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UniProtKB - O75346 (ZN253_HUMAN)

Entry version 159 (08 May 2019)
Sequence version 2 (05 May 2009)
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Protein

Zinc finger protein 253

Gene

ZNF253

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May function as a transcription factor. Seem to have a transcriptional repression activity.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri172 – 194C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri200 – 222C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri228 – 250C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri256 – 278C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri284 – 306C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri312 – 334C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri340 – 362C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri368 – 390C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri396 – 418C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri424 – 446C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri452 – 474C2H2-type 11PROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-212436 Generic Transcription Pathway

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein 253
Alternative name(s):
Bone marrow zinc finger 1
Short name:
BMZF-1
Zinc finger protein 411
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZNF253
Synonyms:BMZF1, ZNF411
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:13497 ZNF253

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		606954 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_O75346

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		56242

Open Targets

More...OpenTargetsi		ENSG00000256771

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA37785

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ZNF253

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000474861 – 499Zinc finger protein 253Add BLAST499

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		O75346

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		O75346

MaxQB - The MaxQuant DataBase

More...MaxQBi		O75346

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O75346

PeptideAtlas

More...PeptideAtlasi		O75346

PRoteomics IDEntifications database

More...PRIDEi		O75346

ProteomicsDB human proteome resource

More...ProteomicsDBi		49914
49915 [O75346-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		O75346

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		O75346

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in bone marrow and in monocytic and immature erythroid cell lines.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000256771 Expressed in 180 organ(s), highest expression level in buccal mucosa cell

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		O75346 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		O75346 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		121110, 1 interactor

Protein interaction database and analysis system

More...IntActi		O75346, 3 interactors

Molecular INTeraction database

More...MINTi		O75346

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000468720

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		O75346

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini4 – 75KRABPROSITE-ProRule annotationAdd BLAST72

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the krueppel C2H2-type zinc-finger protein family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri172 – 194C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri200 – 222C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri228 – 250C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri256 – 278C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri284 – 306C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri312 – 334C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri340 – 362C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri368 – 390C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri396 – 418C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri424 – 446C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri452 – 474C2H2-type 11PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1721 Eukaryota
COG5048 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00950000182792

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000234617

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O75346

KEGG Orthology (KO)

More...KOi		K09228

Identification of Orthologs from Complete Genome Data

More...OMAi		KIHIERK

Database of Orthologous Groups

More...OrthoDBi		1318335at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		O75346

Family and domain databases

Conserved Domains Database

More...CDDi		cd07765 KRAB_A-box, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 11 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 11 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 6 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 11 hits
PS50157 ZINC_FINGER_C2H2_2, 11 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O75346-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGPLQFRDVA IEFSLEEWHC LDTAQRNLYR DVMLENYRNL VFLGIVVSKP 
        60         70         80         90        100
DLVTCLEQGK KPLTMERHEM IAKPPVMSSH FAQDLWPENI QNSFQIGMLR 
       110        120        130        140        150
RYEECRHDNL QLKKGCKSVG EHKVHKGGYN GLNQCLTTTQ KEIFQCDKYG 
       160        170        180        190        200
KVFHKFSNSN TYKTRHTGIN LFKCIICGKA FKRSSTLTTH KKIHTGEKPY 
       210        220        230        240        250
RCEECGKAFN QSANLTTHKR IHTGEKPYRC EECGKAFKQS SNLTTHKKIH 
       260        270        280        290        300
TGEKPYKCEE CGKAFNRSTD LTTHKIVHTG EKPYKCEECG KAFKHPSHVT 
       310        320        330        340        350
THKKIHTRGK PYNCEECGKS FKHCSNLTIH KRIHTGEKPY KCEECGKAFH 
       360        370        380        390        400
LSSHLTTHKI LHTGEKPYRC RECGKAFNHS TTLFSHEKIH TGEKPYKCDE 
       410        420        430        440        450
CGKTFTWPSI LSKHKRTHTG EKPYKCEECG KSFTASSTLT THKRIHTGEK 
       460        470        480        490 
PYKCEECGKA FNWSSDLNKH KKIHIERKPY IVKNVTDLLN VPPLLISIR
Length:499
Mass (Da):57,602
Last modified:May 5, 2009 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i783F3352A58AC767
GO
Isoform 2 (identifier: O75346-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-76: Missing.

Show »
Length:423
Mass (Da):48,746
Checksum:iE2F26598CB121698
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1W2PRC0A0A1W2PRC0_HUMAN
Zinc finger protein 253
ZNF253
274Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EP55K7EP55_HUMAN
Zinc finger protein 253
ZNF253
214Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH14148 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC11257 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti220 – 443Missing in AAC26844 (PubMed:10585455).CuratedAdd BLAST224
Sequence conflicti286 – 313Missing in BAC11185 (PubMed:14702039).CuratedAdd BLAST28
Sequence conflicti371R → I in BAC11185 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0369621 – 76Missing in isoform 2. 1 PublicationAdd BLAST76

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF038951 mRNA Translation: AAC26844.1
AK074757 mRNA Translation: BAC11185.1
AK074872 mRNA Translation: BAC11257.1 Different initiation.
AC011477 Genomic DNA No translation available.
BC014148 mRNA Translation: AAH14148.2 Different initiation.
BC065572 mRNA Translation: AAH65572.1
BC125063 mRNA Translation: AAI25064.1
BC125064 mRNA Translation: AAI25065.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS42532.1 [O75346-1]
CCDS86729.1 [O75346-2]

NCBI Reference Sequences

More...RefSeqi		NP_001318062.1, NM_001331133.1
NP_001318063.1, NM_001331134.1 [O75346-2]
NP_066385.2, NM_021047.2 [O75346-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000355650; ENSP00000347868; ENSG00000256771 [O75346-2]
ENST00000589717; ENSP00000468720; ENSG00000256771 [O75346-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		56242

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:56242

UCSC genome browser

More...UCSCi		uc002noj.4 human [O75346-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF038951 mRNA Translation: AAC26844.1
AK074757 mRNA Translation: BAC11185.1
AK074872 mRNA Translation: BAC11257.1 Different initiation.
AC011477 Genomic DNA No translation available.
BC014148 mRNA Translation: AAH14148.2 Different initiation.
BC065572 mRNA Translation: AAH65572.1
BC125063 mRNA Translation: AAI25064.1
BC125064 mRNA Translation: AAI25065.1
CCDSiCCDS42532.1 [O75346-1]
CCDS86729.1 [O75346-2]
RefSeqiNP_001318062.1, NM_001331133.1
NP_001318063.1, NM_001331134.1 [O75346-2]
NP_066385.2, NM_021047.2 [O75346-1]

3D structure databases

SMRiO75346
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121110, 1 interactor
IntActiO75346, 3 interactors
MINTiO75346
STRINGi9606.ENSP00000468720

PTM databases

iPTMnetiO75346
PhosphoSitePlusiO75346

Polymorphism and mutation databases

BioMutaiZNF253

Proteomic databases

EPDiO75346
jPOSTiO75346
MaxQBiO75346
PaxDbiO75346
PeptideAtlasiO75346
PRIDEiO75346
ProteomicsDBi49914
49915 [O75346-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000355650; ENSP00000347868; ENSG00000256771 [O75346-2]
ENST00000589717; ENSP00000468720; ENSG00000256771 [O75346-1]
GeneIDi56242
KEGGihsa:56242
UCSCiuc002noj.4 human [O75346-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		56242
DisGeNETi56242

GeneCards: human genes, protein and diseases

More...GeneCardsi		ZNF253
HGNCiHGNC:13497 ZNF253
MIMi606954 gene
neXtProtiNX_O75346
OpenTargetsiENSG00000256771
PharmGKBiPA37785

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00950000182792
HOGENOMiHOG000234617
InParanoidiO75346
KOiK09228
OMAiKIHIERK
OrthoDBi1318335at2759
PhylomeDBiO75346

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		56242

Protein Ontology

More...PROi		PR:O75346

The Stanford Online Universal Resource for Clones and ESTs

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Gene expression databases

BgeeiENSG00000256771 Expressed in 180 organ(s), highest expression level in buccal mucosa cell
ExpressionAtlasiO75346 baseline and differential
GenevisibleiO75346 HS

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 11 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 11 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 6 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 11 hits
PS50157 ZINC_FINGER_C2H2_2, 11 hits

ProtoNet; Automatic hierarchical classification of proteins

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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZN253_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O75346
Secondary accession number(s): A4FVA7
, Q0P6G3, Q6P0L2, Q8NCA3, Q8NCF9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: May 5, 2009
Last modified: May 8, 2019
This is version 159 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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