VPS4B

Functionⁱ

Involved in late steps of the endosomal multivesicular bodies (MVB) pathway. Recognizes membrane-associated ESCRT-III assemblies and catalyzes their disassembly, possibly in combination with membrane fission. Redistributes the ESCRT-III components to the cytoplasm for further rounds of MVB sorting. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. In conjunction with the ESCRT machinery also appears to function in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and enveloped virus budding (HIV-1 and other lentiviruses). VPS4A/B are required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413).4 Publications

Catalytic activityⁱ

ATP + H₂O = ADP + phosphate.

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	174 – 181	ATPSequence analysis		8

GO - Molecular functionⁱ

ATPase activity
Source: MGI
Inferred from direct assayⁱ
- 11563910
ATPase activity, coupled
Source: UniProtKB
Inferred from direct assayⁱ
- 18687924
ATP binding Source: UniProtKB-KW
identical protein binding
Source: UniProtKB
Inferred from direct assayⁱ
- 16193069
protein C-terminus binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 17928862
protein homodimerization activity
Source: UniProtKB
Inferred from direct assayⁱ
- 16193069

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cholesterol transport Source: Ensembl
endosomal transport
Source: MGI
Inferred from direct assayⁱ
- 11563910
endosome to lysosome transport via multivesicular body sorting pathway
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 15024011
ESCRT III complex disassembly
Source: ParkinsonsUK-UCL
Non-traceable author statementⁱ
- 20588296
late endosomal microautophagy Source: Ensembl
macroautophagy
Source: ParkinsonsUK-UCL
Non-traceable author statementⁱ
- 20588296
midbody abscission
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 20616062
mitotic metaphase plate congression
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 20616062
multivesicular body assembly
Source: ParkinsonsUK-UCL
Non-traceable author statementⁱ
- 20588296
negative regulation of cell death
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 20616062
negative regulation of exosomal secretion
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 24105262
nucleus organization
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 20616062
positive regulation of centriole elongation
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 20616062
positive regulation of exosomal secretion
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 22660413
positive regulation of G2/M transition of mitotic cell cycle
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 20616062
positive regulation of viral life cycle
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 16193069
positive regulation of viral process
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 17940959
positive regulation of viral release from host cell
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 14505570
potassium ion transport Source: Ensembl
protein depolymerization
Source: UniProtKB
Inferred from direct assayⁱ
- 18687924
protein transport Source: UniProtKB-KW
regulation of centrosome duplication
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 20616062
regulation of mitotic spindle assembly
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 20616062
regulation of viral process
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 14505570
response to lipid
Source: UniProtKB
Inferred from direct assayⁱ
- 16757520
ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 22547407
ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 22547407
viral budding via host ESCRT complex
Source: UniProtKB
Inferred from genetic interactionⁱ
- 24107264
viral life cycle Source: Reactome
viral release from host cell
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 16193069

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Hydrolase
Biological process	Cell cycle, Cell division, Protein transport, Transport
Ligand	ATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactomeⁱ	R-HSA-162588 Budding and maturation of HIV virion R-HSA-917729 Endosomal Sorting Complex Required For Transport (ESCRT)

Reactomeⁱ

R-HSA-162588 Budding and maturation of HIV virion
R-HSA-917729 Endosomal Sorting Complex Required For Transport (ESCRT)

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Vacuolar protein sorting-associated protein 4B (EC:3.6.4.6) Alternative name(s): Cell migration-inducing gene 1 protein Suppressor of K(+) transport growth defect 1 Short name: Protein SKD1
Gene namesⁱ	Name:VPS4B Synonyms:SKD1, VPS42 ORF Names:MIG1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 18

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000119541.9
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:10895 VPS4B
MIMⁱ	609983 gene
neXtProtⁱ	NX_O75351

Keywords - Cellular componentⁱ

Endosome, Membrane

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	15	A → D: Reduces HIV-1 release 10-fold; when associated with D-66. 1 Publication	1
Mutagenesisⁱ	15	A → D: Reduces HIV-1 release 2-fold. 1 Publication	1
Mutagenesisⁱ	66	L → D: Reduces HIV-1 release 10-fold; when associated with D-15. 1 Publication	1
Mutagenesisⁱ	66	L → D: Reduces HIV-1 release 3-fold. 1 Publication	1
Mutagenesisⁱ	208 – 209	WL → AA: Strongly impairs HIV-1 release. 1 Publication	2
Mutagenesisⁱ	210	G → A: Impairs HIV-1 release. 1 Publication	1
Mutagenesisⁱ	235	E → Q: Defective in vacuolar protein sorting. 1 Publication	1
Mutagenesisⁱ	390 – 396	Missing : Abolishes interaction with VTA1. 1 Publication	7

Organism-specific databases

DisGeNET More...DisGeNETⁱ	9525
MalaCards human disease database More...MalaCardsⁱ	VPS4B
Open Targets More...OpenTargetsⁱ	ENSG00000119541
Orphanetⁱ	99789 Dentin dysplasia type I
PharmGKBⁱ	PA35795

Chemistry databases

ChEMBLⁱ	CHEMBL2311229

ChEMBLⁱ

CHEMBL2311229

Polymorphism and mutation databases

BioMutaⁱ	VPS4B

BioMutaⁱ

VPS4B

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000084767	1 – 444	Vacuolar protein sorting-associated protein 4BAdd BLAST		444

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	93	PhosphoserineCombined sources	1
Modified residueⁱ	102	PhosphoserineCombined sources	1
Modified residueⁱ	108	PhosphoserineCombined sources	1
Modified residueⁱ	410	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	O75351
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	O75351
PaxDbⁱ	O75351
PeptideAtlas More...PeptideAtlasⁱ	O75351
PRIDEⁱ	O75351
ProteomicsDBⁱ	49918

PTM databases

iPTMnetⁱ	O75351
PhosphoSitePlusⁱ	O75351

Expressionⁱ

Tissue specificityⁱ

Ubiquitously expressed.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000119541 Expressed in 227 organ(s), highest expression level in esophagus squamous epithelium
CleanExⁱ	HS_VPS4B
ExpressionAtlasⁱ	O75351 baseline and differential
Genevisibleⁱ	O75351 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB046445 HPA040393 HPA057649

HPAⁱ

CAB046445
HPA040393
HPA057649

Interactionⁱ

Subunit structureⁱ

Proposed to be monomeric or homodimeric in nucleotide-free form and to oligomerize upon binding to ATP to form two stacked hexameric or heptameric rings with a central pore through which ESCRT-III substrates are translocated in an ATP-dependent manner. In vitro, associates on the inside of a helical tubular structure formed by a CHMP2A-CHMP3 polymer. Interacts with CHMP1A, CHMP1B, CHMP2A, CHMP4B and CHMP6. Interacts with VPS4A; the interaction suggests a heteromeric assembly with VPS4A. Interacts with VTA1.7 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
CHMP2B	Q9UQN3-1	2	EBI-2514459,EBI-15663586
CHMP5	Q9NZZ3	5	EBI-2514459,EBI-751303
ZFYVE19	Q96K21	5	EBI-2514459,EBI-6448240
ZFYVE19	Q96K21-3	3	EBI-2514459,EBI-10187928

GO - Molecular functionⁱ

identical protein binding
Source: UniProtKB
Inferred from direct assayⁱ
- 16193069
protein C-terminus binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 17928862
protein homodimerization activity
Source: UniProtKB
Inferred from direct assayⁱ
- 16193069

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	114901, 49 interactors
ComplexPortalⁱ	CPX-338 VPS4A/B complex
Database of interacting proteins More...DIPⁱ	DIP-53790N
IntActⁱ	O75351, 10 interactors
STRINGⁱ	9606.ENSP00000238497

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Turnⁱ	1 – 3	Combined sources	3
Helixⁱ	6 – 24	Combined sources	19
Helixⁱ	27 – 47	Combined sources	21
Helixⁱ	52 – 81	Combined sources	30
Beta strandⁱ	87 – 89	Combined sources	3
Beta strandⁱ	125 – 127	Combined sources	3
Helixⁱ	133 – 135	Combined sources	3
Helixⁱ	140 – 155	Combined sources	16
Helixⁱ	157 – 159	Combined sources	3
Beta strandⁱ	168 – 178	Combined sources	11
Helixⁱ	180 – 190	Combined sources	11
Beta strandⁱ	195 – 200	Combined sources	6
Helixⁱ	213 – 225	Combined sources	13
Beta strandⁱ	227 – 234	Combined sources	8
Turnⁱ	235 – 237	Combined sources	3
Helixⁱ	238 – 240	Combined sources	3
Beta strandⁱ	243 – 245	Combined sources	3
Helixⁱ	250 – 263	Combined sources	14
Beta strandⁱ	265 – 267	Combined sources	3
Beta strandⁱ	272 – 279	Combined sources	8
Turnⁱ	281 – 283	Combined sources	3
Helixⁱ	286 – 290	Combined sources	5
Beta strandⁱ	294 – 297	Combined sources	4
Helixⁱ	303 – 314	Combined sources	12
Helixⁱ	323 – 331	Combined sources	9
Helixⁱ	338 – 349	Combined sources	12
Helixⁱ	351 – 358	Combined sources	8
Beta strandⁱ	360 – 368	Combined sources	9
Beta strandⁱ	375 – 383	Combined sources	9
Beta strandⁱ	386 – 388	Combined sources	3
Beta strandⁱ	391 – 393	Combined sources	3
Helixⁱ	396 – 398	Combined sources	3
Helixⁱ	401 – 403	Combined sources	3
Helixⁱ	411 – 419	Combined sources	9
Helixⁱ	427 – 438	Combined sources	12

Show more details

3D structure databases

ProteinModelPortalⁱ	O75351
SMRⁱ	O75351
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	O75351

EvolutionaryTraceⁱ

O75351

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	4 – 82	MITAdd BLAST		79

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	19 – 82	Sequence analysisAdd BLAST		64

Domainⁱ

The MIT domain serves as an adapter for ESCRT-III proteins. It forms an asymmetric three-helix bundle that binds amphipathic MIM (MIT interacting motif) helices along the groove between MIT helices 2 and 3 present in a subset of ESCRT-III proteins thus establishing the canonical MIM-MIT interaction. In an extended conformation along the groove between helices 1 and 3, also binds to a type-2 MIT interacting motif (MIM2).1 Publication

Sequence similaritiesⁱ

Belongs to the AAA ATPase family.Curated

Keywords - Domainⁱ

Coiled coil

Phylogenomic databases

eggNOGⁱ	KOG0739 Eukaryota ENOG410XRHN LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00550000074466
HOGENOMⁱ	HOG000225146
HOVERGENⁱ	HBG057074
InParanoidⁱ	O75351
KEGG Orthology (KO) More...KOⁱ	K12196
OMAⁱ	THFKKVK
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0Q8J
PhylomeDBⁱ	O75351
TreeFamⁱ	TF105012

Family and domain databases

InterProⁱ	View protein in InterPro IPR003593 AAA+_ATPase IPR003959 ATPase_AAA_core IPR003960 ATPase_AAA_CS IPR007330 MIT IPR036181 MIT_dom_sf IPR027417 P-loop_NTPase IPR015415 Vps4_C
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00004 AAA, 1 hit PF04212 MIT, 1 hit PF09336 Vps4_C, 1 hit
SMARTⁱ	View protein in SMART SM00382 AAA, 1 hit SM00745 MIT, 1 hit
SUPFAMⁱ	SSF116846 SSF116846, 1 hit SSF52540 SSF52540, 1 hit
PROSITEⁱ	View protein in PROSITE PS00674 AAA, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show all Align All

O75351-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSSTSPNLQK AIDLASKAAQ EDKAGNYEEA LQLYQHAVQY FLHVVKYEAQ 
        60         70         80         90        100
GDKAKQSIRA KCTEYLDRAE KLKEYLKNKE KKAQKPVKEG QPSPADEKGN 
       110        120        130        140        150
DSDGEGESDD PEKKKLQNQL QGAIVIERPN VKWSDVAGLE GAKEALKEAV 
       160        170        180        190        200
ILPIKFPHLF TGKRTPWRGI LLFGPPGTGK SYLAKAVATE ANNSTFFSIS 
       210        220        230        240        250
SSDLVSKWLG ESEKLVKNLF QLARENKPSI IFIDEIDSLC GSRSENESEA 
       260        270        280        290        300
ARRIKTEFLV QMQGVGVDND GILVLGATNI PWVLDSAIRR RFEKRIYIPL 
       310        320        330        340        350
PEPHARAAMF KLHLGTTQNS LTEADFRELG RKTDGYSGAD ISIIVRDALM 
       360        370        380        390        400
QPVRKVQSAT HFKKVRGPSR ADPNHLVDDL LTPCSPGDPG AIEMTWMDVP 
       410        420        430        440 
GDKLLEPVVS MSDMLRSLSN TKPTVNEHDL LKLKKFTEDF GQEG

Length:444

Mass (Da):49,302

Last modified:January 16, 2004 - v2

Checksum:ⁱ9D565E4B20AF73FB

GO

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

K7EKZ3	K7EKZ3_HUMAN	Vacuolar protein sorting-associated... Vacuolar protein sorting-associated protein 4B	VPS4B	128	Annotation score:
K7EL71	K7EL71_HUMAN	Vacuolar protein sorting-associated... Vacuolar protein sorting-associated protein 4B	VPS4B	111	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	114	K → R in AAC39874 (PubMed:9653160).Curated	1
Sequence conflictⁱ	127	E → D in AAC39874 (PubMed:9653160).Curated	1
Sequence conflictⁱ	342	S → G in AAC39874 (PubMed:9653160).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_023385	58	I → M Common polymorphism; induces thermal instability. 1 PublicationCorresponds to variant dbSNP:rs17688948Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF195514 mRNA Translation: AAG33022.1 AF282904 Genomic DNA Translation: AAG01471.1 AF038960 mRNA Translation: AAC39874.1 AY232629 mRNA Translation: AAP59551.1 CH471096 Genomic DNA Translation: EAW63143.1 BC039574 mRNA Translation: AAH39574.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS11983.1
NCBI Reference Sequences More...RefSeqⁱ	NP_004860.2, NM_004869.3
UniGeneⁱ	Hs.126550

Genome annotation databases

Ensemblⁱ	ENST00000238497; ENSP00000238497; ENSG00000119541
GeneIDⁱ	9525
KEGGⁱ	hsa:9525
UCSC genome browser More...UCSCⁱ	uc002lix.4 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O75351	Vacuolar protein sorting 4B (Yeast), isoform CRA_a		HUMAN		444	UniRef100_O75351
VPS4B isoform 3		PANTR		444
VPS4B isoform 1		PONAB		444
Uncharacterized protein		PANPA		444

Protein	Similar proteins		Species	Score	Length	Source
O75351	Vacuolar protein sorting-associated protein 4B		PONAB		444	UniRef90_O75351
Vacuolar protein sorting-associated protein 4B	)	MOUSE		444
Vacuolar protein sorting 4B (Yeast), isoform CRA_a		HUMAN		444
VPS4B isoform 3		PANTR		444
Uncharacterized protein		PANPA		444
+132

Protein	Similar proteins		Species	Score	Length	Source
O75351	Vacuolar protein sorting-associated protein 4A	)	HUMAN		437	UniRef50_Q9UN37
Vacuolar protein sorting-associated protein 4B		BOVIN		444
Vacuolar protein sorting-associated protein 4		CANAL		439
Vacuolar protein sorting-associated protein 4B		PONAB		444
Vacuolar protein sorting-associated protein 4B	)	MOUSE		444
+773

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF195514 mRNA Translation: AAG33022.1 AF282904 Genomic DNA Translation: AAG01471.1 AF038960 mRNA Translation: AAC39874.1 AY232629 mRNA Translation: AAP59551.1 CH471096 Genomic DNA Translation: EAW63143.1 BC039574 mRNA Translation: AAH39574.1
CCDSⁱ	CCDS11983.1
RefSeqⁱ	NP_004860.2, NM_004869.3
UniGeneⁱ	Hs.126550

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1WR0	NMR	-	A	1-77	[»]
	1XWI	X-ray	2.80	A	123-444	[»]
	2CPT	NMR	-	A	1-104	[»]
	2JQH	NMR	-	A	1-86	[»]
	2JQK	NMR	-	A	1-86	[»]
	4U7Y	X-ray	2.50	A	1-89	[»]
ProteinModelPortalⁱ	O75351
SMRⁱ	O75351
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	114901, 49 interactors
ComplexPortalⁱ	CPX-338 VPS4A/B complex
DIPⁱ	DIP-53790N
IntActⁱ	O75351, 10 interactors
STRINGⁱ	9606.ENSP00000238497

Chemistry databases

ChEMBLⁱ	CHEMBL2311229

ChEMBLⁱ

CHEMBL2311229

PTM databases

iPTMnetⁱ	O75351
PhosphoSitePlusⁱ	O75351

Polymorphism and mutation databases

BioMutaⁱ	VPS4B

BioMutaⁱ

VPS4B

Proteomic databases

EPDⁱ	O75351
MaxQBⁱ	O75351
PaxDbⁱ	O75351
PeptideAtlasⁱ	O75351
PRIDEⁱ	O75351
ProteomicsDBⁱ	49918

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	9525
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000238497; ENSP00000238497; ENSG00000119541
GeneIDⁱ	9525
KEGGⁱ	hsa:9525
UCSCⁱ	uc002lix.4 human

Organism-specific databases

CTDⁱ	9525
DisGeNETⁱ	9525
EuPathDBⁱ	HostDB:ENSG00000119541.9
GeneCardsⁱ	VPS4B
HGNCⁱ	HGNC:10895 VPS4B
HPAⁱ	CAB046445 HPA040393 HPA057649
MalaCardsⁱ	VPS4B
MIMⁱ	609983 gene
neXtProtⁱ	NX_O75351
OpenTargetsⁱ	ENSG00000119541
Orphanetⁱ	99789 Dentin dysplasia type I
PharmGKBⁱ	PA35795
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0739 Eukaryota ENOG410XRHN LUCA
GeneTreeⁱ	ENSGT00550000074466
HOGENOMⁱ	HOG000225146
HOVERGENⁱ	HBG057074
InParanoidⁱ	O75351
KOⁱ	K12196
OMAⁱ	THFKKVK
OrthoDBⁱ	EOG091G0Q8J
PhylomeDBⁱ	O75351
TreeFamⁱ	TF105012

Enzyme and pathway databases

Reactomeⁱ	R-HSA-162588 Budding and maturation of HIV virion R-HSA-917729 Endosomal Sorting Complex Required For Transport (ESCRT)

Reactomeⁱ

R-HSA-162588 Budding and maturation of HIV virion
R-HSA-917729 Endosomal Sorting Complex Required For Transport (ESCRT)

Miscellaneous databases

ChiTaRSⁱ	VPS4B human
EvolutionaryTraceⁱ	O75351
GeneWikiⁱ	VPS4B
GenomeRNAiⁱ	9525
Protein Ontology More...PROⁱ	PR:O75351
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000119541 Expressed in 227 organ(s), highest expression level in esophagus squamous epithelium
CleanExⁱ	HS_VPS4B
ExpressionAtlasⁱ	O75351 baseline and differential
Genevisibleⁱ	O75351 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR003593 AAA+_ATPase IPR003959 ATPase_AAA_core IPR003960 ATPase_AAA_CS IPR007330 MIT IPR036181 MIT_dom_sf IPR027417 P-loop_NTPase IPR015415 Vps4_C
Pfamⁱ	View protein in Pfam PF00004 AAA, 1 hit PF04212 MIT, 1 hit PF09336 Vps4_C, 1 hit
SMARTⁱ	View protein in SMART SM00382 AAA, 1 hit SM00745 MIT, 1 hit
SUPFAMⁱ	SSF116846 SSF116846, 1 hit SSF52540 SSF52540, 1 hit
PROSITEⁱ	View protein in PROSITE PS00674 AAA, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	VPS4B_HUMAN
Accessionⁱ	O75351Primary (citable) accession number: O75351 Secondary accession number(s): Q69HW4, Q9GZS7
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
	Last sequence update:	January 16, 2004
	Last modified:	November 7, 2018
	This is version 178 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 18
Human chromosome 18: entries, gene names and cross-references to MIM
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - O75351 (VPS4B_HUMAN)

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Vacuolar protein sorting-associated protein 4B

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Endosome

Other locations

Cytoskeleton

Cytosol

Endosome

Extracellular region or secreted

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Coiled coil

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ