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Protein

Zinc finger protein 217

Gene

ZNF217

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Binds to the promoters of target genes and functions as repressor. Promotes cell proliferation and antagonizes cell death. Promotes phosphorylation of AKT1 at 'Ser-473'.4 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri65 – 88C2H2-type 1PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri128 – 150C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri156 – 178C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri216 – 238C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri375 – 397C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri471 – 493C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri499 – 521C2H2-type 7PROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-9018519 Estrogen-dependent gene expression

SIGNOR Signaling Network Open Resource

More...
SIGNORi
O75362

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein 217
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZNF217
Synonyms:ZABC1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 20

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000171940.13

Human Gene Nomenclature Database

More...
HGNCi
HGNC:13009 ZNF217

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
602967 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O75362

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
7764

Open Targets

More...
OpenTargetsi
ENSG00000171940

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA37588

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ZNF217

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000474601 – 1048Zinc finger protein 217Add BLAST1048

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei106PhosphoserineCombined sources1
Modified residuei321PhosphoserineCombined sources1
Modified residuei322PhosphothreonineCombined sources1
Modified residuei407PhosphoserineCombined sources1
Modified residuei593PhosphoserineCombined sources1
Modified residuei648PhosphothreonineCombined sources1
Modified residuei662PhosphoserineCombined sources1
Modified residuei795PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki819Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
O75362

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
O75362

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O75362

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O75362

PeptideAtlas

More...
PeptideAtlasi
O75362

PRoteomics IDEntifications database

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PRIDEi
O75362

ProteomicsDB human proteome resource

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ProteomicsDBi
49925

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O75362

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O75362

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000171940 Expressed in 206 organ(s), highest expression level in endometrium epithelium

CleanEx database of gene expression profiles

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CleanExi
HS_ZNF217

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
O75362 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
O75362 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA051857

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of a histone deacetylase complex that contains HDAC2, KDM1A, CTBP1 and ZNF217. May be a component of a BHC histone deacetylase complex that contains HDAC1, HDAC2, HMG20B/BRAF35, KDM1A, RCOR1/CoREST, PHF21A/BHC80, ZMYM2, ZNF217, ZMYM3, GSE1 and GTF2I. Interacts with CTBP1 and CTBP2.3 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
113547, 27 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
O75362

Protein interaction database and analysis system

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IntActi
O75362, 6 interactors

Molecular INTeraction database

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MINTi
O75362

STRING: functional protein association networks

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STRINGi
9606.ENSP00000304308

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11048
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2HU2X-ray2.85B752-760[»]
3UK3X-ray2.10C/D469-523[»]
4F2JX-ray2.64C469-523[»]
4IS1X-ray2.10C/D469-523[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
O75362

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
O75362

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
O75362

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri65 – 88C2H2-type 1PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri128 – 150C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri156 – 178C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri216 – 238C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri375 – 397C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri471 – 493C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri499 – 521C2H2-type 7PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1721 Eukaryota
COG5048 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000159884

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000276541

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG061769

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
O75362

Identification of Orthologs from Complete Genome Data

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OMAi
IEHSKVH

Database of Orthologous Groups

More...
OrthoDBi
1318335at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O75362

TreeFam database of animal gene trees

More...
TreeFami
TF332241

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00096 zf-C2H2, 3 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00355 ZnF_C2H2, 8 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57667 SSF57667, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 6 hits
PS50157 ZINC_FINGER_C2H2_2, 7 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

O75362-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQSKVTGNMP TQSLLMYMDG PEVIGSSLGS PMEMEDALSM KGTAVVPFRA
60 70 80 90 100
TQEKNVIQIE GYMPLDCMFC SQTFTHSEDL NKHVLMQHRP TLCEPAVLRV
110 120 130 140 150
EAEYLSPLDK SQVRTEPPKE KNCKENEFSC EVCGQTFRVA FDVEIHMRTH
160 170 180 190 200
KDSFTYGCNM CGRRFKEPWF LKNHMRTHNG KSGARSKLQQ GLESSPATIN
210 220 230 240 250
EVVQVHAAES ISSPYKICMV CGFLFPNKES LIEHRKVHTK KTAFGTSSAQ
260 270 280 290 300
TDSPQGGMPS SREDFLQLFN LRPKSHPETG KKPVRCIPQL DPFTTFQAWQ
310 320 330 340 350
LATKGKVAIC QEVKESGQEG STDNDDSSSE KELGETNKGS CAGLSQEKEK
360 370 380 390 400
CKHSHGEAPS VDADPKLPSS KEKPTHCSEC GKAFRTYHQL VLHSRVHKKD
410 420 430 440 450
RRAGAESPTM SVDGRQPGTC SPDLAAPLDE NGAVDRGEGG SEDGSEDGLP
460 470 480 490 500
EGIHLDKNDD GGKIKHLTSS RECSYCGKFF RSNYYLNIHL RTHTGEKPYK
510 520 530 540 550
CEFCEYAAAQ KTSLRYHLER HHKEKQTDVA AEVKNDGKNQ DTEDALLTAD
560 570 580 590 600
SAQTKNLKRF FDGAKDVTGS PPAKQLKEMP SVFQNVLGSA VLSPAHKDTQ
610 620 630 640 650
DFHKNAADDS ADKVNKNPTP AYLDLLKKRS AVETQANNLI CRTKADVTPP
660 670 680 690 700
PDGSTTHNLE VSPKEKQTET AADCRYRPSV DCHEKPLNLS VGALHNCPAI
710 720 730 740 750
SLSKSLIPSI TCPFCTFKTF YPEVLMMHQR LEHKYNPDVH KNCRNKSLLR
760 770 780 790 800
SRRTGCPPAL LGKDVPPLSS FCKPKPKSAF PAQSKSLPSA KGKQSPPGPG
810 820 830 840 850
KAPLTSGIDS STLAPSNLKS HRPQQNVGVQ GAATRQQQSE MFPKTSVSPA
860 870 880 890 900
PDKTKRPETK LKPLPVAPSQ PTLGSSNING SIDYPAKNDS PWAPPGRDYF
910 920 930 940 950
CNRSASNTAA EFGEPLPKRL KSSVVALDVD QPGANYRRGY DLPKYHMVRG
960 970 980 990 1000
ITSLLPQDCV YPSQALPPKP RFLSSSEVDS PNVLTVQKPY GGSGPLYTCV
1010 1020 1030 1040
PAGSPASSST LEGKRPVSYQ HLSNSMAQKR NYENFIGNAH YRPNDKKT
Length:1,048
Mass (Da):115,272
Last modified:November 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i797FC620817D1E1F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2A326A2A326_HUMAN
Zinc finger protein 217
ZNF217
95Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q9BZ31Q9BZ31_HUMAN
Zinc finger protein 217
ZNF217
149Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_035572323D → N in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs767530299Ensembl.1
Natural variantiVAR_052795739V → I. Corresponds to variant dbSNP:rs6063966Ensembl.1
Natural variantiVAR_061939889D → G. Corresponds to variant dbSNP:rs34323943Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF041259 mRNA Translation: AAC39895.1
AL157838 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW75580.1
BC113427 mRNA Translation: AAI13428.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS13443.1

NCBI Reference Sequences

More...
RefSeqi
NP_006517.1, NM_006526.2
XP_016883548.1, XM_017028059.1

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.155040
Hs.711564

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000302342; ENSP00000304308; ENSG00000171940
ENST00000371471; ENSP00000360526; ENSG00000171940

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
7764

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:7764

UCSC genome browser

More...
UCSCi
uc002xwq.5 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF041259 mRNA Translation: AAC39895.1
AL157838 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW75580.1
BC113427 mRNA Translation: AAI13428.1
CCDSiCCDS13443.1
RefSeqiNP_006517.1, NM_006526.2
XP_016883548.1, XM_017028059.1
UniGeneiHs.155040
Hs.711564

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2HU2X-ray2.85B752-760[»]
3UK3X-ray2.10C/D469-523[»]
4F2JX-ray2.64C469-523[»]
4IS1X-ray2.10C/D469-523[»]
ProteinModelPortaliO75362
SMRiO75362
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113547, 27 interactors
CORUMiO75362
IntActiO75362, 6 interactors
MINTiO75362
STRINGi9606.ENSP00000304308

PTM databases

iPTMnetiO75362
PhosphoSitePlusiO75362

Polymorphism and mutation databases

BioMutaiZNF217

Proteomic databases

EPDiO75362
jPOSTiO75362
MaxQBiO75362
PaxDbiO75362
PeptideAtlasiO75362
PRIDEiO75362
ProteomicsDBi49925

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000302342; ENSP00000304308; ENSG00000171940
ENST00000371471; ENSP00000360526; ENSG00000171940
GeneIDi7764
KEGGihsa:7764
UCSCiuc002xwq.5 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
7764
DisGeNETi7764
EuPathDBiHostDB:ENSG00000171940.13

GeneCards: human genes, protein and diseases

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GeneCardsi
ZNF217
HGNCiHGNC:13009 ZNF217
HPAiHPA051857
MIMi602967 gene
neXtProtiNX_O75362
OpenTargetsiENSG00000171940
PharmGKBiPA37588

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00940000159884
HOGENOMiHOG000276541
HOVERGENiHBG061769
InParanoidiO75362
OMAiIEHSKVH
OrthoDBi1318335at2759
PhylomeDBiO75362
TreeFamiTF332241

Enzyme and pathway databases

ReactomeiR-HSA-9018519 Estrogen-dependent gene expression
SIGNORiO75362

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ZNF217 human
EvolutionaryTraceiO75362

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
ZNF217

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
7764

Protein Ontology

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PROi
PR:O75362

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000171940 Expressed in 206 organ(s), highest expression level in endometrium epithelium
CleanExiHS_ZNF217
ExpressionAtlasiO75362 baseline and differential
GenevisibleiO75362 HS

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 3 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 8 hits
SUPFAMiSSF57667 SSF57667, 3 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 6 hits
PS50157 ZINC_FINGER_C2H2_2, 7 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZN217_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O75362
Secondary accession number(s): E1P5Y6, Q14DB8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: November 1, 1998
Last modified: January 16, 2019
This is version 174 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
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