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Protein

Ectonucleoside triphosphate diphosphohydrolase 6

Gene

ENTPD6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Might support glycosylation reactions in the Golgi apparatus and, when released from cells, might catalyze the hydrolysis of extracellular nucleotides. Hydrolyzes preferentially nucleoside 5'-diphosphates, nucleoside 5'-triphosphates are hydrolyzed only to a minor extent, there is no hydrolysis of nucleoside 5'-monophosphates. The order of activity with different substrates is GDP > IDP >> UDP = CDP >> ADP (By similarity).By similarity

Catalytic activityi

A nucleoside diphosphate + H2O = a nucleoside phosphate + phosphate.

Cofactori

Ca2+By similarity, Mg2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei224Proton acceptorBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
LigandCalcium, Magnesium

Enzyme and pathway databases

BRENDAi3.6.1.6 2681
ReactomeiR-HSA-8850843 Phosphate bond hydrolysis by NTPDase proteins

Names & Taxonomyi

Protein namesi
Recommended name:
Ectonucleoside triphosphate diphosphohydrolase 6 (EC:3.6.1.6)
Short name:
NTPDase 6
Alternative name(s):
CD39 antigen-like 2
Gene namesi
Name:ENTPD6
Synonyms:CD39L2, IL6ST2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000197586.12
HGNCiHGNC:3368 ENTPD6
MIMi603160 gene
neXtProtiNX_O75354

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 39CytoplasmicSequence analysisAdd BLAST39
Transmembranei40 – 60Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini61 – 484LumenalSequence analysisAdd BLAST424

Keywords - Cellular componenti

Golgi apparatus, Membrane, Secreted

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi215C → S: No change in activity. 1 Publication1

Organism-specific databases

DisGeNETi955
OpenTargetsiENSG00000197586
PharmGKBiPA27803

Polymorphism and mutation databases

BioMutaiENTPD6

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002099131 – 484Ectonucleoside triphosphate diphosphohydrolase 6Add BLAST484

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi220N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi284N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi325 ↔ 3561 Publication
Disulfide bondi416 ↔ 4301 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiO75354
PaxDbiO75354
PeptideAtlasiO75354
PRIDEiO75354
ProteomicsDBi49920
49921 [O75354-2]

PTM databases

iPTMnetiO75354
PhosphoSitePlusiO75354

Expressioni

Tissue specificityi

Expressed in most tissues, but predominantly in heart.1 Publication

Gene expression databases

BgeeiENSG00000197586 Expressed in 207 organ(s), highest expression level in adenohypophysis
CleanExiHS_ENTPD6
ExpressionAtlasiO75354 baseline and differential
GenevisibleiO75354 HS

Organism-specific databases

HPAiHPA015491
HPA069555

Interactioni

Protein-protein interaction databases

BioGridi107393, 13 interactors
IntActiO75354, 5 interactors
MINTiO75354
STRINGi9606.ENSP00000365840

Structurei

3D structure databases

ProteinModelPortaliO75354
SMRiO75354
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GDA1/CD39 NTPase family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1385 Eukaryota
COG5371 LUCA
GeneTreeiENSGT00510000046675
HOGENOMiHOG000220904
HOVERGENiHBG018208
InParanoidiO75354
KOiK01511
OMAiKIPNNGN
OrthoDBiEOG091G06ET
PhylomeDBiO75354
TreeFamiTF315029

Family and domain databases

InterProiView protein in InterPro
IPR000407 GDA1_CD39_NTPase
PANTHERiPTHR11782 PTHR11782, 1 hit
PfamiView protein in Pfam
PF01150 GDA1_CD39, 1 hit
PROSITEiView protein in PROSITE
PS01238 GDA1_CD39_NTPASE, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 10 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O75354-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKKGIRYETS RKTSYIFQQP QHGPWQTRMR KISNHGSLRV AKVAYPLGLC
60 70 80 90 100
VGVFIYVAYI KWHRATATQA FFSITRAAPG ARWGQQAHSP LGTAADGHEV
110 120 130 140 150
FYGIMFDAGS TGTRVHVFQF TRPPRETPTL THETFKALKP GLSAYADDVE
160 170 180 190 200
KSAQGIRELL DVAKQDIPFD FWKATPLVLK ATAGLRLLPG EKAQKLLQKV
210 220 230 240 250
KKVFKASPFL VGDDCVSIMN GTDEGVSAWI TINFLTGSLK TPGGSSVGML
260 270 280 290 300
DLGGGSTQIA FLPRVEGTLQ ASPPGYLTAL RMFNRTYKLY SYSYLGLGLM
310 320 330 340 350
SARLAILGGV EGQPAKDGKE LVSPCLSPSF KGEWEHAEVT YRVSGQKAAA
360 370 380 390 400
SLHELCAARV SEVLQNRVHR TEEVKHVDFY AFSYYYDLAA GVGLIDAEKG
410 420 430 440 450
GSLVVGDFEI AAKYVCRTLE TQPQSSPFSC MDLTYVSLLL QEFGFPRSKV
460 470 480
LKLTRKIDNV ETSWALGAIF HYIDSLNRQK SPAS
Length:484
Mass (Da):53,246
Last modified:January 11, 2011 - v3
Checksum:i3CBA96040BC196CB
GO
Isoform 2 (identifier: O75354-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-18: MKKGIRYETSRKTSYIFQ → M

Show »
Length:467
Mass (Da):51,159
Checksum:i6F6A134332D87D20
GO
Isoform 3 (identifier: O75354-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     19-19: Missing.

Note: No experimental confirmation available.
Show »
Length:483
Mass (Da):53,118
Checksum:iF416E68E031BC8CD
GO

Computationally mapped potential isoform sequencesi

There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5QPI9Q5QPI9_HUMAN
Ectonucleoside triphosphate diphosp...
ENTPD6
437Annotation score:
Q5QPJ4Q5QPJ4_HUMAN
Ectonucleoside triphosphate diphosp...
ENTPD6
188Annotation score:
Q5QPJ6Q5QPJ6_HUMAN
Ectonucleoside triphosphate diphosp...
ENTPD6
296Annotation score:
Q5QPJ3Q5QPJ3_HUMAN
Ectonucleoside triphosphate diphosp...
ENTPD6
300Annotation score:
Q5QPI7Q5QPI7_HUMAN
Ectonucleoside triphosphate diphosp...
ENTPD6
226Annotation score:
Q5QPJ7Q5QPJ7_HUMAN
Ectonucleoside triphosphate diphosp...
ENTPD6
194Annotation score:
H0Y3D0H0Y3D0_HUMAN
Ectonucleoside triphosphate diphosp...
ENTPD6
295Annotation score:
H0Y473H0Y473_HUMAN
Ectonucleoside triphosphate diphosp...
ENTPD6
313Annotation score:
H0Y5X0H0Y5X0_HUMAN
Ectonucleoside triphosphate diphosp...
ENTPD6
150Annotation score:
H0Y6Q1H0Y6Q1_HUMAN
Ectonucleoside triphosphate diphosp...
ENTPD6
311Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02781214S → N1 PublicationCorresponds to variant dbSNP:rs2076559Ensembl.1
Natural variantiVAR_017863138L → V1 PublicationCorresponds to variant dbSNP:rs1044567Ensembl.1
Natural variantiVAR_050309157R → Q. Corresponds to variant dbSNP:rs34007133Ensembl.1
Natural variantiVAR_027813202K → E5 PublicationsCorresponds to variant dbSNP:rs6050446Ensembl.1
Natural variantiVAR_027814323S → N. Corresponds to variant dbSNP:rs6138541Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0391221 – 18MKKGI…SYIFQ → M in isoform 2. 1 PublicationAdd BLAST18
Alternative sequenceiVSP_05431419Missing in isoform 3. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF039916 mRNA Translation: AAC39883.1
AY327581 mRNA Translation: AAP92131.1
AL834158 mRNA Translation: CAD38864.2
AL035252 Genomic DNA No translation available.
CH471133 Genomic DNA Translation: EAX10095.1
CH471133 Genomic DNA Translation: EAX10097.1
CH471133 Genomic DNA Translation: EAX10098.1
BC025980 mRNA Translation: AAH25980.1
CCDSiCCDS13170.1 [O75354-1]
CCDS46586.1 [O75354-2]
CCDS82604.1 [O75354-3]
RefSeqiNP_001107561.1, NM_001114089.3
NP_001238.2, NM_001247.4
NP_001304870.1, NM_001317941.2
NP_001309307.1, NM_001322378.1
NP_001309308.1, NM_001322379.1
NP_001309309.1, NM_001322380.1
NP_001309310.1, NM_001322381.1
NP_001309311.1, NM_001322382.1
NP_001309312.1, NM_001322383.1
NP_001309313.1, NM_001322384.1
NP_001309314.1, NM_001322385.1
NP_001309315.1, NM_001322386.1
NP_001309316.1, NM_001322387.1
NP_001309317.1, NM_001322388.1
NP_001309318.1, NM_001322389.1
NP_001309319.1, NM_001322390.1
NP_001309320.1, NM_001322391.1
NP_001309321.1, NM_001322392.1
NP_001309322.1, NM_001322393.1
NP_001309323.1, NM_001322394.1
NP_001309324.1, NM_001322395.1
NP_001309325.1, NM_001322396.1
NP_001309326.1, NM_001322397.1
NP_001309327.1, NM_001322398.1
XP_006723728.1, XM_006723665.2 [O75354-3]
XP_011527698.1, XM_011529396.1 [O75354-1]
XP_011527699.1, XM_011529397.1 [O75354-3]
UniGeneiHs.500375
Hs.667826

Genome annotation databases

EnsembliENST00000354989; ENSP00000347084; ENSG00000197586 [O75354-2]
ENST00000360031; ENSP00000353131; ENSG00000197586 [O75354-3]
ENST00000376652; ENSP00000365840; ENSG00000197586 [O75354-1]
GeneIDi955
KEGGihsa:955
UCSCiuc002wuj.3 human [O75354-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF039916 mRNA Translation: AAC39883.1
AY327581 mRNA Translation: AAP92131.1
AL834158 mRNA Translation: CAD38864.2
AL035252 Genomic DNA No translation available.
CH471133 Genomic DNA Translation: EAX10095.1
CH471133 Genomic DNA Translation: EAX10097.1
CH471133 Genomic DNA Translation: EAX10098.1
BC025980 mRNA Translation: AAH25980.1
CCDSiCCDS13170.1 [O75354-1]
CCDS46586.1 [O75354-2]
CCDS82604.1 [O75354-3]
RefSeqiNP_001107561.1, NM_001114089.3
NP_001238.2, NM_001247.4
NP_001304870.1, NM_001317941.2
NP_001309307.1, NM_001322378.1
NP_001309308.1, NM_001322379.1
NP_001309309.1, NM_001322380.1
NP_001309310.1, NM_001322381.1
NP_001309311.1, NM_001322382.1
NP_001309312.1, NM_001322383.1
NP_001309313.1, NM_001322384.1
NP_001309314.1, NM_001322385.1
NP_001309315.1, NM_001322386.1
NP_001309316.1, NM_001322387.1
NP_001309317.1, NM_001322388.1
NP_001309318.1, NM_001322389.1
NP_001309319.1, NM_001322390.1
NP_001309320.1, NM_001322391.1
NP_001309321.1, NM_001322392.1
NP_001309322.1, NM_001322393.1
NP_001309323.1, NM_001322394.1
NP_001309324.1, NM_001322395.1
NP_001309325.1, NM_001322396.1
NP_001309326.1, NM_001322397.1
NP_001309327.1, NM_001322398.1
XP_006723728.1, XM_006723665.2 [O75354-3]
XP_011527698.1, XM_011529396.1 [O75354-1]
XP_011527699.1, XM_011529397.1 [O75354-3]
UniGeneiHs.500375
Hs.667826

3D structure databases

ProteinModelPortaliO75354
SMRiO75354
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107393, 13 interactors
IntActiO75354, 5 interactors
MINTiO75354
STRINGi9606.ENSP00000365840

PTM databases

iPTMnetiO75354
PhosphoSitePlusiO75354

Polymorphism and mutation databases

BioMutaiENTPD6

Proteomic databases

MaxQBiO75354
PaxDbiO75354
PeptideAtlasiO75354
PRIDEiO75354
ProteomicsDBi49920
49921 [O75354-2]

Protocols and materials databases

DNASUi955
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000354989; ENSP00000347084; ENSG00000197586 [O75354-2]
ENST00000360031; ENSP00000353131; ENSG00000197586 [O75354-3]
ENST00000376652; ENSP00000365840; ENSG00000197586 [O75354-1]
GeneIDi955
KEGGihsa:955
UCSCiuc002wuj.3 human [O75354-1]

Organism-specific databases

CTDi955
DisGeNETi955
EuPathDBiHostDB:ENSG00000197586.12
GeneCardsiENTPD6
HGNCiHGNC:3368 ENTPD6
HPAiHPA015491
HPA069555
MIMi603160 gene
neXtProtiNX_O75354
OpenTargetsiENSG00000197586
PharmGKBiPA27803
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1385 Eukaryota
COG5371 LUCA
GeneTreeiENSGT00510000046675
HOGENOMiHOG000220904
HOVERGENiHBG018208
InParanoidiO75354
KOiK01511
OMAiKIPNNGN
OrthoDBiEOG091G06ET
PhylomeDBiO75354
TreeFamiTF315029

Enzyme and pathway databases

BRENDAi3.6.1.6 2681
ReactomeiR-HSA-8850843 Phosphate bond hydrolysis by NTPDase proteins

Miscellaneous databases

ChiTaRSiENTPD6 human
GeneWikiiENTPD6
GenomeRNAii955
PROiPR:O75354
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000197586 Expressed in 207 organ(s), highest expression level in adenohypophysis
CleanExiHS_ENTPD6
ExpressionAtlasiO75354 baseline and differential
GenevisibleiO75354 HS

Family and domain databases

InterProiView protein in InterPro
IPR000407 GDA1_CD39_NTPase
PANTHERiPTHR11782 PTHR11782, 1 hit
PfamiView protein in Pfam
PF01150 GDA1_CD39, 1 hit
PROSITEiView protein in PROSITE
PS01238 GDA1_CD39_NTPASE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiENTP6_HUMAN
AccessioniPrimary (citable) accession number: O75354
Secondary accession number(s): A6NCX6
, D3DW49, Q5QPJ2, Q5QPJ5, Q7Z5B5, Q8N3H3, Q8TAS7, Q9UJD1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 29, 2001
Last sequence update: January 11, 2011
Last modified: November 7, 2018
This is version 169 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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