MPDU1

Functionⁱ

Required for normal utilization of mannose-dolichol phosphate (Dol-P-Man) in the synthesis of N-linked and O-linked oligosaccharides and GPI anchors.By similarity

GO - Biological processⁱ

dolichol-linked oligosaccharide biosynthetic process
Source: UniProtKB
Traceable author statementⁱ
- 11733564
oligosaccharide biosynthetic process
Source: UniProtKB
Inferred from direct assayⁱ
- 11179430
protein folding
Source: UniProtKB
Non-traceable author statementⁱ
- 11179430

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Transport

Biological process

Transport

Enzyme and pathway databases

Reactomeⁱ	R-HSA-446193 Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-4687000 Defective MPDU1 causes MPDU1-CDG (CDG-1f)

Reactomeⁱ

R-HSA-446193 Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
R-HSA-4687000 Defective MPDU1 causes MPDU1-CDG (CDG-1f)

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Mannose-P-dolichol utilization defect 1 protein Alternative name(s): Suppressor of Lec15 and Lec35 glycosylation mutation homolog Short name: SL15
Gene namesⁱ	Name:MPDU1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 17

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000129255.14
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:7207 MPDU1
MIMⁱ	604041 gene
neXtProtⁱ	NX_O75352

Topology

Feature key	Position(s)	DescriptionActions	Length
Transmembraneⁱ	37 – 57	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	74 – 94	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	100 – 120	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	128 – 145	HelicalSequence analysisAdd BLAST	18
Transmembraneⁱ	151 – 171	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	185 – 205	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	213 – 233	HelicalSequence analysisAdd BLAST	21

Keywords - Cellular componentⁱ

Membrane

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Congenital disorder of glycosylation 1F (CDG1F)2 Publications

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA form of congenital disorder of glycosylation, a multisystem disorder caused by a defect in glycoprotein biosynthesis and characterized by under-glycosylated serum glycoproteins. Congenital disorders of glycosylation result in a wide variety of clinical features, such as defects in the nervous system development, psychomotor retardation, dysmorphic features, hypotonia, coagulation disorders, and immunodeficiency. The broad spectrum of features reflects the critical role of N-glycoproteins during embryonic development, differentiation, and maintenance of cell functions.

Keywords - Diseaseⁱ

Congenital disorder of glycosylation, Disease mutation

Organism-specific databases

DisGeNET More...DisGeNETⁱ	9526
MalaCards human disease database More...MalaCardsⁱ	MPDU1
MIMⁱ	609180 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000129255
Orphanetⁱ	79323 MPDU1-CDG
PharmGKBⁱ	PA30913

Polymorphism and mutation databases

BioMutaⁱ	MPDU1

BioMutaⁱ

MPDU1

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedCombined sources
ChainⁱPRO_0000221034	2 – 247	Mannose-P-dolichol utilization defect 1 proteinAdd BLAST		246

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	2	N-acetylalanineCombined sources		1

Keywords - PTMⁱ

Acetylation

Proteomic databases

EPDⁱ	O75352
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	O75352
PaxDbⁱ	O75352
PeptideAtlas More...PeptideAtlasⁱ	O75352
PRIDEⁱ	O75352
ProteomicsDBⁱ	49919
TopDownProteomicsⁱ	O75352-1 [O75352-1]

PTM databases

iPTMnetⁱ	O75352
PhosphoSitePlusⁱ	O75352
SwissPalmⁱ	O75352

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000129255 Expressed in 184 organ(s), highest expression level in adult mammalian kidney
CleanExⁱ	HS_MPDU1
ExpressionAtlasⁱ	O75352 baseline and differential
Genevisibleⁱ	O75352 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA014845

HPAⁱ

HPA014845

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	114902, 10 interactors
IntActⁱ	O75352, 5 interactors
STRINGⁱ	9606.ENSP00000250124

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	O75352
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	39 – 105	PQ-loop 1Add BLAST		67
Domainⁱ	159 – 216	PQ-loop 2Add BLAST		58

Sequence similaritiesⁱ

Belongs to the MPDU1 (TC 2.A.43.3) family. [View classification]Curated

Keywords - Domainⁱ

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG3211 Eukaryota ENOG4111FE3 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00510000047079
HOGENOMⁱ	HOG000189346
HOVERGENⁱ	HBG000421
InParanoidⁱ	O75352
KEGG Orthology (KO) More...KOⁱ	K09660
OMAⁱ	IQSCNIP
PhylomeDBⁱ	O75352
TreeFamⁱ	TF324895

Family and domain databases

InterProⁱ	View protein in InterPro IPR016817 MannP-dilichol_defect-1 IPR006603 PQ-loop_rpt
PANTHERⁱ	PTHR12226 PTHR12226, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF04193 PQ-loop, 2 hits
PIRSFⁱ	PIRSF023381 MannP-dilichol_defect-1p, 1 hit
SMARTⁱ	View protein in SMART SM00679 CTNS, 2 hits

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 13 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: O75352-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAEADGPLK RLLVPILLPE KCYDQLFVQW DLLHVPCLKI LLSKGLGLGI 
        60         70         80         90        100
VAGSLLVKLP QVFKILGAKS AEGLSLQSVM LELVALTGTM VYSITNNFPF 
       110        120        130        140        150
SSWGEALFLM LQTITICFLV MHYRGQTVKG VAFLACYGLV LLVLLSPLTP 
       160        170        180        190        200
LTVVTLLQAS NVPAVVVGRL LQAATNYHNG HTGQLSAITV FLLFGGSLAR 
       210        220        230        240 
IFTSIQETGD PLMAGTFVVS SLCNGLIAAQ LLFYWNAKPP HKQKKAQ

Length:247

Mass (Da):26,638

Last modified:November 25, 2008 - v2

Checksum:ⁱ8C840B26F06DFD9B

GO

Isoform 2 (identifier: O75352-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
101-186: SSWGEALFLM...YHNGHTGQLS → RCRFPRLLRP...SGVSIPFSQL
187-247: Missing.

« Hide

        10         20         30         40         50
MAAEADGPLK RLLVPILLPE KCYDQLFVQW DLLHVPCLKI LLSKGLGLGI 
        60         70         80         90        100
VAGSLLVKLP QVFKILGAKS AEGLSLQSVM LELVALTGTM VYSITNNFPF 
       110        120        130        140        150
RCRFPRLLRP GPAGASLTSD ALDCSHPAPG LQCACCGGGE ASPGSHQLPQ 
       160        170        180 
RAHRPALSHH SLPAVWGLPG PNLHFHSGVS IPFSQL

Note: No experimental confirmation available.

Show »

Length:186

Mass (Da):19,752

Checksum:ⁱ5B5E26595ECF5692

GO

Computationally mapped potential isoform sequencesⁱ

There are 13 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name	Protein names	Gene names	Length	Annotation

	J3QRD5	J3QRD5_HUMAN	Mannose-P-dolichol utilization defe... Mannose-P-dolichol utilization defect 1 protein	MPDU1	193	Annotation score:
	J3QW43	J3QW43_HUMAN	Mannose-P-dolichol utilization defe... Mannose-P-dolichol utilization defect 1 protein	MPDU1	192	Annotation score:
	I3L295	I3L295_HUMAN	Mannose-P-dolichol utilization defe... Mannose-P-dolichol utilization defect 1 isoform 2 (Mannose-P-dolichol utilization defect 1 protein)	MPDU1	109	Annotation score:
	J3QS48	J3QS48_HUMAN	Mannose-P-dolichol utilization defe... Mannose-P-dolichol utilization defect 1 protein	MPDU1	101	Annotation score:
	J3KT75	J3KT75_HUMAN	Mannose-P-dolichol utilization defe... Mannose-P-dolichol utilization defect 1 protein	MPDU1	154	Annotation score:
	J3KTK8	J3KTK8_HUMAN	Mannose-P-dolichol utilization defe... Mannose-P-dolichol utilization defect 1 protein	MPDU1	116	Annotation score:
	J3QQZ4	J3QQZ4_HUMAN	Mannose-P-dolichol utilization defe... Mannose-P-dolichol utilization defect 1 protein	MPDU1	152	Annotation score:
	I3L1D2	I3L1D2_HUMAN	Mannose-P-dolichol utilization defe... Mannose-P-dolichol utilization defect 1 protein	MPDU1	61	Annotation score:
	I3L405	I3L405_HUMAN	Mannose-P-dolichol utilization defe... Mannose-P-dolichol utilization defect 1 protein	MPDU1	54	Annotation score:
	I3L261	I3L261_HUMAN	Mannose-P-dolichol utilization defe... Mannose-P-dolichol utilization defect 1 protein	MPDU1	61	Annotation score:
There are more potential isoformsShow all

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	66	L → R in AAC39875 (PubMed:9653160).Curated		1
Sequence conflictⁱ	181	H → Y in AAC39875 (PubMed:9653160).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_021388	73	G → E in CDG1F. 1 PublicationCorresponds to variant dbSNP:rs104894586EnsemblClinVar.	1
Natural variantⁱVAR_021389	74	L → S in CDG1F. 1 PublicationCorresponds to variant dbSNP:rs104894589EnsemblClinVar.	1
Natural variantⁱVAR_021390	119	L → P in CDG1F. 1 PublicationCorresponds to variant dbSNP:rs104894587EnsemblClinVar.	1
Natural variantⁱVAR_047757	225	G → S. Corresponds to variant dbSNP:rs16956808EnsemblClinVar.	1
Natural variantⁱVAR_047758	229	A → T1 PublicationCorresponds to variant dbSNP:rs10852891EnsemblClinVar.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_056349	101 – 186	SSWGE…TGQLS → RCRFPRLLRPGPAGASLTSD ALDCSHPAPGLQCACCGGGE ASPGSHQLPQRAHRPALSHH SLPAVWGLPGPNLHFHSGVS IPFSQL in isoform 2. 1 PublicationAdd BLAST		86
Alternative sequenceⁱVSP_056350	187 – 247	Missing in isoform 2. 1 PublicationAdd BLAST		61

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF038961 mRNA Translation: AAC39875.1 AK075299 mRNA Translation: BAG52103.1 AK300083 mRNA Translation: BAG61886.1 AC016876 Genomic DNA No translation available. FJ695203 Genomic DNA No translation available. CH471108 Genomic DNA Translation: EAW90161.1 BC001898 mRNA Translation: AAH01898.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS11115.1 [O75352-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_001317002.1, NM_001330073.1 NP_004861.2, NM_004870.3 [O75352-1]
UniGeneⁱ	Hs.246381

Genome annotation databases

Ensemblⁱ	ENST00000250124; ENSP00000250124; ENSG00000129255 [O75352-1] ENST00000423172; ENSP00000414071; ENSG00000129255 [O75352-2]
GeneIDⁱ	9526
KEGGⁱ	hsa:9526
UCSC genome browser More...UCSCⁱ	uc002ghw.4 human [O75352-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O75352	Mannose-P-dolichol utilization defect 1 isoform 1 (Fragment)		HUMAN		247	UniRef100_O75352
MPDU1 isoform 3		PANTR		247
Uncharacterized protein		PANPA		247

Protein	Similar proteins		Species	Score	Length	Source
O75352	Mannose-P-dolichol utilization defect 1 protein		MOUSE		247	UniRef90_O75352
Mannose-P-dolichol utilization defect 1 protein		CRIGR		247
Mannose-P-dolichol utilization defect 1 isoform 1 (Fragment)		HUMAN		247
MPDU1 isoform 3		PANTR		247
Uncharacterized protein		PANPA		247
+56
O75352-2	MPDU1 isoform 1		PANTR		186	UniRef90_O75352-2
Uncharacterized protein		PANPA		186
Uncharacterized protein		CALJA		186
Uncharacterized protein		MACFA		186
Uncharacterized protein		COLAP		186
+11

Protein	Similar proteins		Species	Score	Length	Source
O75352	Mannose-P-dolichol utilization defect 1 protein		MOUSE		247	UniRef50_O75352
Mannose-P-dolichol utilization defect 1 protein		CRIGR		247
Mannose-P-dolichol utilization defect 1 isoform 1 (Fragment)		HUMAN		247
MPDU1 isoform 3		PANTR		247
Uncharacterized protein		PANPA		247
+88
O75352-2	Uncharacterized protein		NOMLE		186	UniRef50_O75352-2
Uncharacterized protein		CALJA		186
Uncharacterized protein		PAPAN		186
Uncharacterized protein		RHIRO		186
Uncharacterized protein		RHIBE		186
+39

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF038961 mRNA Translation: AAC39875.1 AK075299 mRNA Translation: BAG52103.1 AK300083 mRNA Translation: BAG61886.1 AC016876 Genomic DNA No translation available. FJ695203 Genomic DNA No translation available. CH471108 Genomic DNA Translation: EAW90161.1 BC001898 mRNA Translation: AAH01898.1
CCDSⁱ	CCDS11115.1 [O75352-1]
RefSeqⁱ	NP_001317002.1, NM_001330073.1 NP_004861.2, NM_004870.3 [O75352-1]
UniGeneⁱ	Hs.246381

3D structure databases

ProteinModelPortalⁱ	O75352
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	114902, 10 interactors
IntActⁱ	O75352, 5 interactors
STRINGⁱ	9606.ENSP00000250124

PTM databases

iPTMnetⁱ	O75352
PhosphoSitePlusⁱ	O75352
SwissPalmⁱ	O75352

Polymorphism and mutation databases

BioMutaⁱ	MPDU1

BioMutaⁱ

MPDU1

Proteomic databases

EPDⁱ	O75352
MaxQBⁱ	O75352
PaxDbⁱ	O75352
PeptideAtlasⁱ	O75352
PRIDEⁱ	O75352
ProteomicsDBⁱ	49919
TopDownProteomicsⁱ	O75352-1 [O75352-1]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	9526
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000250124; ENSP00000250124; ENSG00000129255 [O75352-1] ENST00000423172; ENSP00000414071; ENSG00000129255 [O75352-2]
GeneIDⁱ	9526
KEGGⁱ	hsa:9526
UCSCⁱ	uc002ghw.4 human [O75352-1]

Organism-specific databases

CTDⁱ	9526
DisGeNETⁱ	9526
EuPathDBⁱ	HostDB:ENSG00000129255.14
GeneCardsⁱ	MPDU1
H-InvDBⁱ	HIX0013504
HGNCⁱ	HGNC:7207 MPDU1
HPAⁱ	HPA014845
MalaCardsⁱ	MPDU1
MIMⁱ	604041 gene 609180 phenotype
neXtProtⁱ	NX_O75352
OpenTargetsⁱ	ENSG00000129255
Orphanetⁱ	79323 MPDU1-CDG
PharmGKBⁱ	PA30913
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3211 Eukaryota ENOG4111FE3 LUCA
GeneTreeⁱ	ENSGT00510000047079
HOGENOMⁱ	HOG000189346
HOVERGENⁱ	HBG000421
InParanoidⁱ	O75352
KOⁱ	K09660
OMAⁱ	IQSCNIP
PhylomeDBⁱ	O75352
TreeFamⁱ	TF324895

Enzyme and pathway databases

Reactomeⁱ	R-HSA-446193 Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-4687000 Defective MPDU1 causes MPDU1-CDG (CDG-1f)

Reactomeⁱ

R-HSA-446193 Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
R-HSA-4687000 Defective MPDU1 causes MPDU1-CDG (CDG-1f)

Miscellaneous databases

ChiTaRSⁱ	MPDU1 human
GeneWikiⁱ	MPDU1
GenomeRNAiⁱ	9526
Protein Ontology More...PROⁱ	PR:O75352
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000129255 Expressed in 184 organ(s), highest expression level in adult mammalian kidney
CleanExⁱ	HS_MPDU1
ExpressionAtlasⁱ	O75352 baseline and differential
Genevisibleⁱ	O75352 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR016817 MannP-dilichol_defect-1 IPR006603 PQ-loop_rpt
PANTHERⁱ	PTHR12226 PTHR12226, 1 hit
Pfamⁱ	View protein in Pfam PF04193 PQ-loop, 2 hits
PIRSFⁱ	PIRSF023381 MannP-dilichol_defect-1p, 1 hit
SMARTⁱ	View protein in SMART SM00679 CTNS, 2 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	MPU1_HUMAN
Accessionⁱ	O75352Primary (citable) accession number: O75352 Secondary accession number(s): B3KQP1, B4DT74, Q9BUU8
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 8, 2000
	Last sequence update:	November 25, 2008
	Last modified:	November 7, 2018
	This is version 150 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM

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UniProtKB - O75352 (MPU1_HUMAN)

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Mannose-P-dolichol utilization defect 1 protein

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Endoplasmic reticulum

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ