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Protein

Arachidonate 12-lipoxygenase, 12R-type

Gene

ALOX12B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Mainly converts arachidonic acid to (12R)-hydroperoxyeicosatetraenoic acid/(12R)-HPETE and minor stereoisomers. In the skin, acts upstream of ALOXE3 on the lineolate moiety of esterified omega-hydroxyacyl-sphingosine (EOS) ceramides to produce an epoxy-ketone derivative, a crucial step in the conjugation of omega-hydroxyceramide to membrane proteins. Therefore plays a crucial role in the synthesis of corneocytes lipid envelope and the establishment of the skin barrier to water loss. May also play a role in the regulation of the expression of airway mucins.3 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Fe cationPROSITE-ProRule annotationNote: Binds 1 Fe cation per subunit.PROSITE-ProRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: hydroperoxy eicosatetraenoic acid biosynthesis

This protein is involved in the pathway hydroperoxy eicosatetraenoic acid biosynthesis, which is part of Lipid metabolism.1 Publication
View all proteins of this organism that are known to be involved in the pathway hydroperoxy eicosatetraenoic acid biosynthesis and in Lipid metabolism.

Pathwayi: sphingolipid metabolism

This protein is involved in the pathway sphingolipid metabolism, which is part of Lipid metabolism.1 Publication
View all proteins of this organism that are known to be involved in the pathway sphingolipid metabolism and in Lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi398Iron; catalyticPROSITE-ProRule annotation1
Metal bindingi403Iron; catalyticPROSITE-ProRule annotation1
Metal bindingi578Iron; catalyticPROSITE-ProRule annotation1
Metal bindingi582Iron; catalyticPROSITE-ProRule annotation1
Metal bindingi701Iron; via carboxylate; catalyticPROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDioxygenase, Oxidoreductase
Biological processFatty acid metabolism, Lipid metabolism
LigandIron, Metal-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
1.13.11.31 2681

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-2142712 Synthesis of 12-eicosatetraenoic acid derivatives

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00222

UPA00881

Chemistry databases

SwissLipids knowledge resource for lipid biology

More...
SwissLipidsi
SLP:000000655

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Arachidonate 12-lipoxygenase, 12R-type (EC:1.13.11.-)
Short name:
12R-LOX
Short name:
12R-lipoxygenase
Alternative name(s):
Epidermis-type lipoxygenase 12
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ALOX12B
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000179477.9

Human Gene Nomenclature Database

More...
HGNCi
HGNC:430 ALOX12B

Online Mendelian Inheritance in Man (OMIM)

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MIMi
603741 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O75342

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Ichthyosis, congenital, autosomal recessive 2 (ARCI2)5 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of autosomal recessive congenital ichthyosis, a disorder of keratinization with abnormal differentiation and desquamation of the epidermis, resulting in abnormal skin scaling over the whole body. The main skin phenotypes are lamellar ichthyosis (LI) and non-bullous congenital ichthyosiform erythroderma (NCIE), although phenotypic overlap within the same patient or among patients from the same family can occur. Lamellar ichthyosis is a condition often associated with an embedment in a collodion-like membrane at birth; skin scales later develop, covering the entire body surface. Non-bullous congenital ichthyosiform erythroderma characterized by fine whitish scaling on an erythrodermal background; larger brownish scales are present on the buttocks, neck and legs.
See also OMIM:242100
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_06954524L → P in ARCI2. 1 PublicationCorresponds to variant dbSNP:rs201575829Ensembl.1
Natural variantiVAR_06954667I → F in ARCI2. 1 PublicationCorresponds to variant dbSNP:rs397514533EnsemblClinVar.1
Natural variantiVAR_069547114R → W in ARCI2. 1 PublicationCorresponds to variant dbSNP:rs397514526EnsemblClinVar.1
Natural variantiVAR_069548127P → S in ARCI2. 1 PublicationCorresponds to variant dbSNP:rs72842957EnsemblClinVar.1
Natural variantiVAR_069549195F → L in ARCI2; complete loss of the enzyme activity. 1 PublicationCorresponds to variant dbSNP:rs200516538Ensembl.1
Natural variantiVAR_069550318Y → C in ARCI2. 1 Publication1
Natural variantiVAR_069551382K → E in ARCI2; complete loss of the enzyme activity. 1 Publication1
Natural variantiVAR_069552383T → M in ARCI2. 1 PublicationCorresponds to variant dbSNP:rs760428119Ensembl.1
Natural variantiVAR_069553416N → K in ARCI2. 1 PublicationCorresponds to variant dbSNP:rs1039399607Ensembl.1
Natural variantiVAR_015173426L → P in ARCI2; complete loss of the enzyme activity. 2 PublicationsCorresponds to variant dbSNP:rs137853023EnsemblClinVar.1
Natural variantiVAR_069554462G → D in ARCI2. 1 PublicationCorresponds to variant dbSNP:rs774958790Ensembl.1
Natural variantiVAR_069555488R → H in ARCI2; complete loss of the enzyme activity. 1 PublicationCorresponds to variant dbSNP:rs763468558Ensembl.1
Natural variantiVAR_069556521Y → C in ARCI2. 2 PublicationsCorresponds to variant dbSNP:rs199766569EnsemblClinVar.1
Natural variantiVAR_069557527V → M in ARCI2. 1 PublicationCorresponds to variant dbSNP:rs199545653EnsemblClinVar.1
Natural variantiVAR_015174578H → Q in ARCI2; complete loss of the enzyme activity. 2 PublicationsCorresponds to variant dbSNP:rs137853024EnsemblClinVar.1
Natural variantiVAR_069558597A → E in ARCI2. 1 PublicationCorresponds to variant dbSNP:rs752509098EnsemblClinVar.1
Natural variantiVAR_069559664A → P in ARCI2; complete loss of the enzyme activity. 1 Publication1
Natural variantiVAR_069560679R → L in ARCI2. 1 PublicationCorresponds to variant dbSNP:rs397514528EnsemblClinVar.1

Keywords - Diseasei

Disease mutation, Ichthyosis

Organism-specific databases

DisGeNET

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DisGeNETi
242

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

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GeneReviewsi
ALOX12B

MalaCards human disease database

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MalaCardsi
ALOX12B
MIMi242100 phenotype

Open Targets

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OpenTargetsi
ENSG00000179477

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
79394 Congenital non-bullous ichthyosiform erythroderma
313 Lamellar ichthyosis
281122 Self-improving collodion baby

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA24722

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ALOX12B

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002206891 – 701Arachidonate 12-lipoxygenase, 12R-typeAdd BLAST701

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
O75342

MaxQB - The MaxQuant DataBase

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MaxQBi
O75342

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
O75342

PeptideAtlas

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PeptideAtlasi
O75342

PRoteomics IDEntifications database

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PRIDEi
O75342

ProteomicsDB human proteome resource

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ProteomicsDBi
49910

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
O75342

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
O75342

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in B-cells, hair follicles, foreskin keratinocytes and adult skin. Also expressed in psoriatic tissue.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000179477 Expressed in 81 organ(s), highest expression level in skin of leg

CleanEx database of gene expression profiles

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CleanExi
HS_ALOX12B

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
O75342 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA024002

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
ALOXE3Q9BYJ12EBI-6925925,EBI-6925949

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
106743, 31 interactors

Protein interaction database and analysis system

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IntActi
O75342, 3 interactors

Molecular INTeraction database

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MINTi
O75342

STRING: functional protein association networks

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STRINGi
9606.ENSP00000315167

Chemistry databases

BindingDB database of measured binding affinities

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BindingDBi
O75342

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
O75342

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
O75342

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini2 – 119PLATPROSITE-ProRule annotationAdd BLAST118
Domaini120 – 701LipoxygenasePROSITE-ProRule annotationAdd BLAST582

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the lipoxygenase family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IF0U Eukaryota
ENOG410YN4N LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000162032

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000234358

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG005150

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
O75342

KEGG Orthology (KO)

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KOi
K08021

Identification of Orthologs from Complete Genome Data

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OMAi
TQGESHK

Database of Orthologous Groups

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OrthoDBi
692811at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
O75342

TreeFam database of animal gene trees

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TreeFami
TF105320

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR000907 LipOase
IPR013819 LipOase_C
IPR036226 LipOase_C_sf
IPR020834 LipOase_CS
IPR020833 LipOase_Fe_BS
IPR001885 LipOase_mml
IPR001024 PLAT/LH2_dom
IPR036392 PLAT/LH2_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR11771 PTHR11771, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00305 Lipoxygenase, 1 hit
PF01477 PLAT, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00087 LIPOXYGENASE
PR00467 MAMLPOXGNASE

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00308 LH2, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF48484 SSF48484, 1 hit
SSF49723 SSF49723, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00711 LIPOXYGENASE_1, 1 hit
PS00081 LIPOXYGENASE_2, 1 hit
PS51393 LIPOXYGENASE_3, 1 hit
PS50095 PLAT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

O75342-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MATYKVRVAT GTDLLSGTRD SISLTIVGTQ GESHKQLLNH FGRDFATGAV
60 70 80 90 100
GQYTVQCPQD LGELIIIRLH KERYAFFPKD PWYCNYVQIC APNGRIYHFP
110 120 130 140 150
AYQWMDGYET LALREATGKT TADDSLPVLL EHRKEEIRAK QDFYHWRVFL
160 170 180 190 200
PGLPSYVHIP SYRPPVRRHR NPNRPEWNGY IPGFPILINF KATKFLNLNL
210 220 230 240 250
RYSFLKTASF FVRLGPMALA FKVRGLLDCK HSWKRLKDIR KIFPGKKSVV
260 270 280 290 300
SEYVAEHWAE DTFFGYQYLN GVNPGLIRRC TRIPDKFPVT DDMVAPFLGE
310 320 330 340 350
GTCLQAELEK GNIYLADYRI MEGIPTVELS GRKQHHCAPL CLLHFGPEGK
360 370 380 390 400
MMPIAIQLSQ TPGPDCPIFL PSDSEWDWLL AKTWVRYAEF YSHEAIAHLL
410 420 430 440 450
ETHLIAEAFC LALLRNLPMC HPLYKLLIPH TRYTVQINSI GRAVLLNEGG
460 470 480 490 500
LSAKGMSLGV EGFAGVMVRA LSELTYDSLY LPNDFVERGV QDLPGYYYRD
510 520 530 540 550
DSLAVWNALE KYVTEIITYY YPSDAAVEGD PELQSWVQEI FKECLLGRES
560 570 580 590 600
SGFPRCLRTV PELIRYVTIV IYTCSAKHAA VNTGQMEFTA WMPNFPASMR
610 620 630 640 650
NPPIQTKGLT TLETFMDTLP DVKTTCITLL VLWTLSREPD DRRPLGHFPD
660 670 680 690 700
IHFVEEAPRR SIEAFRQRLN QISHDIRQRN KCLPIPYYYL DPVLIENSIS

I
Length:701
Mass (Da):80,356
Last modified:November 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC334075759F8B077
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A3B3IRK2A0A3B3IRK2_HUMAN
Arachidonate 12-lipoxygenase, 12R-t...
ALOX12B
389Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06954524L → P in ARCI2. 1 PublicationCorresponds to variant dbSNP:rs201575829Ensembl.1
Natural variantiVAR_06954667I → F in ARCI2. 1 PublicationCorresponds to variant dbSNP:rs397514533EnsemblClinVar.1
Natural variantiVAR_05000094G → S. Corresponds to variant dbSNP:rs8077661EnsemblClinVar.1
Natural variantiVAR_069547114R → W in ARCI2. 1 PublicationCorresponds to variant dbSNP:rs397514526EnsemblClinVar.1
Natural variantiVAR_069548127P → S in ARCI2. 1 PublicationCorresponds to variant dbSNP:rs72842957EnsemblClinVar.1
Natural variantiVAR_069549195F → L in ARCI2; complete loss of the enzyme activity. 1 PublicationCorresponds to variant dbSNP:rs200516538Ensembl.1
Natural variantiVAR_069550318Y → C in ARCI2. 1 Publication1
Natural variantiVAR_069551382K → E in ARCI2; complete loss of the enzyme activity. 1 Publication1
Natural variantiVAR_069552383T → M in ARCI2. 1 PublicationCorresponds to variant dbSNP:rs760428119Ensembl.1
Natural variantiVAR_069553416N → K in ARCI2. 1 PublicationCorresponds to variant dbSNP:rs1039399607Ensembl.1
Natural variantiVAR_015173426L → P in ARCI2; complete loss of the enzyme activity. 2 PublicationsCorresponds to variant dbSNP:rs137853023EnsemblClinVar.1
Natural variantiVAR_069554462G → D in ARCI2. 1 PublicationCorresponds to variant dbSNP:rs774958790Ensembl.1
Natural variantiVAR_069555488R → H in ARCI2; complete loss of the enzyme activity. 1 PublicationCorresponds to variant dbSNP:rs763468558Ensembl.1
Natural variantiVAR_069556521Y → C in ARCI2. 2 PublicationsCorresponds to variant dbSNP:rs199766569EnsemblClinVar.1
Natural variantiVAR_069557527V → M in ARCI2. 1 PublicationCorresponds to variant dbSNP:rs199545653EnsemblClinVar.1
Natural variantiVAR_015174578H → Q in ARCI2; complete loss of the enzyme activity. 2 PublicationsCorresponds to variant dbSNP:rs137853024EnsemblClinVar.1
Natural variantiVAR_069558597A → E in ARCI2. 1 PublicationCorresponds to variant dbSNP:rs752509098EnsemblClinVar.1
Natural variantiVAR_069559664A → P in ARCI2; complete loss of the enzyme activity. 1 Publication1
Natural variantiVAR_069560679R → L in ARCI2. 1 PublicationCorresponds to variant dbSNP:rs397514528EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF038461 mRNA Translation: AAC39770.1
AF059250 mRNA Translation: AAC79680.1
AJ305026, AJ305027 Genomic DNA Translation: CAC34520.1
BC041058 mRNA Translation: AAH41058.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS11129.1

NCBI Reference Sequences

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RefSeqi
NP_001130.1, NM_001139.2

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.136574

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000319144; ENSP00000315167; ENSG00000179477
ENST00000647874; ENSP00000497784; ENSG00000179477

Database of genes from NCBI RefSeq genomes

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GeneIDi
242

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:242

UCSC genome browser

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UCSCi
uc002gjy.1 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Protein Spotlight

about water - Issue 153 of September 2013

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF038461 mRNA Translation: AAC39770.1
AF059250 mRNA Translation: AAC79680.1
AJ305026, AJ305027 Genomic DNA Translation: CAC34520.1
BC041058 mRNA Translation: AAH41058.1
CCDSiCCDS11129.1
RefSeqiNP_001130.1, NM_001139.2
UniGeneiHs.136574

3D structure databases

ProteinModelPortaliO75342
SMRiO75342
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi106743, 31 interactors
IntActiO75342, 3 interactors
MINTiO75342
STRINGi9606.ENSP00000315167

Chemistry databases

BindingDBiO75342
SwissLipidsiSLP:000000655

PTM databases

iPTMnetiO75342
PhosphoSitePlusiO75342

Polymorphism and mutation databases

BioMutaiALOX12B

Proteomic databases

jPOSTiO75342
MaxQBiO75342
PaxDbiO75342
PeptideAtlasiO75342
PRIDEiO75342
ProteomicsDBi49910

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000319144; ENSP00000315167; ENSG00000179477
ENST00000647874; ENSP00000497784; ENSG00000179477
GeneIDi242
KEGGihsa:242
UCSCiuc002gjy.1 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
242
DisGeNETi242
EuPathDBiHostDB:ENSG00000179477.9

GeneCards: human genes, protein and diseases

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GeneCardsi
ALOX12B
GeneReviewsiALOX12B
HGNCiHGNC:430 ALOX12B
HPAiHPA024002
MalaCardsiALOX12B
MIMi242100 phenotype
603741 gene
neXtProtiNX_O75342
OpenTargetsiENSG00000179477
Orphaneti79394 Congenital non-bullous ichthyosiform erythroderma
313 Lamellar ichthyosis
281122 Self-improving collodion baby
PharmGKBiPA24722

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IF0U Eukaryota
ENOG410YN4N LUCA
GeneTreeiENSGT00940000162032
HOGENOMiHOG000234358
HOVERGENiHBG005150
InParanoidiO75342
KOiK08021
OMAiTQGESHK
OrthoDBi692811at2759
PhylomeDBiO75342
TreeFamiTF105320

Enzyme and pathway databases

UniPathwayi
UPA00222

UPA00881

BRENDAi1.13.11.31 2681
ReactomeiR-HSA-2142712 Synthesis of 12-eicosatetraenoic acid derivatives

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
ALOX12B

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
242

Protein Ontology

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PROi
PR:O75342

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000179477 Expressed in 81 organ(s), highest expression level in skin of leg
CleanExiHS_ALOX12B
GenevisibleiO75342 HS

Family and domain databases

InterProiView protein in InterPro
IPR000907 LipOase
IPR013819 LipOase_C
IPR036226 LipOase_C_sf
IPR020834 LipOase_CS
IPR020833 LipOase_Fe_BS
IPR001885 LipOase_mml
IPR001024 PLAT/LH2_dom
IPR036392 PLAT/LH2_dom_sf
PANTHERiPTHR11771 PTHR11771, 1 hit
PfamiView protein in Pfam
PF00305 Lipoxygenase, 1 hit
PF01477 PLAT, 1 hit
PRINTSiPR00087 LIPOXYGENASE
PR00467 MAMLPOXGNASE
SMARTiView protein in SMART
SM00308 LH2, 1 hit
SUPFAMiSSF48484 SSF48484, 1 hit
SSF49723 SSF49723, 1 hit
PROSITEiView protein in PROSITE
PS00711 LIPOXYGENASE_1, 1 hit
PS00081 LIPOXYGENASE_2, 1 hit
PS51393 LIPOXYGENASE_3, 1 hit
PS50095 PLAT, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLX12B_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O75342
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: November 1, 1998
Last modified: January 16, 2019
This is version 167 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  7. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
UniProt is an ELIXIR core data resource
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