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Protein

Nuclear receptor corepressor 1

Gene

NCOR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Mediates transcriptional repression by certain nuclear receptors (PubMed:20812024). Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024).2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChromatin regulator, DNA-binding, Repressor
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-1251985 Nuclear signaling by ERBB4
R-HSA-1368071 NR1D1 (REV-ERBA) represses gene expression
R-HSA-1989781 PPARA activates gene expression
R-HSA-2122947 NOTCH1 Intracellular Domain Regulates Transcription
R-HSA-2151201 Transcriptional activation of mitochondrial biogenesis
R-HSA-2173795 Downregulation of SMAD2/3:SMAD4 transcriptional activity
R-HSA-2644606 Constitutive Signaling by NOTCH1 PEST Domain Mutants
R-HSA-2894862 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
R-HSA-3214815 HDACs deacetylate histones
R-HSA-381340 Transcriptional regulation of white adipocyte differentiation
R-HSA-400206 Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
R-HSA-400253 Circadian Clock
R-HSA-5617472 Activation of anterior HOX genes in hindbrain development during early embryogenesis
R-HSA-9022537 Loss of MECP2 binding ability to the NCoR/SMRT complex
R-HSA-9022692 Regulation of MECP2 expression and activity

SIGNOR Signaling Network Open Resource

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SIGNORi
O75376

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nuclear receptor corepressor 1
Short name:
N-CoR
Short name:
N-CoR1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NCOR1
Synonyms:KIAA1047
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000141027.20

Human Gene Nomenclature Database

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HGNCi
HGNC:7672 NCOR1

Online Mendelian Inheritance in Man (OMIM)

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MIMi
600849 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O75376

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
9611

Open Targets

More...
OpenTargetsi
ENSG00000141027

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA31477

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3038484

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
NCOR1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000556171 – 2440Nuclear receptor corepressor 1Add BLAST2440

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei172PhosphoserineCombined sources1
Modified residuei224PhosphoserineCombined sources1
Modified residuei999PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki1106Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources
Cross-linki1106Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residuei1111PhosphoserineCombined sources1
Cross-linki1184Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei1195PhosphoserineCombined sources1
Modified residuei1196PhosphoserineCombined sources1
Modified residuei1249PhosphoserineCombined sources1
Modified residuei1263PhosphoserineCombined sources1
Modified residuei1281PhosphoserineCombined sources1
Modified residuei1322PhosphoserineCombined sources1
Modified residuei1336N6-acetyllysineBy similarity1
Modified residuei1367PhosphothreonineBy similarity1
Cross-linki1389Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei1412N6-acetyllysine; alternateCombined sources1
Cross-linki1412Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residuei1450PhosphoserineCombined sources1
Modified residuei1472PhosphoserineCombined sources1
Cross-linki1518Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei1592PhosphoserineCombined sources1
Modified residuei1977PhosphoserineCombined sources1
Modified residuei1981PhosphoserineCombined sources1
Modified residuei2102PhosphoserineBy similarity1
Modified residuei2120PhosphoserineCombined sources1
Modified residuei2136PhosphoserineCombined sources1
Modified residuei2151PhosphoserineCombined sources1
Modified residuei2184PhosphoserineCombined sources1
Modified residuei2399PhosphothreonineCombined sources1
Modified residuei2436PhosphoserineCombined sources1
Modified residuei2438PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Ubiquitinated; mediated by SIAH2 and leading to its subsequent proteasomal degradation.By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
O75376

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
O75376

MaxQB - The MaxQuant DataBase

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MaxQBi
O75376

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
O75376

PeptideAtlas

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PeptideAtlasi
O75376

PRoteomics IDEntifications database

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PRIDEi
O75376

ProteomicsDB human proteome resource

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ProteomicsDBi
49948
49949 [O75376-2]

PTM databases

CarbonylDB database of protein carbonylation sites

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CarbonylDBi
O75376

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
O75376

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
O75376

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000141027 Expressed in 227 organ(s), highest expression level in corpus callosum

CleanEx database of gene expression profiles

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CleanExi
HS_NCOR1

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
O75376 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
O75376 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB072830
HPA043246
HPA050288
HPA051168

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Forms a large corepressor complex that contains SIN3A/B and histone deacetylases HDAC1 and HDAC2. This complex associates with the thyroid receptor (TR) and the retinoid acid receptor (RAR) in the absence of ligand. Interacts directly with RARA; the interaction is facilitated with RARA trimethylation. Component of the N-Cor repressor complex, at least composed of CBFA2T3, HEXIM1, NCOR1, NCOR2, HDAC3, TBL1X, TBL1XR1, CORO2A and GPS2. Interacts with ZBTB33; the interaction serves to recruit the N-CoR complex to promoter regions containing methylated CpG dinucleotides. Interacts with TRIM28 and KDM3A. Interacts (via the RD1 domain) with BAZ1A (via its N-terminal); the interaction corepresses a number of NCOR1-regulated genes. Interacts with BCL6, C1D, DACH1, HEXIM1, HDAC7, RORA, RORC, SAP30, SIAH2, SIN3A and SIN3B. May interact with DEAF1. Interacts with RXRA. Interacts with SETD5 (By similarity). Interacts with VDR (PubMed:28698609). Interacts with ZBTB7A (PubMed:20812024). Interacts with AR (PubMed:20812024).By similarity15 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
114973, 177 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
O75376

Database of interacting proteins

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DIPi
DIP-29402N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

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ELMi
O75376

Protein interaction database and analysis system

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IntActi
O75376, 71 interactors

Molecular INTeraction database

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MINTi
O75376

STRING: functional protein association networks

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STRINGi
9606.ENSP00000268712

Chemistry databases

BindingDB database of measured binding affinities

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BindingDBi
O75376

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

12440
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2EQRNMR-A433-486[»]
3H52X-ray2.80M/N2258-2276[»]
3KMZX-ray2.10C/D2047-2065[»]
3N00X-ray2.60B2045-2065[»]
4MDDX-ray2.40C/D2260-2274[»]
4WVDX-ray2.90C/D2259-2275[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
O75376

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
O75376

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
O75376

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini435 – 486SANT 1PROSITE-ProRule annotationAdd BLAST52
Domaini623 – 674SANT 2PROSITE-ProRule annotationAdd BLAST52

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 373Interaction with ZBTB33 and HEXIM12 PublicationsAdd BLAST373
Regioni254 – 312Interaction with SIN3A/BAdd BLAST59
Regioni988 – 1816Interaction with ETOAdd BLAST829
Regioni1501 – 2440Interaction with C1DBy similarityAdd BLAST940
Regioni2032 – 2115ID1By similarityAdd BLAST84
Regioni2047 – 2050Required for interaction with RARA in the absence of its ligandBy similarity4
Regioni2212 – 2273ID2By similarityAdd BLAST62

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili174 – 216Sequence analysisAdd BLAST43
Coiled coili299 – 328Sequence analysisAdd BLAST30
Coiled coili501 – 557Sequence analysisAdd BLAST57

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi1933 – 1937CORNR box 15
Motifi2055 – 2059CORNR box 25
Motifi2263 – 2267CORNR box 35

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi58 – 64Poly-Gln7
Compositional biasi593 – 603Poly-AlaAdd BLAST11
Compositional biasi607 – 617Pro-richAdd BLAST11
Compositional biasi1032 – 1035Poly-Pro4
Compositional biasi1707 – 1712Poly-Ala6
Compositional biasi1952 – 1963Poly-SerAdd BLAST12

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The N-terminal region contains three independent domains that are capable of mediating transcriptional repression (RD1, RD2 and RD3).
The C-terminal region contains two separate nuclear receptor-interacting domains (ID1 and ID2), each of which contains a conserved sequence referred to as the CORNR box. This motif is necessary and sufficient for binding to unligated nuclear hormone receptors, while sequences flanking the CORNR box determine the precise nuclear hormone receptor specificity (By similarity).By similarity

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1878 Eukaryota
ENOG410YDXP LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155093

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000113746

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG057767

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
O75376

KEGG Orthology (KO)

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KOi
K04650

Identification of Orthologs from Complete Genome Data

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OMAi
MGNFDDK

Database of Orthologous Groups

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OrthoDBi
1554997at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
O75376

TreeFam database of animal gene trees

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TreeFami
TF106423

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00167 SANT, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR009057 Homeobox-like_sf
IPR031557 N-CoR_GPS2_interact
IPR001005 SANT/Myb
IPR017884 SANT_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15784 GPS2_interact, 1 hit
PF00249 Myb_DNA-binding, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00717 SANT, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46689 SSF46689, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51293 SANT, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 12 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O75376-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSSSGYPPNQ GAFSTEQSRY PPHSVQYTFP NTRHQQEFAV PDYRSSHLEV
60 70 80 90 100
SQASQLLQQQ QQQQLRRRPS LLSEFHPGSD RPQERRTSYE PFHPGPSPVD
110 120 130 140 150
HDSLESKRPR LEQVSDSHFQ RVSAAVLPLV HPLPEGLRAS ADAKKDPAFG
160 170 180 190 200
GKHEAPSSPI SGQPCGDDQN ASPSKLSKEE LIQSMDRVDR EIAKVEQQIL
210 220 230 240 250
KLKKKQQQLE EEAAKPPEPE KPVSPPPVEQ KHRSIVQIIY DENRKKAEEA
260 270 280 290 300
HKIFEGLGPK VELPLYNQPS DTKVYHENIK TNQVMRKKLI LFFKRRNHAR
310 320 330 340 350
KQREQKICQR YDQLMEAWEK KVDRIENNPR RKAKESKTRE YYEKQFPEIR
360 370 380 390 400
KQREQQERFQ RVGQRGAGLS ATIARSEHEI SEIIDGLSEQ ENNEKQMRQL
410 420 430 440 450
SVIPPMMFDA EQRRVKFINM NGLMEDPMKV YKDRQFMNVW TDHEKEIFKD
460 470 480 490 500
KFIQHPKNFG LIASYLERKS VPDCVLYYYL TKKNENYKAL VRRNYGKRRG
510 520 530 540 550
RNQQIARPSQ EEKVEEKEED KAEKTEKKEE EKKDEEEKDE KEDSKENTKE
560 570 580 590 600
KDKIDGTAEE TEEREQATPR GRKTANSQGR RKGRITRSMT NEAAAASAAA
610 620 630 640 650
AAATEEPPPP LPPPPEPIST EPVETSRWTE EEMEVAKKGL VEHGRNWAAI
660 670 680 690 700
AKMVGTKSEA QCKNFYFNYK RRHNLDNLLQ QHKQKTSRKP REERDVSQCE
710 720 730 740 750
SVASTVSAQE DEDIEASNEE ENPEDSEVEA VKPSEDSPEN ATSRGNTEPA
760 770 780 790 800
VELEPTTETA PSTSPSLAVP STKPAEDESV ETQVNDSISA ETAEQMDVDQ
810 820 830 840 850
QEHSAEEGSV CDPPPATKAD SVDVEVRVPE NHASKVEGDN TKERDLDRAS
860 870 880 890 900
EKVEPRDEDL VVAQQINAQR PEPQSDNDSS ATCSADEDVD GEPERQRMFP
910 920 930 940 950
MDSKPSLLNP TGSILVSSPL KPNPLDLPQL QHRAAVIPPM VSCTPCNIPI
960 970 980 990 1000
GTPVSGYALY QRHIKAMHES ALLEEQRQRQ EQIDLECRSS TSPCGTSKSP
1010 1020 1030 1040 1050
NREWEVLQPA PHQVITNLPE GVRLPTTRPT RPPPPLIPSS KTTVASEKPS
1060 1070 1080 1090 1100
FIMGGSISQG TPGTYLTSHN QASYTQETPK PSVGSISLGL PRQQESAKSA
1110 1120 1130 1140 1150
TLPYIKQEEF SPRSQNSQPE GLLVRAQHEG VVRGTAGAIQ EGSITRGTPT
1160 1170 1180 1190 1200
SKISVESIPS LRGSITQGTP ALPQTGIPTE ALVKGSISRM PIEDSSPEKG
1210 1220 1230 1240 1250
REEAASKGHV IYEGKSGHIL SYDNIKNARE GTRSPRTAHE ISLKRSYESV
1260 1270 1280 1290 1300
EGNIKQGMSM RESPVSAPLE GLICRALPRG SPHSDLKERT VLSGSIMQGT
1310 1320 1330 1340 1350
PRATTESFED GLKYPKQIKR ESPPIRAFEG AITKGKPYDG ITTIKEMGRS
1360 1370 1380 1390 1400
IHEIPRQDIL TQESRKTPEV VQSTRPIIEG SISQGTPIKF DNNSGQSAIK
1410 1420 1430 1440 1450
HNVKSLITGP SKLSRGMPPL EIVPENIKVV ERGKYEDVKA GETVRSRHTS
1460 1470 1480 1490 1500
VVSSGPSVLR STLHEAPKAQ LSPGIYDDTS ARRTPVSYQN TMSRGSPMMN
1510 1520 1530 1540 1550
RTSDVTISSN KSTNHERKST LTPTQRESIP AKSPVPGVDP VVSHSPFDPH
1560 1570 1580 1590 1600
HRGSTAGEVY RSHLPTHLDP AMPFHRALDP AAAAYLFQRQ LSPTPGYPSQ
1610 1620 1630 1640 1650
YQLYAMENTR QTILNDYITS QQMQVNLRPD VARGLSPREQ PLGLPYPATR
1660 1670 1680 1690 1700
GIIDLTNMPP TILVPHPGGT STPPMDRITY IPGTQITFPP RPYNSASMSP
1710 1720 1730 1740 1750
GHPTHLAAAA SAERERERER EKERERERIA AASSDLYLRP GSEQPGRPGS
1760 1770 1780 1790 1800
HGYVRSPSPS VRTQETMLQQ RPSVFQGTNG TSVITPLDPT AQLRIMPLPA
1810 1820 1830 1840 1850
GGPSISQGLP ASRYNTAADA LAALVDAAAS APQMDVSKTK ESKHEAARLE
1860 1870 1880 1890 1900
ENLRSRSAAV SEQQQLEQKT LEVEKRSVQC LYTSSAFPSG KPQPHSSVVY
1910 1920 1930 1940 1950
SEAGKDKGPP PKSRYEEELR TRGKTTITAA NFIDVIITRQ IASDKDARER
1960 1970 1980 1990 2000
GSQSSDSSSS LSSHRYETPS DAIEVISPAS SPAPPQEKLQ TYQPEVVKAN
2010 2020 2030 2040 2050
QAENDPTRQY EGPLHHYRPQ QESPSPQQQL PPSSQAEGMG QVPRTHRLIT
2060 2070 2080 2090 2100
LADHICQIIT QDFARNQVSS QTPQQPPTST FQNSPSALVS TPVRTKTSNR
2110 2120 2130 2140 2150
YSPESQAQSV HHQRPGSRVS PENLVDKSRG SRPGKSPERS HVSSEPYEPI
2160 2170 2180 2190 2200
SPPQVPVVHE KQDSLLLLSQ RGAEPAEQRN DARSPGSISY LPSFFTKLEN
2210 2220 2230 2240 2250
TSPMVKSKKQ EIFRKLNSSG GGDSDMAAAQ PGTEIFNLPA VTTSGSVSSR
2260 2270 2280 2290 2300
GHSFADPASN LGLEDIIRKA LMGSFDDKVE DHGVVMSQPM GVVPGTANTS
2310 2320 2330 2340 2350
VVTSGETRRE EGDPSPHSGG VCKPKLISKS NSRKSKSPIP GQGYLGTERP
2360 2370 2380 2390 2400
SSVSSVHSEG DYHRQTPGWA WEDRPSSTGS TQFPYNPLTM RMLSSTPPTP
2410 2420 2430 2440
IACAPSAVNQ AAPHQQNRIW EREPAPLLSA QYETLSDSDD
Length:2,440
Mass (Da):270,210
Last modified:May 10, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1647FE060373A125
GO
Isoform 2 (identifier: O75376-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     727-727: E → EGAENSSDTESAPSPSP
     1842-1961: SKHEAARLEE...SQSSDSSSSL → I

Show »
Length:2,337
Mass (Da):258,602
Checksum:i6837EA3886E1E03C
GO
Isoform 3 (identifier: O75376-3) [UniParc]FASTAAdd to basket
Also known as: b

The sequence of this isoform differs from the canonical sequence as follows:
     37-145: Missing.
     727-727: E → EGAENSSDTESAPSPSP
     1006-1007: VL → GR
     1008-2440: Missing.

Note: No experimental confirmation available.
Show »
Length:914
Mass (Da):103,919
Checksum:i8210E2A279ACD8A8
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 12 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A088AWL3A0A088AWL3_HUMAN
Nuclear receptor corepressor 1
NCOR1
2,343Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7EW50E7EW50_HUMAN
Nuclear receptor corepressor 1
NCOR1
545Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7EVU5E7EVU5_HUMAN
Nuclear receptor corepressor 1
NCOR1
537Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KS51J3KS51_HUMAN
Nuclear receptor corepressor 1
NCOR1
546Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7EVK1E7EVK1_HUMAN
Nuclear receptor corepressor 1
NCOR1
1,071Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KS29J3KS29_HUMAN
Nuclear receptor corepressor 1
NCOR1
184Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JAP0C9JAP0_HUMAN
Nuclear receptor corepressor 1
NCOR1
125Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QKP0J3QKP0_HUMAN
Nuclear receptor corepressor 1
NCOR1
217Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KRE4J3KRE4_HUMAN
Nuclear receptor corepressor 1
NCOR1
183Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y459H0Y459_HUMAN
Nuclear receptor corepressor 1
NCOR1
92Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA82999 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti5G → V in AAO32942 (Ref. 2) Curated1
Sequence conflicti20Y → S in AAO32942 (Ref. 2) Curated1
Sequence conflicti26Q → K in AAO32942 (Ref. 2) Curated1
Sequence conflicti31N → S in AAO32942 (Ref. 2) Curated1
Sequence conflicti33R → H in AAO32942 (Ref. 2) Curated1
Sequence conflicti392N → S in AAO32942 (Ref. 2) Curated1
Sequence conflicti1014V → L in AAC33550 (PubMed:9724795).Curated1
Sequence conflicti1508 – 1509SS → PP in AAC33550 (PubMed:9724795).Curated2
Sequence conflicti1561R → W in AAC33550 (PubMed:9724795).Curated1
Sequence conflicti1567H → Q in AAC33550 (PubMed:9724795).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_04646837 – 145Missing in isoform 3. 1 PublicationAdd BLAST109
Alternative sequenceiVSP_010207727E → EGAENSSDTESAPSPSP in isoform 2 and isoform 3. 3 Publications1
Alternative sequenceiVSP_0464691006 – 1007VL → GR in isoform 3. 1 Publication2
Alternative sequenceiVSP_0464701008 – 2440Missing in isoform 3. 1 PublicationAdd BLAST1433
Alternative sequenceiVSP_0102081842 – 1961SKHEA…SSSSL → I in isoform 2. 2 PublicationsAdd BLAST120

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF044209 mRNA Translation: AAC33550.1
AF303586 mRNA Translation: AAO32942.1
AB028970 mRNA Translation: BAA82999.2 Different initiation.
AC002553 Genomic DNA No translation available.
AC005971 Genomic DNA No translation available.
CH471222 Genomic DNA Translation: EAX04494.1
BC167431 mRNA Translation: AAI67431.1
AB019524 mRNA Translation: BAA75814.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS11175.1 [O75376-1]
CCDS54094.1 [O75376-3]
CCDS54095.1 [O75376-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001177367.1, NM_001190438.1 [O75376-3]
NP_001177369.1, NM_001190440.1 [O75376-2]
NP_006302.2, NM_006311.3 [O75376-1]
XP_011522388.1, XM_011524086.2 [O75376-2]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.462323

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000268712; ENSP00000268712; ENSG00000141027 [O75376-1]
ENST00000395848; ENSP00000379189; ENSG00000141027 [O75376-3]
ENST00000395851; ENSP00000379192; ENSG00000141027 [O75376-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
9611

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:9611

UCSC genome browser

More...
UCSCi
uc002gpn.4 human [O75376-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF044209 mRNA Translation: AAC33550.1
AF303586 mRNA Translation: AAO32942.1
AB028970 mRNA Translation: BAA82999.2 Different initiation.
AC002553 Genomic DNA No translation available.
AC005971 Genomic DNA No translation available.
CH471222 Genomic DNA Translation: EAX04494.1
BC167431 mRNA Translation: AAI67431.1
AB019524 mRNA Translation: BAA75814.1
CCDSiCCDS11175.1 [O75376-1]
CCDS54094.1 [O75376-3]
CCDS54095.1 [O75376-2]
RefSeqiNP_001177367.1, NM_001190438.1 [O75376-3]
NP_001177369.1, NM_001190440.1 [O75376-2]
NP_006302.2, NM_006311.3 [O75376-1]
XP_011522388.1, XM_011524086.2 [O75376-2]
UniGeneiHs.462323

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2EQRNMR-A433-486[»]
3H52X-ray2.80M/N2258-2276[»]
3KMZX-ray2.10C/D2047-2065[»]
3N00X-ray2.60B2045-2065[»]
4MDDX-ray2.40C/D2260-2274[»]
4WVDX-ray2.90C/D2259-2275[»]
ProteinModelPortaliO75376
SMRiO75376
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114973, 177 interactors
CORUMiO75376
DIPiDIP-29402N
ELMiO75376
IntActiO75376, 71 interactors
MINTiO75376
STRINGi9606.ENSP00000268712

Chemistry databases

BindingDBiO75376
ChEMBLiCHEMBL3038484

PTM databases

CarbonylDBiO75376
iPTMnetiO75376
PhosphoSitePlusiO75376

Polymorphism and mutation databases

BioMutaiNCOR1

Proteomic databases

EPDiO75376
jPOSTiO75376
MaxQBiO75376
PaxDbiO75376
PeptideAtlasiO75376
PRIDEiO75376
ProteomicsDBi49948
49949 [O75376-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000268712; ENSP00000268712; ENSG00000141027 [O75376-1]
ENST00000395848; ENSP00000379189; ENSG00000141027 [O75376-3]
ENST00000395851; ENSP00000379192; ENSG00000141027 [O75376-2]
GeneIDi9611
KEGGihsa:9611
UCSCiuc002gpn.4 human [O75376-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9611
DisGeNETi9611
EuPathDBiHostDB:ENSG00000141027.20

GeneCards: human genes, protein and diseases

More...
GeneCardsi
NCOR1
HGNCiHGNC:7672 NCOR1
HPAiCAB072830
HPA043246
HPA050288
HPA051168
MIMi600849 gene
neXtProtiNX_O75376
OpenTargetsiENSG00000141027
PharmGKBiPA31477

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1878 Eukaryota
ENOG410YDXP LUCA
GeneTreeiENSGT00940000155093
HOGENOMiHOG000113746
HOVERGENiHBG057767
InParanoidiO75376
KOiK04650
OMAiMGNFDDK
OrthoDBi1554997at2759
PhylomeDBiO75376
TreeFamiTF106423

Enzyme and pathway databases

ReactomeiR-HSA-1251985 Nuclear signaling by ERBB4
R-HSA-1368071 NR1D1 (REV-ERBA) represses gene expression
R-HSA-1989781 PPARA activates gene expression
R-HSA-2122947 NOTCH1 Intracellular Domain Regulates Transcription
R-HSA-2151201 Transcriptional activation of mitochondrial biogenesis
R-HSA-2173795 Downregulation of SMAD2/3:SMAD4 transcriptional activity
R-HSA-2644606 Constitutive Signaling by NOTCH1 PEST Domain Mutants
R-HSA-2894862 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
R-HSA-3214815 HDACs deacetylate histones
R-HSA-381340 Transcriptional regulation of white adipocyte differentiation
R-HSA-400206 Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
R-HSA-400253 Circadian Clock
R-HSA-5617472 Activation of anterior HOX genes in hindbrain development during early embryogenesis
R-HSA-9022537 Loss of MECP2 binding ability to the NCoR/SMRT complex
R-HSA-9022692 Regulation of MECP2 expression and activity
SIGNORiO75376

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
NCOR1 human
EvolutionaryTraceiO75376

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
Nuclear_receptor_co-repressor_1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
9611

Protein Ontology

More...
PROi
PR:O75376

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000141027 Expressed in 227 organ(s), highest expression level in corpus callosum
CleanExiHS_NCOR1
ExpressionAtlasiO75376 baseline and differential
GenevisibleiO75376 HS

Family and domain databases

CDDicd00167 SANT, 2 hits
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR031557 N-CoR_GPS2_interact
IPR001005 SANT/Myb
IPR017884 SANT_dom
PfamiView protein in Pfam
PF15784 GPS2_interact, 1 hit
PF00249 Myb_DNA-binding, 1 hit
SMARTiView protein in SMART
SM00717 SANT, 2 hits
SUPFAMiSSF46689 SSF46689, 2 hits
PROSITEiView protein in PROSITE
PS51293 SANT, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNCOR1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O75376
Secondary accession number(s): B3DLF8
, E9PGV6, Q86YY0, Q9UPV5, Q9UQ18
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 10, 2004
Last modified: January 16, 2019
This is version 202 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
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