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UniProtKB - O75354 (ENTP6_HUMAN)

Entry version 189 (29 Sep 2021)
Sequence version 3 (11 Jan 2011)
Previous versions | rss
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Protein

Ectonucleoside triphosphate diphosphohydrolase 6

Gene

ENTPD6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the hydrolysis of nucleoside triphosphates and diphosphates in a calcium- or magnesium-dependent manner. Has a strong preference for nucleoside diphosphates, preferentially hydrolyzes GDP, IDP, and UDP, with slower hydrolysis of CDP, ITP, GTP, CTP, ADP, and UTP and virtually no hydrolysis of ATP (PubMed:10948193, PubMed:14529283, PubMed:11041856).

The membrane bound form might support glycosylation reactions in the Golgi apparatus and, when released from cells, might catalyze the hydrolysis of extracellular nucleotides (PubMed:10948193, PubMed:14529283, PubMed:11041856).

3 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Ca2+3 Publications, Mg2+3 PublicationsNote: Strongly and equally activated by either Ca2+ or Mg2+.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Glycosylation does not appear to be required for enzymatic activity.1 Publication

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=130 µM for GDP (in the presence of Ca2+)1 Publication
  1. Vmax=60000 µmol/h/mg enzyme with GDP as substrate1 Publication

pH dependencei

Optimum pH is 7.0 to 7.4.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei224Proton acceptorBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase
LigandCalcium, Magnesium

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		3.6.1.6, 2681

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		O75354

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-8850843, Phosphate bond hydrolysis by NTPDase proteins

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ectonucleoside triphosphate diphosphohydrolase 6 (EC:3.6.1.63 Publications)
Short name:
NTPDase 6
Alternative name(s):
CD39 antigen-like 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ENTPD6
Synonyms:CD39L2, IL6ST2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 20

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:3368, ENTPD6

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		603160, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_O75354

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000197586

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 39CytoplasmicSequence analysisAdd BLAST39
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei40 – 60Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini61 – 484LumenalSequence analysisAdd BLAST424

Keywords - Cellular componenti

Cell membrane, Golgi apparatus, Membrane, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi215C → S: Does not affect nucleoside-triphosphatase activity. Does not affeet KM for GDP. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		955

Open Targets

More...OpenTargetsi		ENSG00000197586

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA27803

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		O75354, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ENTPD6

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002099131 – 484Ectonucleoside triphosphate diphosphohydrolase 6Add BLAST484

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi220N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi284N-linked (GlcNAc...) asparagine1 Publication1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi325 ↔ 3561 Publication
Disulfide bondi416 ↔ 4301 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

The secreted form may be produced by intracellular processing.1 Publication
N-glycosylated.2 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		O75354

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		O75354

MaxQB - The MaxQuant DataBase

More...MaxQBi		O75354

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O75354

PeptideAtlas

More...PeptideAtlasi		O75354

PRoteomics IDEntifications database

More...PRIDEi		O75354

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		49920 [O75354-1]
49921 [O75354-2]
63663

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		O75354, 3 sites, 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		O75354

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		O75354

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in most tissues, but predominantly in heart.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000197586, Expressed in adenohypophysis and 221 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		O75354, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		O75354, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000197586, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer.

1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		107393, 18 interactors

Protein interaction database and analysis system

More...IntActi		O75354, 9 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000365840

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		O75354, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		O75354

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the GDA1/CD39 NTPase family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1385, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT01030000234689

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O75354

Identification of Orthologs from Complete Genome Data

More...OMAi		EWQHAEI

Database of Orthologous Groups

More...OrthoDBi		1337265at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		O75354

TreeFam database of animal gene trees

More...TreeFami		TF315029

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000407, GDA1_CD39_NTPase

The PANTHER Classification System

More...PANTHERi		PTHR11782, PTHR11782, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01150, GDA1_CD39, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS01238, GDA1_CD39_NTPASE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 10 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O75354-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKKGIRYETS RKTSYIFQQP QHGPWQTRMR KISNHGSLRV AKVAYPLGLC 
        60         70         80         90        100
VGVFIYVAYI KWHRATATQA FFSITRAAPG ARWGQQAHSP LGTAADGHEV 
       110        120        130        140        150
FYGIMFDAGS TGTRVHVFQF TRPPRETPTL THETFKALKP GLSAYADDVE 
       160        170        180        190        200
KSAQGIRELL DVAKQDIPFD FWKATPLVLK ATAGLRLLPG EKAQKLLQKV 
       210        220        230        240        250
KKVFKASPFL VGDDCVSIMN GTDEGVSAWI TINFLTGSLK TPGGSSVGML 
       260        270        280        290        300
DLGGGSTQIA FLPRVEGTLQ ASPPGYLTAL RMFNRTYKLY SYSYLGLGLM 
       310        320        330        340        350
SARLAILGGV EGQPAKDGKE LVSPCLSPSF KGEWEHAEVT YRVSGQKAAA 
       360        370        380        390        400
SLHELCAARV SEVLQNRVHR TEEVKHVDFY AFSYYYDLAA GVGLIDAEKG 
       410        420        430        440        450
GSLVVGDFEI AAKYVCRTLE TQPQSSPFSC MDLTYVSLLL QEFGFPRSKV 
       460        470        480 
LKLTRKIDNV ETSWALGAIF HYIDSLNRQK SPAS
Length:484
Mass (Da):53,246
Last modified:January 11, 2011 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3CBA96040BC196CB
GO
Isoform 2 (identifier: O75354-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-18: MKKGIRYETSRKTSYIFQ → M

Show »
Length:467
Mass (Da):51,159
Checksum:i6F6A134332D87D20
GO
Isoform 3 (identifier: O75354-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     19-19: Missing.

Show »
Length:483
Mass (Da):53,118
Checksum:iF416E68E031BC8CD
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5QPI9Q5QPI9_HUMAN
Ectonucleoside triphosphate diphosp...
ENTPD6
437Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5QPJ6Q5QPJ6_HUMAN
Ectonucleoside triphosphate diphosp...
ENTPD6
296Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5QPJ3Q5QPJ3_HUMAN
Ectonucleoside triphosphate diphosp...
ENTPD6
300Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5QPI7Q5QPI7_HUMAN
Ectonucleoside triphosphate diphosp...
ENTPD6
226Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5QPJ7Q5QPJ7_HUMAN
Ectonucleoside triphosphate diphosp...
ENTPD6
194Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y3D0H0Y3D0_HUMAN
Ectonucleoside triphosphate diphosp...
ENTPD6
295Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5QPJ4Q5QPJ4_HUMAN
Ectonucleoside triphosphate diphosp...
ENTPD6
188Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y473H0Y473_HUMAN
Ectonucleoside triphosphate diphosp...
ENTPD6
313Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y5X0H0Y5X0_HUMAN
Ectonucleoside triphosphate diphosp...
ENTPD6
150Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y6Q1H0Y6Q1_HUMAN
Ectonucleoside triphosphate diphosp...
ENTPD6
311Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02781214S → N1 PublicationCorresponds to variant dbSNP:rs2076559Ensembl.1
Natural variantiVAR_017863138L → V1 PublicationCorresponds to variant dbSNP:rs1044567Ensembl.1
Natural variantiVAR_050309157R → Q. Corresponds to variant dbSNP:rs34007133Ensembl.1
Natural variantiVAR_027813202K → E5 PublicationsCorresponds to variant dbSNP:rs6050446Ensembl.1
Natural variantiVAR_027814323S → N. Corresponds to variant dbSNP:rs6138541Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0391221 – 18MKKGI…SYIFQ → M in isoform 2. 1 PublicationAdd BLAST18
Alternative sequenceiVSP_05431419Missing in isoform 3. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF039916 mRNA Translation: AAC39883.1
AY327581 mRNA Translation: AAP92131.1
AL834158 mRNA Translation: CAD38864.2
AL035252 Genomic DNA No translation available.
CH471133 Genomic DNA Translation: EAX10095.1
CH471133 Genomic DNA Translation: EAX10097.1
CH471133 Genomic DNA Translation: EAX10098.1
BC025980 mRNA Translation: AAH25980.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS13170.1 [O75354-1]
CCDS46586.1 [O75354-2]
CCDS82604.1 [O75354-3]

NCBI Reference Sequences

More...RefSeqi		NP_001107561.1, NM_001114089.3 [O75354-2]
NP_001238.2, NM_001247.4 [O75354-1]
NP_001304870.1, NM_001317941.2 [O75354-3]
NP_001309307.1, NM_001322378.1 [O75354-1]
NP_001309308.1, NM_001322379.1
NP_001309309.1, NM_001322380.1
NP_001309310.1, NM_001322381.1
NP_001309311.1, NM_001322382.1
NP_001309312.1, NM_001322383.1
NP_001309313.1, NM_001322384.1
NP_001309314.1, NM_001322385.1
NP_001309315.1, NM_001322386.1
NP_001309316.1, NM_001322387.1
NP_001309317.1, NM_001322388.1
NP_001309318.1, NM_001322389.1
NP_001309319.1, NM_001322390.1
NP_001309320.1, NM_001322391.1
NP_001309321.1, NM_001322392.1
NP_001309322.1, NM_001322393.1
NP_001309323.1, NM_001322394.1
NP_001309324.1, NM_001322395.1
NP_001309325.1, NM_001322396.1
NP_001309326.1, NM_001322397.1
NP_001309327.1, NM_001322398.1
XP_006723728.1, XM_006723665.2 [O75354-3]
XP_011527698.1, XM_011529396.1 [O75354-1]
XP_011527699.1, XM_011529397.1 [O75354-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000354989; ENSP00000347084; ENSG00000197586 [O75354-2]
ENST00000360031; ENSP00000353131; ENSG00000197586 [O75354-3]
ENST00000376652; ENSP00000365840; ENSG00000197586 [O75354-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		955

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:955

UCSC genome browser

More...UCSCi		uc002wuj.3, human [O75354-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF039916 mRNA Translation: AAC39883.1
AY327581 mRNA Translation: AAP92131.1
AL834158 mRNA Translation: CAD38864.2
AL035252 Genomic DNA No translation available.
CH471133 Genomic DNA Translation: EAX10095.1
CH471133 Genomic DNA Translation: EAX10097.1
CH471133 Genomic DNA Translation: EAX10098.1
BC025980 mRNA Translation: AAH25980.1
CCDSiCCDS13170.1 [O75354-1]
CCDS46586.1 [O75354-2]
CCDS82604.1 [O75354-3]
RefSeqiNP_001107561.1, NM_001114089.3 [O75354-2]
NP_001238.2, NM_001247.4 [O75354-1]
NP_001304870.1, NM_001317941.2 [O75354-3]
NP_001309307.1, NM_001322378.1 [O75354-1]
NP_001309308.1, NM_001322379.1
NP_001309309.1, NM_001322380.1
NP_001309310.1, NM_001322381.1
NP_001309311.1, NM_001322382.1
NP_001309312.1, NM_001322383.1
NP_001309313.1, NM_001322384.1
NP_001309314.1, NM_001322385.1
NP_001309315.1, NM_001322386.1
NP_001309316.1, NM_001322387.1
NP_001309317.1, NM_001322388.1
NP_001309318.1, NM_001322389.1
NP_001309319.1, NM_001322390.1
NP_001309320.1, NM_001322391.1
NP_001309321.1, NM_001322392.1
NP_001309322.1, NM_001322393.1
NP_001309323.1, NM_001322394.1
NP_001309324.1, NM_001322395.1
NP_001309325.1, NM_001322396.1
NP_001309326.1, NM_001322397.1
NP_001309327.1, NM_001322398.1
XP_006723728.1, XM_006723665.2 [O75354-3]
XP_011527698.1, XM_011529396.1 [O75354-1]
XP_011527699.1, XM_011529397.1 [O75354-3]

3D structure databases

SMRiO75354
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi107393, 18 interactors
IntActiO75354, 9 interactors
STRINGi9606.ENSP00000365840

PTM databases

GlyGeniO75354, 3 sites, 1 O-linked glycan (1 site)
iPTMnetiO75354
PhosphoSitePlusiO75354

Genetic variation databases

BioMutaiENTPD6

Proteomic databases

jPOSTiO75354
MassIVEiO75354
MaxQBiO75354
PaxDbiO75354
PeptideAtlasiO75354
PRIDEiO75354
ProteomicsDBi49920 [O75354-1]
49921 [O75354-2]
63663

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		24986, 99 antibodies

The DNASU plasmid repository

More...DNASUi		955

Genome annotation databases

EnsembliENST00000354989; ENSP00000347084; ENSG00000197586 [O75354-2]
ENST00000360031; ENSP00000353131; ENSG00000197586 [O75354-3]
ENST00000376652; ENSP00000365840; ENSG00000197586 [O75354-1]
GeneIDi955
KEGGihsa:955
UCSCiuc002wuj.3, human [O75354-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		955
DisGeNETi955

GeneCards: human genes, protein and diseases

More...GeneCardsi		ENTPD6
HGNCiHGNC:3368, ENTPD6
HPAiENSG00000197586, Low tissue specificity
MIMi603160, gene
neXtProtiNX_O75354
OpenTargetsiENSG00000197586
PharmGKBiPA27803
VEuPathDBiHostDB:ENSG00000197586

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1385, Eukaryota
GeneTreeiENSGT01030000234689
InParanoidiO75354
OMAiEWQHAEI
OrthoDBi1337265at2759
PhylomeDBiO75354
TreeFamiTF315029

Enzyme and pathway databases

BRENDAi3.6.1.6, 2681
PathwayCommonsiO75354
ReactomeiR-HSA-8850843, Phosphate bond hydrolysis by NTPDase proteins

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		955, 2 hits in 1016 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ENTPD6, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		ENTPD6

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		955
PharosiO75354, Tbio

Protein Ontology

More...PROi		PR:O75354
RNActiO75354, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000197586, Expressed in adenohypophysis and 221 other tissues
ExpressionAtlasiO75354, baseline and differential
GenevisibleiO75354, HS

Family and domain databases

InterProiView protein in InterPro
IPR000407, GDA1_CD39_NTPase
PANTHERiPTHR11782, PTHR11782, 1 hit
PfamiView protein in Pfam
PF01150, GDA1_CD39, 1 hit
PROSITEiView protein in PROSITE
PS01238, GDA1_CD39_NTPASE, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiENTP6_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O75354
Secondary accession number(s): A6NCX6
, D3DW49, Q5QPJ2, Q5QPJ5, Q7Z5B5, Q8N3H3, Q8TAS7, Q9UJD1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 29, 2001
Last sequence update: January 11, 2011
Last modified: September 29, 2021
This is version 189 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
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