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Protein

SH3 domain-binding glutamic acid-rich-like protein

Gene

SH3BGRL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • SH3/SH2 adaptor activity Source: ProtInc
  • SH3 domain binding Source: UniProtKB-KW

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
SH3 domain-binding glutamic acid-rich-like protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SH3BGRL
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000131171.12

Human Gene Nomenclature Database

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HGNCi
HGNC:10823 SH3BGRL

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
300190 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O75368

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
6451

Open Targets

More...
OpenTargetsi
ENSG00000131171

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA35731

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SH3BGRL

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002207451 – 114SH3 domain-binding glutamic acid-rich-like proteinAdd BLAST114

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
O75368

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
O75368

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O75368

PeptideAtlas

More...
PeptideAtlasi
O75368

PRoteomics IDEntifications database

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PRIDEi
O75368

ProteomicsDB human proteome resource

More...
ProteomicsDBi
49937

Consortium for Top Down Proteomics

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TopDownProteomicsi
O75368

2D gel databases

DOSAC-COBS 2D-PAGE database

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DOSAC-COBS-2DPAGEi
O75368

USC-OGP 2-DE database

More...
OGPi
O75368

REPRODUCTION-2DPAGE

More...
REPRODUCTION-2DPAGEi
O75368

Two-dimensional polyacrylamide gel electrophoresis database from the Geneva University Hospital

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SWISS-2DPAGEi
O75368

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O75368

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O75368

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000131171 Expressed in 243 organ(s), highest expression level in cauda epididymis

CleanEx database of gene expression profiles

More...
CleanExi
HS_SH3BGRL

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
O75368 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O75368 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA051248

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
112349, 16 interactors

Protein interaction database and analysis system

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IntActi
O75368, 2 interactors

Molecular INTeraction database

More...
MINTi
O75368

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000362308

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1114
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1U6TX-ray1.90A2-114[»]
1WRYNMR-A1-108[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
O75368

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O75368

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
O75368

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi61 – 67SH3-bindingSequence analysis7

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SH3BGR family.Curated

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

SH3-binding

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4023 Eukaryota
ENOG4111N7M LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156017

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000095212

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG054781

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O75368

Identification of Orthologs from Complete Genome Data

More...
OMAi
EEKYCGN

Database of Orthologous Groups

More...
OrthoDBi
1508713at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O75368

TreeFam database of animal gene trees

More...
TreeFami
TF105574

Family and domain databases

Conserved Domains Database

More...
CDDi
cd03030 GRX_SH3BGR, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006993 Glut_rich_SH3-bd
IPR036249 Thioredoxin-like_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04908 SH3BGR, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF008142 SH3-bind_E-rich_L, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52833 SSF52833, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O75368-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVIRVYIASS SGSTAIKKKQ QDVLGFLEAN KIGFEEKDIA ANEENRKWMR
60 70 80 90 100
ENVPENSRPA TGYPLPPQIF NESQYRGDYD AFFEARENNA VYAFLGLTAP
110
PGSKEAEVQA KQQA
Length:114
Mass (Da):12,774
Last modified:November 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD72AC2A095F1AA8B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti35E → K (PubMed:11230166).Curated1
Sequence conflicti35E → K (Ref. 3) Curated1
Sequence conflicti113Q → R (PubMed:11230166).Curated1
Sequence conflicti113Q → R (Ref. 3) Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF042081 mRNA Translation: AAC27445.1
AL136718 mRNA Translation: CAB66652.1
CR533478 mRNA Translation: CAG38509.1
AL357115 Genomic DNA No translation available.
BC016709 mRNA Translation: AAH16709.1
BC103762 mRNA Translation: AAI03763.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS14449.1

Protein sequence database of the Protein Information Resource

More...
PIRi
JE0178

NCBI Reference Sequences

More...
RefSeqi
NP_003013.1, NM_003022.2

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.108029

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000373212; ENSP00000362308; ENSG00000131171

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
6451

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:6451

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF042081 mRNA Translation: AAC27445.1
AL136718 mRNA Translation: CAB66652.1
CR533478 mRNA Translation: CAG38509.1
AL357115 Genomic DNA No translation available.
BC016709 mRNA Translation: AAH16709.1
BC103762 mRNA Translation: AAI03763.1
CCDSiCCDS14449.1
PIRiJE0178
RefSeqiNP_003013.1, NM_003022.2
UniGeneiHs.108029

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1U6TX-ray1.90A2-114[»]
1WRYNMR-A1-108[»]
ProteinModelPortaliO75368
SMRiO75368
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112349, 16 interactors
IntActiO75368, 2 interactors
MINTiO75368
STRINGi9606.ENSP00000362308

PTM databases

iPTMnetiO75368
PhosphoSitePlusiO75368

Polymorphism and mutation databases

BioMutaiSH3BGRL

2D gel databases

DOSAC-COBS-2DPAGEiO75368
OGPiO75368
REPRODUCTION-2DPAGEiO75368
SWISS-2DPAGEiO75368

Proteomic databases

EPDiO75368
jPOSTiO75368
PaxDbiO75368
PeptideAtlasiO75368
PRIDEiO75368
ProteomicsDBi49937
TopDownProteomicsiO75368

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000373212; ENSP00000362308; ENSG00000131171
GeneIDi6451
KEGGihsa:6451

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
6451
DisGeNETi6451
EuPathDBiHostDB:ENSG00000131171.12

GeneCards: human genes, protein and diseases

More...
GeneCardsi
SH3BGRL
HGNCiHGNC:10823 SH3BGRL
HPAiHPA051248
MIMi300190 gene
neXtProtiNX_O75368
OpenTargetsiENSG00000131171
PharmGKBiPA35731

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4023 Eukaryota
ENOG4111N7M LUCA
GeneTreeiENSGT00940000156017
HOGENOMiHOG000095212
HOVERGENiHBG054781
InParanoidiO75368
OMAiEEKYCGN
OrthoDBi1508713at2759
PhylomeDBiO75368
TreeFamiTF105574

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
SH3BGRL human
EvolutionaryTraceiO75368

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
SH3BGRL

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
6451

Protein Ontology

More...
PROi
PR:O75368

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000131171 Expressed in 243 organ(s), highest expression level in cauda epididymis
CleanExiHS_SH3BGRL
ExpressionAtlasiO75368 baseline and differential
GenevisibleiO75368 HS

Family and domain databases

CDDicd03030 GRX_SH3BGR, 1 hit
InterProiView protein in InterPro
IPR006993 Glut_rich_SH3-bd
IPR036249 Thioredoxin-like_sf
PfamiView protein in Pfam
PF04908 SH3BGR, 1 hit
PIRSFiPIRSF008142 SH3-bind_E-rich_L, 1 hit
SUPFAMiSSF52833 SSF52833, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSH3L1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O75368
Secondary accession number(s): Q3SYL1
, Q5JT50, Q6FIE8, Q9H0N8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: November 1, 1998
Last modified: January 16, 2019
This is version 160 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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