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Protein

Liprin-alpha-4

Gene

PPFIA4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates (By similarity).By similarity

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-181429 Serotonin Neurotransmitter Release Cycle
R-HSA-181430 Norepinephrine Neurotransmitter Release Cycle
R-HSA-210500 Glutamate Neurotransmitter Release Cycle
R-HSA-212676 Dopamine Neurotransmitter Release Cycle
R-HSA-264642 Acetylcholine Neurotransmitter Release Cycle
R-HSA-388844 Receptor-type tyrosine-protein phosphatases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Liprin-alpha-4
Alternative name(s):
Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-4
Short name:
PTPRF-interacting protein alpha-4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PPFIA4
Synonyms:KIAA0897
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000143847.15

Human Gene Nomenclature Database

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HGNCi
HGNC:9248 PPFIA4

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
603145 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O75335

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
8497

Open Targets

More...
OpenTargetsi
ENSG00000143847

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA33569

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PPFIA4

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001910321 – 1185Liprin-alpha-4Add BLAST1185

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei640PhosphoserineBy similarity1
Modified residuei681PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
O75335

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O75335

PeptideAtlas

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PeptideAtlasi
O75335

PRoteomics IDEntifications database

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PRIDEi
O75335

ProteomicsDB human proteome resource

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ProteomicsDBi
49906
49907 [O75335-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O75335

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
O75335

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed only in the heart, brain, and skeletal muscle.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000143847 Expressed in 146 organ(s), highest expression level in right hemisphere of cerebellum

CleanEx database of gene expression profiles

More...
CleanExi
HS_PPFIA4

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
O75335 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O75335 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA053419
HPA054132

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Forms homodimers and heterodimers with liprins-alpha and liprins-beta. Interacts with the second PTPase domain of PTPRD, PTPRF and PTPRS. Binds RIMS1, RIMS2, GIT1, KIF1A and GRIP1 (By similarity).By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
114069, 4 interactors

Protein interaction database and analysis system

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IntActi
O75335, 3 interactors

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
O75335

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
O75335

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini829 – 895SAM 1PROSITE-ProRule annotationAdd BLAST67
Domaini944 – 1008SAM 2PROSITE-ProRule annotationAdd BLAST65
Domaini1032 – 1101SAM 3PROSITE-ProRule annotationAdd BLAST70

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili24 – 123Sequence analysisAdd BLAST100
Coiled coili165 – 499Sequence analysisAdd BLAST335

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The N-terminal coiled coil regions mediate homodimerization preferentially and heterodimerization type alpha/alpha. The C-terminal, non-coiled coil regions mediate heterodimerization type alpha/beta and interaction with PTPRD, PTPRF and PTPRS (By similarity).By similarity

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the liprin family. Liprin-alpha subfamily.Curated

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153628

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000017513

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG052330

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O75335

TreeFam database of animal gene trees

More...
TreeFami
TF314207

Family and domain databases

Conserved Domains Database

More...
CDDi
cd09562 SAM_liprin-alpha1_2_3_4_repeat, 1 hit
cd09565 SAM_liprin-alpha1_2_3_4_repeat, 1 hit
cd09568 SAM_liprin-alpha1_2_3_4_repeat, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029515 Liprin
IPR037620 Liprin-alpha_SAM_rpt_1
IPR037621 Liprin-alpha_SAM_rpt_2
IPR037622 Liprin-alpha_SAM_rpt_3
IPR030439 PPFIA4
IPR001660 SAM
IPR013761 SAM/pointed_sf

The PANTHER Classification System

More...
PANTHERi
PTHR12587 PTHR12587, 1 hit
PTHR12587:SF5 PTHR12587:SF5, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00536 SAM_1, 2 hits
PF07647 SAM_2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00454 SAM, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47769 SSF47769, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50105 SAM_DOMAIN, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 3 (identifier: O75335-3) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MCEVMPTINE GDRLGPPHGA DADANFEQLM VNMLDEREKL LESLRESQET
60 70 80 90 100
LAATQSRLQD AIHERDQLQR HLNSALPQEF ATLTRELSMC REQLLEREEE
110 120 130 140 150
ISELKAERNN TRLLLEHLEC LVSRHERSLR MTVVKRQAQS PSGVSSEVEV
160 170 180 190 200
LKALKSLFEH HKALDEKVRE RLRAALERVT TLEEQLAGAH QQVSALQQGA
210 220 230 240 250
GVRDGAAEEE GTVELGPKRL WKEDTGRVEE LQELLEKQNF ELSQARERLV
260 270 280 290 300
TLTTTVTELE EDLGTARRDL IKSEELSSKH QRDLREALAQ KEDMEERITT
310 320 330 340 350
LEKRYLAAQR EATSIHDLND KLENELANKE SLHRQCEEKA RHLQELLEVA
360 370 380 390 400
EQKLQQTMRK AETLPEVEAE LAQRIAALTK AEERHGNIEE HLRQLEGQLE
410 420 430 440 450
EKNQELARTA VQVRQREKMN EDHNKRLSDT VDRLLSESNE RLQLHLKERM
460 470 480 490 500
AALEEKNTLI QELESSQRQI EEQHHHKGRL SEEIEKLRQE VDQLKGRGGP
510 520 530 540 550
FVDGVHSRSH MGSAADVRFS LGTTTHAPPG VHRRYSALRE ESAKLALPLT
560 570 580 590 600
VTLRSPTWMR MSQGVCCNLE YHSSGTLCGS SGPLPVPEMI QEEKESTELR
610 620 630 640 650
AEEIETRVTS GSMEALNLKQ LRKRGSIPTS LTALSLASAS PPLSGRSTPK
660 670 680 690 700
LTSRSAAQDL DRMGVMTLPS DLRKHRRKLL SPVSREENRE DKATIKCETS
710 720 730 740 750
PPSSPRTLRL EKLGHPALSQ EEGKSALEDQ GSNPSSSNSS QDSLHKGAKR
760 770 780 790 800
KGIKSSIGRL FGKKEKGRLI QLSRDGATGH VLLTDSEFSM QEPMVPAKLG
810 820 830 840 850
TQAEKDRRLK KKHQLLEDAR RKGMPFAQWD GPTVVSWLEL WVGMPAWYVA
860 870 880 890 900
ACRANVKSGA IMSALSDTEI QREIGISNAL HRLKLRLAIQ EMVSLTSPSA
910 920 930 940 950
PPTSRTSSGN VWVTHEEMET LETSTKTDSE EGSWAQTLAY GDMNHEWIGN
960 970 980 990 1000
EWLPSLGLPQ YRSYFMECLV DARMLDHLTK KDLRVHLKMV DSFHRTSLQY
1010 1020 1030 1040 1050
GIMCLKRLNY DRKELEKRRE ESQHEIKDVL VWTNDQVVHW VQSIGLRDYA
1060 1070 1080 1090 1100
GNLHESGVHG ALLALDENFD HNTLALILQI PTQNTQARQV MEREFNNLLA
1110 1120 1130 1140 1150
LGTDRKLDDG DDKVFRRAPS WRKRFRPREH HGRGGMLSAS AETLPAGFRV
1160 1170 1180
STLGTLQPPP APPKKIMPEA HSHYLYGHML SAFRD
Length:1,185
Mass (Da):134,404
Last modified:February 19, 2014 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0DD1431820D2313E
GO
Isoform 1 (identifier: O75335-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-510: Missing.
     545-588: LALPLTVTLR...GSSGPLPVPE → DWETSPLPGM...QLDAINEEIR

Show »
Length:701
Mass (Da):78,078
Checksum:iC35D54A8719A16FC
GO
Isoform 2 (identifier: O75335-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-510: Missing.
     545-588: LALPLTVTLR...GSSGPLPVPE → DWETSPLPGM...QLDAINEEIR
     928-936: Missing.

Note: No experimental confirmation available.
Show »
Length:692
Mass (Da):77,088
Checksum:i06995B02FADD56B4
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B1APN9B1APN9_HUMAN
Liprin-alpha-4
PPFIA4
1,186Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QZB5M0QZB5_HUMAN
Liprin-alpha-4
PPFIA4
953Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R219M0R219_HUMAN
Liprin-alpha-4
PPFIA4
191Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti803A → S in AAI44263 (PubMed:16710414).Curated1
Sequence conflicti1134G → A in AAC26102 (PubMed:9624153).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0536681 – 510Missing in isoform 1 and isoform 2. 4 PublicationsAdd BLAST510
Alternative sequenceiVSP_053669545 – 588LALPL…LPVPE → DWETSPLPGMLAPAAGPAFD SDPEISDVDEDEPGGLVGSA DVVSPSGHSDAQTLAMMLQE QLDAINEEIR in isoform 1 and isoform 2. 4 PublicationsAdd BLAST44
Alternative sequenceiVSP_053670928 – 936Missing in isoform 2. 2 Publications9

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
EF428334 mRNA Translation: ABR09268.1
AK126624 mRNA Translation: BAC86617.1
AC096632 Genomic DNA No translation available.
AC105940 Genomic DNA No translation available.
AL451082 Genomic DNA No translation available.
BC132923 mRNA Translation: AAI32924.1
BC132925 mRNA Translation: AAI32926.1
BC144262 mRNA Translation: AAI44263.1
AF034801 mRNA Translation: AAC26102.1
AB020704 mRNA Translation: BAA74920.1

NCBI Reference Sequences

More...
RefSeqi
NP_001291260.1, NM_001304331.1
NP_001291261.1, NM_001304332.1

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.153648
Hs.730047

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000272198; ENSP00000272198; ENSG00000143847 [O75335-1]
ENST00000295706; ENSP00000295706; ENSG00000143847 [O75335-2]
ENST00000447715; ENSP00000402576; ENSG00000143847 [O75335-3]
ENST00000599966; ENSP00000471264; ENSG00000143847 [O75335-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
8497

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:8497

UCSC genome browser

More...
UCSCi
uc001gyz.3 human [O75335-3]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF428334 mRNA Translation: ABR09268.1
AK126624 mRNA Translation: BAC86617.1
AC096632 Genomic DNA No translation available.
AC105940 Genomic DNA No translation available.
AL451082 Genomic DNA No translation available.
BC132923 mRNA Translation: AAI32924.1
BC132925 mRNA Translation: AAI32926.1
BC144262 mRNA Translation: AAI44263.1
AF034801 mRNA Translation: AAC26102.1
AB020704 mRNA Translation: BAA74920.1
RefSeqiNP_001291260.1, NM_001304331.1
NP_001291261.1, NM_001304332.1
UniGeneiHs.153648
Hs.730047

3D structure databases

ProteinModelPortaliO75335
SMRiO75335
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114069, 4 interactors
IntActiO75335, 3 interactors

PTM databases

iPTMnetiO75335
PhosphoSitePlusiO75335

Polymorphism and mutation databases

BioMutaiPPFIA4

Proteomic databases

EPDiO75335
MaxQBiO75335
PeptideAtlasiO75335
PRIDEiO75335
ProteomicsDBi49906
49907 [O75335-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000272198; ENSP00000272198; ENSG00000143847 [O75335-1]
ENST00000295706; ENSP00000295706; ENSG00000143847 [O75335-2]
ENST00000447715; ENSP00000402576; ENSG00000143847 [O75335-3]
ENST00000599966; ENSP00000471264; ENSG00000143847 [O75335-2]
GeneIDi8497
KEGGihsa:8497
UCSCiuc001gyz.3 human [O75335-3]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
8497
DisGeNETi8497
EuPathDBiHostDB:ENSG00000143847.15

GeneCards: human genes, protein and diseases

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GeneCardsi
PPFIA4
HGNCiHGNC:9248 PPFIA4
HPAiHPA053419
HPA054132
MIMi603145 gene
neXtProtiNX_O75335
OpenTargetsiENSG00000143847
PharmGKBiPA33569

Human Unidentified Gene-Encoded large proteins database

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HUGEi
Search...

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

GeneTreeiENSGT00940000153628
HOGENOMiHOG000017513
HOVERGENiHBG052330
InParanoidiO75335
TreeFamiTF314207

Enzyme and pathway databases

ReactomeiR-HSA-181429 Serotonin Neurotransmitter Release Cycle
R-HSA-181430 Norepinephrine Neurotransmitter Release Cycle
R-HSA-210500 Glutamate Neurotransmitter Release Cycle
R-HSA-212676 Dopamine Neurotransmitter Release Cycle
R-HSA-264642 Acetylcholine Neurotransmitter Release Cycle
R-HSA-388844 Receptor-type tyrosine-protein phosphatases

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
PPFIA4 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
PPFIA4

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
8497

Protein Ontology

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PROi
PR:O75335

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000143847 Expressed in 146 organ(s), highest expression level in right hemisphere of cerebellum
CleanExiHS_PPFIA4
ExpressionAtlasiO75335 baseline and differential
GenevisibleiO75335 HS

Family and domain databases

CDDicd09562 SAM_liprin-alpha1_2_3_4_repeat, 1 hit
cd09565 SAM_liprin-alpha1_2_3_4_repeat, 1 hit
cd09568 SAM_liprin-alpha1_2_3_4_repeat, 1 hit
InterProiView protein in InterPro
IPR029515 Liprin
IPR037620 Liprin-alpha_SAM_rpt_1
IPR037621 Liprin-alpha_SAM_rpt_2
IPR037622 Liprin-alpha_SAM_rpt_3
IPR030439 PPFIA4
IPR001660 SAM
IPR013761 SAM/pointed_sf
PANTHERiPTHR12587 PTHR12587, 1 hit
PTHR12587:SF5 PTHR12587:SF5, 1 hit
PfamiView protein in Pfam
PF00536 SAM_1, 2 hits
PF07647 SAM_2, 1 hit
SMARTiView protein in SMART
SM00454 SAM, 3 hits
SUPFAMiSSF47769 SSF47769, 3 hits
PROSITEiView protein in PROSITE
PS50105 SAM_DOMAIN, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLIPA4_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O75335
Secondary accession number(s): A2RUJ5
, B1APN8, B1N949, B7ZM43, O94971
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 16, 2004
Last sequence update: February 19, 2014
Last modified: December 5, 2018
This is version 142 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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