UniProtKB - O75382 (TRIM3_HUMAN)
Tripartite motif-containing protein 3
TRIM3
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 22 – 63 | RING-typePROSITE-ProRule annotationAdd BLAST | 42 | |
Zinc fingeri | 110 – 151 | B box-typePROSITE-ProRule annotationAdd BLAST | 42 |
GO - Molecular functioni
- identical protein binding Source: IntAct
- protein C-terminus binding Source: ProtInc
- ubiquitin protein ligase activity Source: GO_Central
- zinc ion binding Source: InterPro
GO - Biological processi
- nervous system development Source: ProtInc
- proteasome-mediated ubiquitin-dependent protein catabolic process Source: GO_Central
- protein polyubiquitination Source: GO_Central
- protein transport Source: UniProtKB-KW
Keywordsi
Biological process | Protein transport, Transport |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | O75382 |
Reactomei | R-HSA-877300, Interferon gamma signaling |
Names & Taxonomyi
Protein namesi | Recommended name: Tripartite motif-containing protein 3Alternative name(s): Brain-expressed RING finger protein RING finger protein 22 RING finger protein 97 |
Gene namesi | Name:TRIM3 Synonyms:BERP, RNF22, RNF97 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:10064, TRIM3 |
MIMi | 605493, gene |
neXtProti | NX_O75382 |
VEuPathDBi | HostDB:ENSG00000110171.18 |
Subcellular locationi
Golgi apparatus
- trans-Golgi network By similarity
Endosome
- Early endosome 1 Publication
Other locations
Endosome
- early endosome Source: UniProtKB-SubCell
Golgi apparatus
- Golgi apparatus Source: UniProtKB-SubCell
Other locations
Keywords - Cellular componenti
Cell projection, Cytoplasm, Endosome, Golgi apparatusPathology & Biotechi
Organism-specific databases
DisGeNETi | 10612 |
OpenTargetsi | ENSG00000110171 |
PharmGKBi | PA35534 |
Miscellaneous databases
Pharosi | O75382, Tbio |
Genetic variation databases
BioMutai | TRIM3 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources | |||
ChainiPRO_0000056197 | 2 – 744 | Tripartite motif-containing protein 3Add BLAST | 743 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineCombined sources | 1 | |
Modified residuei | 7 | PhosphoserineCombined sources | 1 | |
Modified residuei | 427 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | O75382 |
jPOSTi | O75382 |
MassIVEi | O75382 |
MaxQBi | O75382 |
PaxDbi | O75382 |
PeptideAtlasi | O75382 |
PRIDEi | O75382 |
ProteomicsDBi | 26042 49955 [O75382-1] 49956 [O75382-2] 49957 [O75382-3] |
PTM databases
iPTMneti | O75382 |
PhosphoSitePlusi | O75382 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000110171, Expressed in right hemisphere of cerebellum and 204 other tissues |
ExpressionAtlasi | O75382, baseline and differential |
Genevisiblei | O75382, HS |
Organism-specific databases
HPAi | ENSG00000110171, Tissue enhanced (brain) |
Interactioni
Subunit structurei
Binary interactionsi
Hide detailsO75382
GO - Molecular functioni
- identical protein binding Source: IntAct
- protein C-terminus binding Source: ProtInc
Protein-protein interaction databases
BioGRIDi | 115858, 54 interactors |
CORUMi | O75382 |
IntActi | O75382, 24 interactors |
MINTi | O75382 |
STRINGi | 9606.ENSP00000433102 |
Miscellaneous databases
RNActi | O75382, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 317 – 418 | FilaminAdd BLAST | 102 | |
Repeati | 473 – 516 | NHL 1Add BLAST | 44 | |
Repeati | 520 – 563 | NHL 2Add BLAST | 44 | |
Repeati | 564 – 605 | NHL 3Add BLAST | 42 | |
Repeati | 609 – 652 | NHL 4Add BLAST | 44 | |
Repeati | 656 – 699 | NHL 5Add BLAST | 44 | |
Repeati | 700 – 743 | NHL 6Add BLAST | 44 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 2 – 290 | Interaction with KIF21BBy similarityAdd BLAST | 289 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 153 – 224 | Sequence analysisAdd BLAST | 72 |
Domaini
Sequence similaritiesi
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 22 – 63 | RING-typePROSITE-ProRule annotationAdd BLAST | 42 | |
Zinc fingeri | 110 – 151 | B box-typePROSITE-ProRule annotationAdd BLAST | 42 |
Keywords - Domaini
Coiled coil, Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG2177, Eukaryota |
GeneTreei | ENSGT00940000158173 |
HOGENOMi | CLU_008645_5_0_1 |
InParanoidi | O75382 |
OMAi | EPCETAM |
OrthoDBi | 489543at2759 |
PhylomeDBi | O75382 |
TreeFami | TF331018 |
Family and domain databases
CDDi | cd00021, BBOX, 1 hit |
Gene3Di | 2.120.10.30, 2 hits 2.60.40.10, 1 hit 3.30.40.10, 1 hit |
InterProi | View protein in InterPro IPR011042, 6-blade_b-propeller_TolB-like IPR003649, Bbox_C IPR017868, Filamin/ABP280_repeat-like IPR001298, Filamin/ABP280_rpt IPR013783, Ig-like_fold IPR014756, Ig_E-set IPR001258, NHL_repeat IPR013017, NHL_repeat_subgr IPR027370, Znf-RING_LisH IPR000315, Znf_B-box IPR001841, Znf_RING IPR013083, Znf_RING/FYVE/PHD IPR017907, Znf_RING_CS |
Pfami | View protein in Pfam PF00630, Filamin, 1 hit PF01436, NHL, 6 hits PF00643, zf-B_box, 1 hit PF13445, zf-RING_UBOX, 1 hit |
SMARTi | View protein in SMART SM00502, BBC, 1 hit SM00336, BBOX, 1 hit SM00557, IG_FLMN, 1 hit SM00184, RING, 1 hit |
SUPFAMi | SSF81296, SSF81296, 1 hit |
PROSITEi | View protein in PROSITE PS50194, FILAMIN_REPEAT, 1 hit PS51125, NHL, 6 hits PS50119, ZF_BBOX, 1 hit PS00518, ZF_RING_1, 1 hit PS50089, ZF_RING_2, 1 hit |
s (4+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAKREDSPGP EVQPMDKQFL VCSICLDRYQ CPKVLPCLHT FCERCLQNYI
60 70 80 90 100
PAQSLTLSCP VCRQTSILPE QGVSALQNNF FISSLMEAMQ QAPDGAHDPE
110 120 130 140 150
DPHPLSVVAG RPLSCPNHEG KTMEFYCEAC ETAMCGECRA GEHREHGTVL
160 170 180 190 200
LRDVVEQHKA ALQRQLEAVR GRLPQLSAAI ALVGGISQQL QERKAEALAQ
210 220 230 240 250
ISAAFEDLEQ ALQQRKQALV SDLETICGAK QKVLQSQLDT LRQGQEHIGS
260 270 280 290 300
SCSFAEQALR LGSAPEVLLV RKHMRERLAA LAAQAFPERP HENAQLELVL
310 320 330 340 350
EVDGLRRSVL NLGALLTTSA TAHETVATGE GLRQALVGQP ASLTVTTKDK
360 370 380 390 400
DGRLVRTGSA ELRAEITGPD GTRLPVPVVD HKNGTYELVY TARTEGELLL
410 420 430 440 450
SVLLYGQPVR GSPFRVRALR PGDLPPSPDD VKRRVKSPGG PGSHVRQKAV
460 470 480 490 500
RRPSSMYSTG GKRKDNPIED ELVFRVGSRG REKGEFTNLQ GVSAASSGRI
510 520 530 540 550
VVADSNNQCI QVFSNEGQFK FRFGVRGRSP GQLQRPTGVA VDTNGDIIVA
560 570 580 590 600
DYDNRWVSIF SPEGKFKTKI GAGRLMGPKG VAVDRNGHII VVDNKSCCVF
610 620 630 640 650
TFQPNGKLVG RFGGRGATDR HFAGPHFVAV NNKNEIVVTD FHNHSVKVYS
660 670 680 690 700
ADGEFLFKFG SHGEGNGQFN APTGVAVDSN GNIIVADWGN SRIQVFDSSG
710 720 730 740
SFLSYINTSA EPLYGPQGLA LTSDGHVVVA DAGNHCFKAY RYLQ
The sequence of this isoform differs from the canonical sequence as follows:
146-156: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
224-302: Missing.
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A1W2PPI7 | A0A1W2PPI7_HUMAN | Tripartite motif-containing protein... | TRIM3 | 703 | Annotation score: | ||
E9PMK8 | E9PMK8_HUMAN | Tripartite motif-containing protein... | TRIM3 | 260 | Annotation score: | ||
E9PMW5 | E9PMW5_HUMAN | Tripartite motif-containing protein... | TRIM3 | 96 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 113 | L → F in AAC24809 (PubMed:11170753).Curated | 1 | |
Sequence conflicti | 113 | L → F in AAG53474 (PubMed:11331580).Curated | 1 | |
Sequence conflicti | 113 | L → F in AAG53475 (PubMed:11331580).Curated | 1 | |
Sequence conflicti | 113 | L → F in AAG53476 (PubMed:11331580).Curated | 1 | |
Sequence conflicti | 236 | S → T in AAC24809 (PubMed:11170753).Curated | 1 | |
Sequence conflicti | 236 | S → T in AAG53474 (PubMed:11331580).Curated | 1 | |
Sequence conflicti | 236 | S → T in AAG53475 (PubMed:11331580).Curated | 1 | |
Sequence conflicti | 347 | T → A in AAC24809 (PubMed:11170753).Curated | 1 | |
Sequence conflicti | 347 | T → A in AAG53474 (PubMed:11331580).Curated | 1 | |
Sequence conflicti | 347 | T → A in AAG53475 (PubMed:11331580).Curated | 1 | |
Sequence conflicti | 347 | T → A in AAG53476 (PubMed:11331580).Curated | 1 | |
Sequence conflicti | 450 | V → L in BAH12882 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 631 | N → S in AAC24809 (PubMed:11170753).Curated | 1 | |
Sequence conflicti | 631 | N → S in AAG53474 (PubMed:11331580).Curated | 1 | |
Sequence conflicti | 631 | N → S in AAG53475 (PubMed:11331580).Curated | 1 | |
Sequence conflicti | 631 | N → S in AAG53476 (PubMed:11331580).Curated | 1 | |
Sequence conflicti | 636 | I → V in AAC24809 (PubMed:11170753).Curated | 1 | |
Sequence conflicti | 636 | I → V in AAG53474 (PubMed:11331580).Curated | 1 | |
Sequence conflicti | 636 | I → V in AAG53475 (PubMed:11331580).Curated | 1 | |
Sequence conflicti | 636 | I → V in AAG53476 (PubMed:11331580).Curated | 1 | |
Sequence conflicti | 646 | V → E in AAC24809 (PubMed:11170753).Curated | 1 | |
Sequence conflicti | 646 | V → E in AAG53474 (PubMed:11331580).Curated | 1 | |
Sequence conflicti | 646 | V → E in AAG53475 (PubMed:11331580).Curated | 1 | |
Sequence conflicti | 646 | V → E in AAG53476 (PubMed:11331580).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_052124 | 298 | L → R. Corresponds to variant dbSNP:rs10128723Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_044780 | 1 – 119 | Missing in isoform 4. 1 PublicationAdd BLAST | 119 | |
Alternative sequenceiVSP_044781 | 120 | G → M in isoform 4. 1 Publication | 1 | |
Alternative sequenceiVSP_005758 | 146 – 156 | Missing in isoform Beta. 1 PublicationAdd BLAST | 11 | |
Alternative sequenceiVSP_005759 | 224 – 302 | Missing in isoform Gamma. 1 PublicationAdd BLAST | 79 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF045239 mRNA Translation: AAC24809.1 AF220020 mRNA Translation: AAG53474.1 AF220021 mRNA Translation: AAG53475.1 AF220022 mRNA Translation: AAG53476.1 AK291396 mRNA Translation: BAF84085.1 AK298843 mRNA Translation: BAH12882.1 AC084337 Genomic DNA No translation available. CH471064 Genomic DNA Translation: EAW68709.1 BC096827 mRNA Translation: AAH96827.1 |
CCDSi | CCDS58115.1 [O75382-4] CCDS7764.1 [O75382-1] |
RefSeqi | NP_001234935.1, NM_001248006.1 [O75382-1] NP_001234936.1, NM_001248007.1 [O75382-4] NP_006449.2, NM_006458.3 [O75382-1] NP_150594.2, NM_033278.3 [O75382-1] XP_011518146.1, XM_011519844.1 XP_011518147.1, XM_011519845.2 [O75382-4] XP_016872587.1, XM_017017098.1 [O75382-1] XP_016872588.1, XM_017017099.1 |
Genome annotation databases
Ensembli | ENST00000345851; ENSP00000340797; ENSG00000110171 [O75382-1] ENST00000359518; ENSP00000352508; ENSG00000110171 [O75382-1] ENST00000525074; ENSP00000433102; ENSG00000110171 [O75382-1] ENST00000536344; ENSP00000445460; ENSG00000110171 [O75382-4] |
GeneIDi | 10612 |
KEGGi | hsa:10612 |
UCSCi | uc001mdh.4, human [O75382-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF045239 mRNA Translation: AAC24809.1 AF220020 mRNA Translation: AAG53474.1 AF220021 mRNA Translation: AAG53475.1 AF220022 mRNA Translation: AAG53476.1 AK291396 mRNA Translation: BAF84085.1 AK298843 mRNA Translation: BAH12882.1 AC084337 Genomic DNA No translation available. CH471064 Genomic DNA Translation: EAW68709.1 BC096827 mRNA Translation: AAH96827.1 |
CCDSi | CCDS58115.1 [O75382-4] CCDS7764.1 [O75382-1] |
RefSeqi | NP_001234935.1, NM_001248006.1 [O75382-1] NP_001234936.1, NM_001248007.1 [O75382-4] NP_006449.2, NM_006458.3 [O75382-1] NP_150594.2, NM_033278.3 [O75382-1] XP_011518146.1, XM_011519844.1 XP_011518147.1, XM_011519845.2 [O75382-4] XP_016872587.1, XM_017017098.1 [O75382-1] XP_016872588.1, XM_017017099.1 |
3D structure databases
SMRi | O75382 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 115858, 54 interactors |
CORUMi | O75382 |
IntActi | O75382, 24 interactors |
MINTi | O75382 |
STRINGi | 9606.ENSP00000433102 |
PTM databases
iPTMneti | O75382 |
PhosphoSitePlusi | O75382 |
Genetic variation databases
BioMutai | TRIM3 |
Proteomic databases
EPDi | O75382 |
jPOSTi | O75382 |
MassIVEi | O75382 |
MaxQBi | O75382 |
PaxDbi | O75382 |
PeptideAtlasi | O75382 |
PRIDEi | O75382 |
ProteomicsDBi | 26042 49955 [O75382-1] 49956 [O75382-2] 49957 [O75382-3] |
Protocols and materials databases
Antibodypediai | 11249, 239 antibodies |
Genome annotation databases
Ensembli | ENST00000345851; ENSP00000340797; ENSG00000110171 [O75382-1] ENST00000359518; ENSP00000352508; ENSG00000110171 [O75382-1] ENST00000525074; ENSP00000433102; ENSG00000110171 [O75382-1] ENST00000536344; ENSP00000445460; ENSG00000110171 [O75382-4] |
GeneIDi | 10612 |
KEGGi | hsa:10612 |
UCSCi | uc001mdh.4, human [O75382-1] |
Organism-specific databases
CTDi | 10612 |
DisGeNETi | 10612 |
GeneCardsi | TRIM3 |
HGNCi | HGNC:10064, TRIM3 |
HPAi | ENSG00000110171, Tissue enhanced (brain) |
MIMi | 605493, gene |
neXtProti | NX_O75382 |
OpenTargetsi | ENSG00000110171 |
PharmGKBi | PA35534 |
VEuPathDBi | HostDB:ENSG00000110171.18 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2177, Eukaryota |
GeneTreei | ENSGT00940000158173 |
HOGENOMi | CLU_008645_5_0_1 |
InParanoidi | O75382 |
OMAi | EPCETAM |
OrthoDBi | 489543at2759 |
PhylomeDBi | O75382 |
TreeFami | TF331018 |
Enzyme and pathway databases
PathwayCommonsi | O75382 |
Reactomei | R-HSA-877300, Interferon gamma signaling |
Miscellaneous databases
BioGRID-ORCSi | 10612, 3 hits in 877 CRISPR screens |
ChiTaRSi | TRIM3, human |
GeneWikii | TRIM3 |
GenomeRNAii | 10612 |
Pharosi | O75382, Tbio |
PROi | PR:O75382 |
RNActi | O75382, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000110171, Expressed in right hemisphere of cerebellum and 204 other tissues |
ExpressionAtlasi | O75382, baseline and differential |
Genevisiblei | O75382, HS |
Family and domain databases
CDDi | cd00021, BBOX, 1 hit |
Gene3Di | 2.120.10.30, 2 hits 2.60.40.10, 1 hit 3.30.40.10, 1 hit |
InterProi | View protein in InterPro IPR011042, 6-blade_b-propeller_TolB-like IPR003649, Bbox_C IPR017868, Filamin/ABP280_repeat-like IPR001298, Filamin/ABP280_rpt IPR013783, Ig-like_fold IPR014756, Ig_E-set IPR001258, NHL_repeat IPR013017, NHL_repeat_subgr IPR027370, Znf-RING_LisH IPR000315, Znf_B-box IPR001841, Znf_RING IPR013083, Znf_RING/FYVE/PHD IPR017907, Znf_RING_CS |
Pfami | View protein in Pfam PF00630, Filamin, 1 hit PF01436, NHL, 6 hits PF00643, zf-B_box, 1 hit PF13445, zf-RING_UBOX, 1 hit |
SMARTi | View protein in SMART SM00502, BBC, 1 hit SM00336, BBOX, 1 hit SM00557, IG_FLMN, 1 hit SM00184, RING, 1 hit |
SUPFAMi | SSF81296, SSF81296, 1 hit |
PROSITEi | View protein in PROSITE PS50194, FILAMIN_REPEAT, 1 hit PS51125, NHL, 6 hits PS50119, ZF_BBOX, 1 hit PS00518, ZF_RING_1, 1 hit PS50089, ZF_RING_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TRIM3_HUMAN | |
Accessioni | O75382Primary (citable) accession number: O75382 Secondary accession number(s): B7Z5E6 Q9C039 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 6, 2002 |
Last sequence update: | November 25, 2008 | |
Last modified: | February 10, 2021 | |
This is version 191 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families