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UniProtKB - O75382 (TRIM3_HUMAN)

Entry version 186 (22 Apr 2020)
Sequence version 2 (25 Nov 2008)
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Protein

Tripartite motif-containing protein 3

Gene

TRIM3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Probably involved in vesicular trafficking via its association with the CART complex (PubMed:15772161). The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation (PubMed:15772161). Positively regulates motility of microtubule-dependent motor protein KIF21B (By similarity).By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri22 – 63RING-typePROSITE-ProRule annotationAdd BLAST42
Zinc fingeri110 – 151B box-typePROSITE-ProRule annotationAdd BLAST42

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processProtein transport, Transport
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-877300 Interferon gamma signaling

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Tripartite motif-containing protein 3
Alternative name(s):
Brain-expressed RING finger protein
RING finger protein 22
RING finger protein 97
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TRIM3
Synonyms:BERP, RNF22, RNF97
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:10064 TRIM3

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		605493 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_O75382

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cytoplasm, Endosome, Golgi apparatus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		10612

Open Targets

More...OpenTargetsi		ENSG00000110171

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA35534

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		O75382 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		TRIM3

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000561972 – 744Tripartite motif-containing protein 3Add BLAST743

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1
Modified residuei7PhosphoserineCombined sources1
Modified residuei427PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		O75382

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		O75382

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		O75382

MaxQB - The MaxQuant DataBase

More...MaxQBi		O75382

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O75382

PeptideAtlas

More...PeptideAtlasi		O75382

PRoteomics IDEntifications database

More...PRIDEi		O75382

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		26042
49955 [O75382-1]
49956 [O75382-2]
49957 [O75382-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		O75382

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		O75382

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in brain, heart, uterus and testis.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000110171 Expressed in right hemisphere of cerebellum and 191 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		O75382 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		O75382 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000110171 Tissue enhanced (brain)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Associates with myosin-Vb (MYO5B) and alpha-actinin-4 (ACTN4) (By similarity).

Component of the CART complex, at least composed of ACTN4, HGS/HRS, MYO5B and TRIM3 (PubMed:15772161).

Interacts with ZFYVE28/LST2 (PubMed:19460345).

Interacts with KIF21B (By similarity).

By similarity2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Show more details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		115858, 28 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		O75382

Protein interaction database and analysis system

More...IntActi		O75382, 23 interactors

Molecular INTeraction database

More...MINTi		O75382

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000433102

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		O75382 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		O75382

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati317 – 418FilaminAdd BLAST102
Repeati473 – 516NHL 1Add BLAST44
Repeati520 – 563NHL 2Add BLAST44
Repeati564 – 605NHL 3Add BLAST42
Repeati609 – 652NHL 4Add BLAST44
Repeati656 – 699NHL 5Add BLAST44
Repeati700 – 743NHL 6Add BLAST44

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni2 – 290Interaction with KIF21BBy similarityAdd BLAST289

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili153 – 224Sequence analysisAdd BLAST72

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The interaction with MYO5B is dependent upon its NHL repeats, which form a beta-propeller (NHL) domain containing six blades.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TRIM/RBCC family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri22 – 63RING-typePROSITE-ProRule annotationAdd BLAST42
Zinc fingeri110 – 151B box-typePROSITE-ProRule annotationAdd BLAST42

Keywords - Domaini

Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG410ITF9 Eukaryota
ENOG410ZAM4 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000158173

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_008645_5_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O75382

KEGG Orthology (KO)

More...KOi		K11997

Identification of Orthologs from Complete Genome Data

More...OMAi		HSFPEHP

Database of Orthologous Groups

More...OrthoDBi		489543at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		O75382

TreeFam database of animal gene trees

More...TreeFami		TF331018

Family and domain databases

Conserved Domains Database

More...CDDi		cd00021 BBOX, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.120.10.30, 2 hits
2.60.40.10, 1 hit
3.30.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR011042 6-blade_b-propeller_TolB-like
IPR003649 Bbox_C
IPR017868 Filamin/ABP280_repeat-like
IPR001298 Filamin/ABP280_rpt
IPR013783 Ig-like_fold
IPR014756 Ig_E-set
IPR001258 NHL_repeat
IPR013017 NHL_repeat_subgr
IPR027370 Znf-RING_LisH
IPR000315 Znf_B-box
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
IPR017907 Znf_RING_CS

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00630 Filamin, 1 hit
PF01436 NHL, 6 hits
PF00643 zf-B_box, 1 hit
PF13445 zf-RING_UBOX, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00502 BBC, 1 hit
SM00336 BBOX, 1 hit
SM00557 IG_FLMN, 1 hit
SM00184 RING, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF81296 SSF81296, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50194 FILAMIN_REPEAT, 1 hit
PS51125 NHL, 6 hits
PS50119 ZF_BBOX, 1 hit
PS00518 ZF_RING_1, 1 hit
PS50089 ZF_RING_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform Alpha (identifier: O75382-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAKREDSPGP EVQPMDKQFL VCSICLDRYQ CPKVLPCLHT FCERCLQNYI 
        60         70         80         90        100
PAQSLTLSCP VCRQTSILPE QGVSALQNNF FISSLMEAMQ QAPDGAHDPE 
       110        120        130        140        150
DPHPLSVVAG RPLSCPNHEG KTMEFYCEAC ETAMCGECRA GEHREHGTVL 
       160        170        180        190        200
LRDVVEQHKA ALQRQLEAVR GRLPQLSAAI ALVGGISQQL QERKAEALAQ 
       210        220        230        240        250
ISAAFEDLEQ ALQQRKQALV SDLETICGAK QKVLQSQLDT LRQGQEHIGS 
       260        270        280        290        300
SCSFAEQALR LGSAPEVLLV RKHMRERLAA LAAQAFPERP HENAQLELVL 
       310        320        330        340        350
EVDGLRRSVL NLGALLTTSA TAHETVATGE GLRQALVGQP ASLTVTTKDK 
       360        370        380        390        400
DGRLVRTGSA ELRAEITGPD GTRLPVPVVD HKNGTYELVY TARTEGELLL 
       410        420        430        440        450
SVLLYGQPVR GSPFRVRALR PGDLPPSPDD VKRRVKSPGG PGSHVRQKAV 
       460        470        480        490        500
RRPSSMYSTG GKRKDNPIED ELVFRVGSRG REKGEFTNLQ GVSAASSGRI 
       510        520        530        540        550
VVADSNNQCI QVFSNEGQFK FRFGVRGRSP GQLQRPTGVA VDTNGDIIVA 
       560        570        580        590        600
DYDNRWVSIF SPEGKFKTKI GAGRLMGPKG VAVDRNGHII VVDNKSCCVF 
       610        620        630        640        650
TFQPNGKLVG RFGGRGATDR HFAGPHFVAV NNKNEIVVTD FHNHSVKVYS 
       660        670        680        690        700
ADGEFLFKFG SHGEGNGQFN APTGVAVDSN GNIIVADWGN SRIQVFDSSG 
       710        720        730        740 
SFLSYINTSA EPLYGPQGLA LTSDGHVVVA DAGNHCFKAY RYLQ
Length:744
Mass (Da):80,830
Last modified:November 25, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFF9829CB52314DD2
GO
Isoform Beta (identifier: O75382-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     146-156: Missing.

Show »
Length:733
Mass (Da):79,610
Checksum:iA31439D4CDEBA6B7
GO
Isoform Gamma (identifier: O75382-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     224-302: Missing.

Show »
Length:665
Mass (Da):72,101
Checksum:i640D87E904DBDA4E
GO
Isoform 4 (identifier: O75382-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-119: Missing.
     120-120: G → M

Show »
Length:625
Mass (Da):67,726
Checksum:i8813BB2C040EB51C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1W2PPI7A0A1W2PPI7_HUMAN
Tripartite motif-containing protein...
TRIM3
703Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PMK8E9PMK8_HUMAN
Tripartite motif-containing protein...
TRIM3
260Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PMW5E9PMW5_HUMAN
Tripartite motif-containing protein...
TRIM3
96Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti113L → F in AAC24809 (PubMed:11170753).Curated1
Sequence conflicti113L → F in AAG53474 (PubMed:11331580).Curated1
Sequence conflicti113L → F in AAG53475 (PubMed:11331580).Curated1
Sequence conflicti113L → F in AAG53476 (PubMed:11331580).Curated1
Sequence conflicti236S → T in AAC24809 (PubMed:11170753).Curated1
Sequence conflicti236S → T in AAG53474 (PubMed:11331580).Curated1
Sequence conflicti236S → T in AAG53475 (PubMed:11331580).Curated1
Sequence conflicti347T → A in AAC24809 (PubMed:11170753).Curated1
Sequence conflicti347T → A in AAG53474 (PubMed:11331580).Curated1
Sequence conflicti347T → A in AAG53475 (PubMed:11331580).Curated1
Sequence conflicti347T → A in AAG53476 (PubMed:11331580).Curated1
Sequence conflicti450V → L in BAH12882 (PubMed:14702039).Curated1
Sequence conflicti631N → S in AAC24809 (PubMed:11170753).Curated1
Sequence conflicti631N → S in AAG53474 (PubMed:11331580).Curated1
Sequence conflicti631N → S in AAG53475 (PubMed:11331580).Curated1
Sequence conflicti631N → S in AAG53476 (PubMed:11331580).Curated1
Sequence conflicti636I → V in AAC24809 (PubMed:11170753).Curated1
Sequence conflicti636I → V in AAG53474 (PubMed:11331580).Curated1
Sequence conflicti636I → V in AAG53475 (PubMed:11331580).Curated1
Sequence conflicti636I → V in AAG53476 (PubMed:11331580).Curated1
Sequence conflicti646V → E in AAC24809 (PubMed:11170753).Curated1
Sequence conflicti646V → E in AAG53474 (PubMed:11331580).Curated1
Sequence conflicti646V → E in AAG53475 (PubMed:11331580).Curated1
Sequence conflicti646V → E in AAG53476 (PubMed:11331580).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_052124298L → R. Corresponds to variant dbSNP:rs10128723Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0447801 – 119Missing in isoform 4. 1 PublicationAdd BLAST119
Alternative sequenceiVSP_044781120G → M in isoform 4. 1 Publication1
Alternative sequenceiVSP_005758146 – 156Missing in isoform Beta. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_005759224 – 302Missing in isoform Gamma. 1 PublicationAdd BLAST79

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF045239 mRNA Translation: AAC24809.1
AF220020 mRNA Translation: AAG53474.1
AF220021 mRNA Translation: AAG53475.1
AF220022 mRNA Translation: AAG53476.1
AK291396 mRNA Translation: BAF84085.1
AK298843 mRNA Translation: BAH12882.1
AC084337 Genomic DNA No translation available.
CH471064 Genomic DNA Translation: EAW68709.1
BC096827 mRNA Translation: AAH96827.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS58115.1 [O75382-4]
CCDS7764.1 [O75382-1]

NCBI Reference Sequences

More...RefSeqi		NP_001234935.1, NM_001248006.1 [O75382-1]
NP_001234936.1, NM_001248007.1 [O75382-4]
NP_006449.2, NM_006458.3 [O75382-1]
NP_150594.2, NM_033278.3 [O75382-1]
XP_011518146.1, XM_011519844.1
XP_011518147.1, XM_011519845.2 [O75382-4]
XP_016872587.1, XM_017017098.1 [O75382-1]
XP_016872588.1, XM_017017099.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000345851; ENSP00000340797; ENSG00000110171 [O75382-1]
ENST00000359518; ENSP00000352508; ENSG00000110171 [O75382-1]
ENST00000525074; ENSP00000433102; ENSG00000110171 [O75382-1]
ENST00000536344; ENSP00000445460; ENSG00000110171 [O75382-4]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		10612

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:10612

UCSC genome browser

More...UCSCi		uc001mdh.4 human [O75382-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF045239 mRNA Translation: AAC24809.1
AF220020 mRNA Translation: AAG53474.1
AF220021 mRNA Translation: AAG53475.1
AF220022 mRNA Translation: AAG53476.1
AK291396 mRNA Translation: BAF84085.1
AK298843 mRNA Translation: BAH12882.1
AC084337 Genomic DNA No translation available.
CH471064 Genomic DNA Translation: EAW68709.1
BC096827 mRNA Translation: AAH96827.1
CCDSiCCDS58115.1 [O75382-4]
CCDS7764.1 [O75382-1]
RefSeqiNP_001234935.1, NM_001248006.1 [O75382-1]
NP_001234936.1, NM_001248007.1 [O75382-4]
NP_006449.2, NM_006458.3 [O75382-1]
NP_150594.2, NM_033278.3 [O75382-1]
XP_011518146.1, XM_011519844.1
XP_011518147.1, XM_011519845.2 [O75382-4]
XP_016872587.1, XM_017017098.1 [O75382-1]
XP_016872588.1, XM_017017099.1

3D structure databases

SMRiO75382
ModBaseiSearch...

Protein-protein interaction databases

BioGridi115858, 28 interactors
CORUMiO75382
IntActiO75382, 23 interactors
MINTiO75382
STRINGi9606.ENSP00000433102

PTM databases

iPTMnetiO75382
PhosphoSitePlusiO75382

Polymorphism and mutation databases

BioMutaiTRIM3

Proteomic databases

EPDiO75382
jPOSTiO75382
MassIVEiO75382
MaxQBiO75382
PaxDbiO75382
PeptideAtlasiO75382
PRIDEiO75382
ProteomicsDBi26042
49955 [O75382-1]
49956 [O75382-2]
49957 [O75382-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		11249 233 antibodies

Genome annotation databases

EnsembliENST00000345851; ENSP00000340797; ENSG00000110171 [O75382-1]
ENST00000359518; ENSP00000352508; ENSG00000110171 [O75382-1]
ENST00000525074; ENSP00000433102; ENSG00000110171 [O75382-1]
ENST00000536344; ENSP00000445460; ENSG00000110171 [O75382-4]
GeneIDi10612
KEGGihsa:10612
UCSCiuc001mdh.4 human [O75382-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		10612
DisGeNETi10612

GeneCards: human genes, protein and diseases

More...GeneCardsi		TRIM3
HGNCiHGNC:10064 TRIM3
HPAiENSG00000110171 Tissue enhanced (brain)
MIMi605493 gene
neXtProtiNX_O75382
OpenTargetsiENSG00000110171
PharmGKBiPA35534

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG410ITF9 Eukaryota
ENOG410ZAM4 LUCA
GeneTreeiENSGT00940000158173
HOGENOMiCLU_008645_5_0_1
InParanoidiO75382
KOiK11997
OMAiHSFPEHP
OrthoDBi489543at2759
PhylomeDBiO75382
TreeFamiTF331018

Enzyme and pathway databases

ReactomeiR-HSA-877300 Interferon gamma signaling

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		TRIM3 human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		TRIM3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		10612
PharosiO75382 Tbio

Protein Ontology

More...PROi		PR:O75382
RNActiO75382 protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000110171 Expressed in right hemisphere of cerebellum and 191 other tissues
ExpressionAtlasiO75382 baseline and differential
GenevisibleiO75382 HS

Family and domain databases

CDDicd00021 BBOX, 1 hit
Gene3Di2.120.10.30, 2 hits
2.60.40.10, 1 hit
3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR011042 6-blade_b-propeller_TolB-like
IPR003649 Bbox_C
IPR017868 Filamin/ABP280_repeat-like
IPR001298 Filamin/ABP280_rpt
IPR013783 Ig-like_fold
IPR014756 Ig_E-set
IPR001258 NHL_repeat
IPR013017 NHL_repeat_subgr
IPR027370 Znf-RING_LisH
IPR000315 Znf_B-box
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
IPR017907 Znf_RING_CS
PfamiView protein in Pfam
PF00630 Filamin, 1 hit
PF01436 NHL, 6 hits
PF00643 zf-B_box, 1 hit
PF13445 zf-RING_UBOX, 1 hit
SMARTiView protein in SMART
SM00502 BBC, 1 hit
SM00336 BBOX, 1 hit
SM00557 IG_FLMN, 1 hit
SM00184 RING, 1 hit
SUPFAMiSSF81296 SSF81296, 1 hit
PROSITEiView protein in PROSITE
PS50194 FILAMIN_REPEAT, 1 hit
PS51125 NHL, 6 hits
PS50119 ZF_BBOX, 1 hit
PS00518 ZF_RING_1, 1 hit
PS50089 ZF_RING_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTRIM3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O75382
Secondary accession number(s): B7Z5E6
, F5H2Q8, Q4V9L4, Q9C038, Q9C039
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 6, 2002
Last sequence update: November 25, 2008
Last modified: April 22, 2020
This is version 186 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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