UniProtKB - O75346 (ZN253_HUMAN)
Protein
Zinc finger protein 253
Gene
ZNF253
Organism
Homo sapiens (Human)
Status
Functioni
May function as a transcription factor. Seem to have a transcriptional repression activity.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 172 – 194 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 200 – 222 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 228 – 250 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 256 – 278 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 284 – 306 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 312 – 334 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 340 – 362 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 368 – 390 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 396 – 418 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 424 – 446 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 452 – 474 | C2H2-type 11PROSITE-ProRule annotationAdd BLAST | 23 |
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- negative regulation of transcription, DNA-templated Source: UniProtKB
- regulation of transcription, DNA-templated Source: GO_Central
Keywordsi
Molecular function | DNA-binding, Repressor |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | O75346 |
Reactomei | R-HSA-212436, Generic Transcription Pathway |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger protein 253Alternative name(s): Bone marrow zinc finger 1 Short name: BMZF-1 Zinc finger protein 411 |
Gene namesi | Name:ZNF253 Synonyms:BMZF1, ZNF411 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000256771.2 |
HGNCi | HGNC:13497, ZNF253 |
MIMi | 606954, gene |
neXtProti | NX_O75346 |
Subcellular locationi
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 56242 |
OpenTargetsi | ENSG00000256771 |
PharmGKBi | PA37785 |
Miscellaneous databases
Pharosi | O75346, Tdark |
Polymorphism and mutation databases
BioMutai | ZNF253 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000047486 | 1 – 499 | Zinc finger protein 253Add BLAST | 499 |
Proteomic databases
EPDi | O75346 |
jPOSTi | O75346 |
MassIVEi | O75346 |
MaxQBi | O75346 |
PaxDbi | O75346 |
PeptideAtlasi | O75346 |
PRIDEi | O75346 |
ProteomicsDBi | 49914 [O75346-1] 49915 [O75346-2] |
PTM databases
iPTMneti | O75346 |
PhosphoSitePlusi | O75346 |
Expressioni
Tissue specificityi
Expressed in bone marrow and in monocytic and immature erythroid cell lines.
Gene expression databases
Bgeei | ENSG00000256771, Expressed in buccal mucosa cell and 195 other tissues |
ExpressionAtlasi | O75346, baseline and differential |
Genevisiblei | O75346, HS |
Organism-specific databases
HPAi | ENSG00000256771, Low tissue specificity |
Interactioni
Protein-protein interaction databases
BioGRIDi | 121110, 1 interactor |
IntActi | O75346, 3 interactors |
MINTi | O75346 |
STRINGi | 9606.ENSP00000468720 |
Miscellaneous databases
RNActi | O75346, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 4 – 75 | KRABPROSITE-ProRule annotationAdd BLAST | 72 |
Sequence similaritiesi
Belongs to the krueppel C2H2-type zinc-finger protein family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 172 – 194 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 200 – 222 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 228 – 250 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 256 – 278 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 284 – 306 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 312 – 334 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 340 – 362 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 368 – 390 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 396 – 418 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 424 – 446 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 452 – 474 | C2H2-type 11PROSITE-ProRule annotationAdd BLAST | 23 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT01010000222367 |
HOGENOMi | CLU_002678_44_0_1 |
InParanoidi | O75346 |
OMAi | HIERKPY |
OrthoDBi | 1318335at2759 |
PhylomeDBi | O75346 |
Family and domain databases
CDDi | cd07765, KRAB_A-box, 1 hit |
InterProi | View protein in InterPro IPR001909, KRAB IPR036051, KRAB_dom_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF01352, KRAB, 1 hit PF00096, zf-C2H2, 11 hits |
SMARTi | View protein in SMART SM00349, KRAB, 1 hit SM00355, ZnF_C2H2, 11 hits |
SUPFAMi | SSF109640, SSF109640, 1 hit SSF57667, SSF57667, 6 hits |
PROSITEi | View protein in PROSITE PS50805, KRAB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 11 hits PS50157, ZINC_FINGER_C2H2_2, 11 hits |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: O75346-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MGPLQFRDVA IEFSLEEWHC LDTAQRNLYR DVMLENYRNL VFLGIVVSKP
60 70 80 90 100
DLVTCLEQGK KPLTMERHEM IAKPPVMSSH FAQDLWPENI QNSFQIGMLR
110 120 130 140 150
RYEECRHDNL QLKKGCKSVG EHKVHKGGYN GLNQCLTTTQ KEIFQCDKYG
160 170 180 190 200
KVFHKFSNSN TYKTRHTGIN LFKCIICGKA FKRSSTLTTH KKIHTGEKPY
210 220 230 240 250
RCEECGKAFN QSANLTTHKR IHTGEKPYRC EECGKAFKQS SNLTTHKKIH
260 270 280 290 300
TGEKPYKCEE CGKAFNRSTD LTTHKIVHTG EKPYKCEECG KAFKHPSHVT
310 320 330 340 350
THKKIHTRGK PYNCEECGKS FKHCSNLTIH KRIHTGEKPY KCEECGKAFH
360 370 380 390 400
LSSHLTTHKI LHTGEKPYRC RECGKAFNHS TTLFSHEKIH TGEKPYKCDE
410 420 430 440 450
CGKTFTWPSI LSKHKRTHTG EKPYKCEECG KSFTASSTLT THKRIHTGEK
460 470 480 490
PYKCEECGKA FNWSSDLNKH KKIHIERKPY IVKNVTDLLN VPPLLISIR
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A1W2PRC0 | A0A1W2PRC0_HUMAN | Zinc finger protein 253 | ZNF253 | 274 | Annotation score: | ||
K7EP55 | K7EP55_HUMAN | Zinc finger protein 253 | ZNF253 | 214 | Annotation score: |
Sequence cautioni
The sequence AAH14148 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC11257 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 220 – 443 | Missing in AAC26844 (PubMed:10585455).CuratedAdd BLAST | 224 | |
Sequence conflicti | 286 – 313 | Missing in BAC11185 (PubMed:14702039).CuratedAdd BLAST | 28 | |
Sequence conflicti | 371 | R → I in BAC11185 (PubMed:14702039).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_036962 | 1 – 76 | Missing in isoform 2. 1 PublicationAdd BLAST | 76 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF038951 mRNA Translation: AAC26844.1 AK074757 mRNA Translation: BAC11185.1 AK074872 mRNA Translation: BAC11257.1 Different initiation. AC011477 Genomic DNA No translation available. BC014148 mRNA Translation: AAH14148.2 Different initiation. BC065572 mRNA Translation: AAH65572.1 BC125063 mRNA Translation: AAI25064.1 BC125064 mRNA Translation: AAI25065.1 |
CCDSi | CCDS42532.1 [O75346-1] CCDS86729.1 [O75346-2] |
RefSeqi | NP_001318062.1, NM_001331133.1 NP_001318063.1, NM_001331134.1 [O75346-2] NP_066385.2, NM_021047.2 [O75346-1] |
Genome annotation databases
Ensembli | ENST00000355650; ENSP00000347868; ENSG00000256771 [O75346-2] ENST00000589717; ENSP00000468720; ENSG00000256771 [O75346-1] |
GeneIDi | 56242 |
KEGGi | hsa:56242 |
UCSCi | uc002noj.4, human [O75346-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF038951 mRNA Translation: AAC26844.1 AK074757 mRNA Translation: BAC11185.1 AK074872 mRNA Translation: BAC11257.1 Different initiation. AC011477 Genomic DNA No translation available. BC014148 mRNA Translation: AAH14148.2 Different initiation. BC065572 mRNA Translation: AAH65572.1 BC125063 mRNA Translation: AAI25064.1 BC125064 mRNA Translation: AAI25065.1 |
CCDSi | CCDS42532.1 [O75346-1] CCDS86729.1 [O75346-2] |
RefSeqi | NP_001318062.1, NM_001331133.1 NP_001318063.1, NM_001331134.1 [O75346-2] NP_066385.2, NM_021047.2 [O75346-1] |
3D structure databases
SMRi | O75346 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 121110, 1 interactor |
IntActi | O75346, 3 interactors |
MINTi | O75346 |
STRINGi | 9606.ENSP00000468720 |
PTM databases
iPTMneti | O75346 |
PhosphoSitePlusi | O75346 |
Polymorphism and mutation databases
BioMutai | ZNF253 |
Proteomic databases
EPDi | O75346 |
jPOSTi | O75346 |
MassIVEi | O75346 |
MaxQBi | O75346 |
PaxDbi | O75346 |
PeptideAtlasi | O75346 |
PRIDEi | O75346 |
ProteomicsDBi | 49914 [O75346-1] 49915 [O75346-2] |
Protocols and materials databases
Antibodypediai | 56721, 42 antibodies |
Genome annotation databases
Ensembli | ENST00000355650; ENSP00000347868; ENSG00000256771 [O75346-2] ENST00000589717; ENSP00000468720; ENSG00000256771 [O75346-1] |
GeneIDi | 56242 |
KEGGi | hsa:56242 |
UCSCi | uc002noj.4, human [O75346-1] |
Organism-specific databases
CTDi | 56242 |
DisGeNETi | 56242 |
EuPathDBi | HostDB:ENSG00000256771.2 |
GeneCardsi | ZNF253 |
HGNCi | HGNC:13497, ZNF253 |
HPAi | ENSG00000256771, Low tissue specificity |
MIMi | 606954, gene |
neXtProti | NX_O75346 |
OpenTargetsi | ENSG00000256771 |
PharmGKBi | PA37785 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT01010000222367 |
HOGENOMi | CLU_002678_44_0_1 |
InParanoidi | O75346 |
OMAi | HIERKPY |
OrthoDBi | 1318335at2759 |
PhylomeDBi | O75346 |
Enzyme and pathway databases
PathwayCommonsi | O75346 |
Reactomei | R-HSA-212436, Generic Transcription Pathway |
Miscellaneous databases
BioGRID-ORCSi | 56242, 262 hits in 842 CRISPR screens |
GenomeRNAii | 56242 |
Pharosi | O75346, Tdark |
PROi | PR:O75346 |
RNActi | O75346, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000256771, Expressed in buccal mucosa cell and 195 other tissues |
ExpressionAtlasi | O75346, baseline and differential |
Genevisiblei | O75346, HS |
Family and domain databases
CDDi | cd07765, KRAB_A-box, 1 hit |
InterProi | View protein in InterPro IPR001909, KRAB IPR036051, KRAB_dom_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF01352, KRAB, 1 hit PF00096, zf-C2H2, 11 hits |
SMARTi | View protein in SMART SM00349, KRAB, 1 hit SM00355, ZnF_C2H2, 11 hits |
SUPFAMi | SSF109640, SSF109640, 1 hit SSF57667, SSF57667, 6 hits |
PROSITEi | View protein in PROSITE PS50805, KRAB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 11 hits PS50157, ZINC_FINGER_C2H2_2, 11 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ZN253_HUMAN | |
Accessioni | O75346Primary (citable) accession number: O75346 Secondary accession number(s): A4FVA7 Q8NCF9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 24, 2001 |
Last sequence update: | May 5, 2009 | |
Last modified: | December 2, 2020 | |
This is version 169 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM