 257 | CytoplasmicSequence analysisAdd BLAST | 16 | |
Transmembranei | 258 – 280 | Helical; Name=6Sequence analysisAdd BLAST | 23 | |
Topological domaini | 281 – 300 | ExtracellularSequence analysisAdd BLAST | 20 | |
Transmembranei | 301 – 320 | Helical; Name=7Sequence analysisAdd BLAST | 20 | |
Topological domaini | 321 – 356 | CytoplasmicSequence analysisAdd BLAST | 36 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 2854 |
OpenTargetsi | ENSG00000142511 |
PharmGKBi | PA28875 |
Miscellaneous databases
Pharosi | O75388, Tchem |
Chemistry databases
GuidetoPHARMACOLOGYi | 99 |
Polymorphism and mutation databases
BioMutai | GPR32 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000069552 | 1 – 356 | Probable G-protein coupled receptor 32Add BLAST | 356 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 30 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 114 ↔ 191 | PROSITE-ProRule annotation | ||
Glycosylationi | 199 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PaxDbi | O75388 |
PeptideAtlasi | O75388 |
PRIDEi | O75388 |
ProteomicsDBi | 49962 |
PTM databases
GlyGeni | O75388, 2 sites |
iPTMneti | O75388 |
PhosphoSitePlusi | O75388 |
Expressioni
Gene expression databases
Bgeei | ENSG00000142511, Expressed in adrenal tissue and 5 other tissues |
ExpressionAtlasi | O75388, baseline and differential |
Genevisiblei | O75388, HS |
Organism-specific databases
HPAi | ENSG00000142511, Tissue enriched (parathyroid) |
Interactioni
Protein-protein interaction databases
STRINGi | 9606.ENSP00000270590 |
Miscellaneous databases
RNActi | O75388, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502SYVA, Eukaryota |
GeneTreei | ENSGT01010000222346 |
HOGENOMi | CLU_009579_8_0_1 |
InParanoidi | O75388 |
OMAi | WACKLYI |
OrthoDBi | 910274at2759 |
PhylomeDBi | O75388 |
TreeFami | TF341723 |
Family and domain databases
InterProi | View protein in InterPro IPR000826, Formyl_rcpt-rel IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
PANTHERi | PTHR24225, PTHR24225, 1 hit |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
i Sequence
Sequence statusi: Complete.
O75388-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNGVSEGTRG CSDRQPGVLT RDRSCSRKMN SSGCLSEEVG SLRPLTVVIL
60 70 80 90 100
SASIVVGVLG NGLVLWMTVF RMARTVSTVC FFHLALADFM LSLSLPIAMY
110 120 130 140 150
YIVSRQWLLG EWACKLYITF VFLSYFASNC LLVFISVDRC ISVLYPVWAL
160 170 180 190 200
NHRTVQRASW LAFGVWLLAA ALCSAHLKFR TTRKWNGCTH CYLAFNSDNE
210 220 230 240 250
TAQIWIEGVV EGHIIGTIGH FLLGFLGPLA IIGTCAHLIR AKLLREGWVH
260 270 280 290 300
ANRPKRLLLV LVSAFFIFWS PFNVVLLVHL WRRVMLKEIY HPRMLLILQA
310 320 330 340 350
SFALGCVNSS LNPFLYVFVG RDFQEKFFQS LTSALARAFG EEEFLSSCPR
GNAPRE
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 167 | L → P in AAH67453 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 186 | N → D in AAH67453 (PubMed:15489334).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_011860 | 327 | F → L. Corresponds to variant dbSNP:rs1864011Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF045764 Genomic DNA Translation: AAC39801.1 BC067453 mRNA Translation: AAH67453.1 BC067454 mRNA Translation: AAH67454.1 BC095544 mRNA Translation: AAH95544.1 |
CCDSi | CCDS12801.1 |
RefSeqi | NP_001497.1, NM_001506.2 |
Genome annotation databases
Ensembli | ENST00000270590; ENSP00000270590; ENSG00000142511 |
GeneIDi | 2854 |
KEGGi | hsa:2854 |
UCSCi | uc010ycf.3, human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF045764 Genomic DNA Translation: AAC39801.1 BC067453 mRNA Translation: AAH67453.1 BC067454 mRNA Translation: AAH67454.1 BC095544 mRNA Translation: AAH95544.1 |
CCDSi | CCDS12801.1 |
RefSeqi | NP_001497.1, NM_001506.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 9606.ENSP00000270590 |
Chemistry databases
GuidetoPHARMACOLOGYi | 99 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
GlyGeni | O75388, 2 sites |
iPTMneti | O75388 |
PhosphoSitePlusi | O75388 |
Polymorphism and mutation databases
BioMutai | GPR32 |
Proteomic databases
PaxDbi | O75388 |
PeptideAtlasi | O75388 |
PRIDEi | O75388 |
ProteomicsDBi | 49962 |
Protocols and materials databases
Antibodypediai | 18901, 291 antibodies |
DNASUi | 2854 |
Genome annotation databases
Ensembli | ENST00000270590; ENSP00000270590; ENSG00000142511 |
GeneIDi | 2854 |
KEGGi | hsa:2854 |
UCSCi | uc010ycf.3, human |
Organism-specific databases
CTDi | 2854 |
DisGeNETi | 2854 |
EuPathDBi | HostDB:ENSG00000142511.4 |
GeneCardsi | GPR32 |
HGNCi | HGNC:4487, GPR32 |
HPAi | ENSG00000142511, Tissue enriched (parathyroid) |
MIMi | 603195, gene |
neXtProti | NX_O75388 |
OpenTargetsi | ENSG00000142511 |
PharmGKBi | PA28875 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502SYVA, Eukaryota |
GeneTreei | ENSGT01010000222346 |
HOGENOMi | CLU_009579_8_0_1 |
InParanoidi | O75388 |
OMAi | WACKLYI |
OrthoDBi | 910274at2759 |
PhylomeDBi | O75388 |
TreeFami | TF341723 |
Enzyme and pathway databases
PathwayCommonsi | O75388 |
Reactomei | R-HSA-418555, G alpha (s) signalling events R-HSA-9660821, ADORA2B mediated anti-inflammatory cytokines production |
Miscellaneous databases
BioGRID-ORCSi | 2854, 2 hits in 836 CRISPR screens |
ChiTaRSi | GPR32, human |
GeneWikii | GPR32 |
GenomeRNAii | 2854 |
Pharosi | O75388, Tchem |
PROi | PR:O75388 |
RNActi | O75388, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000142511, Expressed in adrenal tissue and 5 other tissues |
ExpressionAtlasi | O75388, baseline and differential |
Genevisiblei | O75388, HS |
Family and domain databases
InterProi | View protein in InterPro IPR000826, Formyl_rcpt-rel IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
PANTHERi | PTHR24225, PTHR24225, 1 hit |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | GPR32_HUMAN | |
Accessioni | O75388Primary (citable) accession number: O75388 Secondary accession number(s): Q502U7, Q6NWS5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 30, 2000 |
Last sequence update: | November 1, 1998 | |
Last modified: | December 2, 2020 | |
This is version 154 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries