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Protein

Cartilage intermediate layer protein 1

Gene

CILP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Probably plays a role in cartilage scaffolding. May act by antagonizing TGF-beta1 (TGFB1) and IGF1 functions. Has the ability to suppress IGF1-induced proliferation and sulfated proteoglycan synthesis, and inhibits ligand-induced IGF1R autophosphorylation. May inhibit TGFB1-mediated induction of cartilage matrix genes via its interaction with TGFB1. Overexpression may lead to impair chondrocyte growth and matrix repair and indirectly promote inorganic pyrophosphate (PPi) supersaturation in aging and osteoarthritis cartilage.2 Publications

Miscellaneous

Antibodies against CILP are detected in patients with early-stage knee osteoarthritis and rheumatoid arthritis.

Caution

Was originally thought to constitute the ATP pyrophosphatase enzyme (NTPPH). However, it was later shown (PubMed:12746903 and PubMed:15864306) that it is not the case.Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-2404192 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cartilage intermediate layer protein 1
Short name:
CILP-1
Alternative name(s):
Cartilage intermediate-layer protein
Cleaved into the following 2 chains:
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CILP
ORF Names:UNQ602/PRO1188
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000138615.5

Human Gene Nomenclature Database

More...
HGNCi
HGNC:1980 CILP

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
603489 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O75339

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Extracellular matrix, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Intervertebral disc disease (IDD)1 Publication
Disease susceptibility is associated with variations affecting the gene represented in this entry.1 Publication
Disease descriptionA common musculo-skeletal disorder caused by degeneration of intervertebral disks of the lumbar spine. It results in low-back pain and unilateral leg pain.
See also OMIM:603932

Organism-specific databases

DisGeNET

More...
DisGeNETi
8483

MalaCards human disease database

More...
MalaCardsi
CILP
MIMi603932 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000138615

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA26518

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CILP

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 21Sequence analysisAdd BLAST21
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001467122 – 1184Cartilage intermediate layer protein 1Add BLAST1163
ChainiPRO_000001467222 – ?724Cartilage intermediate layer protein 1 C1Add BLAST703
ChainiPRO_0000014673?725 – 1184Cartilage intermediate layer protein 1 C2Add BLAST460

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi129N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi132N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi161 ↔ 195By similarity
Disulfide bondi165 ↔ 200By similarity
Disulfide bondi177 ↔ 185By similarity
Disulfide bondi330 ↔ 376By similarity
Glycosylationi346N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi420N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi550N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi631N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1000N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1056N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Cleaved into 2 chains possibly by a furin-like protease upon or preceding secretion.

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
O75339

PeptideAtlas

More...
PeptideAtlasi
O75339

PRoteomics IDEntifications database

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PRIDEi
O75339

ProteomicsDB human proteome resource

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ProteomicsDBi
49908

PTM databases

GlyConnect protein glycosylation platform

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GlyConnecti
1075

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
O75339

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
O75339

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Specifically expressed in cartilage. Localizes in the intermediates layer of articular cartilage but neither in the superficial nor in the deepest regions. Specifically and highly expressed in intervertebral disk tissue. Expression increases with aging in hip articular cartilage. Overexpressed in articular hyaline cartilage from patients with calcium pyrophosphate dihydrate crystal deposition disease (CPPD). Expression in intervertebral disk tissue from individuals with lumbar disk disease increases as disk degeneration progresses.4 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000138615 Expressed in 162 organ(s), highest expression level in tendon of biceps brachii

CleanEx database of gene expression profiles

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CleanExi
HS_CILP

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
O75339 HS

Organism-specific databases

Human Protein Atlas

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HPAi
HPA003195

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer. Interacts with TGFB1.2 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
114057, 2 interactors

Protein interaction database and analysis system

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IntActi
O75339, 1 interactor

STRING: functional protein association networks

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STRINGi
9606.ENSP00000261883

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
O75339

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
O75339

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini149 – 201TSP type-1PROSITE-ProRule annotationAdd BLAST53
Domaini309 – 395Ig-like C2-typeAdd BLAST87

Keywords - Domaini

Immunoglobulin domain, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IJBD Eukaryota
ENOG410XXZR LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00390000008152

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000111676

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG081175

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
O75339

Identification of Orthologs from Complete Genome Data

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OMAi
VPQPYLN

Database of Orthologous Groups

More...
OrthoDBi
EOG091G010Q

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O75339

TreeFam database of animal gene trees

More...
TreeFami
TF330132

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.20.100.10, 1 hit
2.60.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR008969 CarboxyPept-like_regulatory
IPR039675 CILP1/CILP2
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR000884 TSP1_rpt
IPR036383 TSP1_rpt_sf
IPR025155 WxxW_domain

The PANTHER Classification System

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PANTHERi
PTHR15031 PTHR15031, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13330 Mucin2_WxxW, 1 hit
PF00090 TSP_1, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00409 IG, 1 hit
SM00408 IGc2, 1 hit
SM00209 TSP1, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48726 SSF48726, 1 hit
SSF49464 SSF49464, 1 hit
SSF82895 SSF82895, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS50092 TSP1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

O75339-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVGTKAWVFS FLVLEVTSVL GRQTMLTQSV RRVQPGKKNP SIFAKPADTL
60 70 80 90 100
ESPGEWTTWF NIDYPGGKGD YERLDAIRFY YGDRVCARPL RLEARTTDWT
110 120 130 140 150
PAGSTGQVVH GSPREGFWCL NREQRPGQNC SNYTVRFLCP PGSLRRDTER
160 170 180 190 200
IWSPWSPWSK CSAACGQTGV QTRTRICLAE MVSLCSEASE EGQHCMGQDC
210 220 230 240 250
TACDLTCPMG QVNADCDACM CQDFMLHGAV SLPGGAPASG AAIYLLTKTP
260 270 280 290 300
KLLTQTDSDG RFRIPGLCPD GKSILKITKV KFAPIVLTMP KTSLKAATIK
310 320 330 340 350
AEFVRAETPY MVMNPETKAR RAGQSVSLCC KATGKPRPDK YFWYHNDTLL
360 370 380 390 400
DPSLYKHESK LVLRKLQQHQ AGEYFCKAQS DAGAVKSKVA QLIVIASDET
410 420 430 440 450
PCNPVPESYL IRLPHDCFQN ATNSFYYDVG RCPVKTCAGQ QDNGIRCRDA
460 470 480 490 500
VQNCCGISKT EEREIQCSGY TLPTKVAKEC SCQRCTETRS IVRGRVSAAD
510 520 530 540 550
NGEPMRFGHV YMGNSRVSMT GYKGTFTLHV PQDTERLVLT FVDRLQKFVN
560 570 580 590 600
TTKVLPFNKK GSAVFHEIKM LRRKKPITLE AMETNIIPLG EVVGEDPMAE
610 620 630 640 650
LEIPSRSFYR QNGEPYIGKV KASVTFLDPR NISTATAAQT DLNFINDEGD
660 670 680 690 700
TFPLRTYGMF SVDFRDEVTS EPLNAGKVKV HLDSTQVKMP EHISTVKLWS
710 720 730 740 750
LNPDTGLWEE EGDFKFENQR RNKREDRTFL VGNLEIRERR LFNLDVPESR
760 770 780 790 800
RCFVKVRAYR SERFLPSEQI QGVVISVINL EPRTGFLSNP RAWGRFDSVI
810 820 830 840 850
TGPNGACVPA FCDDQSPDAY SAYVLASLAG EELQAVESSP KFNPNAIGVP
860 870 880 890 900
QPYLNKLNYR RTDHEDPRVK KTAFQISMAK PRPNSAEESN GPIYAFENLR
910 920 930 940 950
ACEEAPPSAA HFRFYQIEGD RYDYNTVPFN EDDPMSWTED YLAWWPKPME
960 970 980 990 1000
FRACYIKVKI VGPLEVNVRS RNMGGTHRQT VGKLYGIRDV RSTRDRDQPN
1010 1020 1030 1040 1050
VSAACLEFKC SGMLYDQDRV DRTLVKVIPQ GSCRRASVNP MLHEYLVNHL
1060 1070 1080 1090 1100
PLAVNNDTSE YTMLAPLDPL GHNYGIYTVT DQDPRTAKEI ALGRCFDGTS
1110 1120 1130 1140 1150
DGSSRIMKSN VGVALTFNCV ERQVGRQSAF QYLQSTPAQS PAAGTVQGRV
1160 1170 1180
PSRRQQRASR GGQRQGGVVA SLRFPRVAQQ PLIN
Length:1,184
Mass (Da):132,565
Last modified:January 11, 2011 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i190B0316404D3B84
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti54G → M AA sequence (PubMed:9722584).Curated1
Sequence conflicti288T → D AA sequence (PubMed:9722584).Curated1
Sequence conflicti305R → D AA sequence (PubMed:9722584).Curated1
Sequence conflicti347D → T AA sequence (PubMed:9722584).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02276859W → L3 PublicationsCorresponds to variant dbSNP:rs2585033Ensembl.1
Natural variantiVAR_022769327S → F1 Publication1
Natural variantiVAR_022770395I → T Common polymorphism; associated with susceptibility to lumbar disk disease in Japanese; increases binding and inhibition of TGFB1. 5 PublicationsCorresponds to variant dbSNP:rs2073711EnsemblClinVar.1
Natural variantiVAR_069430495R → H1 PublicationCorresponds to variant dbSNP:rs149286218Ensembl.1
Natural variantiVAR_022771575K → E6 PublicationsCorresponds to variant dbSNP:rs2679118Ensembl.1
Natural variantiVAR_022772895A → V1 PublicationCorresponds to variant dbSNP:rs771628304Ensembl.1
Natural variantiVAR_022773979Q → R6 PublicationsCorresponds to variant dbSNP:rs2679117Ensembl.1
Natural variantiVAR_0694311032S → T1 PublicationCorresponds to variant dbSNP:rs768702821Ensembl.1
Natural variantiVAR_0227741101D → N1 PublicationCorresponds to variant dbSNP:rs769023414Ensembl.1
Natural variantiVAR_0227751166G → S5 PublicationsCorresponds to variant dbSNP:rs938952Ensembl.1
Natural variantiVAR_0227761168V → A1 PublicationCorresponds to variant dbSNP:rs747702148Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF035408 mRNA Translation: AAC33838.1
AB022430 Genomic DNA Translation: BAA76692.1
AF035455
, AF035448, AF035451, AF035453, AF035449 Genomic DNA Translation: AAF14689.1
AY358904 mRNA Translation: AAQ89263.1
AK313352 mRNA Translation: BAG36154.1
AC068213 Genomic DNA No translation available.
BC035776 mRNA Translation: AAH35776.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS10203.1

Protein sequence database of the Protein Information Resource

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PIRi
T09484

NCBI Reference Sequences

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RefSeqi
NP_003604.3, NM_003613.3

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.442180

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000261883; ENSP00000261883; ENSG00000138615

Database of genes from NCBI RefSeq genomes

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GeneIDi
8483

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:8483

UCSC genome browser

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UCSCi
uc002aon.3 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF035408 mRNA Translation: AAC33838.1
AB022430 Genomic DNA Translation: BAA76692.1
AF035455
, AF035448, AF035451, AF035453, AF035449 Genomic DNA Translation: AAF14689.1
AY358904 mRNA Translation: AAQ89263.1
AK313352 mRNA Translation: BAG36154.1
AC068213 Genomic DNA No translation available.
BC035776 mRNA Translation: AAH35776.1
CCDSiCCDS10203.1
PIRiT09484
RefSeqiNP_003604.3, NM_003613.3
UniGeneiHs.442180

3D structure databases

ProteinModelPortaliO75339
SMRiO75339
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114057, 2 interactors
IntActiO75339, 1 interactor
STRINGi9606.ENSP00000261883

PTM databases

GlyConnecti1075
iPTMnetiO75339
PhosphoSitePlusiO75339

Polymorphism and mutation databases

BioMutaiCILP

Proteomic databases

PaxDbiO75339
PeptideAtlasiO75339
PRIDEiO75339
ProteomicsDBi49908

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
8483
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000261883; ENSP00000261883; ENSG00000138615
GeneIDi8483
KEGGihsa:8483
UCSCiuc002aon.3 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
8483
DisGeNETi8483
EuPathDBiHostDB:ENSG00000138615.5

GeneCards: human genes, protein and diseases

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GeneCardsi
CILP
HGNCiHGNC:1980 CILP
HPAiHPA003195
MalaCardsiCILP
MIMi603489 gene
603932 phenotype
neXtProtiNX_O75339
OpenTargetsiENSG00000138615
PharmGKBiPA26518

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IJBD Eukaryota
ENOG410XXZR LUCA
GeneTreeiENSGT00390000008152
HOGENOMiHOG000111676
HOVERGENiHBG081175
InParanoidiO75339
OMAiVPQPYLN
OrthoDBiEOG091G010Q
PhylomeDBiO75339
TreeFamiTF330132

Enzyme and pathway databases

ReactomeiR-HSA-2404192 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
CILP human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
CILP

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
8483

Protein Ontology

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PROi
PR:O75339

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000138615 Expressed in 162 organ(s), highest expression level in tendon of biceps brachii
CleanExiHS_CILP
GenevisibleiO75339 HS

Family and domain databases

Gene3Di2.20.100.10, 1 hit
2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR008969 CarboxyPept-like_regulatory
IPR039675 CILP1/CILP2
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR000884 TSP1_rpt
IPR036383 TSP1_rpt_sf
IPR025155 WxxW_domain
PANTHERiPTHR15031 PTHR15031, 1 hit
PfamiView protein in Pfam
PF13330 Mucin2_WxxW, 1 hit
PF00090 TSP_1, 1 hit
SMARTiView protein in SMART
SM00409 IG, 1 hit
SM00408 IGc2, 1 hit
SM00209 TSP1, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
SSF49464 SSF49464, 1 hit
SSF82895 SSF82895, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS50092 TSP1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCILP1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O75339
Secondary accession number(s): B2R8F7, Q6UW99, Q8IYI5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: January 11, 2011
Last modified: November 7, 2018
This is version 148 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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