PDCD6

Functionⁱ

Calcium sensor that plays a key role in processes such as endoplasmic reticulum (ER)-Golgi vesicular transport, endosomal biogenesis or membrane repair. Acts as an adapter that bridges unrelated proteins or stabilizes weak protein-protein complexes in response to calcium: calcium-binding triggers exposure of apolar surface, promoting interaction with different sets of proteins thanks to 3 different hydrophobic pockets, leading to translocation to membranes (PubMed:20691033, PubMed:25667979). Involved in ER-Golgi transport by promoting the association between PDCD6IP and TSG101, thereby bridging together the ESCRT-III and ESCRT-I complexes (PubMed:19520058). Together with PEF1, acts as calcium-dependent adapter for the BCR(KLHL12) complex, a complex involved in ER-Golgi transport by regulating the size of COPII coats (PubMed:27716508). In response to cytosolic calcium increase, the heterodimer formed with PEF1 interacts with, and bridges together the BCR(KLHL12) complex and SEC31 (SEC31A or SEC31B), promoting monoubiquitination of SEC31 and subsequent collagen export, which is required for neural crest specification (PubMed:27716508). Involved in the regulation of the distribution and function of MCOLN1 in the endosomal pathway (PubMed:19864416). Promotes localization and polymerization of TFG at endoplasmic reticulum exit site (PubMed:27813252). Required for T-cell receptor-, Fas-, and glucocorticoid-induced apoptosis (By similarity). May mediate Ca²⁺-regulated signals along the death pathway: interaction with DAPK1 can accelerate apoptotic cell death by increasing caspase-3 activity (PubMed:16132846). Its role in apoptosis may however be indirect, as suggested by knockout experiments (By similarity). May inhibit KDR/VEGFR2-dependent angiogenesis; the function involves inhibition of VEGF-induced phosphorylation of the Akt signaling pathway (PubMed:21893193). In case of infection by HIV-1 virus, indirectly inhibits HIV-1 production by affecting viral Gag expression and distribution (PubMed:27784779).By similarity9 Publications

Isoform 2: Has a lower Ca²⁺ affinity than isoform 1 (By similarity).By similarity

Sites

Feature key	Position(s)	DescriptionActions	Length
Metal bindingⁱ	36	Calcium 14 Publications	1
Metal bindingⁱ	38	Calcium 14 Publications	1
Metal bindingⁱ	40	Calcium 14 Publications	1
Metal bindingⁱ	42	Calcium 1; via carbonyl oxygen4 Publications	1
Metal bindingⁱ	47	Calcium 14 Publications	1
Metal bindingⁱ	103	Calcium 24 Publications	1
Metal bindingⁱ	105	Calcium 24 Publications	1
Metal bindingⁱ	107	Calcium 24 Publications	1
Metal bindingⁱ	109	Calcium 2; via carbonyl oxygen4 Publications	1
Metal bindingⁱ	114	Calcium 24 Publications	1
Metal bindingⁱ	169	MagnesiumBy similarity	1
Metal bindingⁱ	171	MagnesiumBy similarity	1
Metal bindingⁱ	173	MagnesiumBy similarity	1
Metal bindingⁱ	175	Magnesium; via carbonyl oxygenBy similarity	1

Regions

Feature key	Position(s)	DescriptionActions	Length
Calcium bindingⁱ	36 – 47	14 PublicationsAdd BLAST	12
Calcium bindingⁱ	73 – 84	2PROSITE-ProRule annotationAdd BLAST	12
Calcium bindingⁱ	103 – 114	34 PublicationsAdd BLAST	12

GO - Molecular functionⁱ

calcium-dependent protein binding
Source: UniProtKB
Inferred from physical interactionⁱ
calcium ion binding
Source: UniProtKB
Inferred from direct assayⁱ
- 25667979
identical protein binding
Source: IntAct
Inferred from physical interactionⁱ
magnesium ion binding Source: UniProtKB
molecular adaptor activity
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 19520058
- 27716508
protein dimerization activity
Source: UniProtKB
Inferred from physical interactionⁱ
- 11883899
protein homodimerization activity
Source: UniProtKB
Inferred from direct assayⁱ
- 25667979
protein membrane anchor
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 16957052

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

activation of cysteine-type endopeptidase activity involved in apoptotic process Source: Ensembl
angiogenesis Source: UniProtKB-KW
apoptotic signaling pathway
Source: ProtInc
Traceable author statementⁱ
- 8560270
cellular response to heat
Source: UniProtKB
Inferred from direct assayⁱ
- 21122810
COPII vesicle coating
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 27716508
ER to Golgi vesicle-mediated transport
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 27716508
- 27813252
intracellular protein transport
Source: UniProtKB
Inferred from direct assayⁱ
- 21122810
negative regulation of protein kinase B signaling
Source: UniProtKB
Inferred from direct assayⁱ
- 21893193
negative regulation of TOR signaling
Source: UniProtKB
Inferred from direct assayⁱ
- 21893193
negative regulation of vascular endothelial growth factor receptor signaling pathway
Source: UniProtKB
Inferred from direct assayⁱ
- 21893193
neural crest cell development
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 27716508
neural crest formation
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 27716508
positive regulation of angiogenesis
Source: UniProtKB
Inferred from direct assayⁱ
- 21893193
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
Source: UniProtKB
Inferred from direct assayⁱ
- 16132846
positive regulation of endothelial cell migration
Source: UniProtKB
Inferred from direct assayⁱ
- 21893193
positive regulation of endothelial cell proliferation
Source: UniProtKB
Inferred from direct assayⁱ
- 21893193
positive regulation of protein monoubiquitination
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 27716508
response to calcium ion Source: UniProtKB
vascular endothelial growth factor receptor-2 signaling pathway
Source: UniProtKB
Inferred from direct assayⁱ
- 21893193

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Angiogenesis, Apoptosis
Ligand	Calcium, Magnesium, Metal-binding

Protein family/group databases

TCDBⁱ	3.A.5.9.1 the general secretory pathway (sec) family

TCDBⁱ

3.A.5.9.1 the general secretory pathway (sec) family

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Programmed cell death protein 6 Alternative name(s): Apoptosis-linked gene 2 protein homologBy similarity Short name: ALG-2By similarity
Gene namesⁱ	Name:PDCD6 Synonyms:ALG2By similarity
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 5

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000249915.7
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:8765 PDCD6
MIMⁱ	601057 gene
neXtProtⁱ	NX_O75340

Keywords - Cellular componentⁱ

Cytoplasm, Cytoplasmic vesicle, Endoplasmic reticulum, Endosome, Membrane, Nucleus

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	47	E → A: Loss of interaction with SEC31A and PLSCR3, and loss of localization to the endoplasmic reticulum; when associated with A-114. 3 Publications	1
Mutagenesisⁱ	52	L → A: Stronly impaired interaction with SEC31A. Slightly reduced interaction with PDCD6IP. 1 Publication	1
Mutagenesisⁱ	53	S → G: Slightly reduced interaction with SEC31A. Does not affect interaction with PDCD6IP. 1 Publication	1
Mutagenesisⁱ	57	W → A: Does not affect interaction with SEC31A. Reduces the interaction with HEBP2, PDCD6IP and ANXA7. 3 Publications	1
Mutagenesisⁱ	60	F → A: Abolishes the interaction with SEC31A, PDCD6IP, ANXA7 and ANXA11. 2 Publications	1
Mutagenesisⁱ	85	F → A: Stronly impaired interaction with SEC31A and TFG. Does not affect interaction with PDCD6IP. 2 Publications	1
Mutagenesisⁱ	89	W → A: Does not affect interaction with SEC31A. Does not affect interaction with PDCD6IP. 1 Publication	1
Mutagenesisⁱ	91	Y → A: Abolishes the interaction with PDCD6IP, ANXA7 and ANXA11. 1 Publication	1
Mutagenesisⁱ	92	I → A: Does not affect interaction with SEC31A. Does not affect interaction with PDCD6IP. 1 Publication	1
Mutagenesisⁱ	95	W → A: Abolishes the interaction with PDCD6IP, ANXA7 and ANXA11. 1 Publication	1
Mutagenesisⁱ	114	E → A: Loss of interaction with SEC31A and PLSCR3, and loss of localization to the endoplasmic reticulum; when associated with A-47. 2 Publications	1
Mutagenesisⁱ	122	F → A: Increases interaction with PDCD6IP and ANXA7. Impairs interaction with ANXA11. Augments stauroporine-induced cell death. 1 Publication	1
Mutagenesisⁱ	122	F → G: Increases interaction with PDCD6IP. Impairs interaction with ANXA11. 1 Publication	1
Mutagenesisⁱ	122	F → S: Increases interaction with PDCD6IP. Impairs interaction with ANAX7 and ANXA11. 1 Publication	1
Mutagenesisⁱ	122	F → W: Impairs interaction with ANXA11. 1 Publication	1
Mutagenesisⁱ	148	F → S: Slightly reduced interaction with SEC31A. Does not affect interaction with PDCD6IP. 1 Publication	1
Mutagenesisⁱ	180	Y → A: Abolishes the interaction with PDCD6IP, TSG101, ANXA7 and ANXA11. Does not affect interaction with TFG and SEC31A. 2 Publications	1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	10016
Open Targets More...OpenTargetsⁱ	ENSG00000249915
PharmGKBⁱ	PA33115

Polymorphism and mutation databases

BioMutaⁱ	PDCD6

BioMutaⁱ

PDCD6

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedCombined sources
ChainⁱPRO_0000073729	2 – 191	Programmed cell death protein 6Add BLAST		190

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	2	N-acetylalanineCombined sources		1

Keywords - PTMⁱ

Acetylation

Proteomic databases

EPDⁱ	O75340
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	O75340
PaxDbⁱ	O75340
PeptideAtlas More...PeptideAtlasⁱ	O75340
PRIDEⁱ	O75340
ProteomicsDBⁱ	49909
TopDownProteomicsⁱ	O75340-1 [O75340-1]

PTM databases

iPTMnetⁱ	O75340
PhosphoSitePlusⁱ	O75340

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000249915 Expressed in 225 organ(s), highest expression level in endometrium epithelium
CleanExⁱ	HS_ALG2 HS_PDCD6
ExpressionAtlasⁱ	O75340 baseline and differential
Genevisibleⁱ	O75340 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA047221

HPAⁱ

HPA047221

Interactionⁱ

Subunit structureⁱ

Homodimer and heterodimer; heterodimerizes (via the EF-hand 5) with PEF1 (PubMed:11278427, PubMed:11883899, PubMed:27784779). Isoform 1 and isoform 2 self-associate; probably forming homodimers. Interacts with CPNE4 (via VWFA domain) (By similarity). Interacts with PDCD6IP; the interaction is calcium-dependent (PubMed:16957052, PubMed:18256029, PubMed:18940611, PubMed:20691033, PubMed:25667979). Interacts with RBM22 (PubMed:17045351). Interacts with PLSCR4 (PubMed:18256029). Interacts with ANXA7 and TSG101 (PubMed:18256029, PubMed:20691033). Interacts with DAPK1 (PubMed:16132846). Interacts with SEC31A; the interaction is calcium-dependent and promotes monoubiquitination of SEC31A (PubMed:16957052, PubMed:18256029, PubMed:27716508, PubMed:25667979). Interacts with ANXA11 (via N-terminus); the interaction is calcium-dependent (PubMed:11883939, PubMed:18256029, PubMed:18940611). Interacts with PLSCR3 (via N-terminus); the interaction is calcium-dependent (PubMed:18256029). Interacts with MCOLN1; the interaction is calcium-dependent (PubMed:19864416). Interacts with KDR; the interaction is calcium-dependent (PubMed:21893193). Interacts with HEBP2; the interaction is calcium-dependent (PubMed:27784779). Interacts with TFG (PubMed:27813252). Isoform 1: Interacts with SHISA5, leading to stabilize it (PubMed:17889823). Isoform 2: Does not interact with SHISA5 (PubMed:17889823). Isoform 2: Does not interact with PDCD6IP, TSG101, ANXA7 and ANXA11 (PubMed:18256029, PubMed:20691033).By similarity16 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
itself		4	EBI-352915,EBI-352915
ANXA11	P50995	4	EBI-352915,EBI-715243
ANXA11	Q5T0G8	3	EBI-352915,EBI-10245225
DAPK1	P53355	3	EBI-352915,EBI-358616
DCTN2	Q13561	4	EBI-352915,EBI-715074
HEBP2	Q9Y5Z4	6	EBI-352915,EBI-741593
KDR	P35968	4	EBI-352915,EBI-1005487
PDCD6IP	Q8WUM4	11	EBI-352915,EBI-310624
PEF1	Q9UBV8	11	EBI-352915,EBI-724639
PLSCR3	Q9NRY6	9	EBI-352915,EBI-750734
PTPN23	Q9H3S7	3	EBI-352915,EBI-724478
SEC31A	O94979	6	EBI-352915,EBI-1767898
VPS37C	A5D8V6	5	EBI-352915,EBI-2559305

GO - Molecular functionⁱ

calcium-dependent protein binding
Source: UniProtKB
Inferred from physical interactionⁱ
identical protein binding
Source: IntAct
Inferred from physical interactionⁱ
protein dimerization activity
Source: UniProtKB
Inferred from physical interactionⁱ
- 11883899
protein homodimerization activity
Source: UniProtKB
Inferred from direct assayⁱ
- 25667979
protein membrane anchor
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 16957052

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	115333, 131 interactors
CORUMⁱ	O75340
Database of interacting proteins More...DIPⁱ	DIP-33217N
ELMⁱ	O75340
IntActⁱ	O75340, 64 interactors
Molecular INTeraction database More...MINTⁱ	O75340
STRINGⁱ	9606.ENSP00000264933

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	26 – 35	Combined sources	10
Beta strandⁱ	36 – 40	Combined sources	5
Beta strandⁱ	41 – 43	Combined sources	3
Helixⁱ	45 – 51	Combined sources	7
Beta strandⁱ	55 – 58	Combined sources	4
Helixⁱ	62 – 72	Combined sources	11
Beta strandⁱ	74 – 80	Combined sources	7
Helixⁱ	82 – 102	Combined sources	21
Beta strandⁱ	107 – 110	Combined sources	4
Helixⁱ	112 – 121	Combined sources	10
Helixⁱ	128 – 138	Combined sources	11
Beta strandⁱ	143 – 147	Combined sources	5
Helixⁱ	148 – 168	Combined sources	21
Beta strandⁱ	172 – 174	Combined sources	3
Helixⁱ	180 – 188	Combined sources	9

Show more details

3D structure databases

ProteinModelPortalⁱ	O75340
SMRⁱ	O75340
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	O75340

EvolutionaryTraceⁱ

O75340

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	23 – 58	EF-hand 1PROSITE-ProRule annotationAdd BLAST	36
Domainⁱ	59 – 89	EF-hand 2PROSITE-ProRule annotationAdd BLAST	31
Domainⁱ	90 – 125	EF-hand 3PROSITE-ProRule annotationAdd BLAST	36
Domainⁱ	126 – 161	EF-hand 4PROSITE-ProRule annotationAdd BLAST	36
Domainⁱ	162 – 191	EF-hand 5PROSITE-ProRule annotationAdd BLAST	30

Domainⁱ

Interacts with different set of proteins thanks to 3 different hydrophobic pockets (PubMed:20691033, PubMed:25667979). Hydrophobic pockets 1 and 2, which mediate interaction with PDCD6IP, are largely formed by residues from EF-hand 3 (EF3) to 5 (EF5), as well as by Tyr-180 (EF5) of a dimerizing molecule (Pocket 1) and from EF-hand (EF2) to 4 (EF4) (Pocket 2) (PubMed:20691033). Hydrophobic pocket 3, which mediates interaction with SEC31A, is mainly formed by residues from EF-hand 1 (EF1) to 3 (EF3) (PubMed:25667979).2 Publications

EF-hand 1 (EF1) and 3 (EF3) are the high-affinity calcium-binding sites, while EF-hand 5 (EF5) binds calcium with low-affinity (PubMed:18940611, PubMed:20691033). A one-residue insertion in the EF5-binding loop prevents the glutamyl residue at the C-terminal end of the loop from serving as the canonical bidentate calcium ligand (PubMed:18940611, PubMed:20691033). EF5 acts as a high-affinity magnesium-binding domain instead (By similarity). Magnesium, may affect dimerization (By similarity). EF5 may bind either calcium or magnesium depending on the context (By similarity).By similarity2 Publications

Keywords - Domainⁱ

Repeat

Phylogenomic databases

eggNOGⁱ	KOG0037 Eukaryota ENOG410YKQK LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00620000087734
HOGENOMⁱ	HOG000231984
HOVERGENⁱ	HBG004492
InParanoidⁱ	O75340
OMAⁱ	QCCIVLQ
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0ISY
PhylomeDBⁱ	O75340
TreeFamⁱ	TF314682

Family and domain databases

InterProⁱ	View protein in InterPro IPR011992 EF-hand-dom_pair IPR018247 EF_Hand_1_Ca_BS IPR002048 EF_hand_dom
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF13202 EF-hand_5, 1 hit PF13499 EF-hand_7, 1 hit
SMARTⁱ	View protein in SMART SM00054 EFh, 5 hits
SUPFAMⁱ	SSF47473 SSF47473, 1 hit
PROSITEⁱ	View protein in PROSITE PS00018 EF_HAND_1, 2 hits PS50222 EF_HAND_2, 3 hits

Sequences (3+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 3 described isoforms and 6 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: O75340-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAYSYRPGP GAGPGPAAGA ALPDQSFLWN VFQRVDKDRS GVISDTELQQ 
        60         70         80         90        100
ALSNGTWTPF NPVTVRSIIS MFDRENKAGV NFSEFTGVWK YITDWQNVFR 
       110        120        130        140        150
TYDRDNSGMI DKNELKQALS GFGYRLSDQF HDILIRKFDR QGRGQIAFDD 
       160        170        180        190 
FIQGCIVLQR LTDIFRRYDT DQDGWIQVSY EQYLSMVFSI V

Length:191

Mass (Da):21,868

Last modified:November 1, 1998 - v1

Checksum:ⁱD0B5944CF3C696AD

GO

Isoform 2 (identifier: O75340-2) [UniParc]FASTA Add to basket

Also known as: ALG-2(delta)GF122

The sequence of this isoform differs from the canonical sequence as follows:
121-122: Missing.

« Hide

        10         20         30         40         50
MAAYSYRPGP GAGPGPAAGA ALPDQSFLWN VFQRVDKDRS GVISDTELQQ 
        60         70         80         90        100
ALSNGTWTPF NPVTVRSIIS MFDRENKAGV NFSEFTGVWK YITDWQNVFR 
       110        120        130        140        150
TYDRDNSGMI DKNELKQALS GYRLSDQFHD ILIRKFDRQG RGQIAFDDFI 
       160        170        180 
QGCIVLQRLT DIFRRYDTDQ DGWIQVSYEQ YLSMVFSIV

Show »

Length:189

Mass (Da):21,664

Checksum:ⁱ8F93724C044DD93A

GO

Isoform 3 (identifier: O75340-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
70-191: Missing.

« Hide

        10         20         30         40         50
MAAYSYRPGP GAGPGPAAGA ALPDQSFLWN VFQRVDKDRS GVISDTELQQ 
        60 
ALSNGTWTPF NPVTVRSII

Note: No experimental confirmation available.

Show »

Length:69

Mass (Da):7,349

Checksum:ⁱ8410709B76C52B47

GO

Computationally mapped potential isoform sequencesⁱ

There are 6 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

A0A024QZ42	A0A024QZ42_HUMAN	HCG1985580, isoform CRA_c HCG1985580, isoform CRA_c (Programmed cell death protein 6)	PDCD6 hCG_1985580	121	Annotation score:
A0A087WZ38	A0A087WZ38_HUMAN	Programmed cell death protein 6 Programmed cell death protein 6	PDCD6	123	Annotation score:
H0Y9X3	H0Y9X3_HUMAN	Programmed cell death protein 6 Programmed cell death protein 6	PDCD6	104	Annotation score:
E7EPW6	E7EPW6_HUMAN	Programmed cell death protein 6 Programmed cell death protein 6	PDCD6	73	Annotation score:
Q86W51	Q86W51_HUMAN	PDCD6 protein PDCD6 protein (Programmed cell death protein 6)	PDCD6	55	Annotation score:
D6RA21	D6RA21_HUMAN	Programmed cell death protein 6 Programmed cell death protein 6	PDCD6	39	Annotation score:

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_035459	123	G → C in a breast cancer sample; somatic mutation. 1 Publication		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_045542	70 – 191	Missing in isoform 3. 1 PublicationAdd BLAST		122
Alternative sequenceⁱVSP_045113	121 – 122	Missing in isoform 2. 1 Publication		2

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF035606 mRNA Translation: AAC27697.1 U58773 mRNA Translation: AAF14336.1 AK315370 mRNA Translation: BAG37763.1 BT020072 mRNA Translation: AAV38875.1 AC010442 Genomic DNA No translation available. AC021087 Genomic DNA No translation available. AC118458 Genomic DNA No translation available. CH471235 Genomic DNA Translation: EAW50991.1 BC012384 mRNA Translation: AAH12384.1 BC106706 mRNA Translation: AAI06707.1 BC110291 mRNA Translation: AAI10292.1 CB991882 mRNA No translation available.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS3854.1 [O75340-1] CCDS58940.1 [O75340-2] CCDS58941.1 [O75340-3]
NCBI Reference Sequences More...RefSeqⁱ	NP_001254485.1, NM_001267556.1 [O75340-2] NP_001254486.1, NM_001267557.1 NP_001254487.1, NM_001267558.1 NP_001254488.1, NM_001267559.1 [O75340-3] NP_037364.1, NM_013232.3 [O75340-1]
UniGeneⁱ	Hs.50823

Genome annotation databases

Ensemblⁱ	ENST00000264933; ENSP00000264933; ENSG00000249915 [O75340-1] ENST00000505221; ENSP00000422085; ENSG00000249915 [O75340-3] ENST00000507528; ENSP00000423815; ENSG00000249915 [O75340-2]
GeneIDⁱ	10016
KEGGⁱ	hsa:10016
UCSC genome browser More...UCSCⁱ	uc003jat.1 human [O75340-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O75340	Aryl-hydrocarbon receptor repressor		MACMU		191	UniRef100_O75340
Uncharacterized protein		PONAB		191
Uncharacterized protein		PAPAN		191
Aryl-hydrocarbon receptor repressor		GORGO		191
Uncharacterized protein		MACFA		191
+4
O75340-2	Programmed cell death protein 6		MACMU		189	UniRef100_H9FNC2
UPI000CEF6724		PONAB		221
O75340-3	PDCD6 protein		HUMAN		55	UniRef100_Q86W51
PDCD6 isoform 5		PANTR		191
Uncharacterized protein		PANPA		121
Uncharacterized protein		MACMU		69
Uncharacterized protein		PAPAN		69
+16

Protein	Similar proteins		Species	Score	Length	Source
O75340	Programmed cell death protein 6		RAT		191	UniRef90_O75340
Programmed cell death protein 6	)	MOUSE		191
Aryl-hydrocarbon receptor repressor		MACMU		191
Uncharacterized protein		PONAB		191
Uncharacterized protein		PAPAN		191
+126

Protein	Similar proteins		Species	Score	Length	Source
O75340	Programmed cell death protein 6		RAT		191	UniRef50_O75340
Programmed cell death protein 6	)	MOUSE		191
Aryl-hydrocarbon receptor repressor		MACMU		191
Uncharacterized protein		PONAB		191
Uncharacterized protein		PAPAN		191
+218

Cross-referencesⁱ

Web resourcesⁱ

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF035606 mRNA Translation: AAC27697.1 U58773 mRNA Translation: AAF14336.1 AK315370 mRNA Translation: BAG37763.1 BT020072 mRNA Translation: AAV38875.1 AC010442 Genomic DNA No translation available. AC021087 Genomic DNA No translation available. AC118458 Genomic DNA No translation available. CH471235 Genomic DNA Translation: EAW50991.1 BC012384 mRNA Translation: AAH12384.1 BC106706 mRNA Translation: AAI06707.1 BC110291 mRNA Translation: AAI10292.1 CB991882 mRNA No translation available.
CCDSⁱ	CCDS3854.1 [O75340-1] CCDS58940.1 [O75340-2] CCDS58941.1 [O75340-3]
RefSeqⁱ	NP_001254485.1, NM_001267556.1 [O75340-2] NP_001254486.1, NM_001267557.1 NP_001254487.1, NM_001267558.1 NP_001254488.1, NM_001267559.1 [O75340-3] NP_037364.1, NM_013232.3 [O75340-1]
UniGeneⁱ	Hs.50823

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2ZN8	X-ray	2.70	A	2-191	[»]
	2ZN9	X-ray	2.40	A/B	20-191	[»]
	2ZND	X-ray	1.70	A	20-191	[»]
	2ZNE	X-ray	2.20	A/B	24-191	[»]
	2ZRS	X-ray	3.10	A/B/C/D/E/F/G/H	24-191	[»]
	2ZRT	X-ray	3.30	A/B/C/D/E/F/G/H	24-191	[»]
	3AAJ	X-ray	2.40	A/B	24-191	[»]
	3AAK	X-ray	2.70	A	20-191	[»]
	3WXA	X-ray	2.36	A/B	20-191	[»]
	5GQQ	X-ray	2.20	C/D	24-191	[»]
ProteinModelPortalⁱ	O75340
SMRⁱ	O75340
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	115333, 131 interactors
CORUMⁱ	O75340
DIPⁱ	DIP-33217N
ELMⁱ	O75340
IntActⁱ	O75340, 64 interactors
MINTⁱ	O75340
STRINGⁱ	9606.ENSP00000264933

Protein family/group databases

TCDBⁱ	3.A.5.9.1 the general secretory pathway (sec) family

TCDBⁱ

3.A.5.9.1 the general secretory pathway (sec) family

PTM databases

iPTMnetⁱ	O75340
PhosphoSitePlusⁱ	O75340

Polymorphism and mutation databases

BioMutaⁱ	PDCD6

BioMutaⁱ

PDCD6

Proteomic databases

EPDⁱ	O75340
MaxQBⁱ	O75340
PaxDbⁱ	O75340
PeptideAtlasⁱ	O75340
PRIDEⁱ	O75340
ProteomicsDBⁱ	49909
TopDownProteomicsⁱ	O75340-1 [O75340-1]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	10016
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000264933; ENSP00000264933; ENSG00000249915 [O75340-1] ENST00000505221; ENSP00000422085; ENSG00000249915 [O75340-3] ENST00000507528; ENSP00000423815; ENSG00000249915 [O75340-2]
GeneIDⁱ	10016
KEGGⁱ	hsa:10016
UCSCⁱ	uc003jat.1 human [O75340-1]

Organism-specific databases

CTDⁱ	10016
DisGeNETⁱ	10016
EuPathDBⁱ	HostDB:ENSG00000249915.7
GeneCardsⁱ	PDCD6
HGNCⁱ	HGNC:8765 PDCD6
HPAⁱ	HPA047221
MIMⁱ	601057 gene
neXtProtⁱ	NX_O75340
OpenTargetsⁱ	ENSG00000249915
PharmGKBⁱ	PA33115
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0037 Eukaryota ENOG410YKQK LUCA
GeneTreeⁱ	ENSGT00620000087734
HOGENOMⁱ	HOG000231984
HOVERGENⁱ	HBG004492
InParanoidⁱ	O75340
OMAⁱ	QCCIVLQ
OrthoDBⁱ	EOG091G0ISY
PhylomeDBⁱ	O75340
TreeFamⁱ	TF314682

Miscellaneous databases

ChiTaRSⁱ	PDCD6 human
EvolutionaryTraceⁱ	O75340
GeneWikiⁱ	PDCD6
GenomeRNAiⁱ	10016
Protein Ontology More...PROⁱ	PR:O75340
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000249915 Expressed in 225 organ(s), highest expression level in endometrium epithelium
CleanExⁱ	HS_ALG2 HS_PDCD6
ExpressionAtlasⁱ	O75340 baseline and differential
Genevisibleⁱ	O75340 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR011992 EF-hand-dom_pair IPR018247 EF_Hand_1_Ca_BS IPR002048 EF_hand_dom
Pfamⁱ	View protein in Pfam PF13202 EF-hand_5, 1 hit PF13499 EF-hand_7, 1 hit
SMARTⁱ	View protein in SMART SM00054 EFh, 5 hits
SUPFAMⁱ	SSF47473 SSF47473, 1 hit
PROSITEⁱ	View protein in PROSITE PS00018 EF_HAND_1, 2 hits PS50222 EF_HAND_2, 3 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	PDCD6_HUMAN
Accessionⁱ	O75340Primary (citable) accession number: O75340 Secondary accession number(s): B2RD16 , E7ESR3, Q2YDC2, Q5TZS0
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 11, 2001
	Last sequence update:	November 1, 1998
	Last modified:	November 7, 2018
	This is version 178 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 5
Human chromosome 5: entries, gene names and cross-references to MIM

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UniProtKB - O75340 (PDCD6_HUMAN)

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Programmed cell death protein 6

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

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GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ