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Protein

SH3 domain-binding glutamic acid-rich-like protein

Gene

SH3BGRL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • SH3/SH2 adaptor activity Source: ProtInc
  • SH3 domain binding Source: UniProtKB-KW

Names & Taxonomyi

Protein namesi
Recommended name:
SH3 domain-binding glutamic acid-rich-like protein
Gene namesi
Name:SH3BGRL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000131171.12
HGNCiHGNC:10823 SH3BGRL
MIMi300190 gene
neXtProtiNX_O75368

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi6451
OpenTargetsiENSG00000131171
PharmGKBiPA35731

Polymorphism and mutation databases

BioMutaiSH3BGRL

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002207451 – 114SH3 domain-binding glutamic acid-rich-like proteinAdd BLAST114

Proteomic databases

EPDiO75368
PaxDbiO75368
PeptideAtlasiO75368
PRIDEiO75368
ProteomicsDBi49937
TopDownProteomicsiO75368

2D gel databases

DOSAC-COBS-2DPAGEiO75368
OGPiO75368
REPRODUCTION-2DPAGEiO75368
SWISS-2DPAGEiO75368

PTM databases

iPTMnetiO75368
PhosphoSitePlusiO75368

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiENSG00000131171
CleanExiHS_SH3BGRL
ExpressionAtlasiO75368 baseline and differential
GenevisibleiO75368 HS

Organism-specific databases

HPAiHPA051248

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
EGFRP005332EBI-2854777,EBI-297353

GO - Molecular functioni

  • SH3/SH2 adaptor activity Source: ProtInc
  • SH3 domain binding Source: UniProtKB-KW

Protein-protein interaction databases

BioGridi112349, 16 interactors
IntActiO75368, 2 interactors
MINTiO75368
STRINGi9606.ENSP00000362308

Structurei

Secondary structure

1114
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi3 – 7Combined sources5
Helixi14 – 29Combined sources16
Beta strandi34 – 38Combined sources5
Helixi43 – 52Combined sources10
Helixi55 – 57Combined sources3
Beta strandi60 – 63Combined sources4
Beta strandi68 – 71Combined sources4
Beta strandi74 – 78Combined sources5
Helixi79 – 87Combined sources9
Helixi91 – 95Combined sources5
Helixi104 – 114Combined sources11

3D structure databases

ProteinModelPortaliO75368
SMRiO75368
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO75368

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi61 – 67SH3-bindingSequence analysis7

Sequence similaritiesi

Belongs to the SH3BGR family.Curated

Keywords - Domaini

SH3-binding

Phylogenomic databases

eggNOGiKOG4023 Eukaryota
ENOG4111N7M LUCA
GeneTreeiENSGT00440000039098
HOGENOMiHOG000095212
HOVERGENiHBG054781
InParanoidiO75368
OMAiEEKYCGN
OrthoDBiEOG091G10PC
PhylomeDBiO75368
TreeFamiTF105574

Family and domain databases

CDDicd03030 GRX_SH3BGR, 1 hit
InterProiView protein in InterPro
IPR006993 Glut_rich_SH3-bd
IPR036249 Thioredoxin-like_sf
PfamiView protein in Pfam
PF04908 SH3BGR, 1 hit
PIRSFiPIRSF008142 SH3-bind_E-rich_L, 1 hit
SUPFAMiSSF52833 SSF52833, 1 hit

Sequencei

Sequence statusi: Complete.

O75368-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVIRVYIASS SGSTAIKKKQ QDVLGFLEAN KIGFEEKDIA ANEENRKWMR
60 70 80 90 100
ENVPENSRPA TGYPLPPQIF NESQYRGDYD AFFEARENNA VYAFLGLTAP
110
PGSKEAEVQA KQQA
Length:114
Mass (Da):12,774
Last modified:November 1, 1998 - v1
Checksum:iD72AC2A095F1AA8B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti35E → K (PubMed:11230166).Curated1
Sequence conflicti35E → K (Ref. 3) Curated1
Sequence conflicti113Q → R (PubMed:11230166).Curated1
Sequence conflicti113Q → R (Ref. 3) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF042081 mRNA Translation: AAC27445.1
AL136718 mRNA Translation: CAB66652.1
CR533478 mRNA Translation: CAG38509.1
AL357115 Genomic DNA No translation available.
BC016709 mRNA Translation: AAH16709.1
BC103762 mRNA Translation: AAI03763.1
CCDSiCCDS14449.1
PIRiJE0178
RefSeqiNP_003013.1, NM_003022.2
UniGeneiHs.108029

Genome annotation databases

EnsembliENST00000373212; ENSP00000362308; ENSG00000131171
GeneIDi6451
KEGGihsa:6451

Entry informationi

Entry nameiSH3L1_HUMAN
AccessioniPrimary (citable) accession number: O75368
Secondary accession number(s): Q3SYL1
, Q5JT50, Q6FIE8, Q9H0N8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: November 1, 1998
Last modified: July 18, 2018
This is version 157 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

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