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UniProtKB - O75330 (HMMR_HUMAN)

Protein

Hyaluronan mediated motility receptor

Gene

HMMR

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor for hyaluronic acid (HA) (By similarity). Involved in cell motility (By similarity). When hyaluronan binds to HMMR, the phosphorylation of a number of proteins, including PTK2/FAK1 occurs. May also be involved in cellular transformation and metastasis formation, and in regulating extracellular-regulated kinase (ERK) activity. May act as a regulator of adipogenisis (By similarity).By similarity

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

LigandHyaluronic acid

Enzyme and pathway databases

ReactomeiR-HSA-2160916 Hyaluronan uptake and degradation
R-HSA-8854518 AURKA Activation by TPX2

Protein family/group databases

MoonDBiO75330 Curated

Names & Taxonomyi

Protein namesi
Recommended name:
Hyaluronan mediated motility receptor
Alternative name(s):
Intracellular hyaluronic acid-binding protein
Receptor for hyaluronan-mediated motility
CD_antigen: CD168
Gene namesi
Name:HMMR
Synonyms:IHABP, RHAMM
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000072571.19
HGNCiHGNC:5012 HMMR
MIMi600936 gene
neXtProtiNX_O75330

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi3161
MalaCardsiHMMR
OpenTargetsiENSG00000072571
PharmGKBiPA29340

Chemistry databases

DrugBankiDB08818 Hyaluronic acid

Polymorphism and mutation databases

BioMutaiHMMR

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000840071 – 724Hyaluronan mediated motility receptorAdd BLAST724

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei20PhosphoserineCombined sources1
Glycosylationi133N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi477N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi567N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi588N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei703PhosphothreonineCombined sources1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiO75330
MaxQBiO75330
PaxDbiO75330
PeptideAtlasiO75330
PRIDEiO75330
ProteomicsDBi49897
49898 [O75330-2]
49899 [O75330-3]
49900 [O75330-4]

2D gel databases

REPRODUCTION-2DPAGEiO75330

PTM databases

iPTMnetiO75330
PhosphoSitePlusiO75330

Expressioni

Tissue specificityi

Expressed in breast cancer cell lines and in normal breast tissue.

Gene expression databases

BgeeiENSG00000072571 Expressed in 143 organ(s), highest expression level in sperm
CleanExiHS_HMMR
ExpressionAtlasiO75330 baseline and differential
GenevisibleiO75330 HS

Organism-specific databases

HPAiCAB002433
HPA040025
HPA043926
HPA061524

Interactioni

Subunit structurei

Subunit of the HARC complex. Interacts with ANKRD26 (PubMed:22666460).By similarity1 Publication

Binary interactionsi

Protein-protein interaction databases

BioGridi109404, 52 interactors
CORUMiO75330
DIPiDIP-56496N
IntActiO75330, 30 interactors
MINTiO75330
STRINGi9606.ENSP00000377492

Structurei

3D structure databases

ProteinModelPortaliO75330
SMRiO75330
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni635 – 645Hyaluronic acid-bindingSequence analysisAdd BLAST11
Regioni657 – 666Hyaluronic acid-bindingSequence analysis10

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IJ28 Eukaryota
ENOG4111G1K LUCA
GeneTreeiENSGT00390000007135
HOVERGENiHBG044411
InParanoidiO75330
KOiK06267
OMAiSMMAKQE
OrthoDBiEOG091G03MO
PhylomeDBiO75330
TreeFamiTF333963

Family and domain databases

InterProiView protein in InterPro
IPR031794 HMMR_C
IPR031787 HMMR_N
IPR026203 IHABP
PANTHERiPTHR18956 PTHR18956, 2 hits
PfamiView protein in Pfam
PF15908 HMMR_C, 1 hit
PF15905 HMMR_N, 1 hit

Sequences (4+)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O75330-1) [UniParc]FASTAAdd to basket
Also known as: A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSFPKAPLKR FNDPSGCAPS PGAYDVKTLE VLKGPVSFQK SQRFKQQKES 
        60         70         80         90        100
KQNLNVDKDT TLPASARKVK SSESKESQKN DKDLKILEKE IRVLLQERGA 
       110        120        130        140        150
QDRRIQDLET ELEKMEARLN AALREKTSLS ANNATLEKQL IELTRTNELL 
       160        170        180        190        200
KSKFSENGNQ KNLRILSLEL MKLRNKRETK MRGMMAKQEG MEMKLQVTQR 
       210        220        230        240        250
SLEESQGKIA QLEGKLVSIE KEKIDEKSET EKLLEYIEEI SCASDQVEKY 
       260        270        280        290        300
KLDIAQLEEN LKEKNDEILS LKQSLEENIV ILSKQVEDLN VKCQLLEKEK 
       310        320        330        340        350
EDHVNRNREH NENLNAEMQN LKQKFILEQQ EREKLQQKEL QIDSLLQQEK 
       360        370        380        390        400
ELSSSLHQKL CSFQEEMVKE KNLFEEELKQ TLDELDKLQQ KEEQAERLVK 
       410        420        430        440        450
QLEEEAKSRA EELKLLEEKL KGKEAELEKS SAAHTQATLL LQEKYDSMVQ 
       460        470        480        490        500
SLEDVTAQFE SYKALTASEI EDLKLENSSL QEKAAKAGKN AEDVQHQILA 
       510        520        530        540        550
TESSNQEYVR MLLDLQTKSA LKETEIKEIT VSFLQKITDL QNQLKQQEED 
       560        570        580        590        600
FRKQLEDEEG RKAEKENTTA ELTEEINKWR LLYEELYNKT KPFQLQLDAF 
       610        620        630        640        650
EVEKQALLNE HGAAQEQLNK IRDSYAKLLG HQNLKQKIKH VVKLKDENSQ 
       660        670        680        690        700
LKSEVSKLRC QLAKKKQSET KLQEELNKVL GIKHFDPSKA FHHESKENFA 
       710        720 
LKTPLKEGNT NCYRAPMECQ ESWK
Length:724
Mass (Da):84,100
Last modified:April 17, 2007 - v2
Checksum:iF2C3C0DBA863955F
GO
Isoform 2 (identifier: O75330-2) [UniParc]FASTAAdd to basket
Also known as: B

The sequence of this isoform differs from the canonical sequence as follows:
     76-90: Missing.

Show »
Length:709
Mass (Da):82,301
Checksum:i29E7F070B99FD30C
GO
Isoform 3 (identifier: O75330-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     75-75: K → KK

Show »
Length:725
Mass (Da):84,229
Checksum:i2515512EEDFB1DA1
GO
Isoform 4 (identifier: O75330-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-90: MSFPKAPLKR...DKDLKILEKE → MTLL

Show »
Length:638
Mass (Da):74,495
Checksum:iBFD153D3EC20FE5D
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E5RIH2E5RIH2_HUMAN
Hyaluronan mediated motility recept...
HMMR
92Annotation score:
E5RI30E5RI30_HUMAN
Hyaluronan mediated motility recept...
HMMR
101Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti103R → S in AAC32548 (PubMed:9601098).Curated1
Sequence conflicti277E → D in AAC52049 (PubMed:8890751).Curated1
Sequence conflicti298K → T in AAC52049 (PubMed:8890751).Curated1
Sequence conflicti322K → E in AAC52049 (PubMed:8890751).Curated1
Sequence conflicti330 – 332QER → REH in AAC52049 (PubMed:8890751).Curated3
Sequence conflicti547Q → R in BAF83266 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02415592R → C1 PublicationCorresponds to variant dbSNP:rs299284Ensembl.1
Natural variantiVAR_031661305N → K. Corresponds to variant dbSNP:rs2303077Ensembl.1
Natural variantiVAR_056917320N → K. Corresponds to variant dbSNP:rs2303077Ensembl.1
Natural variantiVAR_024156332R → H. Corresponds to variant dbSNP:rs2303078Ensembl.1
Natural variantiVAR_020044368V → A2 PublicationsCorresponds to variant dbSNP:rs299290Ensembl.1
Natural variantiVAR_024157484A → V2 PublicationsCorresponds to variant dbSNP:rs299295Ensembl.1
Natural variantiVAR_056918557D → H. Corresponds to variant dbSNP:rs2230362Ensembl.1
Natural variantiVAR_056919595L → I. Corresponds to variant dbSNP:rs2230363Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0412661 – 90MSFPK…ILEKE → MTLL in isoform 4. 1 PublicationAdd BLAST90
Alternative sequenceiVSP_03837875K → KK in isoform 3. 2 Publications1
Alternative sequenceiVSP_00428676 – 90Missing in isoform 2. 1 PublicationAdd BLAST15

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U29343 mRNA Translation: AAC52049.1
AF032862 mRNA Translation: AAC32548.1
AK290577 mRNA Translation: BAF83266.1
AK303616 mRNA Translation: BAG64626.1
AC112205 Genomic DNA No translation available.
CH471062 Genomic DNA Translation: EAW61522.1
CH471062 Genomic DNA Translation: EAW61523.1
CH471062 Genomic DNA Translation: EAW61524.1
CH471062 Genomic DNA Translation: EAW61525.1
BC108904 mRNA Translation: AAI08905.1
CCDSiCCDS4362.1 [O75330-1]
CCDS4363.1 [O75330-2]
CCDS47334.1 [O75330-3]
CCDS47335.1 [O75330-4]
PIRiJC5016
RefSeqiNP_001136028.1, NM_001142556.1 [O75330-3]
NP_001136029.1, NM_001142557.1 [O75330-4]
NP_036616.2, NM_012484.2 [O75330-1]
NP_036617.2, NM_012485.2 [O75330-2]
UniGeneiHs.740467

Genome annotation databases

EnsembliENST00000353866; ENSP00000185942; ENSG00000072571 [O75330-2]
ENST00000358715; ENSP00000351554; ENSG00000072571 [O75330-1]
ENST00000393915; ENSP00000377492; ENSG00000072571 [O75330-3]
ENST00000432118; ENSP00000402673; ENSG00000072571 [O75330-4]
GeneIDi3161
KEGGihsa:3161
UCSCiuc003lzf.5 human [O75330-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U29343 mRNA Translation: AAC52049.1
AF032862 mRNA Translation: AAC32548.1
AK290577 mRNA Translation: BAF83266.1
AK303616 mRNA Translation: BAG64626.1
AC112205 Genomic DNA No translation available.
CH471062 Genomic DNA Translation: EAW61522.1
CH471062 Genomic DNA Translation: EAW61523.1
CH471062 Genomic DNA Translation: EAW61524.1
CH471062 Genomic DNA Translation: EAW61525.1
BC108904 mRNA Translation: AAI08905.1
CCDSiCCDS4362.1 [O75330-1]
CCDS4363.1 [O75330-2]
CCDS47334.1 [O75330-3]
CCDS47335.1 [O75330-4]
PIRiJC5016
RefSeqiNP_001136028.1, NM_001142556.1 [O75330-3]
NP_001136029.1, NM_001142557.1 [O75330-4]
NP_036616.2, NM_012484.2 [O75330-1]
NP_036617.2, NM_012485.2 [O75330-2]
UniGeneiHs.740467

3D structure databases

ProteinModelPortaliO75330
SMRiO75330
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109404, 52 interactors
CORUMiO75330
DIPiDIP-56496N
IntActiO75330, 30 interactors
MINTiO75330
STRINGi9606.ENSP00000377492

Chemistry databases

DrugBankiDB08818 Hyaluronic acid

Protein family/group databases

MoonDBiO75330 Curated

PTM databases

iPTMnetiO75330
PhosphoSitePlusiO75330

Polymorphism and mutation databases

BioMutaiHMMR

2D gel databases

REPRODUCTION-2DPAGEiO75330

Proteomic databases

EPDiO75330
MaxQBiO75330
PaxDbiO75330
PeptideAtlasiO75330
PRIDEiO75330
ProteomicsDBi49897
49898 [O75330-2]
49899 [O75330-3]
49900 [O75330-4]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000353866; ENSP00000185942; ENSG00000072571 [O75330-2]
ENST00000358715; ENSP00000351554; ENSG00000072571 [O75330-1]
ENST00000393915; ENSP00000377492; ENSG00000072571 [O75330-3]
ENST00000432118; ENSP00000402673; ENSG00000072571 [O75330-4]
GeneIDi3161
KEGGihsa:3161
UCSCiuc003lzf.5 human [O75330-1]

Organism-specific databases

CTDi3161
DisGeNETi3161
EuPathDBiHostDB:ENSG00000072571.19
GeneCardsiHMMR
H-InvDBiHIX0032412
HGNCiHGNC:5012 HMMR
HPAiCAB002433
HPA040025
HPA043926
HPA061524
MalaCardsiHMMR
MIMi600936 gene
neXtProtiNX_O75330
OpenTargetsiENSG00000072571
PharmGKBiPA29340
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJ28 Eukaryota
ENOG4111G1K LUCA
GeneTreeiENSGT00390000007135
HOVERGENiHBG044411
InParanoidiO75330
KOiK06267
OMAiSMMAKQE
OrthoDBiEOG091G03MO
PhylomeDBiO75330
TreeFamiTF333963

Enzyme and pathway databases

ReactomeiR-HSA-2160916 Hyaluronan uptake and degradation
R-HSA-8854518 AURKA Activation by TPX2

Miscellaneous databases

GeneWikiiHyaluronan-mediated_motility_receptor
GenomeRNAii3161
PROiPR:O75330
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000072571 Expressed in 143 organ(s), highest expression level in sperm
CleanExiHS_HMMR
ExpressionAtlasiO75330 baseline and differential
GenevisibleiO75330 HS

Family and domain databases

InterProiView protein in InterPro
IPR031794 HMMR_C
IPR031787 HMMR_N
IPR026203 IHABP
PANTHERiPTHR18956 PTHR18956, 2 hits
PfamiView protein in Pfam
PF15908 HMMR_C, 1 hit
PF15905 HMMR_N, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHMMR_HUMAN
AccessioniPrimary (citable) accession number: O75330
Secondary accession number(s): A8K3G2
, B4E114, D3DQK9, D3DQL0, E9PCS0, Q32N02, Q92767
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: April 17, 2007
Last modified: November 7, 2018
This is version 159 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  5. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
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