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Entry version 151 (08 May 2019)
Sequence version 2 (13 Jun 2012)
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Protein

Liprin-alpha-2

Gene

PPFIA2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Alters PTPRF cellular localization and induces PTPRF clustering. May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-181429 Serotonin Neurotransmitter Release Cycle
R-HSA-181430 Norepinephrine Neurotransmitter Release Cycle
R-HSA-210500 Glutamate Neurotransmitter Release Cycle
R-HSA-212676 Dopamine Neurotransmitter Release Cycle
R-HSA-264642 Acetylcholine Neurotransmitter Release Cycle
R-HSA-388844 Receptor-type tyrosine-protein phosphatases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Liprin-alpha-2
Alternative name(s):
Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-2
Short name:
PTPRF-interacting protein alpha-2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PPFIA2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:9246 PPFIA2

Online Mendelian Inheritance in Man (OMIM)

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MIMi
603143 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O75334

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
8499

Open Targets

More...
OpenTargetsi
ENSG00000139220

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA33567

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PPFIA2

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001910271 – 1257Liprin-alpha-2Add BLAST1257

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei236PhosphoserineBy similarity1
Modified residuei237PhosphothreonineBy similarity1
Modified residuei239PhosphoserineBy similarity1
Modified residuei687PhosphoserineBy similarity1
Modified residuei689PhosphoserineBy similarity1
Modified residuei817PhosphoserineBy similarity1
Modified residuei820PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
O75334

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
O75334

MaxQB - The MaxQuant DataBase

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MaxQBi
O75334

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O75334

PeptideAtlas

More...
PeptideAtlasi
O75334

PRoteomics IDEntifications database

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PRIDEi
O75334

ProteomicsDB human proteome resource

More...
ProteomicsDBi
49902
49903 [O75334-2]
49904 [O75334-3]
49905 [O75334-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O75334

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
O75334

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed only in brain.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000139220 Expressed in 139 organ(s), highest expression level in corpus callosum

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
O75334 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
O75334 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Forms homodimers and heterodimers with liprins-alpha and liprins-beta. Interacts with the second PTPase domain of PTPRD, PTPRF and PTPRS.1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
114071, 16 interactors

Protein interaction database and analysis system

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IntActi
O75334, 3 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000450337

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11257
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3TACX-ray2.20B866-1193[»]
3TADX-ray2.90A/B866-1193[»]
6IUHX-ray1.80C/D642-671[»]

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O75334

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini898 – 964SAM 1PROSITE-ProRule annotationAdd BLAST67
Domaini1020 – 1084SAM 2PROSITE-ProRule annotationAdd BLAST65
Domaini1108 – 1177SAM 3PROSITE-ProRule annotationAdd BLAST70

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili29 – 154Sequence analysisAdd BLAST126
Coiled coili185 – 541Sequence analysisAdd BLAST357
Coiled coili643 – 695Sequence analysisAdd BLAST53
Coiled coili1081 – 1107Sequence analysisAdd BLAST27

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi115 – 528Glu-richAdd BLAST414
Compositional biasi622 – 627Poly-Asp6

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The N-terminal coiled coil regions mediate homodimerization preferentially and heterodimerization type alpha/alpha. The C-terminal, non-coiled coil regions mediate heterodimerization type alpha/beta and interaction with PTPRD, PTPRF and PTPRS.

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the liprin family. Liprin-alpha subfamily.Curated

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0249 Eukaryota
ENOG410XP8Z LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00950000182675

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000017513

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O75334

Identification of Orthologs from Complete Genome Data

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OMAi
ATADMMS

Database of Orthologous Groups

More...
OrthoDBi
440941at2759

TreeFam database of animal gene trees

More...
TreeFami
TF314207

Family and domain databases

Conserved Domains Database

More...
CDDi
cd09562 SAM_liprin-alpha1_2_3_4_repeat, 1 hit
cd09565 SAM_liprin-alpha1_2_3_4_repeat, 1 hit
cd09568 SAM_liprin-alpha1_2_3_4_repeat, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029515 Liprin
IPR037620 Liprin-alpha_SAM_rpt_1
IPR037621 Liprin-alpha_SAM_rpt_2
IPR037622 Liprin-alpha_SAM_rpt_3
IPR030441 PPFIA2
IPR001660 SAM
IPR013761 SAM/pointed_sf

The PANTHER Classification System

More...
PANTHERi
PTHR12587 PTHR12587, 1 hit
PTHR12587:SF6 PTHR12587:SF6, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00536 SAM_1, 2 hits
PF07647 SAM_2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00454 SAM, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47769 SSF47769, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50105 SAM_DOMAIN, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (8+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 8 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 8 described isoforms and 10 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O75334-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MMCEVMPTIN EDTPMSQRGS QSSGSDSDSH FEQLMVNMLD ERDRLLDTLR
60 70 80 90 100
ETQESLSLAQ QRLQDVIYDR DSLQRQLNSA LPQDIESLTG GLAGSKGADP
110 120 130 140 150
PEFAALTKEL NACREQLLEK EEEISELKAE RNNTRLLLEH LECLVSRHER
160 170 180 190 200
SLRMTVVKRQ AQSPSGVSSE VEVLKALKSL FEHHKALDEK VRERLRVSLE
210 220 230 240 250
RVSALEEELA AANQEIVALR EQNVHIQRKM ASSEGSTESE HLEGMEPGQK
260 270 280 290 300
VHEKRLSNGS IDSTDETSQI VELQELLEKQ NYEMAQMKER LAALSSRVGE
310 320 330 340 350
VEQEAETARK DLIKTEEMNT KYQRDIREAM AQKEDMEERI TTLEKRYLSA
360 370 380 390 400
QRESTSIHDM NDKLENELAN KEAILRQMEE KNRQLQERLE LAEQKLQQTM
410 420 430 440 450
RKAETLPEVE AELAQRIAAL TKAEERHGNI EERMRHLEGQ LEEKNQELQR
460 470 480 490 500
ARQREKMNEE HNKRLSDTVD RLLTESNERL QLHLKERMAA LEEKNVLIQE
510 520 530 540 550
SETFRKNLEE SLHDKERLAE EIEKLRSELD QLKMRTGSLI EPTIPRTHLD
560 570 580 590 600
TSAELRYSVG SLVDSQSDYR TTKVIRRPRR GRMGVRRDEP KVKSLGDHEW
610 620 630 640 650
NRTQQIGVLS SHPFESDTEM SDIDDDDRET IFSSMDLLSP SGHSDAQTLA
660 670 680 690 700
MMLQEQLDAI NKEIRLIQEE KESTELRAEE IENRVASVSL EGLNLARVHP
710 720 730 740 750
GTSITASVTA SSLASSSPPS GHSTPKLTPR SPAREMDRMG VMTLPSDLRK
760 770 780 790 800
HRRKIAVVEE DGREDKATIK CETSPPPTPR ALRMTHTLPS SYHNDARSSL
810 820 830 840 850
SVSLEPESLG LGSANSSQDS LHKAPKKKGI KSSIGRLFGK KEKARLGQLR
860 870 880 890 900
GFMETEAAAQ ESLGLGKLGT QAEKDRRLKK KHELLEEARR KGLPFAQWDG
910 920 930 940 950
PTVVAWLELW LGMPAWYVAA CRANVKSGAI MSALSDTEIQ REIGISNPLH
960 970 980 990 1000
RLKLRLAIQE MVSLTSPSAP PTSRTPSGNV WVTHEEMENL AAPAKTKESE
1010 1020 1030 1040 1050
EGSWAQCPVF LQTLAYGDMN HEWIGNEWLP SLGLPQYRSY FMECLVDARM
1060 1070 1080 1090 1100
LDHLTKKDLR VHLKMVDSFH RTSLQYGIMC LKRLNYDRKE LERRREASQH
1110 1120 1130 1140 1150
EIKDVLVWSN DRVIRWIQAI GLREYANNIL ESGVHGSLIA LDENFDYSSL
1160 1170 1180 1190 1200
ALLLQIPTQN TQARQILERE YNNLLALGTE RRLDESDDKN FRRGSTWRRQ
1210 1220 1230 1240 1250
FPPREVHGIS MMPGSSETLP AGFRLTTTSG QSRKMTTDVA SSRLQRLDNS

TVRTYSC
Length:1,257
Mass (Da):143,291
Last modified:June 13, 2012 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBD77601F444EEE10
GO
Isoform 2 (identifier: O75334-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     84-101: Missing.
     881-881: K → NTSG
     1239-1257: VASSRLQRLDNSTVRTYSC → DGVFSVYST

Show »
Length:1,232
Mass (Da):140,673
Checksum:i8A789850F4E1E605
GO
Isoform 3 (identifier: O75334-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1007-1012: Missing.

Show »
Length:1,251
Mass (Da):142,603
Checksum:i18169E6210D89CE5
GO
Isoform 4 (identifier: O75334-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     976-996: Missing.

Show »
Length:1,236
Mass (Da):141,027
Checksum:i27D95B02136893F6
GO
Isoform 5 (identifier: O75334-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-74: Missing.
     75-101: RQLNSALPQDIESLTGGLAGSKGADPP → MIFSDMNTVSGSPKVHPPNGTRFYTFQ
     976-996: Missing.
     1007-1012: Missing.

Note: No experimental confirmation available.
Show »
Length:1,156
Mass (Da):132,170
Checksum:iF276981E4A68B4DF
GO
Isoform 6 (identifier: O75334-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-74: Missing.
     75-101: RQLNSALPQDIESLTGGLAGSKGADPP → MIFSDMNTVSGSPKVHPPNGTRFYTFQ
     191-215: Missing.
     1007-1012: Missing.

Note: No experimental confirmation available.
Show »
Length:1,152
Mass (Da):131,584
Checksum:iEDBA76B39345FEE0
GO
Isoform 7 (identifier: O75334-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-433: Missing.
     976-1006: Missing.
     1239-1257: VASSRLQRLDNSTVRTYSC → DGVFSVYST

Note: No experimental confirmation available.
Show »
Length:783
Mass (Da):89,059
Checksum:iEB9A77B8B3279111
GO
Isoform 8 (identifier: O75334-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-783: Missing.
     976-1006: Missing.

Note: No experimental confirmation available.
Show »
Length:443
Mass (Da):50,251
Checksum:iA666F2024D2AA5C6
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3V200G3V200_HUMAN
Liprin-alpha-2
PPFIA2
1,247Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YHK3H0YHK3_HUMAN
Liprin-alpha-2
PPFIA2
1,104Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VYK7F8VYK7_HUMAN
Liprin-alpha-2
PPFIA2
265Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YH95H0YH95_HUMAN
Liprin-alpha-2
PPFIA2
284Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VU88F8VU88_HUMAN
Liprin-alpha-2
PPFIA2
121Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8W1Y8F8W1Y8_HUMAN
Liprin-alpha-2
PPFIA2
124Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VWG6F8VWG6_HUMAN
Liprin-alpha-2
PPFIA2
81Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VWR9F8VWR9_HUMAN
Liprin-alpha-2
PPFIA2
147Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YIJ4H0YIJ4_HUMAN
Liprin-alpha-2
PPFIA2
188Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YHJ4H0YHJ4_HUMAN
Liprin-alpha-2
PPFIA2
188Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti394Q → E in AAC26100 (PubMed:9624153).Curated1
Sequence conflicti426R → T in AAC26100 (PubMed:9624153).Curated1
Sequence conflicti517R → S in AAC26100 (PubMed:9624153).Curated1
Sequence conflicti523E → G in BAH11792 (PubMed:14702039).Curated1
Sequence conflicti697R → M in AAC26100 (PubMed:9624153).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0467181 – 783Missing in isoform 8. 1 PublicationAdd BLAST783
Alternative sequenceiVSP_0467191 – 433Missing in isoform 7. 1 PublicationAdd BLAST433
Alternative sequenceiVSP_0467201 – 74Missing in isoform 5 and isoform 6. 1 PublicationAdd BLAST74
Alternative sequenceiVSP_04672175 – 101RQLNS…GADPP → MIFSDMNTVSGSPKVHPPNG TRFYTFQ in isoform 5 and isoform 6. 1 PublicationAdd BLAST27
Alternative sequenceiVSP_04381984 – 101Missing in isoform 2. 1 PublicationAdd BLAST18
Alternative sequenceiVSP_046722191 – 215Missing in isoform 6. 1 PublicationAdd BLAST25
Alternative sequenceiVSP_043820881K → NTSG in isoform 2. 1 Publication1
Alternative sequenceiVSP_046723976 – 1006Missing in isoform 7 and isoform 8. 1 PublicationAdd BLAST31
Alternative sequenceiVSP_043821976 – 996Missing in isoform 4 and isoform 5. 2 PublicationsAdd BLAST21
Alternative sequenceiVSP_0438221007 – 1012Missing in isoform 3, isoform 5 and isoform 6. 2 Publications6
Alternative sequenceiVSP_0438231239 – 1257VASSR…RTYSC → DGVFSVYST in isoform 2 and isoform 7. 1 PublicationAdd BLAST19

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF034799 mRNA Translation: AAC26100.1
AK123372 mRNA Translation: BAG53897.1
AK126971 mRNA Translation: BAG54412.1
AK294505 mRNA Translation: BAH11792.1
AK296380 mRNA Translation: BAH12335.1
AK299853 mRNA Translation: BAH13149.1
AC011316 Genomic DNA No translation available.
AC069228 Genomic DNA No translation available.
AC078920 Genomic DNA No translation available.
AC079363 Genomic DNA No translation available.
AC079408 Genomic DNA No translation available.
BC104912 mRNA Translation: AAI04913.1
BC143485 mRNA Translation: AAI43486.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS55850.1 [O75334-8]
CCDS55851.1 [O75334-7]
CCDS55852.1 [O75334-6]
CCDS55853.1 [O75334-5]
CCDS55854.1 [O75334-2]
CCDS55855.1 [O75334-4]
CCDS55856.1 [O75334-3]
CCDS55857.1 [O75334-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001207403.1, NM_001220474.2 [O75334-2]
NP_001207404.1, NM_001220475.2 [O75334-4]
NP_001207405.1, NM_001220476.2 [O75334-3]
NP_001207406.1, NM_001220477.2 [O75334-5]
NP_001207407.1, NM_001220478.2 [O75334-6]
NP_001207408.1, NM_001220479.2 [O75334-7]
NP_001207409.1, NM_001220480.2 [O75334-8]
NP_003616.2, NM_003625.4 [O75334-1]
XP_016875569.1, XM_017020080.1 [O75334-1]
XP_016875571.1, XM_017020082.1 [O75334-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000333447; ENSP00000327416; ENSG00000139220 [O75334-6]
ENST00000407050; ENSP00000385093; ENSG00000139220 [O75334-5]
ENST00000443686; ENSP00000388373; ENSG00000139220 [O75334-6]
ENST00000541017; ENSP00000445532; ENSG00000139220 [O75334-8]
ENST00000541570; ENSP00000438337; ENSG00000139220 [O75334-7]
ENST00000548586; ENSP00000449338; ENSG00000139220 [O75334-3]
ENST00000549325; ENSP00000450298; ENSG00000139220 [O75334-2]
ENST00000549396; ENSP00000450337; ENSG00000139220 [O75334-1]
ENST00000552948; ENSP00000447868; ENSG00000139220 [O75334-4]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
8499

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:8499

UCSC genome browser

More...
UCSCi
uc058rjg.1 human [O75334-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF034799 mRNA Translation: AAC26100.1
AK123372 mRNA Translation: BAG53897.1
AK126971 mRNA Translation: BAG54412.1
AK294505 mRNA Translation: BAH11792.1
AK296380 mRNA Translation: BAH12335.1
AK299853 mRNA Translation: BAH13149.1
AC011316 Genomic DNA No translation available.
AC069228 Genomic DNA No translation available.
AC078920 Genomic DNA No translation available.
AC079363 Genomic DNA No translation available.
AC079408 Genomic DNA No translation available.
BC104912 mRNA Translation: AAI04913.1
BC143485 mRNA Translation: AAI43486.1
CCDSiCCDS55850.1 [O75334-8]
CCDS55851.1 [O75334-7]
CCDS55852.1 [O75334-6]
CCDS55853.1 [O75334-5]
CCDS55854.1 [O75334-2]
CCDS55855.1 [O75334-4]
CCDS55856.1 [O75334-3]
CCDS55857.1 [O75334-1]
RefSeqiNP_001207403.1, NM_001220474.2 [O75334-2]
NP_001207404.1, NM_001220475.2 [O75334-4]
NP_001207405.1, NM_001220476.2 [O75334-3]
NP_001207406.1, NM_001220477.2 [O75334-5]
NP_001207407.1, NM_001220478.2 [O75334-6]
NP_001207408.1, NM_001220479.2 [O75334-7]
NP_001207409.1, NM_001220480.2 [O75334-8]
NP_003616.2, NM_003625.4 [O75334-1]
XP_016875569.1, XM_017020080.1 [O75334-1]
XP_016875571.1, XM_017020082.1 [O75334-3]

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3TACX-ray2.20B866-1193[»]
3TADX-ray2.90A/B866-1193[»]
6IUHX-ray1.80C/D642-671[»]
SMRiO75334
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114071, 16 interactors
IntActiO75334, 3 interactors
STRINGi9606.ENSP00000450337

PTM databases

iPTMnetiO75334
PhosphoSitePlusiO75334

Polymorphism and mutation databases

BioMutaiPPFIA2

Proteomic databases

EPDiO75334
jPOSTiO75334
MaxQBiO75334
PaxDbiO75334
PeptideAtlasiO75334
PRIDEiO75334
ProteomicsDBi49902
49903 [O75334-2]
49904 [O75334-3]
49905 [O75334-4]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000333447; ENSP00000327416; ENSG00000139220 [O75334-6]
ENST00000407050; ENSP00000385093; ENSG00000139220 [O75334-5]
ENST00000443686; ENSP00000388373; ENSG00000139220 [O75334-6]
ENST00000541017; ENSP00000445532; ENSG00000139220 [O75334-8]
ENST00000541570; ENSP00000438337; ENSG00000139220 [O75334-7]
ENST00000548586; ENSP00000449338; ENSG00000139220 [O75334-3]
ENST00000549325; ENSP00000450298; ENSG00000139220 [O75334-2]
ENST00000549396; ENSP00000450337; ENSG00000139220 [O75334-1]
ENST00000552948; ENSP00000447868; ENSG00000139220 [O75334-4]
GeneIDi8499
KEGGihsa:8499
UCSCiuc058rjg.1 human [O75334-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
8499
DisGeNETi8499

GeneCards: human genes, protein and diseases

More...
GeneCardsi
PPFIA2

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0010857
HGNCiHGNC:9246 PPFIA2
MIMi603143 gene
neXtProtiNX_O75334
OpenTargetsiENSG00000139220
PharmGKBiPA33567

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0249 Eukaryota
ENOG410XP8Z LUCA
GeneTreeiENSGT00950000182675
HOGENOMiHOG000017513
InParanoidiO75334
OMAiATADMMS
OrthoDBi440941at2759
TreeFamiTF314207

Enzyme and pathway databases

ReactomeiR-HSA-181429 Serotonin Neurotransmitter Release Cycle
R-HSA-181430 Norepinephrine Neurotransmitter Release Cycle
R-HSA-210500 Glutamate Neurotransmitter Release Cycle
R-HSA-212676 Dopamine Neurotransmitter Release Cycle
R-HSA-264642 Acetylcholine Neurotransmitter Release Cycle
R-HSA-388844 Receptor-type tyrosine-protein phosphatases

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
PPFIA2 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
8499

Protein Ontology

More...
PROi
PR:O75334

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000139220 Expressed in 139 organ(s), highest expression level in corpus callosum
ExpressionAtlasiO75334 baseline and differential
GenevisibleiO75334 HS

Family and domain databases

CDDicd09562 SAM_liprin-alpha1_2_3_4_repeat, 1 hit
cd09565 SAM_liprin-alpha1_2_3_4_repeat, 1 hit
cd09568 SAM_liprin-alpha1_2_3_4_repeat, 1 hit
InterProiView protein in InterPro
IPR029515 Liprin
IPR037620 Liprin-alpha_SAM_rpt_1
IPR037621 Liprin-alpha_SAM_rpt_2
IPR037622 Liprin-alpha_SAM_rpt_3
IPR030441 PPFIA2
IPR001660 SAM
IPR013761 SAM/pointed_sf
PANTHERiPTHR12587 PTHR12587, 1 hit
PTHR12587:SF6 PTHR12587:SF6, 1 hit
PfamiView protein in Pfam
PF00536 SAM_1, 2 hits
PF07647 SAM_2, 1 hit
SMARTiView protein in SMART
SM00454 SAM, 3 hits
SUPFAMiSSF47769 SSF47769, 3 hits
PROSITEiView protein in PROSITE
PS50105 SAM_DOMAIN, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLIPA2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O75334
Secondary accession number(s): B3KVT5
, B3KXA0, B7Z2A6, B7Z3U9, B7Z663, B7ZKZ5, E7ERB8, E7ETG6, F8VP68, Q2M3G8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 16, 2004
Last sequence update: June 13, 2012
Last modified: May 8, 2019
This is version 151 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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