UniProtKB - O75347 (TBCA_HUMAN)
Tubulin-specific chaperone A
TBCA
Functioni
GO - Molecular functioni
- beta-tubulin binding Source: InterPro
- chaperone binding Source: ProtInc
- RNA binding Source: UniProtKB
- tubulin binding Source: GO_Central
GO - Biological processi
- post-chaperonin tubulin folding pathway Source: ProtInc
- protein folding Source: GO_Central
- tubulin complex assembly Source: GO_Central
Keywordsi
Molecular function | Chaperone |
Enzyme and pathway databases
PathwayCommonsi | O75347 |
Reactomei | R-HSA-389977, Post-chaperonin tubulin folding pathway |
SIGNORi | O75347 |
Names & Taxonomyi
Protein namesi | Recommended name: Tubulin-specific chaperone AAlternative name(s): TCP1-chaperonin cofactor A Tubulin-folding cofactor A Short name: CFA |
Gene namesi | Name:TBCA |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000171530.13 |
HGNCi | HGNC:11579, TBCA |
MIMi | 610058, gene |
neXtProti | NX_O75347 |
Subcellular locationi
Cytoskeleton
Cytoskeleton
- microtubule Source: UniProtKB-KW
- microtubule cytoskeleton Source: HPA
Cytosol
- cytosol Source: GO_Central
Nucleus
- nucleolus Source: HPA
Other locations
- cytoplasm Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, Cytoskeleton, MicrotubulePathology & Biotechi
Organism-specific databases
DisGeNETi | 6902 |
OpenTargetsi | ENSG00000171530 |
PharmGKBi | PA36343 |
Miscellaneous databases
Pharosi | O75347, Tbio |
Polymorphism and mutation databases
BioMutai | TBCA |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedBy similarity | |||
ChainiPRO_0000080039 | 2 – 108 | Tubulin-specific chaperone AAdd BLAST | 107 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineBy similarity | 1 |
Keywords - PTMi
AcetylationProteomic databases
EPDi | O75347 |
jPOSTi | O75347 |
MassIVEi | O75347 |
PaxDbi | O75347 |
PeptideAtlasi | O75347 |
PRIDEi | O75347 |
ProteomicsDBi | 49916 [O75347-1] 5068 |
TopDownProteomicsi | O75347-1 [O75347-1] |
2D gel databases
OGPi | O75347 |
SWISS-2DPAGEi | O75347 |
PTM databases
iPTMneti | O75347 |
MetOSitei | O75347 |
PhosphoSitePlusi | O75347 |
Expressioni
Gene expression databases
Bgeei | ENSG00000171530, Expressed in left adrenal gland and 132 other tissues |
ExpressionAtlasi | O75347, baseline and differential |
Genevisiblei | O75347, HS |
Organism-specific databases
HPAi | ENSG00000171530, Low tissue specificity |
Interactioni
Subunit structurei
Supercomplex made of cofactors A to E. Cofactors A and D function by capturing and stabilizing tubulin in a quasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex; interaction with cofactor C then causes the release of tubulin polypeptides that are committed to the native state.
Binary interactionsi
O75347
With | #Exp. | IntAct |
---|---|---|
TERF2IP [Q9NYB0] | 2 | EBI-2686341,EBI-750109 |
GO - Molecular functioni
- beta-tubulin binding Source: InterPro
- chaperone binding Source: ProtInc
- tubulin binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 112765, 50 interactors |
IntActi | O75347, 13 interactors |
MINTi | O75347 |
STRINGi | 9606.ENSP00000306362 |
Miscellaneous databases
RNActi | O75347, protein |
Structurei
Secondary structure
3D structure databases
SMRi | O75347 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | O75347 |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG3470, Eukaryota |
GeneTreei | ENSGT00390000009710 |
HOGENOMi | CLU_130569_1_1_1 |
InParanoidi | O75347 |
OrthoDBi | 1471374at2759 |
PhylomeDBi | O75347 |
TreeFami | TF313971 |
Family and domain databases
InterProi | View protein in InterPro IPR004226, TBCA IPR036126, TBCA_sf |
PANTHERi | PTHR21500, PTHR21500, 1 hit |
Pfami | View protein in Pfam PF02970, TBCA, 1 hit |
SUPFAMi | SSF46988, SSF46988, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MADPRVRQIK IKTGVVKRLV KEKVMYEKEA KQQEEKIEKM RAEDGENYDI
60 70 80 90 100
KKQAEILQES RMMIPDCQRR LEAAYLDLQR ILENEKDLEE AEEYKEARLV
LDSVKLEA
Computationally mapped potential isoform sequencesi
There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE5RJD8 | E5RJD8_HUMAN | Tubulin-specific chaperone A | TBCA | 119 | Annotation score: | ||
E5RIW3 | E5RIW3_HUMAN | Tubulin-specific chaperone A | TBCA | 84 | Annotation score: | ||
E5RIX8 | E5RIX8_HUMAN | Tubulin-specific chaperone A | TBCA | 79 | Annotation score: | ||
E5RHG6 | E5RHG6_HUMAN | Tubulin-specific chaperone A | TBCA | 131 | Annotation score: | ||
A0A494C144 | A0A494C144_HUMAN | Tubulin-specific chaperone A | TBCA | 59 | Annotation score: | ||
E5RJM1 | E5RJM1_HUMAN | Tubulin-specific chaperone A | TBCA | 26 | Annotation score: |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_056357 | 83 – 108 | ENEKD…VKLEA → VSKDFCVMFKFFFSIQYMES QKFKYLTLRTSWQYFLFTCP LYRYILK in isoform 2. 1 PublicationAdd BLAST | 26 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF038952 mRNA Translation: AAC39866.1 BT007354 mRNA Translation: AAP36018.1 AK300031 mRNA Translation: BAG61842.1 AC026717 Genomic DNA No translation available. AC035147 Genomic DNA No translation available. AC108482 Genomic DNA No translation available. BC018210 mRNA Translation: AAH18210.1 |
CCDSi | CCDS4040.1 [O75347-1] CCDS75263.1 [O75347-2] |
RefSeqi | NP_001284667.1, NM_001297738.1 [O75347-2] NP_004598.1, NM_004607.2 [O75347-1] |
Genome annotation databases
Ensembli | ENST00000306388; ENSP00000306362; ENSG00000171530 [O75347-2] ENST00000380377; ENSP00000369736; ENSG00000171530 [O75347-1] |
GeneIDi | 6902 |
KEGGi | hsa:6902 |
UCSCi | uc003kfi.2, human [O75347-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF038952 mRNA Translation: AAC39866.1 BT007354 mRNA Translation: AAP36018.1 AK300031 mRNA Translation: BAG61842.1 AC026717 Genomic DNA No translation available. AC035147 Genomic DNA No translation available. AC108482 Genomic DNA No translation available. BC018210 mRNA Translation: AAH18210.1 |
CCDSi | CCDS4040.1 [O75347-1] CCDS75263.1 [O75347-2] |
RefSeqi | NP_001284667.1, NM_001297738.1 [O75347-2] NP_004598.1, NM_004607.2 [O75347-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1H7C | X-ray | 1.80 | A | 2-108 | [»] | |
SMRi | O75347 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 112765, 50 interactors |
IntActi | O75347, 13 interactors |
MINTi | O75347 |
STRINGi | 9606.ENSP00000306362 |
PTM databases
iPTMneti | O75347 |
MetOSitei | O75347 |
PhosphoSitePlusi | O75347 |
Polymorphism and mutation databases
BioMutai | TBCA |
2D gel databases
OGPi | O75347 |
SWISS-2DPAGEi | O75347 |
Proteomic databases
EPDi | O75347 |
jPOSTi | O75347 |
MassIVEi | O75347 |
PaxDbi | O75347 |
PeptideAtlasi | O75347 |
PRIDEi | O75347 |
ProteomicsDBi | 49916 [O75347-1] 5068 |
TopDownProteomicsi | O75347-1 [O75347-1] |
Protocols and materials databases
Antibodypediai | 24499, 255 antibodies |
DNASUi | 6902 |
Genome annotation databases
Ensembli | ENST00000306388; ENSP00000306362; ENSG00000171530 [O75347-2] ENST00000380377; ENSP00000369736; ENSG00000171530 [O75347-1] |
GeneIDi | 6902 |
KEGGi | hsa:6902 |
UCSCi | uc003kfi.2, human [O75347-1] |
Organism-specific databases
CTDi | 6902 |
DisGeNETi | 6902 |
EuPathDBi | HostDB:ENSG00000171530.13 |
GeneCardsi | TBCA |
HGNCi | HGNC:11579, TBCA |
HPAi | ENSG00000171530, Low tissue specificity |
MIMi | 610058, gene |
neXtProti | NX_O75347 |
OpenTargetsi | ENSG00000171530 |
PharmGKBi | PA36343 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3470, Eukaryota |
GeneTreei | ENSGT00390000009710 |
HOGENOMi | CLU_130569_1_1_1 |
InParanoidi | O75347 |
OrthoDBi | 1471374at2759 |
PhylomeDBi | O75347 |
TreeFami | TF313971 |
Enzyme and pathway databases
PathwayCommonsi | O75347 |
Reactomei | R-HSA-389977, Post-chaperonin tubulin folding pathway |
SIGNORi | O75347 |
Miscellaneous databases
BioGRID-ORCSi | 6902, 629 hits in 849 CRISPR screens |
ChiTaRSi | TBCA, human |
EvolutionaryTracei | O75347 |
GeneWikii | TBCA |
GenomeRNAii | 6902 |
Pharosi | O75347, Tbio |
PROi | PR:O75347 |
RNActi | O75347, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000171530, Expressed in left adrenal gland and 132 other tissues |
ExpressionAtlasi | O75347, baseline and differential |
Genevisiblei | O75347, HS |
Family and domain databases
InterProi | View protein in InterPro IPR004226, TBCA IPR036126, TBCA_sf |
PANTHERi | PTHR21500, PTHR21500, 1 hit |
Pfami | View protein in Pfam PF02970, TBCA, 1 hit |
SUPFAMi | SSF46988, SSF46988, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TBCA_HUMAN | |
Accessioni | O75347Primary (citable) accession number: O75347 Secondary accession number(s): B4DT30 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 30, 2000 |
Last sequence update: | January 23, 2007 | |
Last modified: | December 2, 2020 | |
This is version 171 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 5
Human chromosome 5: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families