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Protein

V-type proton ATPase subunit G 1

Gene

ATP6V1G1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe2+ prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation (PubMed:28296633).1 Publication

GO - Molecular functioni

  • ATPase binding Source: UniProtKB
  • proton-exporting ATPase activity, phosphorylative mechanism Source: Ensembl

GO - Biological processi

  • cellular iron ion homeostasis Source: UniProtKB
  • cellular response to increased oxygen levels Source: UniProtKB
  • insulin receptor signaling pathway Source: Reactome
  • ion transmembrane transport Source: Reactome
  • regulation of macroautophagy Source: ParkinsonsUK-UCL
  • transferrin transport Source: Reactome

Keywordsi

Biological processHydrogen ion transport, Ion transport, Transport

Enzyme and pathway databases

BioCyciMetaCyc:HS06241-MONOMER
ReactomeiR-HSA-1222556 ROS, RNS production in phagocytes
R-HSA-77387 Insulin receptor recycling
R-HSA-917977 Transferrin endocytosis and recycling
R-HSA-983712 Ion channel transport

Protein family/group databases

TCDBi3.A.2.2.4 the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily

Names & Taxonomyi

Protein namesi
Recommended name:
V-type proton ATPase subunit G 1
Short name:
V-ATPase subunit G 1
Alternative name(s):
V-ATPase 13 kDa subunit 1
Vacuolar proton pump subunit G 1
Vacuolar proton pump subunit M16
Gene namesi
Name:ATP6V1G1
Synonyms:ATP6G, ATP6G1, ATP6J
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000136888.6
HGNCiHGNC:864 ATP6V1G1
MIMi607296 gene
neXtProtiNX_O75348

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi9550
OpenTargetsiENSG00000136888
PharmGKBiPA25163

Polymorphism and mutation databases

BioMutaiATP6V1G1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001928972 – 118V-type proton ATPase subunit G 1Add BLAST117

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanine1 Publication1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiO75348
PaxDbiO75348
PeptideAtlasiO75348
PRIDEiO75348
ProteomicsDBi49917

PTM databases

iPTMnetiO75348
PhosphoSitePlusiO75348

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

BgeeiENSG00000136888 Expressed in 233 organ(s), highest expression level in metanephros
CleanExiHS_ATP6V1G1
ExpressionAtlasiO75348 baseline and differential
GenevisibleiO75348 HS

Organism-specific databases

HPAiCAB004615
HPA042898

Interactioni

Subunit structurei

V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'' and d).

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi114922, 40 interactors
IntActiO75348, 40 interactors
MINTiO75348
STRINGi9606.ENSP00000363162

Structurei

3D structure databases

ProteinModelPortaliO75348
SMRiO75348
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the V-ATPase G subunit family.Curated

Phylogenomic databases

eggNOGiKOG1772 Eukaryota
ENOG4111XX0 LUCA
GeneTreeiENSGT00390000011172
HOGENOMiHOG000186416
HOVERGENiHBG057827
InParanoidiO75348
KOiK02152
OMAiEFHANYR
OrthoDBiEOG091G0XIZ
PhylomeDBiO75348
TreeFamiTF313777

Family and domain databases

InterProiView protein in InterPro
IPR005124 V-ATPase_G
PANTHERiPTHR12713 PTHR12713, 1 hit
PfamiView protein in Pfam
PF03179 V-ATPase_G, 1 hit
TIGRFAMsiTIGR01147 V_ATP_synt_G, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O75348-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASQSQGIQQ LLQAEKRAAE KVSEARKRKN RRLKQAKEEA QAEIEQYRLQ
60 70 80 90 100
REKEFKAKEA AALGSRGSCS TEVEKETQEK MTILQTYFRQ NRDEVLDNLL
110
AFVCDIRPEI HENYRING
Length:118
Mass (Da):13,758
Last modified:January 23, 2007 - v3
Checksum:iA289C1B96634E34C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF038954 mRNA Translation: AAC39868.1
CR456971 mRNA Translation: CAG33252.1
CR542237 mRNA Translation: CAG47033.1
AL160275 Genomic DNA No translation available.
CH471090 Genomic DNA Translation: EAW87424.1
BC008452 mRNA Translation: AAH08452.1
CCDSiCCDS6807.1
RefSeqiNP_004879.1, NM_004888.3
UniGeneiHs.388654

Genome annotation databases

EnsembliENST00000374050; ENSP00000363162; ENSG00000136888
GeneIDi9550
KEGGihsa:9550
UCSCiuc004bjc.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF038954 mRNA Translation: AAC39868.1
CR456971 mRNA Translation: CAG33252.1
CR542237 mRNA Translation: CAG47033.1
AL160275 Genomic DNA No translation available.
CH471090 Genomic DNA Translation: EAW87424.1
BC008452 mRNA Translation: AAH08452.1
CCDSiCCDS6807.1
RefSeqiNP_004879.1, NM_004888.3
UniGeneiHs.388654

3D structure databases

ProteinModelPortaliO75348
SMRiO75348
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114922, 40 interactors
IntActiO75348, 40 interactors
MINTiO75348
STRINGi9606.ENSP00000363162

Protein family/group databases

TCDBi3.A.2.2.4 the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily

PTM databases

iPTMnetiO75348
PhosphoSitePlusiO75348

Polymorphism and mutation databases

BioMutaiATP6V1G1

Proteomic databases

EPDiO75348
PaxDbiO75348
PeptideAtlasiO75348
PRIDEiO75348
ProteomicsDBi49917

Protocols and materials databases

DNASUi9550
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000374050; ENSP00000363162; ENSG00000136888
GeneIDi9550
KEGGihsa:9550
UCSCiuc004bjc.4 human

Organism-specific databases

CTDi9550
DisGeNETi9550
EuPathDBiHostDB:ENSG00000136888.6
GeneCardsiATP6V1G1
HGNCiHGNC:864 ATP6V1G1
HPAiCAB004615
HPA042898
MIMi607296 gene
neXtProtiNX_O75348
OpenTargetsiENSG00000136888
PharmGKBiPA25163
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1772 Eukaryota
ENOG4111XX0 LUCA
GeneTreeiENSGT00390000011172
HOGENOMiHOG000186416
HOVERGENiHBG057827
InParanoidiO75348
KOiK02152
OMAiEFHANYR
OrthoDBiEOG091G0XIZ
PhylomeDBiO75348
TreeFamiTF313777

Enzyme and pathway databases

BioCyciMetaCyc:HS06241-MONOMER
ReactomeiR-HSA-1222556 ROS, RNS production in phagocytes
R-HSA-77387 Insulin receptor recycling
R-HSA-917977 Transferrin endocytosis and recycling
R-HSA-983712 Ion channel transport

Miscellaneous databases

ChiTaRSiATP6V1G1 human
GeneWikiiATP6V1G1
GenomeRNAii9550
PROiPR:O75348
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000136888 Expressed in 233 organ(s), highest expression level in metanephros
CleanExiHS_ATP6V1G1
ExpressionAtlasiO75348 baseline and differential
GenevisibleiO75348 HS

Family and domain databases

InterProiView protein in InterPro
IPR005124 V-ATPase_G
PANTHERiPTHR12713 PTHR12713, 1 hit
PfamiView protein in Pfam
PF03179 V-ATPase_G, 1 hit
TIGRFAMsiTIGR01147 V_ATP_synt_G, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiVATG1_HUMAN
AccessioniPrimary (citable) accession number: O75348
Secondary accession number(s): Q6IB33
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 169 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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