Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Zinc finger protein 217

Gene

ZNF217

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds to the promoters of target genes and functions as repressor. Promotes cell proliferation and antagonizes cell death. Promotes phosphorylation of AKT1 at 'Ser-473'.4 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri65 – 88C2H2-type 1PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri128 – 150C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri156 – 178C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri216 – 238C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri375 – 397C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri471 – 493C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri499 – 521C2H2-type 7PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-9018519 Estrogen-dependent gene expression
SIGNORiO75362

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 217
Gene namesi
Name:ZNF217
Synonyms:ZABC1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000171940.13
HGNCiHGNC:13009 ZNF217
MIMi602967 gene
neXtProtiNX_O75362

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi7764
OpenTargetsiENSG00000171940
PharmGKBiPA37588

Polymorphism and mutation databases

BioMutaiZNF217

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000474601 – 1048Zinc finger protein 217Add BLAST1048

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei106PhosphoserineCombined sources1
Modified residuei321PhosphoserineCombined sources1
Modified residuei322PhosphothreonineCombined sources1
Modified residuei407PhosphoserineCombined sources1
Modified residuei593PhosphoserineCombined sources1
Modified residuei648PhosphothreonineCombined sources1
Modified residuei662PhosphoserineCombined sources1
Modified residuei795PhosphoserineCombined sources1
Cross-linki819Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiO75362
MaxQBiO75362
PaxDbiO75362
PeptideAtlasiO75362
PRIDEiO75362
ProteomicsDBi49925

PTM databases

iPTMnetiO75362
PhosphoSitePlusiO75362

Expressioni

Gene expression databases

BgeeiENSG00000171940 Expressed in 206 organ(s), highest expression level in endometrium epithelium
CleanExiHS_ZNF217
ExpressionAtlasiO75362 baseline and differential
GenevisibleiO75362 HS

Organism-specific databases

HPAiHPA051857

Interactioni

Subunit structurei

Component of a histone deacetylase complex that contains HDAC2, KDM1A, CTBP1 and ZNF217. May be a component of a BHC histone deacetylase complex that contains HDAC1, HDAC2, HMG20B/BRAF35, KDM1A, RCOR1/CoREST, PHF21A/BHC80, ZMYM2, ZNF217, ZMYM3, GSE1 and GTF2I. Interacts with CTBP1 and CTBP2.3 Publications

Protein-protein interaction databases

BioGridi113547, 12 interactors
CORUMiO75362
IntActiO75362, 6 interactors
MINTiO75362
STRINGi9606.ENSP00000304308

Structurei

Secondary structure

11048
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliO75362
SMRiO75362
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO75362

Family & Domainsi

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri65 – 88C2H2-type 1PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri128 – 150C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri156 – 178C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri216 – 238C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri375 – 397C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri471 – 493C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri499 – 521C2H2-type 7PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00530000063100
HOGENOMiHOG000276541
HOVERGENiHBG061769
InParanoidiO75362
OMAiIEHSKVH
OrthoDBiEOG091G010T
PhylomeDBiO75362
TreeFamiTF332241

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 3 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 8 hits
SUPFAMiSSF57667 SSF57667, 3 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 6 hits
PS50157 ZINC_FINGER_C2H2_2, 7 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

O75362-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQSKVTGNMP TQSLLMYMDG PEVIGSSLGS PMEMEDALSM KGTAVVPFRA
60 70 80 90 100
TQEKNVIQIE GYMPLDCMFC SQTFTHSEDL NKHVLMQHRP TLCEPAVLRV
110 120 130 140 150
EAEYLSPLDK SQVRTEPPKE KNCKENEFSC EVCGQTFRVA FDVEIHMRTH
160 170 180 190 200
KDSFTYGCNM CGRRFKEPWF LKNHMRTHNG KSGARSKLQQ GLESSPATIN
210 220 230 240 250
EVVQVHAAES ISSPYKICMV CGFLFPNKES LIEHRKVHTK KTAFGTSSAQ
260 270 280 290 300
TDSPQGGMPS SREDFLQLFN LRPKSHPETG KKPVRCIPQL DPFTTFQAWQ
310 320 330 340 350
LATKGKVAIC QEVKESGQEG STDNDDSSSE KELGETNKGS CAGLSQEKEK
360 370 380 390 400
CKHSHGEAPS VDADPKLPSS KEKPTHCSEC GKAFRTYHQL VLHSRVHKKD
410 420 430 440 450
RRAGAESPTM SVDGRQPGTC SPDLAAPLDE NGAVDRGEGG SEDGSEDGLP
460 470 480 490 500
EGIHLDKNDD GGKIKHLTSS RECSYCGKFF RSNYYLNIHL RTHTGEKPYK
510 520 530 540 550
CEFCEYAAAQ KTSLRYHLER HHKEKQTDVA AEVKNDGKNQ DTEDALLTAD
560 570 580 590 600
SAQTKNLKRF FDGAKDVTGS PPAKQLKEMP SVFQNVLGSA VLSPAHKDTQ
610 620 630 640 650
DFHKNAADDS ADKVNKNPTP AYLDLLKKRS AVETQANNLI CRTKADVTPP
660 670 680 690 700
PDGSTTHNLE VSPKEKQTET AADCRYRPSV DCHEKPLNLS VGALHNCPAI
710 720 730 740 750
SLSKSLIPSI TCPFCTFKTF YPEVLMMHQR LEHKYNPDVH KNCRNKSLLR
760 770 780 790 800
SRRTGCPPAL LGKDVPPLSS FCKPKPKSAF PAQSKSLPSA KGKQSPPGPG
810 820 830 840 850
KAPLTSGIDS STLAPSNLKS HRPQQNVGVQ GAATRQQQSE MFPKTSVSPA
860 870 880 890 900
PDKTKRPETK LKPLPVAPSQ PTLGSSNING SIDYPAKNDS PWAPPGRDYF
910 920 930 940 950
CNRSASNTAA EFGEPLPKRL KSSVVALDVD QPGANYRRGY DLPKYHMVRG
960 970 980 990 1000
ITSLLPQDCV YPSQALPPKP RFLSSSEVDS PNVLTVQKPY GGSGPLYTCV
1010 1020 1030 1040
PAGSPASSST LEGKRPVSYQ HLSNSMAQKR NYENFIGNAH YRPNDKKT
Length:1,048
Mass (Da):115,272
Last modified:November 1, 1998 - v1
Checksum:i797FC620817D1E1F
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2A326A2A326_HUMAN
Zinc finger protein 217
ZNF217
95Annotation score:
Q9BZ31Q9BZ31_HUMAN
Zinc finger protein 217
ZNF217
149Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_035572323D → N in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs767530299Ensembl.1
Natural variantiVAR_052795739V → I. Corresponds to variant dbSNP:rs6063966Ensembl.1
Natural variantiVAR_061939889D → G. Corresponds to variant dbSNP:rs34323943Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF041259 mRNA Translation: AAC39895.1
AL157838 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW75580.1
BC113427 mRNA Translation: AAI13428.1
CCDSiCCDS13443.1
RefSeqiNP_006517.1, NM_006526.2
XP_016883548.1, XM_017028059.1
UniGeneiHs.155040
Hs.711564

Genome annotation databases

EnsembliENST00000302342; ENSP00000304308; ENSG00000171940
ENST00000371471; ENSP00000360526; ENSG00000171940
GeneIDi7764
KEGGihsa:7764
UCSCiuc002xwq.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF041259 mRNA Translation: AAC39895.1
AL157838 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW75580.1
BC113427 mRNA Translation: AAI13428.1
CCDSiCCDS13443.1
RefSeqiNP_006517.1, NM_006526.2
XP_016883548.1, XM_017028059.1
UniGeneiHs.155040
Hs.711564

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2HU2X-ray2.85B752-760[»]
3UK3X-ray2.10C/D469-523[»]
4F2JX-ray2.64C469-523[»]
4IS1X-ray2.10C/D469-523[»]
ProteinModelPortaliO75362
SMRiO75362
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113547, 12 interactors
CORUMiO75362
IntActiO75362, 6 interactors
MINTiO75362
STRINGi9606.ENSP00000304308

PTM databases

iPTMnetiO75362
PhosphoSitePlusiO75362

Polymorphism and mutation databases

BioMutaiZNF217

Proteomic databases

EPDiO75362
MaxQBiO75362
PaxDbiO75362
PeptideAtlasiO75362
PRIDEiO75362
ProteomicsDBi49925

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000302342; ENSP00000304308; ENSG00000171940
ENST00000371471; ENSP00000360526; ENSG00000171940
GeneIDi7764
KEGGihsa:7764
UCSCiuc002xwq.5 human

Organism-specific databases

CTDi7764
DisGeNETi7764
EuPathDBiHostDB:ENSG00000171940.13
GeneCardsiZNF217
HGNCiHGNC:13009 ZNF217
HPAiHPA051857
MIMi602967 gene
neXtProtiNX_O75362
OpenTargetsiENSG00000171940
PharmGKBiPA37588
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00530000063100
HOGENOMiHOG000276541
HOVERGENiHBG061769
InParanoidiO75362
OMAiIEHSKVH
OrthoDBiEOG091G010T
PhylomeDBiO75362
TreeFamiTF332241

Enzyme and pathway databases

ReactomeiR-HSA-9018519 Estrogen-dependent gene expression
SIGNORiO75362

Miscellaneous databases

ChiTaRSiZNF217 human
EvolutionaryTraceiO75362
GeneWikiiZNF217
GenomeRNAii7764
PROiPR:O75362
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000171940 Expressed in 206 organ(s), highest expression level in endometrium epithelium
CleanExiHS_ZNF217
ExpressionAtlasiO75362 baseline and differential
GenevisibleiO75362 HS

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 3 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 8 hits
SUPFAMiSSF57667 SSF57667, 3 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 6 hits
PS50157 ZINC_FINGER_C2H2_2, 7 hits
ProtoNetiSearch...

Entry informationi

Entry nameiZN217_HUMAN
AccessioniPrimary (citable) accession number: O75362
Secondary accession number(s): E1P5Y6, Q14DB8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: November 1, 1998
Last modified: November 7, 2018
This is version 172 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again