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UniProtKB - O75367 (H2AY_HUMAN)

Entry version 210 (07 Apr 2021)
Sequence version 4 (23 Jan 2007)
Previous versions | rss
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Protein

Core histone macro-H2A.1

Gene

MACROH2A1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription (PubMed:12718888, PubMed:15621527, PubMed:16428466). Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Involved in stable X chromosome inactivation (PubMed:15897469). Inhibits the binding of transcription factors, including NF-kappa-B, and interferes with the activity of remodeling SWI/SNF complexes (PubMed:12718888, PubMed:16428466). Inhibits histone acetylation by EP300 and recruits class I HDACs, which induces a hypoacetylated state of chromatin (PubMed:16428466, PubMed:16107708).5 Publications
Binds ADP-ribose and O-acetyl-ADP-ribose, and may be involved in ADP-ribose-mediated chromatin modulation (PubMed:15902274). Increases the expression of genes involved in redox metabolism, including SOD3 (PubMed:23022728).2 Publications
Represses SOD3 gene expression.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChromatin regulator, DNA-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		O75367

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Core histone macro-H2A.1
Short name:
Histone macroH2A1
Short name:
mH2A1
Alternative name(s):
Histone H2A.y
Short name:
H2A/y
Medulloblastoma antigen MU-MB-50.205
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MACROH2A1Imported
Synonyms:H2AFYImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:4740, MACROH2A1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		610054, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_O75367

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000113648.16

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Chromosome, Nucleosome core, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		9555

MalaCards human disease database

More...MalaCardsi		MACROH2A1

Open Targets

More...OpenTargetsi		ENSG00000113648

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		1275, Brachydactyly-elbow wrist dysplasia syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA29117

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		O75367, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		H2AFY

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000553181 – 372Core histone macro-H2A.1Add BLAST372

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei7N6-lactoyllysine; alternateBy similarity1
Modified residuei9N6-lactoyllysine; alternateBy similarity1
Modified residuei18N6-methyllysine1 Publication1
Modified residuei116N6-acetyllysine; alternateBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki116Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate1 Publication
Cross-linki117Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Modified residuei123N6,N6-dimethyllysine; alternate1 Publication1
Modified residuei123N6-acetyllysine; alternateBy similarity1
Cross-linki123Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residuei129PhosphothreonineCombined sources1 Publication1
Cross-linki167Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei170PhosphoserineCombined sources1
Modified residuei173PhosphoserineCombined sources1
Modified residuei178PhosphothreonineCombined sources1
Cross-linki189Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki323Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Monoubiquitinated at either Lys-116 or Lys-117. May also be polyubiquitinated. Ubiquitination is mediated by the CUL3/SPOP E3 complex and does not promote proteasomal degradation. Instead, it is required for enrichment in inactive X chromosome chromatin.3 Publications

Keywords - PTMi

Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

The CPTAC Assay portal

More...CPTACi		CPTAC-383
CPTAC-384

Encyclopedia of Proteome Dynamics

More...EPDi		O75367

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		O75367

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		O75367

MaxQB - The MaxQuant DataBase

More...MaxQBi		O75367

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O75367

PeptideAtlas

More...PeptideAtlasi		O75367

PRoteomics IDEntifications database

More...PRIDEi		O75367

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		49934 [O75367-1]
49935 [O75367-2]
49936 [O75367-3]

Consortium for Top Down Proteomics

More...TopDownProteomicsi		O75367-1 [O75367-1]
O75367-2 [O75367-2]

2D gel databases

Two-dimensional polyacrylamide gel electrophoresis database from the Geneva University Hospital

More...SWISS-2DPAGEi		O75367

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		O75367, 1 site, 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		O75367

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		O75367

SwissPalm database of S-palmitoylation events

More...SwissPalmi		O75367

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000113648, Expressed in vagina and 247 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		O75367, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		O75367, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000113648, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers.

Interacts with HDAC1 and HDAC2 (By similarity).

Interacts with SPOP.

Part of a complex consisting of MACROH2A1, CUL3 and SPOP.

By similarity3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		114927, 235 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		O75367

Database of interacting proteins

More...DIPi		DIP-44283N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...ELMi		O75367

Protein interaction database and analysis system

More...IntActi		O75367, 68 interactors

Molecular INTeraction database

More...MINTi		O75367

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000423563

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		O75367, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1372
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		O75367

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		O75367

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini2 – 117Histone H2AAdd BLAST116
Domaini184 – 370MacroPROSITE-ProRule annotationAdd BLAST187

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi118 – 162Lys-richAdd BLAST45

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1756, Eukaryota
KOG2633, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000159541

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_062828_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O75367

Identification of Orthologs from Complete Genome Data

More...OMAi		AVIHPTN

Database of Orthologous Groups

More...OrthoDBi		1504122at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		O75367

TreeFam database of animal gene trees

More...TreeFami		TF332276

Family and domain databases

Conserved Domains Database

More...CDDi		cd00074, H2A, 1 hit
cd02904, Macro_H2A-like, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.20.10, 1 hit
3.40.220.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR021171, Core_histone_macro-H2A
IPR009072, Histone-fold
IPR002119, Histone_H2A
IPR007125, Histone_H2A/H2B/H3
IPR032454, Histone_H2A_C
IPR002589, Macro_dom
IPR043472, Macro_dom-like
IPR035796, Macro_H2A

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00125, Histone, 1 hit
PF16211, Histone_H2A_C, 1 hit
PF01661, Macro, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF037942, Core_histone_macro-H2A, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00620, HISTONEH2A

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00506, A1pp, 1 hit
SM00414, H2A, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47113, SSF47113, 1 hit
SSF52949, SSF52949, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51154, MACRO, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 2 (identifier: O75367-1) [UniParc]FASTAAdd to basket
Also known as: mH2A1.21 Publication

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSSRGGKKKS TKTSRSAKAG VIFPVGRMLR YIKKGHPKYR IGVGAPVYMA 
        60         70         80         90        100
AVLEYLTAEI LELAGNAARD NKKGRVTPRH ILLAVANDEE LNQLLKGVTI 
       110        120        130        140        150
ASGGVLPNIH PELLAKKRGS KGKLEAIITP PPAKKAKSPS QKKPVSKKAG 
       160        170        180        190        200
GKKGARKSKK KQGEVSKAAS ADSTTEGTPA DGFTVLSTKS LFLGQKLNLI 
       210        220        230        240        250
HSEISNLAGF EVEAIINPTN ADIDLKDDLG NTLEKKGGKE FVEAVLELRK 
       260        270        280        290        300
KNGPLEVAGA AVSAGHGLPA KFVIHCNSPV WGADKCEELL EKTVKNCLAL 
       310        320        330        340        350
ADDKKLKSIA FPSIGSGRNG FPKQTAAQLI LKAISSYFVS TMSSSIKTVY 
       360        370 
FVLFDSESIG IYVQEMAKLD AN
Note: The preferential expression of isoform 2 over that of isoform 1 requires the presence of DDX5/DDX17.1 Publication
Length:372
Mass (Da):39,617
Last modified:January 23, 2007 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i37DED989EF7E69DC
GO
Isoform 1 (identifier: O75367-2) [UniParc]FASTAAdd to basket
Also known as: mH2A1.11 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     198-229: NLIHSEISNLAGFEVEAIINPTNADIDLKDDL → QVVQADIASIDSDAVVHPTNTDFYIGGEV

Note: Specifically binds ADP-ribose and O-acetyl-ADP-ribose. Important residues for binding are Asp-203, Gly-224, Gly-314 and Phe-348. Preferentially expressed over isoform 2 in the absence of DDX5/DDX17.2 Publications In contrast to other Macro-domain containing proteins, lacks ADP-ribose glycohydrolase activity.1 Publication
Show »
Length:369
Mass (Da):39,184
Checksum:iD21A4CE6C7AA3BB1
GO
Isoform 3 (identifier: O75367-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     159-159: Missing.

Show »
Length:371
Mass (Da):39,489
Checksum:i54320BFD118454D1
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RCF2D6RCF2_HUMAN
Histone H2A
MACROH2A1
165Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B4DJC3B4DJC3_HUMAN
Histone H2A
MACROH2A1
200Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti186L → F in BAB14565 (PubMed:14702039).Curated1
Sequence conflicti210F → S in BAB14565 (PubMed:14702039).Curated1
Sequence conflicti225L → P in AAC33433 (PubMed:9714746).Curated1
Sequence conflicti291E → G in AAH95406 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_038379159Missing in isoform 3. 2 Publications1
Alternative sequenceiVSP_002056198 – 229NLIHS…LKDDL → QVVQADIASIDSDAVVHPTN TDFYIGGEV in isoform 1. 1 PublicationAdd BLAST32

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF041483 mRNA Translation: AAC33433.1
AF044286 mRNA Translation: AAC33434.1
AF054174 mRNA Translation: AAC39908.1
AK023409 mRNA Translation: BAB14565.1
AC026691 Genomic DNA No translation available.
BC013331 mRNA Translation: AAH13331.1
BC095406 mRNA Translation: AAH95406.1
AY134746 mRNA Translation: AAN08620.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS4183.1 [O75367-3]
CCDS4184.1 [O75367-2]
CCDS4185.1 [O75367-1]

NCBI Reference Sequences

More...RefSeqi		NP_001035248.1, NM_001040158.1 [O75367-3]
NP_004884.1, NM_004893.2 [O75367-3]
NP_613075.1, NM_138609.2 [O75367-2]
NP_613258.2, NM_138610.2 [O75367-1]
XP_011542031.1, XM_011543729.2 [O75367-1]
XP_011542032.1, XM_011543730.2 [O75367-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000304332; ENSP00000302572; ENSG00000113648 [O75367-3]
ENST00000312469; ENSP00000310169; ENSG00000113648 [O75367-2]
ENST00000510038; ENSP00000424971; ENSG00000113648 [O75367-1]
ENST00000511689; ENSP00000423563; ENSG00000113648 [O75367-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		9555

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:9555

UCSC genome browser

More...UCSCi		uc003lam.2, human [O75367-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF041483 mRNA Translation: AAC33433.1
AF044286 mRNA Translation: AAC33434.1
AF054174 mRNA Translation: AAC39908.1
AK023409 mRNA Translation: BAB14565.1
AC026691 Genomic DNA No translation available.
BC013331 mRNA Translation: AAH13331.1
BC095406 mRNA Translation: AAH95406.1
AY134746 mRNA Translation: AAN08620.1
CCDSiCCDS4183.1 [O75367-3]
CCDS4184.1 [O75367-2]
CCDS4185.1 [O75367-1]
RefSeqiNP_001035248.1, NM_001040158.1 [O75367-3]
NP_004884.1, NM_004893.2 [O75367-3]
NP_613075.1, NM_138609.2 [O75367-2]
NP_613258.2, NM_138610.2 [O75367-1]
XP_011542031.1, XM_011543729.2 [O75367-1]
XP_011542032.1, XM_011543730.2 [O75367-3]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1U35X-ray3.00C/G1-120[»]
1ZR3X-ray1.66A/B/C/D162-372[»]
1ZR5X-ray2.92A/B161-372[»]
2F8NX-ray2.90G1-120[»]
2FXKX-ray2.54A/B162-372[»]
3HQHX-ray2.30M167-181[»]
3HSVX-ray1.43M172-186[»]
3IIDX-ray1.90A162-372[»]
3IIFX-ray2.10A/B/C162-372[»]
3IVBX-ray1.75M167-181[»]
5IITX-ray2.13A/B/C/D181-369[»]
5LNCX-ray3.29A/B182-369[»]
SMRiO75367
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi114927, 235 interactors
CORUMiO75367
DIPiDIP-44283N
ELMiO75367
IntActiO75367, 68 interactors
MINTiO75367
STRINGi9606.ENSP00000423563

PTM databases

GlyGeniO75367, 1 site, 1 O-linked glycan (1 site)
iPTMnetiO75367
PhosphoSitePlusiO75367
SwissPalmiO75367

Genetic variation databases

BioMutaiH2AFY

2D gel databases

SWISS-2DPAGEiO75367

Proteomic databases

CPTACiCPTAC-383
CPTAC-384
EPDiO75367
jPOSTiO75367
MassIVEiO75367
MaxQBiO75367
PaxDbiO75367
PeptideAtlasiO75367
PRIDEiO75367
ProteomicsDBi49934 [O75367-1]
49935 [O75367-2]
49936 [O75367-3]
TopDownProteomicsiO75367-1 [O75367-1]
O75367-2 [O75367-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		26391, 203 antibodies

The DNASU plasmid repository

More...DNASUi		9555

Genome annotation databases

EnsembliENST00000304332; ENSP00000302572; ENSG00000113648 [O75367-3]
ENST00000312469; ENSP00000310169; ENSG00000113648 [O75367-2]
ENST00000510038; ENSP00000424971; ENSG00000113648 [O75367-1]
ENST00000511689; ENSP00000423563; ENSG00000113648 [O75367-1]
GeneIDi9555
KEGGihsa:9555
UCSCiuc003lam.2, human [O75367-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		9555
DisGeNETi9555

GeneCards: human genes, protein and diseases

More...GeneCardsi		MACROH2A1
HGNCiHGNC:4740, MACROH2A1
HPAiENSG00000113648, Low tissue specificity
MalaCardsiMACROH2A1
MIMi610054, gene
neXtProtiNX_O75367
OpenTargetsiENSG00000113648
Orphaneti1275, Brachydactyly-elbow wrist dysplasia syndrome
PharmGKBiPA29117
VEuPathDBiHostDB:ENSG00000113648.16

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1756, Eukaryota
KOG2633, Eukaryota
GeneTreeiENSGT00940000159541
HOGENOMiCLU_062828_0_0_1
InParanoidiO75367
OMAiAVIHPTN
OrthoDBi1504122at2759
PhylomeDBiO75367
TreeFamiTF332276

Enzyme and pathway databases

PathwayCommonsiO75367

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		9555, 3 hits in 999 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		H2AFY, human
EvolutionaryTraceiO75367

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		H2AFY

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		9555
PharosiO75367, Tbio

Protein Ontology

More...PROi		PR:O75367
RNActiO75367, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000113648, Expressed in vagina and 247 other tissues
ExpressionAtlasiO75367, baseline and differential
GenevisibleiO75367, HS

Family and domain databases

CDDicd00074, H2A, 1 hit
cd02904, Macro_H2A-like, 1 hit
Gene3Di1.10.20.10, 1 hit
3.40.220.10, 1 hit
InterProiView protein in InterPro
IPR021171, Core_histone_macro-H2A
IPR009072, Histone-fold
IPR002119, Histone_H2A
IPR007125, Histone_H2A/H2B/H3
IPR032454, Histone_H2A_C
IPR002589, Macro_dom
IPR043472, Macro_dom-like
IPR035796, Macro_H2A
PfamiView protein in Pfam
PF00125, Histone, 1 hit
PF16211, Histone_H2A_C, 1 hit
PF01661, Macro, 1 hit
PIRSFiPIRSF037942, Core_histone_macro-H2A, 1 hit
PRINTSiPR00620, HISTONEH2A
SMARTiView protein in SMART
SM00506, A1pp, 1 hit
SM00414, H2A, 1 hit
SUPFAMiSSF47113, SSF47113, 1 hit
SSF52949, SSF52949, 1 hit
PROSITEiView protein in PROSITE
PS51154, MACRO, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiH2AY_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O75367
Secondary accession number(s): O75377
, Q503A8, Q7Z5E3, Q96D41, Q9H8P3, Q9UP96
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: January 23, 2007
Last modified: April 7, 2021
This is version 210 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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