UniProtKB - O75330 (HMMR_HUMAN)
Hyaluronan mediated motility receptor
HMMR
Functioni
Receptor for hyaluronic acid (HA) (By similarity).
Involved in cell motility (By similarity).
When hyaluronan binds to HMMR, the phosphorylation of a number of proteins, including PTK2/FAK1 occurs. May also be involved in cellular transformation and metastasis formation, and in regulating extracellular-regulated kinase (ERK) activity. May act as a regulator of adipogenisis (By similarity).
By similarityGO - Molecular functioni
- hyaluronic acid binding Source: UniProtKB-KW
Keywordsi
Ligand | Hyaluronic acid |
Enzyme and pathway databases
PathwayCommonsi | O75330 |
Reactomei | R-HSA-2160916, Hyaluronan uptake and degradation R-HSA-8854518, AURKA Activation by TPX2 |
SignaLinki | O75330 |
Protein family/group databases
MoonDBi | O75330, Curated |
Names & Taxonomyi
Protein namesi | Recommended name: Hyaluronan mediated motility receptorAlternative name(s): Intracellular hyaluronic acid-binding protein Receptor for hyaluronan-mediated motility CD_antigen: CD168 |
Gene namesi | Name:HMMR Synonyms:IHABP, RHAMM |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:5012, HMMR |
MIMi | 600936, gene |
neXtProti | NX_O75330 |
VEuPathDBi | HostDB:ENSG00000072571 |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm By similarity
Cytoskeleton
- spindle By similarity
Other locations
- Cell surface By similarity
Cytoskeleton
- centrosome Source: HPA
- microtubule cytoskeleton Source: HPA
- spindle Source: UniProtKB
Cytosol
- cytosol Source: HPA
Plasma Membrane
- plasma membrane Source: Reactome
Other locations
- cell surface Source: UniProtKB-SubCell
- membrane Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, CytoskeletonPathology & Biotechi
Organism-specific databases
DisGeNETi | 3161 |
MalaCardsi | HMMR |
OpenTargetsi | ENSG00000072571 |
PharmGKBi | PA29340 |
Miscellaneous databases
Pharosi | O75330, Tchem |
Chemistry databases
ChEMBLi | CHEMBL4295676 |
DrugBanki | DB08818, Hyaluronic acid |
Genetic variation databases
BioMutai | HMMR |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000084007 | 1 – 724 | Hyaluronan mediated motility receptorAdd BLAST | 724 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 20 | PhosphoserineCombined sources | 1 | |
Glycosylationi | 133 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 477 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 567 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 588 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 703 | PhosphothreonineCombined sources | 1 |
Keywords - PTMi
Glycoprotein, PhosphoproteinProteomic databases
EPDi | O75330 |
jPOSTi | O75330 |
MassIVEi | O75330 |
MaxQBi | O75330 |
PaxDbi | O75330 |
PeptideAtlasi | O75330 |
PRIDEi | O75330 |
ProteomicsDBi | 49897 [O75330-1] 49898 [O75330-2] 49899 [O75330-3] 49900 [O75330-4] |
2D gel databases
REPRODUCTION-2DPAGEi | O75330 |
PTM databases
GlyGeni | O75330, 5 sites, 1 O-linked glycan (1 site) |
iPTMneti | O75330 |
PhosphoSitePlusi | O75330 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000072571, Expressed in sperm and 158 other tissues |
ExpressionAtlasi | O75330, baseline and differential |
Genevisiblei | O75330, HS |
Organism-specific databases
HPAi | ENSG00000072571, Tissue enhanced (bone marrow, lymphoid tissue, testis) |
Interactioni
Subunit structurei
Binary interactionsi
O75330
With | #Exp. | IntAct |
---|---|---|
BRCA1 [P38398] | 4 | EBI-2556203,EBI-349905 |
MORN4 [Q8NDC4] | 4 | EBI-2556203,EBI-10269566 |
TPX2 [Q9ULW0] | 5 | EBI-2556203,EBI-1037322 |
Isoform 3 [O75330-3]
With | #Exp. | IntAct |
---|---|---|
ATXN3 [P54252] | 3 | EBI-12098658,EBI-946046 |
MORN4 [Q8NDC4] | 3 | EBI-12098658,EBI-10269566 |
WFS1 [O76024] | 3 | EBI-12098658,EBI-720609 |
Protein-protein interaction databases
BioGRIDi | 109404, 91 interactors |
CORUMi | O75330 |
DIPi | DIP-56496N |
IntActi | O75330, 62 interactors |
MINTi | O75330 |
STRINGi | 9606.ENSP00000377492 |
Chemistry databases
BindingDBi | O75330 |
Miscellaneous databases
RNActi | O75330, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 22 | DisorderedSequence analysisAdd BLAST | 22 | |
Regioni | 40 – 81 | DisorderedSequence analysisAdd BLAST | 42 | |
Regioni | 365 – 546 | Required for interaction with FAM83D1 PublicationAdd BLAST | 182 | |
Regioni | 635 – 645 | Hyaluronic acid-bindingSequence analysisAdd BLAST | 11 | |
Regioni | 657 – 666 | Hyaluronic acid-bindingSequence analysis | 10 |
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | ENOG502QQJM, Eukaryota |
GeneTreei | ENSGT00390000007135 |
HOGENOMi | CLU_009698_0_0_1 |
InParanoidi | O75330 |
OMAi | MKSMMAK |
OrthoDBi | 604725at2759 |
PhylomeDBi | O75330 |
TreeFami | TF333963 |
Family and domain databases
InterProi | View protein in InterPro IPR031794, HMMR_C IPR026203, IHABP |
PANTHERi | PTHR18956, PTHR18956, 2 hits |
Pfami | View protein in Pfam PF15908, HMMR_C, 1 hit |
s (4+)i Sequence
Sequence statusi: Complete.
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSFPKAPLKR FNDPSGCAPS PGAYDVKTLE VLKGPVSFQK SQRFKQQKES
60 70 80 90 100
KQNLNVDKDT TLPASARKVK SSESKESQKN DKDLKILEKE IRVLLQERGA
110 120 130 140 150
QDRRIQDLET ELEKMEARLN AALREKTSLS ANNATLEKQL IELTRTNELL
160 170 180 190 200
KSKFSENGNQ KNLRILSLEL MKLRNKRETK MRGMMAKQEG MEMKLQVTQR
210 220 230 240 250
SLEESQGKIA QLEGKLVSIE KEKIDEKSET EKLLEYIEEI SCASDQVEKY
260 270 280 290 300
KLDIAQLEEN LKEKNDEILS LKQSLEENIV ILSKQVEDLN VKCQLLEKEK
310 320 330 340 350
EDHVNRNREH NENLNAEMQN LKQKFILEQQ EREKLQQKEL QIDSLLQQEK
360 370 380 390 400
ELSSSLHQKL CSFQEEMVKE KNLFEEELKQ TLDELDKLQQ KEEQAERLVK
410 420 430 440 450
QLEEEAKSRA EELKLLEEKL KGKEAELEKS SAAHTQATLL LQEKYDSMVQ
460 470 480 490 500
SLEDVTAQFE SYKALTASEI EDLKLENSSL QEKAAKAGKN AEDVQHQILA
510 520 530 540 550
TESSNQEYVR MLLDLQTKSA LKETEIKEIT VSFLQKITDL QNQLKQQEED
560 570 580 590 600
FRKQLEDEEG RKAEKENTTA ELTEEINKWR LLYEELYNKT KPFQLQLDAF
610 620 630 640 650
EVEKQALLNE HGAAQEQLNK IRDSYAKLLG HQNLKQKIKH VVKLKDENSQ
660 670 680 690 700
LKSEVSKLRC QLAKKKQSET KLQEELNKVL GIKHFDPSKA FHHESKENFA
710 720
LKTPLKEGNT NCYRAPMECQ ESWK
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE5RIH2 | E5RIH2_HUMAN | Hyaluronan mediated motility recept... | HMMR | 92 | Annotation score: | ||
E5RI30 | E5RI30_HUMAN | Hyaluronan mediated motility recept... | HMMR | 101 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 103 | R → S in AAC32548 (PubMed:9601098).Curated | 1 | |
Sequence conflicti | 277 | E → D in AAC52049 (PubMed:8890751).Curated | 1 | |
Sequence conflicti | 298 | K → T in AAC52049 (PubMed:8890751).Curated | 1 | |
Sequence conflicti | 322 | K → E in AAC52049 (PubMed:8890751).Curated | 1 | |
Sequence conflicti | 330 – 332 | QER → REH in AAC52049 (PubMed:8890751).Curated | 3 | |
Sequence conflicti | 547 | Q → R in BAF83266 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_024155 | 92 | R → C1 PublicationCorresponds to variant dbSNP:rs299284Ensembl. | 1 | |
Natural variantiVAR_031661 | 305 | N → K. Corresponds to variant dbSNP:rs2303077Ensembl. | 1 | |
Natural variantiVAR_056917 | 320 | N → K. Corresponds to variant dbSNP:rs2303077Ensembl. | 1 | |
Natural variantiVAR_024156 | 332 | R → H. Corresponds to variant dbSNP:rs2303078Ensembl. | 1 | |
Natural variantiVAR_020044 | 368 | V → A2 PublicationsCorresponds to variant dbSNP:rs299290Ensembl. | 1 | |
Natural variantiVAR_024157 | 484 | A → V2 PublicationsCorresponds to variant dbSNP:rs299295Ensembl. | 1 | |
Natural variantiVAR_056918 | 557 | D → H. Corresponds to variant dbSNP:rs2230362Ensembl. | 1 | |
Natural variantiVAR_056919 | 595 | L → I. Corresponds to variant dbSNP:rs2230363Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_041266 | 1 – 90 | MSFPK…ILEKE → MTLL in isoform 4. 1 PublicationAdd BLAST | 90 | |
Alternative sequenceiVSP_038378 | 75 | K → KK in isoform 3. 2 Publications | 1 | |
Alternative sequenceiVSP_004286 | 76 – 90 | Missing in isoform 2. 1 PublicationAdd BLAST | 15 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U29343 mRNA Translation: AAC52049.1 AF032862 mRNA Translation: AAC32548.1 AK290577 mRNA Translation: BAF83266.1 AK303616 mRNA Translation: BAG64626.1 AC112205 Genomic DNA No translation available. CH471062 Genomic DNA Translation: EAW61522.1 CH471062 Genomic DNA Translation: EAW61523.1 CH471062 Genomic DNA Translation: EAW61524.1 CH471062 Genomic DNA Translation: EAW61525.1 BC108904 mRNA Translation: AAI08905.1 |
CCDSi | CCDS4362.1 [O75330-1] CCDS4363.1 [O75330-2] CCDS47334.1 [O75330-3] CCDS47335.1 [O75330-4] |
PIRi | JC5016 |
RefSeqi | NP_001136028.1, NM_001142556.1 [O75330-3] NP_001136029.1, NM_001142557.1 [O75330-4] NP_036616.2, NM_012484.2 [O75330-1] NP_036617.2, NM_012485.2 [O75330-2] |
Genome annotation databases
Ensembli | ENST00000353866.7; ENSP00000185942.6; ENSG00000072571.20 [O75330-2] ENST00000358715.3; ENSP00000351554.3; ENSG00000072571.20 ENST00000393915.9; ENSP00000377492.4; ENSG00000072571.20 [O75330-3] ENST00000432118.6; ENSP00000402673.2; ENSG00000072571.20 [O75330-4] |
GeneIDi | 3161 |
KEGGi | hsa:3161 |
MANE-Selecti | ENST00000393915.9; ENSP00000377492.4; NM_001142556.2; NP_001136028.1 [O75330-3] |
UCSCi | uc003lzf.5, human [O75330-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U29343 mRNA Translation: AAC52049.1 AF032862 mRNA Translation: AAC32548.1 AK290577 mRNA Translation: BAF83266.1 AK303616 mRNA Translation: BAG64626.1 AC112205 Genomic DNA No translation available. CH471062 Genomic DNA Translation: EAW61522.1 CH471062 Genomic DNA Translation: EAW61523.1 CH471062 Genomic DNA Translation: EAW61524.1 CH471062 Genomic DNA Translation: EAW61525.1 BC108904 mRNA Translation: AAI08905.1 |
CCDSi | CCDS4362.1 [O75330-1] CCDS4363.1 [O75330-2] CCDS47334.1 [O75330-3] CCDS47335.1 [O75330-4] |
PIRi | JC5016 |
RefSeqi | NP_001136028.1, NM_001142556.1 [O75330-3] NP_001136029.1, NM_001142557.1 [O75330-4] NP_036616.2, NM_012484.2 [O75330-1] NP_036617.2, NM_012485.2 [O75330-2] |
3D structure databases
AlphaFoldDBi | O75330 |
SMRi | O75330 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 109404, 91 interactors |
CORUMi | O75330 |
DIPi | DIP-56496N |
IntActi | O75330, 62 interactors |
MINTi | O75330 |
STRINGi | 9606.ENSP00000377492 |
Chemistry databases
BindingDBi | O75330 |
ChEMBLi | CHEMBL4295676 |
DrugBanki | DB08818, Hyaluronic acid |
Protein family/group databases
MoonDBi | O75330, Curated |
PTM databases
GlyGeni | O75330, 5 sites, 1 O-linked glycan (1 site) |
iPTMneti | O75330 |
PhosphoSitePlusi | O75330 |
Genetic variation databases
BioMutai | HMMR |
2D gel databases
REPRODUCTION-2DPAGEi | O75330 |
Proteomic databases
EPDi | O75330 |
jPOSTi | O75330 |
MassIVEi | O75330 |
MaxQBi | O75330 |
PaxDbi | O75330 |
PeptideAtlasi | O75330 |
PRIDEi | O75330 |
ProteomicsDBi | 49897 [O75330-1] 49898 [O75330-2] 49899 [O75330-3] 49900 [O75330-4] |
Protocols and materials databases
Antibodypediai | 39622, 471 antibodies from 41 providers |
DNASUi | 3161 |
Genome annotation databases
Ensembli | ENST00000353866.7; ENSP00000185942.6; ENSG00000072571.20 [O75330-2] ENST00000358715.3; ENSP00000351554.3; ENSG00000072571.20 ENST00000393915.9; ENSP00000377492.4; ENSG00000072571.20 [O75330-3] ENST00000432118.6; ENSP00000402673.2; ENSG00000072571.20 [O75330-4] |
GeneIDi | 3161 |
KEGGi | hsa:3161 |
MANE-Selecti | ENST00000393915.9; ENSP00000377492.4; NM_001142556.2; NP_001136028.1 [O75330-3] |
UCSCi | uc003lzf.5, human [O75330-1] |
Organism-specific databases
CTDi | 3161 |
DisGeNETi | 3161 |
GeneCardsi | HMMR |
HGNCi | HGNC:5012, HMMR |
HPAi | ENSG00000072571, Tissue enhanced (bone marrow, lymphoid tissue, testis) |
MalaCardsi | HMMR |
MIMi | 600936, gene |
neXtProti | NX_O75330 |
OpenTargetsi | ENSG00000072571 |
PharmGKBi | PA29340 |
VEuPathDBi | HostDB:ENSG00000072571 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QQJM, Eukaryota |
GeneTreei | ENSGT00390000007135 |
HOGENOMi | CLU_009698_0_0_1 |
InParanoidi | O75330 |
OMAi | MKSMMAK |
OrthoDBi | 604725at2759 |
PhylomeDBi | O75330 |
TreeFami | TF333963 |
Enzyme and pathway databases
PathwayCommonsi | O75330 |
Reactomei | R-HSA-2160916, Hyaluronan uptake and degradation R-HSA-8854518, AURKA Activation by TPX2 |
SignaLinki | O75330 |
Miscellaneous databases
BioGRID-ORCSi | 3161, 25 hits in 1085 CRISPR screens |
ChiTaRSi | HMMR, human |
GeneWikii | Hyaluronan-mediated_motility_receptor |
GenomeRNAii | 3161 |
Pharosi | O75330, Tchem |
PROi | PR:O75330 |
RNActi | O75330, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000072571, Expressed in sperm and 158 other tissues |
ExpressionAtlasi | O75330, baseline and differential |
Genevisiblei | O75330, HS |
Family and domain databases
InterProi | View protein in InterPro IPR031794, HMMR_C IPR026203, IHABP |
PANTHERi | PTHR18956, PTHR18956, 2 hits |
Pfami | View protein in Pfam PF15908, HMMR_C, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | HMMR_HUMAN | |
Accessioni | O75330Primary (citable) accession number: O75330 Secondary accession number(s): A8K3G2 Q92767 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 30, 2000 |
Last sequence update: | April 17, 2007 | |
Last modified: | May 25, 2022 | |
This is version 179 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human cell differentiation molecules
CD nomenclature of surface proteins of human leucocytes and list of entries - Human chromosome 5
Human chromosome 5: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot