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Protein

Semaphorin-7A

Gene

SEMA7A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays an important role in integrin-mediated signaling and functions both in regulating cell migration and immune responses. Promotes formation of focal adhesion complexes, activation of the protein kinase PTK2/FAK1 and subsequent phosphorylation of MAPK1 and MAPK3. Promotes production of proinflammatory cytokines by monocytes and macrophages. Plays an important role in modulating inflammation and T-cell-mediated immune responses. Promotes axon growth in the embryonic olfactory bulb. Promotes attachment, spreading and dendrite outgrowth in melanocytes.3 Publications

GO - Molecular functioni

  • chemorepellent activity Source: GO_Central
  • integrin binding Source: GO_Central
  • neuropilin binding Source: GO_Central
  • semaphorin receptor binding Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
Biological processDifferentiation, Inflammatory response, Neurogenesis

Enzyme and pathway databases

ReactomeiR-HSA-416700 Other semaphorin interactions
SIGNORiO75326

Names & Taxonomyi

Protein namesi
Recommended name:
Semaphorin-7A
Alternative name(s):
CDw108
JMH blood group antigen
John-Milton-Hargen human blood group Ag
Semaphorin-K1
Short name:
Sema K1
Semaphorin-L
Short name:
Sema L
CD_antigen: CD108
Gene namesi
Name:SEMA7A
Synonyms:CD108, SEMAL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000138623.9
HGNCiHGNC:10741 SEMA7A
MIMi607961 gene+phenotype
neXtProtiNX_O75326

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi267R → K: Abolishes ITGB1-dependent enhancement of axon growth; when associated with E-269. 1 Publication1
Mutagenesisi269D → E: Abolishes ITGB1-dependent enhancement of axon growth; when associated with K-267. 1 Publication1

Organism-specific databases

DisGeNETi8482
MalaCardsiSEMA7A
MIMi607961 gene+phenotype
614745 phenotype
OpenTargetsiENSG00000138623
PharmGKBiPA35663

Polymorphism and mutation databases

BioMutaiSEMA7A

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 44Sequence analysisAdd BLAST44
ChainiPRO_000003234745 – 648Semaphorin-7AAdd BLAST604
PropeptideiPRO_0000032348649 – 666Removed in mature formSequence analysisAdd BLAST18

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi105N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi120 ↔ 1261 Publication
Modified residuei135Asymmetric dimethylarginineBy similarity1
Disulfide bondi143 ↔ 1521 Publication
Glycosylationi157N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi258N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi266 ↔ 3661 Publication
Disulfide bondi291 ↔ 3351 Publication
Glycosylationi330N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi493 ↔ 5111 Publication
Disulfide bondi500 ↔ 5411 Publication
Disulfide bondi503 ↔ 5181 Publication
Disulfide bondi566 ↔ 6131 Publication
Disulfide bondi587 ↔ 5961 Publication
Glycosylationi602N-linked (GlcNAc...) asparagine1 Publication1
Lipidationi648GPI-anchor amidated alanineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein, Methylation

Proteomic databases

EPDiO75326
MaxQBiO75326
PaxDbiO75326
PeptideAtlasiO75326
PRIDEiO75326
ProteomicsDBi49896

PTM databases

iPTMnetiO75326
PhosphoSitePlusiO75326
SwissPalmiO75326

Expressioni

Tissue specificityi

Detected in skin keratinocytes and on endothelial cells from skin blood vessels (at protein level). Expressed in fibroblasts, keratinocytes, melanocytes, placenta, testis, ovary, spleen, brain, spinal chord, lung, heart, adrenal gland, lymph nodes, thymus, intestine and kidney.3 Publications

Inductioni

Up-regulated in UV-irradiated fibroblasts, but not in UV-irradiated keratinocytes.1 Publication

Gene expression databases

BgeeiENSG00000138623 Expressed in 195 organ(s), highest expression level in C1 segment of cervical spinal cord
CleanExiHS_SEMA7A
ExpressionAtlasiO75326 baseline and differential
GenevisibleiO75326 HS

Organism-specific databases

HPAiHPA008210
HPA042273

Interactioni

Subunit structurei

Interacts with ITGA1 and ITGB1 (Probable). Interacts with PLXNC1.Curated4 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi114056, 16 interactors
CORUMiO75326
IntActiO75326, 7 interactors
MINTiO75326
STRINGi9606.ENSP00000261918

Structurei

Secondary structure

1666
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliO75326
SMRiO75326
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO75326

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini53 – 490SemaPROSITE-ProRule annotationAdd BLAST438
Domaini544 – 629Ig-like C2-typeAdd BLAST86

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni267 – 269Interaction with integrins3

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi267 – 269Cell attachment siteSequence analysis3

Sequence similaritiesi

Belongs to the semaphorin family.Curated

Keywords - Domaini

Immunoglobulin domain, Signal

Phylogenomic databases

eggNOGiKOG3611 Eukaryota
ENOG410XQZC LUCA
GeneTreeiENSGT00760000119134
HOGENOMiHOG000154284
HOVERGENiHBG079171
InParanoidiO75326
KOiK06529
OMAiRDCENYI
OrthoDBiEOG091G01W0
PhylomeDBiO75326
TreeFamiTF333698

Family and domain databases

Gene3Di2.130.10.10, 1 hit
2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR002165 Plexin_repeat
IPR016201 PSI
IPR001627 Semap_dom
IPR036352 Semap_dom_sf
IPR027231 Semaphorin
IPR015943 WD40/YVTN_repeat-like_dom_sf
PANTHERiPTHR11036 PTHR11036, 1 hit
PfamiView protein in Pfam
PF13895 Ig_2, 1 hit
PF01437 PSI, 1 hit
PF01403 Sema, 1 hit
SMARTiView protein in SMART
SM00423 PSI, 1 hit
SM00630 Sema, 1 hit
SUPFAMiSSF101912 SSF101912, 1 hit
SSF48726 SSF48726, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS51004 SEMA, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: O75326-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTPPPPGRAA PSAPRARVPG PPARLGLPLR LRLLLLLWAA AASAQGHLRS
60 70 80 90 100
GPRIFAVWKG HVGQDRVDFG QTEPHTVLFH EPGSSSVWVG GRGKVYLFDF
110 120 130 140 150
PEGKNASVRT VNIGSTKGSC LDKRDCENYI TLLERRSEGL LACGTNARHP
160 170 180 190 200
SCWNLVNGTV VPLGEMRGYA PFSPDENSLV LFEGDEVYST IRKQEYNGKI
210 220 230 240 250
PRFRRIRGES ELYTSDTVMQ NPQFIKATIV HQDQAYDDKI YYFFREDNPD
260 270 280 290 300
KNPEAPLNVS RVAQLCRGDQ GGESSLSVSK WNTFLKAMLV CSDAATNKNF
310 320 330 340 350
NRLQDVFLLP DPSGQWRDTR VYGVFSNPWN YSAVCVYSLG DIDKVFRTSS
360 370 380 390 400
LKGYHSSLPN PRPGKCLPDQ QPIPTETFQV ADRHPEVAQR VEPMGPLKTP
410 420 430 440 450
LFHSKYHYQK VAVHRMQASH GETFHVLYLT TDRGTIHKVV EPGEQEHSFA
460 470 480 490 500
FNIMEIQPFR RAAAIQTMSL DAERRKLYVS SQWEVSQVPL DLCEVYGGGC
510 520 530 540 550
HGCLMSRDPY CGWDQGRCIS IYSSERSVLQ SINPAEPHKE CPNPKPDKAP
560 570 580 590 600
LQKVSLAPNS RYYLSCPMES RHATYSWRHK ENVEQSCEPG HQSPNCILFI
610 620 630 640 650
ENLTAQQYGH YFCEAQEGSY FREAQHWQLL PEDGIMAEHL LGHACALAAS
660
LWLGVLPTLT LGLLVH
Length:666
Mass (Da):74,824
Last modified:November 1, 1998 - v1
Checksum:iAD3ABE56B5EBE194
GO
Isoform 2 (identifier: O75326-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     111-124: Missing.

Note: No experimental confirmation available.
Show »
Length:652
Mass (Da):73,364
Checksum:i0EB0B9085C9DCCA0
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F5GYX3F5GYX3_HUMAN
Semaphorin-7A
SEMA7A
501Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti545K → E in BAG56808 (PubMed:14702039).Curated1

Polymorphismi

Genetic variations in SEMA7A define the John Milton Hagen blood group system (JMH) [MIMi:614745]. Three different JMH phenotypes have been identified based on the presence or absence of the high-frequency JMH antigen: JMH-weak, JMH-negative, and JMH-variant. The JMH-weak and -negative phenotypes can be either acquired or inherited and are characterized by a reduction or complete loss of JMH expression on red blood cells. Individuals with the JMH-variant phenotype are usually JMH-positive and have alloantibodies compatible with JMH-negative red blood cells. The JMH-variant phenotype results from rare SEMA7A missense variants.1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_029282115S → T1 PublicationCorresponds to variant dbSNP:rs16968733Ensembl.1
Natural variantiVAR_038836207R → Q Rare polymorphism that results in JMH-variant phenotype. 1 PublicationCorresponds to variant dbSNP:rs55637216EnsemblClinVar.1
Natural variantiVAR_038837207R → W Rare polymorphism that results in JMH-variant phenotype. 1 PublicationCorresponds to variant dbSNP:rs56367230EnsemblClinVar.1
Natural variantiVAR_068679347R → L Rare polymorphism that results in JMH-variant phenotype. 1 PublicationCorresponds to variant dbSNP:rs387907241EnsemblClinVar.1
Natural variantiVAR_038838460R → H Rare polymorphism that results in JMH-variant phenotype. 1 PublicationCorresponds to variant dbSNP:rs56204206EnsemblClinVar.1
Natural variantiVAR_038839461R → C Rare polymorphism that results in JMH-variant phenotype. 1 PublicationCorresponds to variant dbSNP:rs56001514EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_045349111 – 124Missing in isoform 2. 1 PublicationAdd BLAST14

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF030698 mRNA Translation: AAC34261.1
AF030697 Genomic DNA Translation: AAC34741.1
AF069493 mRNA Translation: AAC82642.1
AF071542 mRNA Translation: AAC80456.1
AM180445 mRNA Translation: CAJ55398.1
AM180446 mRNA Translation: CAJ55399.1
AM180447 mRNA Translation: CAJ55400.1
AM180448 mRNA Translation: CAJ55401.1
AM180449 mRNA Translation: CAJ55402.1
AM180450 mRNA Translation: CAJ55403.1
AM180451 mRNA Translation: CAJ55404.1
AK293280 mRNA Translation: BAG56808.1
AY885237 Genomic DNA Translation: AAW62253.1
AC012435 Genomic DNA No translation available.
AC090826 Genomic DNA No translation available.
BC101643 mRNA Translation: AAI01644.1
BC101647 mRNA Translation: AAI01648.1
CCDSiCCDS10262.1 [O75326-1]
CCDS53959.1 [O75326-2]
RefSeqiNP_001139501.1, NM_001146029.2 [O75326-2]
NP_001139502.1, NM_001146030.2
NP_003603.1, NM_003612.4 [O75326-1]
UniGeneiHs.24640

Genome annotation databases

EnsembliENST00000261918; ENSP00000261918; ENSG00000138623 [O75326-1]
ENST00000543145; ENSP00000438966; ENSG00000138623 [O75326-2]
GeneIDi8482
KEGGihsa:8482
UCSCiuc002axv.4 human [O75326-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

dbRBC/BGMUT

Blood group antigen gene mutation database

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF030698 mRNA Translation: AAC34261.1
AF030697 Genomic DNA Translation: AAC34741.1
AF069493 mRNA Translation: AAC82642.1
AF071542 mRNA Translation: AAC80456.1
AM180445 mRNA Translation: CAJ55398.1
AM180446 mRNA Translation: CAJ55399.1
AM180447 mRNA Translation: CAJ55400.1
AM180448 mRNA Translation: CAJ55401.1
AM180449 mRNA Translation: CAJ55402.1
AM180450 mRNA Translation: CAJ55403.1
AM180451 mRNA Translation: CAJ55404.1
AK293280 mRNA Translation: BAG56808.1
AY885237 Genomic DNA Translation: AAW62253.1
AC012435 Genomic DNA No translation available.
AC090826 Genomic DNA No translation available.
BC101643 mRNA Translation: AAI01644.1
BC101647 mRNA Translation: AAI01648.1
CCDSiCCDS10262.1 [O75326-1]
CCDS53959.1 [O75326-2]
RefSeqiNP_001139501.1, NM_001146029.2 [O75326-2]
NP_001139502.1, NM_001146030.2
NP_003603.1, NM_003612.4 [O75326-1]
UniGeneiHs.24640

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3NVQX-ray2.40A/E45-634[»]
ProteinModelPortaliO75326
SMRiO75326
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114056, 16 interactors
CORUMiO75326
IntActiO75326, 7 interactors
MINTiO75326
STRINGi9606.ENSP00000261918

PTM databases

iPTMnetiO75326
PhosphoSitePlusiO75326
SwissPalmiO75326

Polymorphism and mutation databases

BioMutaiSEMA7A

Proteomic databases

EPDiO75326
MaxQBiO75326
PaxDbiO75326
PeptideAtlasiO75326
PRIDEiO75326
ProteomicsDBi49896

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000261918; ENSP00000261918; ENSG00000138623 [O75326-1]
ENST00000543145; ENSP00000438966; ENSG00000138623 [O75326-2]
GeneIDi8482
KEGGihsa:8482
UCSCiuc002axv.4 human [O75326-1]

Organism-specific databases

CTDi8482
DisGeNETi8482
EuPathDBiHostDB:ENSG00000138623.9
GeneCardsiSEMA7A
HGNCiHGNC:10741 SEMA7A
HPAiHPA008210
HPA042273
MalaCardsiSEMA7A
MIMi607961 gene+phenotype
614745 phenotype
neXtProtiNX_O75326
OpenTargetsiENSG00000138623
PharmGKBiPA35663
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3611 Eukaryota
ENOG410XQZC LUCA
GeneTreeiENSGT00760000119134
HOGENOMiHOG000154284
HOVERGENiHBG079171
InParanoidiO75326
KOiK06529
OMAiRDCENYI
OrthoDBiEOG091G01W0
PhylomeDBiO75326
TreeFamiTF333698

Enzyme and pathway databases

ReactomeiR-HSA-416700 Other semaphorin interactions
SIGNORiO75326

Miscellaneous databases

ChiTaRSiSEMA7A human
EvolutionaryTraceiO75326
GeneWikiiSEMA7A
GenomeRNAii8482
PROiPR:O75326
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000138623 Expressed in 195 organ(s), highest expression level in C1 segment of cervical spinal cord
CleanExiHS_SEMA7A
ExpressionAtlasiO75326 baseline and differential
GenevisibleiO75326 HS

Family and domain databases

Gene3Di2.130.10.10, 1 hit
2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR002165 Plexin_repeat
IPR016201 PSI
IPR001627 Semap_dom
IPR036352 Semap_dom_sf
IPR027231 Semaphorin
IPR015943 WD40/YVTN_repeat-like_dom_sf
PANTHERiPTHR11036 PTHR11036, 1 hit
PfamiView protein in Pfam
PF13895 Ig_2, 1 hit
PF01437 PSI, 1 hit
PF01403 Sema, 1 hit
SMARTiView protein in SMART
SM00423 PSI, 1 hit
SM00630 Sema, 1 hit
SUPFAMiSSF101912 SSF101912, 1 hit
SSF48726 SSF48726, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS51004 SEMA, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSEM7A_HUMAN
AccessioniPrimary (citable) accession number: O75326
Secondary accession number(s): B4DDP7
, F5H1S0, Q1XE81, Q1XE82, Q1XE83, Q1XE84, Q3MIY5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: November 1, 1998
Last modified: November 7, 2018
This is version 171 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  7. Blood group antigen proteins
    Nomenclature of blood group antigens and list of entries
  8. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
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