UniProtKB - O75340 (PDCD6_HUMAN)
Protein
Programmed cell death protein 6
Gene
PDCD6
Organism
Homo sapiens (Human)
Status
Functioni
Calcium sensor that plays a key role in processes such as endoplasmic reticulum (ER)-Golgi vesicular transport, endosomal biogenesis or membrane repair. Acts as an adapter that bridges unrelated proteins or stabilizes weak protein-protein complexes in response to calcium: calcium-binding triggers exposure of apolar surface, promoting interaction with different sets of proteins thanks to 3 different hydrophobic pockets, leading to translocation to membranes (PubMed:20691033, PubMed:25667979). Involved in ER-Golgi transport by promoting the association between PDCD6IP and TSG101, thereby bridging together the ESCRT-III and ESCRT-I complexes (PubMed:19520058). Together with PEF1, acts as calcium-dependent adapter for the BCR(KLHL12) complex, a complex involved in ER-Golgi transport by regulating the size of COPII coats (PubMed:27716508). In response to cytosolic calcium increase, the heterodimer formed with PEF1 interacts with, and bridges together the BCR(KLHL12) complex and SEC31 (SEC31A or SEC31B), promoting monoubiquitination of SEC31 and subsequent collagen export, which is required for neural crest specification (PubMed:27716508). Involved in the regulation of the distribution and function of MCOLN1 in the endosomal pathway (PubMed:19864416). Promotes localization and polymerization of TFG at endoplasmic reticulum exit site (PubMed:27813252). Required for T-cell receptor-, Fas-, and glucocorticoid-induced apoptosis (By similarity). May mediate Ca2+-regulated signals along the death pathway: interaction with DAPK1 can accelerate apoptotic cell death by increasing caspase-3 activity (PubMed:16132846). Its role in apoptosis may however be indirect, as suggested by knockout experiments (By similarity). May inhibit KDR/VEGFR2-dependent angiogenesis; the function involves inhibition of VEGF-induced phosphorylation of the Akt signaling pathway (PubMed:21893193). In case of infection by HIV-1 virus, indirectly inhibits HIV-1 production by affecting viral Gag expression and distribution (PubMed:27784779).By similarity9 Publications
Has a lower Ca2+ affinity than isoform 1 (By similarity).By similarity
Sites
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| Metal bindingi | 36 | Calcium 14 Publications | 1 | |
| Metal bindingi | 38 | Calcium 14 Publications | 1 | |
| Metal bindingi | 40 | Calcium 14 Publications | 1 | |
| Metal bindingi | 42 | Calcium 1; via carbonyl oxygen4 Publications | 1 | |
| Metal bindingi | 47 | Calcium 14 Publications | 1 | |
| Metal bindingi | 103 | Calcium 24 Publications | 1 | |
| Metal bindingi | 105 | Calcium 24 Publications | 1 | |
| Metal bindingi | 107 | Calcium 24 Publications | 1 | |
| Metal bindingi | 109 | Calcium 2; via carbonyl oxygen4 Publications | 1 | |
| Metal bindingi | 114 | Calcium 24 Publications | 1 | |
| Metal bindingi | 169 | MagnesiumBy similarity | 1 | |
| Metal bindingi | 171 | MagnesiumBy similarity | 1 | |
| Metal bindingi | 173 | MagnesiumBy similarity | 1 | |
| Metal bindingi | 175 | Magnesium; via carbonyl oxygenBy similarity | 1 |
Regions
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| Calcium bindingi | 36 – 47 | 14 PublicationsAdd BLAST | 12 | |
| Calcium bindingi | 73 – 84 | 2PROSITE-ProRule annotationAdd BLAST | 12 | |
| Calcium bindingi | 103 – 114 | 34 PublicationsAdd BLAST | 12 |
GO - Molecular functioni
- calcium-dependent protein binding Source: UniProtKB
- calcium ion binding Source: UniProtKB
- identical protein binding Source: IntAct
- magnesium ion binding Source: UniProtKB
- protein dimerization activity Source: UniProtKB
- protein homodimerization activity Source: UniProtKB
- protein-macromolecule adaptor activity Source: UniProtKB
- protein-membrane adaptor activity Source: UniProtKB
- ubiquitin ligase-substrate adaptor activity Source: GO_Central
GO - Biological processi
- activation of cysteine-type endopeptidase activity involved in apoptotic process Source: Ensembl
- angiogenesis Source: UniProtKB-KW
- apoptotic signaling pathway Source: ProtInc
- cellular response to heat Source: UniProtKB
- COPII vesicle coating Source: UniProtKB
- endoplasmic reticulum to Golgi vesicle-mediated transport Source: UniProtKB
- intracellular protein transport Source: UniProtKB
- negative regulation of protein kinase B signaling Source: UniProtKB
- negative regulation of TOR signaling Source: UniProtKB
- negative regulation of vascular endothelial growth factor receptor signaling pathway Source: UniProtKB
- neural crest cell development Source: UniProtKB
- neural crest formation Source: UniProtKB
- positive regulation of angiogenesis Source: UniProtKB
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: UniProtKB
- positive regulation of endothelial cell migration Source: UniProtKB
- positive regulation of endothelial cell proliferation Source: UniProtKB
- positive regulation of protein monoubiquitination Source: UniProtKB
- response to calcium ion Source: UniProtKB
- vascular endothelial growth factor receptor-2 signaling pathway Source: UniProtKB
Keywordsi
| Biological process | Angiogenesis, Apoptosis |
| Ligand | Calcium, Magnesium, Metal-binding |
Enzyme and pathway databases
| PathwayCommonsi | O75340 |
Protein family/group databases
| TCDBi | 3.A.5.9.1, the general secretory pathway (sec) family |
Names & Taxonomyi
| Protein namesi | Recommended name: Programmed cell death protein 6Alternative name(s): Apoptosis-linked gene 2 protein homologBy similarity Short name: ALG-2By similarity |
| Gene namesi | Name:PDCD6 Synonyms:ALG2By similarity |
| Organismi | Homo sapiens (Human) |
| Taxonomic identifieri | 9606 [NCBI] |
| Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
| Proteomesi |
|
Organism-specific databases
| EuPathDBi | HostDB:ENSG00000249915.7 |
| HGNCi | HGNC:8765, PDCD6 |
| MIMi | 601057, gene |
| neXtProti | NX_O75340 |
Subcellular locationi
Nucleus
- Nucleus 3 Publications
Endosome
- Endosome 1 Publication
Endoplasmic reticulum
- Endoplasmic reticulum membrane 2 Publications; Peripheral membrane protein 1 Publication
Other locations
- COPII-coated vesicle membrane 1 Publication
- Cytoplasm 2 Publications
Note: Interaction with RBM22 induces relocalization from the cytoplasm to the nucleus (PubMed:17045351). Translocated from the cytoplasm to the nucleus after heat shock cell treatment. Accumulates in cytoplasmic vesicle-like organelles after heat shock treatment, which may represent stress granules (PubMed:21122810). In response to calcium increase, relocates from cytoplasm to COPII vesicle coat (PubMed:27716508). Localizes to endoplasmic reticulum exit site (ERES) (PubMed:27813252).4 Publications
Endoplasmic reticulum
- endoplasmic reticulum Source: UniProtKB
- endoplasmic reticulum exit site Source: UniProtKB
- endoplasmic reticulum membrane Source: UniProtKB-SubCell
Endosome
- endosome Source: UniProtKB-SubCell
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Golgi apparatus
- Golgi membrane Source: GOC
Nucleus
- nucleus Source: UniProtKB
Other locations
- COPII vesicle coat Source: UniProtKB
- Cul3-RING ubiquitin ligase complex Source: GO_Central
- cytoplasm Source: UniProtKB
- cytoplasmic vesicle Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, Cytoplasmic vesicle, Endoplasmic reticulum, Endosome, Membrane, NucleusPathology & Biotechi
Mutagenesis
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| Mutagenesisi | 47 | E → A: Loss of interaction with SEC31A and PLSCR3, and loss of localization to the endoplasmic reticulum; when associated with A-114. 3 Publications | 1 | |
| Mutagenesisi | 52 | L → A: Stronly impaired interaction with SEC31A. Slightly reduced interaction with PDCD6IP. 1 Publication | 1 | |
| Mutagenesisi | 53 | S → G: Slightly reduced interaction with SEC31A. Does not affect interaction with PDCD6IP. 1 Publication | 1 | |
| Mutagenesisi | 57 | W → A: Does not affect interaction with SEC31A. Reduces the interaction with HEBP2, PDCD6IP and ANXA7. 3 Publications | 1 | |
| Mutagenesisi | 60 | F → A: Abolishes the interaction with SEC31A, PDCD6IP, ANXA7 and ANXA11. 2 Publications | 1 | |
| Mutagenesisi | 85 | F → A: Stronly impaired interaction with SEC31A and TFG. Does not affect interaction with PDCD6IP. 2 Publications | 1 | |
| Mutagenesisi | 89 | W → A: Does not affect interaction with SEC31A. Does not affect interaction with PDCD6IP. 1 Publication | 1 | |
| Mutagenesisi | 91 | Y → A: Abolishes the interaction with PDCD6IP, ANXA7 and ANXA11. 1 Publication | 1 | |
| Mutagenesisi | 92 | I → A: Does not affect interaction with SEC31A. Does not affect interaction with PDCD6IP. 1 Publication | 1 | |
| Mutagenesisi | 95 | W → A: Abolishes the interaction with PDCD6IP, ANXA7 and ANXA11. 1 Publication | 1 | |
| Mutagenesisi | 114 | E → A: Loss of interaction with SEC31A and PLSCR3, and loss of localization to the endoplasmic reticulum; when associated with A-47. 2 Publications | 1 | |
| Mutagenesisi | 122 | F → A: Increases interaction with PDCD6IP and ANXA7. Impairs interaction with ANXA11. Augments stauroporine-induced cell death. 1 Publication | 1 | |
| Mutagenesisi | 122 | F → G: Increases interaction with PDCD6IP. Impairs interaction with ANXA11. 1 Publication | 1 | |
| Mutagenesisi | 122 | F → S: Increases interaction with PDCD6IP. Impairs interaction with ANAX7 and ANXA11. 1 Publication | 1 | |
| Mutagenesisi | 122 | F → W: Impairs interaction with ANXA11. 1 Publication | 1 | |
| Mutagenesisi | 148 | F → S: Slightly reduced interaction with SEC31A. Does not affect interaction with PDCD6IP. 1 Publication | 1 | |
| Mutagenesisi | 180 | Y → A: Abolishes the interaction with PDCD6IP, TSG101, ANXA7 and ANXA11. Does not affect interaction with TFG and SEC31A. 2 Publications | 1 |
Organism-specific databases
| DisGeNETi | 10016 |
| OpenTargetsi | ENSG00000249915 |
| PharmGKBi | PA33115 |
Miscellaneous databases
| Pharosi | O75340, Tbio |
Chemistry databases
| ChEMBLi | CHEMBL4105994 |
| DrugBanki | DB01373, Calcium DB11093, Calcium citrate DB11348, Calcium Phosphate DB14481, Calcium phosphate dihydrate DB01593, Zinc DB14487, Zinc acetate |
Polymorphism and mutation databases
| BioMutai | PDCD6 |
PTM / Processingi
Molecule processing
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| Initiator methioninei | RemovedCombined sources | |||
| ChainiPRO_0000073729 | 2 – 191 | Programmed cell death protein 6Add BLAST | 190 |
Amino acid modifications
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| Modified residuei | 2 | N-acetylalanineCombined sources | 1 |
Keywords - PTMi
AcetylationProteomic databases
| EPDi | O75340 |
| jPOSTi | O75340 |
| MassIVEi | O75340 |
| MaxQBi | O75340 |
| PaxDbi | O75340 |
| PeptideAtlasi | O75340 |
| PRIDEi | O75340 |
| ProteomicsDBi | 18039 49909 [O75340-1] 61550 |
| TopDownProteomicsi | O75340-1 [O75340-1] |
PTM databases
| iPTMneti | O75340 |
| MetOSitei | O75340 |
| PhosphoSitePlusi | O75340 |
Expressioni
Gene expression databases
| Bgeei | ENSG00000249915, Expressed in endometrium epithelium and 237 other tissues |
| ExpressionAtlasi | O75340, baseline and differential |
| Genevisiblei | O75340, HS |
Organism-specific databases
| HPAi | ENSG00000249915, Low tissue specificity |
Interactioni
Subunit structurei
Homodimer and heterodimer; heterodimerizes (via the EF-hand 5) with PEF1 (PubMed:11278427, PubMed:11883899, PubMed:27784779). Isoform 1 and isoform 2 self-associate; probably forming homodimers.
Interacts with CPNE4 (via VWFA domain) (By similarity).
Interacts with PDCD6IP; the interaction is calcium-dependent (PubMed:16957052, PubMed:18256029, PubMed:18940611, PubMed:20691033, PubMed:25667979).
Interacts with RBM22 (PubMed:17045351).
Interacts with PLSCR4 (PubMed:18256029).
Interacts with ANXA7 and TSG101 (PubMed:18256029, PubMed:20691033).
Interacts with DAPK1 (PubMed:16132846).
Interacts with SEC31A; the interaction is calcium-dependent and promotes monoubiquitination of SEC31A (PubMed:16957052, PubMed:18256029, PubMed:27716508, PubMed:25667979).
Interacts with ANXA11 (via N-terminus); the interaction is calcium-dependent (PubMed:11883939, PubMed:18256029, PubMed:18940611).
Interacts with PLSCR3 (via N-terminus); the interaction is calcium-dependent (PubMed:18256029).
Interacts with MCOLN1; the interaction is calcium-dependent (PubMed:19864416).
Interacts with KDR; the interaction is calcium-dependent (PubMed:21893193).
Interacts with HEBP2; the interaction is calcium-dependent (PubMed:27784779).
Interacts with TFG (PubMed:27813252). Isoform 1:
Interacts with SHISA5, leading to stabilize it (PubMed:17889823). Isoform 2: Does not interact with SHISA5 (PubMed:17889823). Isoform 2: Does not interact with PDCD6IP, TSG101, ANXA7 and ANXA11 (PubMed:18256029, PubMed:20691033).
By similarity16 PublicationsBinary interactionsi
Hide detailsO75340
GO - Molecular functioni
- calcium-dependent protein binding Source: UniProtKB
- identical protein binding Source: IntAct
- protein dimerization activity Source: UniProtKB
- protein homodimerization activity Source: UniProtKB
Protein-protein interaction databases
| BioGRIDi | 115333, 148 interactors |
| CORUMi | O75340 |
| DIPi | DIP-33217N |
| ELMi | O75340 |
| IntActi | O75340, 77 interactors |
| MINTi | O75340 |
| STRINGi | 9606.ENSP00000264933 |
Miscellaneous databases
| RNActi | O75340, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
| SMRi | O75340 |
| ModBasei | Search... |
| PDBe-KBi | Search... |
Miscellaneous databases
| EvolutionaryTracei | O75340 |
Family & Domainsi
Domains and Repeats
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| Domaini | 23 – 58 | EF-hand 1PROSITE-ProRule annotationAdd BLAST | 36 | |
| Domaini | 59 – 89 | EF-hand 2PROSITE-ProRule annotationAdd BLAST | 31 | |
| Domaini | 90 – 125 | EF-hand 3PROSITE-ProRule annotationAdd BLAST | 36 | |
| Domaini | 126 – 161 | EF-hand 4PROSITE-ProRule annotationAdd BLAST | 36 | |
| Domaini | 162 – 191 | EF-hand 5PROSITE-ProRule annotationAdd BLAST | 30 |
Domaini
Interacts with different set of proteins thanks to 3 different hydrophobic pockets (PubMed:20691033, PubMed:25667979). Hydrophobic pockets 1 and 2, which mediate interaction with PDCD6IP, are largely formed by residues from EF-hand 3 (EF3) to 5 (EF5), as well as by Tyr-180 (EF5) of a dimerizing molecule (Pocket 1) and from EF-hand (EF2) to 4 (EF4) (Pocket 2) (PubMed:20691033). Hydrophobic pocket 3, which mediates interaction with SEC31A, is mainly formed by residues from EF-hand 1 (EF1) to 3 (EF3) (PubMed:25667979).2 Publications
EF-hand 1 (EF1) and 3 (EF3) are the high-affinity calcium-binding sites, while EF-hand 5 (EF5) binds calcium with low-affinity (PubMed:18940611, PubMed:20691033). A one-residue insertion in the EF5-binding loop prevents the glutamyl residue at the C-terminal end of the loop from serving as the canonical bidentate calcium ligand (PubMed:18940611, PubMed:20691033). EF5 acts as a high-affinity magnesium-binding domain instead (By similarity). Magnesium, may affect dimerization (By similarity). EF5 may bind either calcium or magnesium depending on the context (By similarity).By similarity2 Publications
Keywords - Domaini
RepeatPhylogenomic databases
| eggNOGi | KOG0037, Eukaryota |
| GeneTreei | ENSGT00940000160982 |
| HOGENOMi | CLU_051357_1_1_1 |
| InParanoidi | O75340 |
| OMAi | SREFLWD |
| PhylomeDBi | O75340 |
| TreeFami | TF314682 |
Family and domain databases
| InterProi | View protein in InterPro IPR011992, EF-hand-dom_pair IPR018247, EF_Hand_1_Ca_BS IPR002048, EF_hand_dom |
| Pfami | View protein in Pfam PF13202, EF-hand_5, 1 hit PF13499, EF-hand_7, 1 hit |
| SMARTi | View protein in SMART SM00054, EFh, 5 hits |
| SUPFAMi | SSF47473, SSF47473, 1 hit |
| PROSITEi | View protein in PROSITE PS00018, EF_HAND_1, 2 hits PS50222, EF_HAND_2, 3 hits |
Sequences (3+)i
Sequence statusi: Complete.
Sequence processingi: The displayed sequence is further processed into a mature form.
This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: O75340-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
10 20 30 40 50
MAAYSYRPGP GAGPGPAAGA ALPDQSFLWN VFQRVDKDRS GVISDTELQQ
60 70 80 90 100
ALSNGTWTPF NPVTVRSIIS MFDRENKAGV NFSEFTGVWK YITDWQNVFR
110 120 130 140 150
TYDRDNSGMI DKNELKQALS GFGYRLSDQF HDILIRKFDR QGRGQIAFDD
160 170 180 190
FIQGCIVLQR LTDIFRRYDT DQDGWIQVSY EQYLSMVFSI V
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket| A0A024QZ42 | A0A024QZ42_HUMAN | HCG1985580, isoform CRA_c | PDCD6 hCG_1985580 | 121 | Annotation score: | ||
| A0A087WZ38 | A0A087WZ38_HUMAN | Programmed cell death protein 6 | PDCD6 | 123 | Annotation score: | ||
| H0Y9X3 | H0Y9X3_HUMAN | Programmed cell death protein 6 | PDCD6 | 104 | Annotation score: | ||
| Q86W51 | Q86W51_HUMAN | PDCD6 protein | PDCD6 | 55 | Annotation score: | ||
| D6RA21 | D6RA21_HUMAN | Programmed cell death protein 6 | PDCD6 | 39 | Annotation score: |
Natural variant
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| Natural variantiVAR_035459 | 123 | G → C in a breast cancer sample; somatic mutation. 1 Publication | 1 |
Alternative sequence
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| Alternative sequenceiVSP_045542 | 70 – 191 | Missing in isoform 3. 1 PublicationAdd BLAST | 122 | |
| Alternative sequenceiVSP_045113 | 121 – 122 | Missing in isoform 2. 1 Publication | 2 |
Sequence databases
| Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF035606 mRNA Translation: AAC27697.1 U58773 mRNA Translation: AAF14336.1 AK315370 mRNA Translation: BAG37763.1 BT020072 mRNA Translation: AAV38875.1 AC010442 Genomic DNA No translation available. AC021087 Genomic DNA No translation available. AC118458 Genomic DNA No translation available. CH471235 Genomic DNA Translation: EAW50991.1 BC012384 mRNA Translation: AAH12384.1 BC106706 mRNA Translation: AAI06707.1 BC110291 mRNA Translation: AAI10292.1 CB991882 mRNA No translation available. |
| CCDSi | CCDS3854.1 [O75340-1] CCDS58940.1 [O75340-2] CCDS58941.1 [O75340-3] |
| RefSeqi | NP_001254485.1, NM_001267556.1 [O75340-2] NP_001254486.1, NM_001267557.1 NP_001254487.1, NM_001267558.1 NP_001254488.1, NM_001267559.1 [O75340-3] NP_037364.1, NM_013232.3 [O75340-1] |
Genome annotation databases
| Ensembli | ENST00000264933; ENSP00000264933; ENSG00000249915 [O75340-1] ENST00000505221; ENSP00000422085; ENSG00000249915 [O75340-3] ENST00000507528; ENSP00000423815; ENSG00000249915 [O75340-2] |
| GeneIDi | 10016 |
| KEGGi | hsa:10016 |
| UCSCi | uc003jat.1, human [O75340-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Web resourcesi
| Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
| Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF035606 mRNA Translation: AAC27697.1 U58773 mRNA Translation: AAF14336.1 AK315370 mRNA Translation: BAG37763.1 BT020072 mRNA Translation: AAV38875.1 AC010442 Genomic DNA No translation available. AC021087 Genomic DNA No translation available. AC118458 Genomic DNA No translation available. CH471235 Genomic DNA Translation: EAW50991.1 BC012384 mRNA Translation: AAH12384.1 BC106706 mRNA Translation: AAI06707.1 BC110291 mRNA Translation: AAI10292.1 CB991882 mRNA No translation available. |
| CCDSi | CCDS3854.1 [O75340-1] CCDS58940.1 [O75340-2] CCDS58941.1 [O75340-3] |
| RefSeqi | NP_001254485.1, NM_001267556.1 [O75340-2] NP_001254486.1, NM_001267557.1 NP_001254487.1, NM_001267558.1 NP_001254488.1, NM_001267559.1 [O75340-3] NP_037364.1, NM_013232.3 [O75340-1] |
3D structure databases
| Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
| 2ZN8 | X-ray | 2.70 | A | 2-191 | [»] | |
| 2ZN9 | X-ray | 2.40 | A/B | 20-191 | [»] | |
| 2ZND | X-ray | 1.70 | A | 20-191 | [»] | |
| 2ZNE | X-ray | 2.20 | A/B | 24-191 | [»] | |
| 2ZRS | X-ray | 3.10 | A/B/C/D/E/F/G/H | 24-191 | [»] | |
| 2ZRT | X-ray | 3.30 | A/B/C/D/E/F/G/H | 24-191 | [»] | |
| 3AAJ | X-ray | 2.40 | A/B | 24-191 | [»] | |
| 3AAK | X-ray | 2.70 | A | 20-191 | [»] | |
| 3WXA | X-ray | 2.36 | A/B | 20-191 | [»] | |
| 5GQQ | X-ray | 2.20 | C/D | 24-191 | [»] | |
| SMRi | O75340 | |||||
| ModBasei | Search... | |||||
| PDBe-KBi | Search... | |||||
Protein-protein interaction databases
| BioGRIDi | 115333, 148 interactors |
| CORUMi | O75340 |
| DIPi | DIP-33217N |
| ELMi | O75340 |
| IntActi | O75340, 77 interactors |
| MINTi | O75340 |
| STRINGi | 9606.ENSP00000264933 |
Chemistry databases
| ChEMBLi | CHEMBL4105994 |
| DrugBanki | DB01373, Calcium DB11093, Calcium citrate DB11348, Calcium Phosphate DB14481, Calcium phosphate dihydrate DB01593, Zinc DB14487, Zinc acetate |
Protein family/group databases
| TCDBi | 3.A.5.9.1, the general secretory pathway (sec) family |
PTM databases
| iPTMneti | O75340 |
| MetOSitei | O75340 |
| PhosphoSitePlusi | O75340 |
Polymorphism and mutation databases
| BioMutai | PDCD6 |
Proteomic databases
| EPDi | O75340 |
| jPOSTi | O75340 |
| MassIVEi | O75340 |
| MaxQBi | O75340 |
| PaxDbi | O75340 |
| PeptideAtlasi | O75340 |
| PRIDEi | O75340 |
| ProteomicsDBi | 18039 49909 [O75340-1] 61550 |
| TopDownProteomicsi | O75340-1 [O75340-1] |
Protocols and materials databases
| Antibodypediai | 36748, 304 antibodies |
| DNASUi | 10016 |
Genome annotation databases
| Ensembli | ENST00000264933; ENSP00000264933; ENSG00000249915 [O75340-1] ENST00000505221; ENSP00000422085; ENSG00000249915 [O75340-3] ENST00000507528; ENSP00000423815; ENSG00000249915 [O75340-2] |
| GeneIDi | 10016 |
| KEGGi | hsa:10016 |
| UCSCi | uc003jat.1, human [O75340-1] |
Organism-specific databases
| CTDi | 10016 |
| DisGeNETi | 10016 |
| EuPathDBi | HostDB:ENSG00000249915.7 |
| GeneCardsi | PDCD6 |
| HGNCi | HGNC:8765, PDCD6 |
| HPAi | ENSG00000249915, Low tissue specificity |
| MIMi | 601057, gene |
| neXtProti | NX_O75340 |
| OpenTargetsi | ENSG00000249915 |
| PharmGKBi | PA33115 |
| GenAtlasi | Search... |
Phylogenomic databases
| eggNOGi | KOG0037, Eukaryota |
| GeneTreei | ENSGT00940000160982 |
| HOGENOMi | CLU_051357_1_1_1 |
| InParanoidi | O75340 |
| OMAi | SREFLWD |
| PhylomeDBi | O75340 |
| TreeFami | TF314682 |
Enzyme and pathway databases
| PathwayCommonsi | O75340 |
Miscellaneous databases
| BioGRID-ORCSi | 10016, 267 hits in 843 CRISPR screens |
| EvolutionaryTracei | O75340 |
| GeneWikii | PDCD6 |
| GenomeRNAii | 10016 |
| Pharosi | O75340, Tbio |
| PROi | PR:O75340 |
| RNActi | O75340, protein |
| SOURCEi | Search... |
Gene expression databases
| Bgeei | ENSG00000249915, Expressed in endometrium epithelium and 237 other tissues |
| ExpressionAtlasi | O75340, baseline and differential |
| Genevisiblei | O75340, HS |
Family and domain databases
| InterProi | View protein in InterPro IPR011992, EF-hand-dom_pair IPR018247, EF_Hand_1_Ca_BS IPR002048, EF_hand_dom |
| Pfami | View protein in Pfam PF13202, EF-hand_5, 1 hit PF13499, EF-hand_7, 1 hit |
| SMARTi | View protein in SMART SM00054, EFh, 5 hits |
| SUPFAMi | SSF47473, SSF47473, 1 hit |
| PROSITEi | View protein in PROSITE PS00018, EF_HAND_1, 2 hits PS50222, EF_HAND_2, 3 hits |
| ProtoNeti | Search... |
| MobiDBi | Search... |
Entry informationi
| Entry namei | PDCD6_HUMAN | |
| Accessioni | O75340Primary (citable) accession number: O75340 Secondary accession number(s): B2RD16 Q5TZS0 | |
| Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 11, 2001 |
| Last sequence update: | November 1, 1998 | |
| Last modified: | December 2, 2020 | |
| This is version 194 of the entry and version 1 of the sequence. See complete history. | ||
| Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
| Annotation program | Chordata Protein Annotation Program | |
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 5
Human chromosome 5: entries, gene names and cross-references to MIM - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
