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UniProtKB - O75330 (HMMR_HUMAN)

Entry version 179 (25 May 2022)
Sequence version 2 (17 Apr 2007)
Previous versions | rss
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Protein

Hyaluronan mediated motility receptor

Gene

HMMR

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Receptor for hyaluronic acid (HA) (By similarity).

Involved in cell motility (By similarity).

When hyaluronan binds to HMMR, the phosphorylation of a number of proteins, including PTK2/FAK1 occurs. May also be involved in cellular transformation and metastasis formation, and in regulating extracellular-regulated kinase (ERK) activity. May act as a regulator of adipogenisis (By similarity).

By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandHyaluronic acid

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		O75330

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-2160916, Hyaluronan uptake and degradation
R-HSA-8854518, AURKA Activation by TPX2

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		O75330

Protein family/group databases

MoonDB Database of extreme multifunctional and moonlighting proteins

More...MoonDBi		O75330, Curated

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Hyaluronan mediated motility receptor
Alternative name(s):
Intracellular hyaluronic acid-binding protein
Receptor for hyaluronan-mediated motility
CD_antigen: CD168
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:HMMR
Synonyms:IHABP, RHAMM
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:5012, HMMR

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		600936, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_O75330

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000072571

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		3161

MalaCards human disease database

More...MalaCardsi		HMMR

Open Targets

More...OpenTargetsi		ENSG00000072571

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA29340

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		O75330, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL4295676

Drug and drug target database

More...DrugBanki		DB08818, Hyaluronic acid

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		HMMR

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000840071 – 724Hyaluronan mediated motility receptorAdd BLAST724

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei20PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi133N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi477N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi567N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi588N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei703PhosphothreonineCombined sources1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		O75330

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		O75330

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		O75330

MaxQB - The MaxQuant DataBase

More...MaxQBi		O75330

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O75330

PeptideAtlas

More...PeptideAtlasi		O75330

PRoteomics IDEntifications database

More...PRIDEi		O75330

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		49897 [O75330-1]
49898 [O75330-2]
49899 [O75330-3]
49900 [O75330-4]

2D gel databases

REPRODUCTION-2DPAGE

More...REPRODUCTION-2DPAGEi		O75330

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		O75330, 5 sites, 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		O75330

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		O75330

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in testis (PubMed:22965910). Expressed in the breast (PubMed:8890751).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000072571, Expressed in sperm and 158 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		O75330, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		O75330, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000072571, Tissue enhanced (bone marrow, lymphoid tissue, testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with ANKRD26 (PubMed:22666460).

Interacts with DYNLL1 (PubMed:22965910).

Interacts with FAM83D/CHICA (PubMed:22965910).

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		109404, 91 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		O75330

Database of interacting proteins

More...DIPi		DIP-56496N

Protein interaction database and analysis system

More...IntActi		O75330, 62 interactors

Molecular INTeraction database

More...MINTi		O75330

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000377492

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		O75330

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		O75330, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		O75330

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		O75330

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 22DisorderedSequence analysisAdd BLAST22
Regioni40 – 81DisorderedSequence analysisAdd BLAST42
Regioni365 – 546Required for interaction with FAM83D1 PublicationAdd BLAST182
Regioni635 – 645Hyaluronic acid-bindingSequence analysisAdd BLAST11
Regioni657 – 666Hyaluronic acid-bindingSequence analysis10

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QQJM, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000007135

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_009698_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O75330

Identification of Orthologs from Complete Genome Data

More...OMAi		MKSMMAK

Database of Orthologous Groups

More...OrthoDBi		604725at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		O75330

TreeFam database of animal gene trees

More...TreeFami		TF333963

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR031794, HMMR_C
IPR026203, IHABP

The PANTHER Classification System

More...PANTHERi		PTHR18956, PTHR18956, 2 hits

Pfam protein domain database

More...Pfami		View protein in Pfam
PF15908, HMMR_C, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O75330-1) [UniParc]FASTAAdd to basket
Also known as: A

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSFPKAPLKR FNDPSGCAPS PGAYDVKTLE VLKGPVSFQK SQRFKQQKES 
        60         70         80         90        100
KQNLNVDKDT TLPASARKVK SSESKESQKN DKDLKILEKE IRVLLQERGA 
       110        120        130        140        150
QDRRIQDLET ELEKMEARLN AALREKTSLS ANNATLEKQL IELTRTNELL 
       160        170        180        190        200
KSKFSENGNQ KNLRILSLEL MKLRNKRETK MRGMMAKQEG MEMKLQVTQR 
       210        220        230        240        250
SLEESQGKIA QLEGKLVSIE KEKIDEKSET EKLLEYIEEI SCASDQVEKY 
       260        270        280        290        300
KLDIAQLEEN LKEKNDEILS LKQSLEENIV ILSKQVEDLN VKCQLLEKEK 
       310        320        330        340        350
EDHVNRNREH NENLNAEMQN LKQKFILEQQ EREKLQQKEL QIDSLLQQEK 
       360        370        380        390        400
ELSSSLHQKL CSFQEEMVKE KNLFEEELKQ TLDELDKLQQ KEEQAERLVK 
       410        420        430        440        450
QLEEEAKSRA EELKLLEEKL KGKEAELEKS SAAHTQATLL LQEKYDSMVQ 
       460        470        480        490        500
SLEDVTAQFE SYKALTASEI EDLKLENSSL QEKAAKAGKN AEDVQHQILA 
       510        520        530        540        550
TESSNQEYVR MLLDLQTKSA LKETEIKEIT VSFLQKITDL QNQLKQQEED 
       560        570        580        590        600
FRKQLEDEEG RKAEKENTTA ELTEEINKWR LLYEELYNKT KPFQLQLDAF 
       610        620        630        640        650
EVEKQALLNE HGAAQEQLNK IRDSYAKLLG HQNLKQKIKH VVKLKDENSQ 
       660        670        680        690        700
LKSEVSKLRC QLAKKKQSET KLQEELNKVL GIKHFDPSKA FHHESKENFA 
       710        720 
LKTPLKEGNT NCYRAPMECQ ESWK
Length:724
Mass (Da):84,100
Last modified:April 17, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF2C3C0DBA863955F
GO
Isoform 2 (identifier: O75330-2) [UniParc]FASTAAdd to basket
Also known as: B

The sequence of this isoform differs from the canonical sequence as follows:
     76-90: Missing.

Show »
Length:709
Mass (Da):82,301
Checksum:i29E7F070B99FD30C
GO
Isoform 3 (identifier: O75330-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     75-75: K → KK

Show »
Length:725
Mass (Da):84,229
Checksum:i2515512EEDFB1DA1
GO
Isoform 4 (identifier: O75330-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-90: MSFPKAPLKR...DKDLKILEKE → MTLL

Show »
Length:638
Mass (Da):74,495
Checksum:iBFD153D3EC20FE5D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E5RIH2E5RIH2_HUMAN
Hyaluronan mediated motility recept...
HMMR
92Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RI30E5RI30_HUMAN
Hyaluronan mediated motility recept...
HMMR
101Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti103R → S in AAC32548 (PubMed:9601098).Curated1
Sequence conflicti277E → D in AAC52049 (PubMed:8890751).Curated1
Sequence conflicti298K → T in AAC52049 (PubMed:8890751).Curated1
Sequence conflicti322K → E in AAC52049 (PubMed:8890751).Curated1
Sequence conflicti330 – 332QER → REH in AAC52049 (PubMed:8890751).Curated3
Sequence conflicti547Q → R in BAF83266 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02415592R → C1 PublicationCorresponds to variant dbSNP:rs299284Ensembl.1
Natural variantiVAR_031661305N → K. Corresponds to variant dbSNP:rs2303077Ensembl.1
Natural variantiVAR_056917320N → K. Corresponds to variant dbSNP:rs2303077Ensembl.1
Natural variantiVAR_024156332R → H. Corresponds to variant dbSNP:rs2303078Ensembl.1
Natural variantiVAR_020044368V → A2 PublicationsCorresponds to variant dbSNP:rs299290Ensembl.1
Natural variantiVAR_024157484A → V2 PublicationsCorresponds to variant dbSNP:rs299295Ensembl.1
Natural variantiVAR_056918557D → H. Corresponds to variant dbSNP:rs2230362Ensembl.1
Natural variantiVAR_056919595L → I. Corresponds to variant dbSNP:rs2230363Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0412661 – 90MSFPK…ILEKE → MTLL in isoform 4. 1 PublicationAdd BLAST90
Alternative sequenceiVSP_03837875K → KK in isoform 3. 2 Publications1
Alternative sequenceiVSP_00428676 – 90Missing in isoform 2. 1 PublicationAdd BLAST15

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U29343 mRNA Translation: AAC52049.1
AF032862 mRNA Translation: AAC32548.1
AK290577 mRNA Translation: BAF83266.1
AK303616 mRNA Translation: BAG64626.1
AC112205 Genomic DNA No translation available.
CH471062 Genomic DNA Translation: EAW61522.1
CH471062 Genomic DNA Translation: EAW61523.1
CH471062 Genomic DNA Translation: EAW61524.1
CH471062 Genomic DNA Translation: EAW61525.1
BC108904 mRNA Translation: AAI08905.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS4362.1 [O75330-1]
CCDS4363.1 [O75330-2]
CCDS47334.1 [O75330-3]
CCDS47335.1 [O75330-4]

Protein sequence database of the Protein Information Resource

More...PIRi		JC5016

NCBI Reference Sequences

More...RefSeqi		NP_001136028.1, NM_001142556.1 [O75330-3]
NP_001136029.1, NM_001142557.1 [O75330-4]
NP_036616.2, NM_012484.2 [O75330-1]
NP_036617.2, NM_012485.2 [O75330-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000353866.7; ENSP00000185942.6; ENSG00000072571.20 [O75330-2]
ENST00000358715.3; ENSP00000351554.3; ENSG00000072571.20
ENST00000393915.9; ENSP00000377492.4; ENSG00000072571.20 [O75330-3]
ENST00000432118.6; ENSP00000402673.2; ENSG00000072571.20 [O75330-4]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		3161

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:3161

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000393915.9; ENSP00000377492.4; NM_001142556.2; NP_001136028.1 [O75330-3]

UCSC genome browser

More...UCSCi		uc003lzf.5, human [O75330-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U29343 mRNA Translation: AAC52049.1
AF032862 mRNA Translation: AAC32548.1
AK290577 mRNA Translation: BAF83266.1
AK303616 mRNA Translation: BAG64626.1
AC112205 Genomic DNA No translation available.
CH471062 Genomic DNA Translation: EAW61522.1
CH471062 Genomic DNA Translation: EAW61523.1
CH471062 Genomic DNA Translation: EAW61524.1
CH471062 Genomic DNA Translation: EAW61525.1
BC108904 mRNA Translation: AAI08905.1
CCDSiCCDS4362.1 [O75330-1]
CCDS4363.1 [O75330-2]
CCDS47334.1 [O75330-3]
CCDS47335.1 [O75330-4]
PIRiJC5016
RefSeqiNP_001136028.1, NM_001142556.1 [O75330-3]
NP_001136029.1, NM_001142557.1 [O75330-4]
NP_036616.2, NM_012484.2 [O75330-1]
NP_036617.2, NM_012485.2 [O75330-2]

3D structure databases

AlphaFoldDBiO75330
SMRiO75330
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi109404, 91 interactors
CORUMiO75330
DIPiDIP-56496N
IntActiO75330, 62 interactors
MINTiO75330
STRINGi9606.ENSP00000377492

Chemistry databases

BindingDBiO75330
ChEMBLiCHEMBL4295676
DrugBankiDB08818, Hyaluronic acid

Protein family/group databases

MoonDBiO75330, Curated

PTM databases

GlyGeniO75330, 5 sites, 1 O-linked glycan (1 site)
iPTMnetiO75330
PhosphoSitePlusiO75330

Genetic variation databases

BioMutaiHMMR

2D gel databases

REPRODUCTION-2DPAGEiO75330

Proteomic databases

EPDiO75330
jPOSTiO75330
MassIVEiO75330
MaxQBiO75330
PaxDbiO75330
PeptideAtlasiO75330
PRIDEiO75330
ProteomicsDBi49897 [O75330-1]
49898 [O75330-2]
49899 [O75330-3]
49900 [O75330-4]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		39622, 471 antibodies from 41 providers

The DNASU plasmid repository

More...DNASUi		3161

Genome annotation databases

EnsembliENST00000353866.7; ENSP00000185942.6; ENSG00000072571.20 [O75330-2]
ENST00000358715.3; ENSP00000351554.3; ENSG00000072571.20
ENST00000393915.9; ENSP00000377492.4; ENSG00000072571.20 [O75330-3]
ENST00000432118.6; ENSP00000402673.2; ENSG00000072571.20 [O75330-4]
GeneIDi3161
KEGGihsa:3161
MANE-SelectiENST00000393915.9; ENSP00000377492.4; NM_001142556.2; NP_001136028.1 [O75330-3]
UCSCiuc003lzf.5, human [O75330-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		3161
DisGeNETi3161

GeneCards: human genes, protein and diseases

More...GeneCardsi		HMMR
HGNCiHGNC:5012, HMMR
HPAiENSG00000072571, Tissue enhanced (bone marrow, lymphoid tissue, testis)
MalaCardsiHMMR
MIMi600936, gene
neXtProtiNX_O75330
OpenTargetsiENSG00000072571
PharmGKBiPA29340
VEuPathDBiHostDB:ENSG00000072571

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502QQJM, Eukaryota
GeneTreeiENSGT00390000007135
HOGENOMiCLU_009698_0_0_1
InParanoidiO75330
OMAiMKSMMAK
OrthoDBi604725at2759
PhylomeDBiO75330
TreeFamiTF333963

Enzyme and pathway databases

PathwayCommonsiO75330
ReactomeiR-HSA-2160916, Hyaluronan uptake and degradation
R-HSA-8854518, AURKA Activation by TPX2
SignaLinkiO75330

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		3161, 25 hits in 1085 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		HMMR, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Hyaluronan-mediated_motility_receptor

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		3161
PharosiO75330, Tchem

Protein Ontology

More...PROi		PR:O75330
RNActiO75330, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000072571, Expressed in sperm and 158 other tissues
ExpressionAtlasiO75330, baseline and differential
GenevisibleiO75330, HS

Family and domain databases

InterProiView protein in InterPro
IPR031794, HMMR_C
IPR026203, IHABP
PANTHERiPTHR18956, PTHR18956, 2 hits
PfamiView protein in Pfam
PF15908, HMMR_C, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHMMR_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O75330
Secondary accession number(s): A8K3G2
, B4E114, D3DQK9, D3DQL0, E9PCS0, Q32N02, Q92767
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: April 17, 2007
Last modified: May 25, 2022
This is version 179 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  3. Human entries with genetic variants
    List of human entries with genetic variants
  4. Human variants curated from literature reports
    Index of human variants curated from literature reports
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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