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UniProtKB - O75363 (BCAS1_HUMAN)
Protein
Breast carcinoma-amplified sequence 1
Gene
BCAS1
Organism
Homo sapiens (Human)
Status
Functioni
Required for myelination.
By similarityGO - Biological processi
- myelination Source: UniProtKB
Enzyme and pathway databases
PathwayCommonsi | O75363 |
SignaLinki | O75363 |
Names & Taxonomyi
Protein namesi | Recommended name: Breast carcinoma-amplified sequence 1Alternative name(s): Amplified and overexpressed in breast cancer Novel amplified in breast cancer 1 |
Gene namesi | Name:BCAS1 Synonyms:AIBC1, NABC1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:974, BCAS1 |
MIMi | 602968, gene |
neXtProti | NX_O75363 |
VEuPathDBi | HostDB:ENSG00000064787 |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm 1 Publication
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Other locations
- cytoplasm Source: UniProtKB
Keywords - Cellular componenti
CytoplasmPathology & Biotechi
Organism-specific databases
DisGeNETi | 8537 |
OpenTargetsi | ENSG00000064787 |
PharmGKBi | PA25284 |
Miscellaneous databases
Pharosi | O75363, Tbio |
Genetic variation databases
BioMutai | BCAS1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000064859 | 1 – 584 | Breast carcinoma-amplified sequence 1Add BLAST | 584 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 124 | PhosphoserineBy similarity | 1 | |
Modified residuei | 192 | PhosphoserineBy similarity | 1 | |
Modified residuei | 314 | PhosphoserineBy similarity | 1 | |
Modified residuei | 381 | PhosphoserineBy similarity | 1 | |
Modified residuei | 399 | PhosphoserineBy similarity | 1 | |
Modified residuei | 480 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 552 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
jPOSTi | O75363 |
MassIVEi | O75363 |
MaxQBi | O75363 |
PaxDbi | O75363 |
PeptideAtlasi | O75363 |
PRIDEi | O75363 |
ProteomicsDBi | 49926 [O75363-1] 49927 [O75363-2] |
PTM databases
iPTMneti | O75363 |
PhosphoSitePlusi | O75363 |
Expressioni
Tissue specificityi
Highly expressed in the brain and, more specifically, in oligodendrocytes (at protein level). Expressed in the prostate, and at lower levels in testis, intestine and colon. Overexpressed in most breast cancer cell lines and down-regulated in some colorectal tumors.3 Publications
Gene expression databases
Bgeei | ENSG00000064787, Expressed in C1 segment of cervical spinal cord and 205 other tissues |
ExpressionAtlasi | O75363, baseline and differential |
Genevisiblei | O75363, HS |
Organism-specific databases
HPAi | ENSG00000064787, Tissue enhanced (brain, choroid plexus) |
Interactioni
Subunit structurei
Homodimer (PubMed:14567997).
Interacts with DYNLL1 and DYNLL2 (By similarity).
By similarity1 PublicationProtein-protein interaction databases
BioGRIDi | 114107, 6 interactors |
IntActi | O75363, 2 interactors |
STRINGi | 9606.ENSP00000379290 |
Miscellaneous databases
RNActi | O75363, protein |
Structurei
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 29 | DisorderedSequence analysisAdd BLAST | 29 | |
Regioni | 59 – 280 | DisorderedSequence analysisAdd BLAST | 222 | |
Regioni | 297 – 377 | DisorderedSequence analysisAdd BLAST | 81 | |
Regioni | 415 – 584 | DisorderedSequence analysisAdd BLAST | 170 | |
Regioni | 565 – 584 | Interacts with DYNLL1 AND DYNLL2By similarityAdd BLAST | 20 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 59 – 73 | Polar residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 111 – 133 | Polar residuesSequence analysisAdd BLAST | 23 | |
Compositional biasi | 189 – 226 | Basic and acidic residuesSequence analysisAdd BLAST | 38 | |
Compositional biasi | 240 – 254 | Basic and acidic residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 312 – 357 | Polar residuesSequence analysisAdd BLAST | 46 | |
Compositional biasi | 424 – 441 | Basic and acidic residuesSequence analysisAdd BLAST | 18 | |
Compositional biasi | 463 – 483 | Polar residuesSequence analysisAdd BLAST | 21 | |
Compositional biasi | 496 – 520 | Basic and acidic residuesSequence analysisAdd BLAST | 25 | |
Compositional biasi | 521 – 540 | Polar residuesSequence analysisAdd BLAST | 20 |
Phylogenomic databases
eggNOGi | ENOG502QTR2, Eukaryota |
GeneTreei | ENSGT00390000003167 |
HOGENOMi | CLU_031051_0_0_1 |
InParanoidi | O75363 |
OMAi | QGAAKNP |
OrthoDBi | 1009953at2759 |
PhylomeDBi | O75363 |
TreeFami | TF335555 |
Family and domain databases
InterProi | View protein in InterPro IPR026115, NABC1 |
PANTHERi | PTHR15016, PTHR15016, 2 hits |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: O75363-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MGNQMSVPQR VEDQENEPEA ETYQDNASAL NGVPVVVSTH TVQHLEEVDL
60 70 80 90 100
GISVKTDNVA TSSPETTEIS AVADANGKNL GKEAKPEAPA AKSRFFLMLS
110 120 130 140 150
RPVPGRTGDQ AADSSLGSVK LDVSSNKAPA NKDPSESWTL PVAAGPGQDT
160 170 180 190 200
DKTPGHAPAQ DKVLSAARDP TLLPPETGGA GGEAPSKPKD SSFFDKFFKL
210 220 230 240 250
DKGQEKVPGD SQQEAKRAEH QDKVDEVPGL SGQSDDVPAG KDIVDGKEKE
260 270 280 290 300
GQELGTADCS VPGDPEGLET AKDDSQAAAI AENNNSIMSF FKTLVSPNKA
310 320 330 340 350
ETKKDPEDTG AEKSPTTSAD LKSDKANFTS QETQGAGKNS KGCNPSGHTQ
360 370 380 390 400
SVTTPEPAKE GTKEKSGPTS LPLGKLFWKK SVKEDSVPTG AEENVVCESP
410 420 430 440 450
VEIIKSKEVE SALQTVDLNE GDAAPEPTEA KLKREESKPR TSLMAFLRQM
460 470 480 490 500
SVKGDGGITH SEEINGKDSS CQTSDSTEKT ITPPEPEPTG APQKGKEGSS
510 520 530 540 550
KDKKSAAEMN KQKSNKQEAK EPAQCTEQAT VDTNSLQNGD KLQKRPEKRQ
560 570 580
QSLGGFFKGL GPKRMLDAQV QTDPVSIGPV GKSK
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketG3XAF7 | G3XAF7_HUMAN | Breast carcinoma amplified sequence... | BCAS1 hCG_37358 | 506 | Annotation score: | ||
H0Y542 | H0Y542_HUMAN | Breast carcinoma-amplified sequence... | BCAS1 | 476 | Annotation score: | ||
H7C1E7 | H7C1E7_HUMAN | Breast carcinoma-amplified sequence... | BCAS1 | 247 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 361 | G → D in CAH18437 (PubMed:17974005).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_026674 | 24 | Q → K. Corresponds to variant dbSNP:rs394732Ensembl. | 1 | |
Natural variantiVAR_026675 | 163 | V → A. Corresponds to variant dbSNP:rs158551Ensembl. | 1 | |
Natural variantiVAR_024251 | 255 | G → E. Corresponds to variant dbSNP:rs6022903Ensembl. | 1 | |
Natural variantiVAR_050691 | 472 | Q → H. Corresponds to variant dbSNP:rs35575210Ensembl. | 1 | |
Natural variantiVAR_026676 | 583 | S → P1 PublicationCorresponds to variant dbSNP:rs1055246Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_018520 | 309 | T → TASKAESVCDGQAGQKTSEI QARGTKKKHLDSPRLGLAFR KFFRHK in isoform 2. 2 Publications | 1 | |
Alternative sequenceiVSP_018521 | 381 – 394 | Missing in isoform 2. 2 PublicationsAdd BLAST | 14 | |
Alternative sequenceiVSP_018522 | 451 – 472 | Missing in isoform 2. 2 PublicationsAdd BLAST | 22 | |
Alternative sequenceiVSP_018523 | 584 | K → KYTGKCVFSHVKKKWPFQEW SY in isoform 2. 2 Publications | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF041260 mRNA Translation: AAC39896.1 AC004501 Genomic DNA No translation available. AC005220 Genomic DNA No translation available. BC126346 mRNA Translation: AAI26347.1 AI904532 mRNA No translation available. CR749643 mRNA Translation: CAH18437.1 |
CCDSi | CCDS13444.1 [O75363-1] |
RefSeqi | NP_003648.2, NM_003657.3 [O75363-1] |
Genome annotation databases
Ensembli | ENST00000395961; ENSP00000379290; ENSG00000064787 |
GeneIDi | 8537 |
KEGGi | hsa:8537 |
UCSCi | uc002xws.3, human [O75363-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF041260 mRNA Translation: AAC39896.1 AC004501 Genomic DNA No translation available. AC005220 Genomic DNA No translation available. BC126346 mRNA Translation: AAI26347.1 AI904532 mRNA No translation available. CR749643 mRNA Translation: CAH18437.1 |
CCDSi | CCDS13444.1 [O75363-1] |
RefSeqi | NP_003648.2, NM_003657.3 [O75363-1] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 114107, 6 interactors |
IntActi | O75363, 2 interactors |
STRINGi | 9606.ENSP00000379290 |
PTM databases
iPTMneti | O75363 |
PhosphoSitePlusi | O75363 |
Genetic variation databases
BioMutai | BCAS1 |
Proteomic databases
jPOSTi | O75363 |
MassIVEi | O75363 |
MaxQBi | O75363 |
PaxDbi | O75363 |
PeptideAtlasi | O75363 |
PRIDEi | O75363 |
ProteomicsDBi | 49926 [O75363-1] 49927 [O75363-2] |
Protocols and materials databases
Antibodypediai | 28750, 176 antibodies from 25 providers |
DNASUi | 8537 |
Genome annotation databases
Ensembli | ENST00000395961; ENSP00000379290; ENSG00000064787 |
GeneIDi | 8537 |
KEGGi | hsa:8537 |
UCSCi | uc002xws.3, human [O75363-1] |
Organism-specific databases
CTDi | 8537 |
DisGeNETi | 8537 |
GeneCardsi | BCAS1 |
HGNCi | HGNC:974, BCAS1 |
HPAi | ENSG00000064787, Tissue enhanced (brain, choroid plexus) |
MIMi | 602968, gene |
neXtProti | NX_O75363 |
OpenTargetsi | ENSG00000064787 |
PharmGKBi | PA25284 |
VEuPathDBi | HostDB:ENSG00000064787 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QTR2, Eukaryota |
GeneTreei | ENSGT00390000003167 |
HOGENOMi | CLU_031051_0_0_1 |
InParanoidi | O75363 |
OMAi | QGAAKNP |
OrthoDBi | 1009953at2759 |
PhylomeDBi | O75363 |
TreeFami | TF335555 |
Enzyme and pathway databases
PathwayCommonsi | O75363 |
SignaLinki | O75363 |
Miscellaneous databases
BioGRID-ORCSi | 8537, 7 hits in 1033 CRISPR screens |
ChiTaRSi | BCAS1, human |
GeneWikii | BCAS1 |
GenomeRNAii | 8537 |
Pharosi | O75363, Tbio |
PROi | PR:O75363 |
RNActi | O75363, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000064787, Expressed in C1 segment of cervical spinal cord and 205 other tissues |
ExpressionAtlasi | O75363, baseline and differential |
Genevisiblei | O75363, HS |
Family and domain databases
InterProi | View protein in InterPro IPR026115, NABC1 |
PANTHERi | PTHR15016, PTHR15016, 2 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | BCAS1_HUMAN | |
Accessioni | O75363Primary (citable) accession number: O75363 Secondary accession number(s): A0AVG5, Q68CZ3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 24, 2001 |
Last sequence update: | June 13, 2006 | |
Last modified: | February 23, 2022 | |
This is version 155 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 20
Human chromosome 20: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot