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Protein

Large neutral amino acids transporter small subunit 3

Gene

SLC43A1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Sodium-independent, high affinity transport of large neutral amino acids. Has narrower substrate selectivity compared to SLC7A5 and SLC7A8 and mainly transports branched-chain amino acids and phenylalanine. Plays a role in the development of human prostate cancer, from prostatic intraepithelial neoplasia to invasive prostate cancer.4 Publications

Miscellaneous

Up-regulated in early prostate cancer development with highest expression level in seminomas of testicular germ cell tumors.2 Publications

GO - Molecular functioni

  • amino acid transmembrane transporter activity Source: Reactome
  • L-amino acid transmembrane transporter activity Source: GO_Central
  • neutral amino acid transmembrane transporter activity Source: UniProtKB

GO - Biological processi

Keywordsi

Biological processAmino-acid transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-352230 Amino acid transport across the plasma membrane

Protein family/group databases

TCDBi2.A.1.44.1 the major facilitator superfamily (mfs)

Names & Taxonomyi

Protein namesi
Recommended name:
Large neutral amino acids transporter small subunit 3
Alternative name(s):
L-type amino acid transporter 3
Prostate cancer overexpressed gene 1 protein
Solute carrier family 43 member 1
Gene namesi
Name:SLC43A1Imported
Synonyms:LAT3Imported, PB391 Publication, POV11 Publication
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000149150.8
HGNCiHGNC:9225 SLC43A1
MIMi603733 gene
neXtProtiNX_O75387

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei20 – 40HelicalSequence analysisAdd BLAST21
Transmembranei78 – 98HelicalSequence analysisAdd BLAST21
Transmembranei105 – 124HelicalSequence analysisAdd BLAST20
Transmembranei131 – 151HelicalSequence analysisAdd BLAST21
Transmembranei168 – 188HelicalSequence analysisAdd BLAST21
Transmembranei191 – 211HelicalSequence analysisAdd BLAST21
Transmembranei304 – 324HelicalSequence analysisAdd BLAST21
Transmembranei357 – 377HelicalSequence analysisAdd BLAST21
Transmembranei419 – 439HelicalSequence analysisAdd BLAST21
Transmembranei446 – 466HelicalSequence analysisAdd BLAST21
Transmembranei485 – 505HelicalSequence analysisAdd BLAST21
Transmembranei510 – 530HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi8501
OpenTargetsiENSG00000149150
PharmGKBiPA33549

Chemistry databases

ChEMBLiCHEMBL4148

Polymorphism and mutation databases

BioMutaiSLC43A1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002186401 – 559Large neutral amino acids transporter small subunit 3Add BLAST559

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi57N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi212N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi229N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei237PhosphoserineCombined sources1
Modified residuei262PhosphoserineCombined sources1
Modified residuei267PhosphoserineCombined sources1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiO75387
MaxQBiO75387
PaxDbiO75387
PeptideAtlasiO75387
PRIDEiO75387
ProteomicsDBi49960
49961 [O75387-2]

PTM databases

iPTMnetiO75387
PhosphoSitePlusiO75387

Expressioni

Tissue specificityi

In adults, found in all tissues examined with highest expression in pancreas. In fetus, highest expression in liver and lower levels in kidney, and lung. High levels found in prostate cancer cells.4 Publications

Gene expression databases

BgeeiENSG00000149150 Expressed in 164 organ(s), highest expression level in body of pancreas
CleanExiHS_SLC43A1
ExpressionAtlasiO75387 baseline and differential
GenevisibleiO75387 HS

Organism-specific databases

HPAiHPA018813
HPA018826

Interactioni

Protein-protein interaction databases

BioGridi114073, 3 interactors
DIPiDIP-47272N
IntActiO75387, 2 interactors
STRINGi9606.ENSP00000278426

Structurei

3D structure databases

ProteinModelPortaliO75387
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHH0 Eukaryota
ENOG410Y95V LUCA
GeneTreeiENSGT00530000063043
HOGENOMiHOG000231937
HOVERGENiHBG072879
InParanoidiO75387
KOiK08228
OMAiAVYPANH
OrthoDBiEOG091G0407
PhylomeDBiO75387
TreeFamiTF328358

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR011701 MFS
IPR020846 MFS_dom
IPR036259 MFS_trans_sf
PfamiView protein in Pfam
PF07690 MFS_1, 1 hit
SUPFAMiSSF103473 SSF103473, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 11 Publication (identifier: O75387-1) [UniParc]FASTAAdd to basket
Also known as: 2.3kb1 Publication

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAPTLQQAYR RRWWMACTAV LENLFFSAVL LGWGSLLIIL KNEGFYSSTC
60 70 80 90 100
PAESSTNTTQ DEQRRWPGCD QQDEMLNLGF TIGSFVLSAT TLPLGILMDR
110 120 130 140 150
FGPRPVRLVG SACFTASCTL MALASRDVEA LSPLIFLALS LNGFGGICLT
160 170 180 190 200
FTSLTLPNMF GNLRSTLMAL MIGSYASSAI TFPGIKLIYD AGVAFVVIMF
210 220 230 240 250
TWSGLACLIF LNCTLNWPIE AFPAPEEVNY TKKIKLSGLA LDHKVTGDLF
260 270 280 290 300
YTHVTTMGQR LSQKAPSLED GSDAFMSPQD VRGTSENLPE RSVPLRKSLC
310 320 330 340 350
SPTFLWSLLT MGMTQLRIIF YMAAVNKMLE YLVTGGQEHE TNEQQQKVAE
360 370 380 390 400
TVGFYSSVFG AMQLLCLLTC PLIGYIMDWR IKDCVDAPTQ GTVLGDARDG
410 420 430 440 450
VATKSIRPRY CKIQKLTNAI SAFTLTNLLL VGFGITCLIN NLHLQFVTFV
460 470 480 490 500
LHTIVRGFFH SACGSLYAAV FPSNHFGTLT GLQSLISAVF ALLQQPLFMA
510 520 530 540 550
MVGPLKGEPF WVNLGLLLFS LLGFLLPSYL FYYRARLQQE YAANGMGPLK

VLSGSEVTA
Length:559
Mass (Da):61,477
Last modified:November 1, 1998 - v1
Checksum:i49B0DECA3D930A45
GO
Isoform 21 Publication (identifier: O75387-2) [UniParc]FASTAAdd to basket
Also known as: 5kb1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     513-559: NLGLLLFSLL...KVLSGSEVTA → RARVGVGGAG...NLQVSKLSAF

Show »
Length:560
Mass (Da):61,051
Checksum:iCC4C698554DF06D1
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PJ68E9PJ68_HUMAN
Large neutral amino acids transport...
SLC43A1
259Annotation score:
E9PJT8E9PJT8_HUMAN
Large neutral amino acids transport...
SLC43A1
110Annotation score:
E9PR87E9PR87_HUMAN
Large neutral amino acids transport...
SLC43A1
171Annotation score:
H0YEH0H0YEH0_HUMAN
Large neutral amino acids transport...
SLC43A1
186Annotation score:
E9PRF0E9PRF0_HUMAN
Large neutral amino acids transport...
SLC43A1
58Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_053670238G → V. Corresponds to variant dbSNP:rs17151933Ensembl.1
Natural variantiVAR_053671443H → Y. Corresponds to variant dbSNP:rs34746107Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_051620513 – 559NLGLL…SEVTA → RARVGVGGAGATLLGAGVGP CMWCHPSLISARGTSEVSNL QVSKLSAF in isoform 2. 1 PublicationAdd BLAST47

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF045584 mRNA Translation: AAC33004.1
AB103033 mRNA Translation: BAD00152.1
BC001639 mRNA Translation: AAH01639.1
CCDSiCCDS7958.1 [O75387-1]
RefSeqiNP_001185739.1, NM_001198810.1 [O75387-1]
NP_003618.1, NM_003627.5 [O75387-1]
XP_016873940.1, XM_017018451.1 [O75387-1]
UniGeneiHs.591952
Hs.735724

Genome annotation databases

EnsembliENST00000278426; ENSP00000278426; ENSG00000149150 [O75387-1]
ENST00000528450; ENSP00000435673; ENSG00000149150 [O75387-1]
GeneIDi8501
KEGGihsa:8501
UCSCiuc001nkk.4 human [O75387-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF045584 mRNA Translation: AAC33004.1
AB103033 mRNA Translation: BAD00152.1
BC001639 mRNA Translation: AAH01639.1
CCDSiCCDS7958.1 [O75387-1]
RefSeqiNP_001185739.1, NM_001198810.1 [O75387-1]
NP_003618.1, NM_003627.5 [O75387-1]
XP_016873940.1, XM_017018451.1 [O75387-1]
UniGeneiHs.591952
Hs.735724

3D structure databases

ProteinModelPortaliO75387
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114073, 3 interactors
DIPiDIP-47272N
IntActiO75387, 2 interactors
STRINGi9606.ENSP00000278426

Chemistry databases

ChEMBLiCHEMBL4148

Protein family/group databases

TCDBi2.A.1.44.1 the major facilitator superfamily (mfs)

PTM databases

iPTMnetiO75387
PhosphoSitePlusiO75387

Polymorphism and mutation databases

BioMutaiSLC43A1

Proteomic databases

EPDiO75387
MaxQBiO75387
PaxDbiO75387
PeptideAtlasiO75387
PRIDEiO75387
ProteomicsDBi49960
49961 [O75387-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000278426; ENSP00000278426; ENSG00000149150 [O75387-1]
ENST00000528450; ENSP00000435673; ENSG00000149150 [O75387-1]
GeneIDi8501
KEGGihsa:8501
UCSCiuc001nkk.4 human [O75387-1]

Organism-specific databases

CTDi8501
DisGeNETi8501
EuPathDBiHostDB:ENSG00000149150.8
GeneCardsiSLC43A1
HGNCiHGNC:9225 SLC43A1
HPAiHPA018813
HPA018826
MIMi603733 gene
neXtProtiNX_O75387
OpenTargetsiENSG00000149150
PharmGKBiPA33549
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IHH0 Eukaryota
ENOG410Y95V LUCA
GeneTreeiENSGT00530000063043
HOGENOMiHOG000231937
HOVERGENiHBG072879
InParanoidiO75387
KOiK08228
OMAiAVYPANH
OrthoDBiEOG091G0407
PhylomeDBiO75387
TreeFamiTF328358

Enzyme and pathway databases

ReactomeiR-HSA-352230 Amino acid transport across the plasma membrane

Miscellaneous databases

ChiTaRSiSLC43A1 human
GeneWikiiSLC43A1
GenomeRNAii8501
PROiPR:O75387
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000149150 Expressed in 164 organ(s), highest expression level in body of pancreas
CleanExiHS_SLC43A1
ExpressionAtlasiO75387 baseline and differential
GenevisibleiO75387 HS

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR011701 MFS
IPR020846 MFS_dom
IPR036259 MFS_trans_sf
PfamiView protein in Pfam
PF07690 MFS_1, 1 hit
SUPFAMiSSF103473 SSF103473, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiLAT3_HUMAN
AccessioniPrimary (citable) accession number: O75387
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: November 1, 1998
Last modified: November 7, 2018
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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