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Protein

Leucine-rich repeat neuronal protein 2

Gene

LRRN2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • signaling receptor activity Source: ProtInc

GO - Biological processi

  • axonogenesis Source: GO_Central
  • cell adhesion Source: ProtInc
  • signal transduction Source: ProtInc

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat neuronal protein 2
Alternative name(s):
Glioma amplified on chromosome 1 protein
Leucine-rich repeat neuronal protein 5
Gene namesi
Name:LRRN2
Synonyms:GAC1, LRRN5
ORF Names:UNQ256/PRO293
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000170382.11
HGNCiHGNC:16914 LRRN2
MIMi605492 gene
neXtProtiNX_O75325

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini19 – 630ExtracellularSequence analysisAdd BLAST612
Transmembranei631 – 651HelicalSequence analysisAdd BLAST21
Topological domaini652 – 713CytoplasmicSequence analysisAdd BLAST62

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi10446
OpenTargetsiENSG00000170382
PharmGKBiPA162394661

Polymorphism and mutation databases

BioMutaiLRRN2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000001484919 – 713Leucine-rich repeat neuronal protein 2Add BLAST695

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi94N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi381N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi445 ↔ 497PROSITE-ProRule annotation
Glycosylationi555N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi583N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiO75325
PaxDbiO75325
PeptideAtlasiO75325
PRIDEiO75325
ProteomicsDBi49895

PTM databases

iPTMnetiO75325
PhosphoSitePlusiO75325

Expressioni

Tissue specificityi

Overamplified in malignant gliomas.

Gene expression databases

BgeeiENSG00000170382
CleanExiHS_LRRN2
ExpressionAtlasiO75325 baseline and differential
GenevisibleiO75325 HS

Organism-specific databases

HPAiHPA029124

Interactioni

Protein-protein interaction databases

BioGridi115711, 18 interactors
IntActiO75325, 1 interactor
STRINGi9606.ENSP00000356143

Structurei

3D structure databases

ProteinModelPortaliO75325
SMRiO75325
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini20 – 69LRRNTAdd BLAST50
Repeati70 – 91LRR 1Add BLAST22
Repeati94 – 115LRR 2Add BLAST22
Repeati118 – 139LRR 3Add BLAST22
Repeati142 – 163LRR 4Add BLAST22
Repeati166 – 187LRR 5Add BLAST22
Repeati190 – 211LRR 6Add BLAST22
Repeati214 – 235LRR 7Add BLAST22
Repeati238 – 259LRR 8Add BLAST22
Repeati262 – 283LRR 9Add BLAST22
Repeati286 – 305LRR 10Add BLAST20
Repeati311 – 333LRR 11Add BLAST23
Repeati336 – 357LRR 12Add BLAST22
Domaini369 – 422LRRCTAdd BLAST54
Domaini422 – 511Ig-like C2-typeAdd BLAST90

Keywords - Domaini

Immunoglobulin domain, Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0619 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00760000118831
HOGENOMiHOG000252914
HOVERGENiHBG052361
InParanoidiO75325
OMAiTEYWACL
OrthoDBiEOG091G066E
PhylomeDBiO75325
TreeFamiTF334360

Family and domain databases

Gene3Di2.60.40.10, 1 hit
3.80.10.10, 2 hits
InterProiView protein in InterPro
IPR000483 Cys-rich_flank_reg_C
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
PfamiView protein in Pfam
PF07679 I-set, 1 hit
PF13855 LRR_8, 3 hits
SMARTiView protein in SMART
SM00409 IG, 1 hit
SM00408 IGc2, 1 hit
SM00369 LRR_TYP, 10 hits
SM00082 LRRCT, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS51450 LRR, 9 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O75325-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLLVAPLLL AWVAGATAAV PVVPWHVPCP PQCACQIRPW YTPRSSYREA
60 70 80 90 100
TTVDCNDLFL TAVPPALPAG TQTLLLQSNS IVRVDQSELG YLANLTELDL
110 120 130 140 150
SQNSFSDARD CDFHALPQLL SLHLEENQLT RLEDHSFAGL ASLQELYLNH
160 170 180 190 200
NQLYRIAPRA FSGLSNLLRL HLNSNLLRAI DSRWFEMLPN LEILMIGGNK
210 220 230 240 250
VDAILDMNFR PLANLRSLVL AGMNLREISD YALEGLQSLE SLSFYDNQLA
260 270 280 290 300
RVPRRALEQV PGLKFLDLNK NPLQRVGPGD FANMLHLKEL GLNNMEELVS
310 320 330 340 350
IDKFALVNLP ELTKLDITNN PRLSFIHPRA FHHLPQMETL MLNNNALSAL
360 370 380 390 400
HQQTVESLPN LQEVGLHGNP IRCDCVIRWA NATGTRVRFI EPQSTLCAEP
410 420 430 440 450
PDLQRLPVRE VPFREMTDHC LPLISPRSFP PSLQVASGES MVLHCRALAE
460 470 480 490 500
PEPEIYWVTP AGLRLTPAHA GRRYRVYPEG TLELRRVTAE EAGLYTCVAQ
510 520 530 540 550
NLVGADTKTV SVVVGRALLQ PGRDEGQGLE LRVQETHPYH ILLSWVTPPN
560 570 580 590 600
TVSTNLTWSS ASSLRGQGAT ALARLPRGTH SYNITRLLQA TEYWACLQVA
610 620 630 640 650
FADAHTQLAC VWARTKEATS CHRALGDRPG LIAILALAVL LLAAGLAAHL
660 670 680 690 700
GTGQPRKGVG GRRPLPPAWA FWGWSAPSVR VVSAPLVLPW NPGRKLPRSS
710
EGETLLPPLS QNS
Length:713
Mass (Da):78,859
Last modified:March 15, 2005 - v2
Checksum:i8B97B131FF61254A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti355V → A in AAH34047 (PubMed:15489334).Curated1
Sequence conflicti355V → A in AAH68541 (PubMed:15489334).Curated1
Sequence conflicti474Y → C in AAC39792 (PubMed:9662332).Curated1
Sequence conflicti676A → P in AAH34047 (PubMed:15489334).Curated1
Sequence conflicti676A → P in AAH68541 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0219217P → L. Corresponds to variant dbSNP:rs3789044Ensembl.1
Natural variantiVAR_04989819A → T1 PublicationCorresponds to variant dbSNP:rs36012907Ensembl.1
Natural variantiVAR_021922518L → V. Corresponds to variant dbSNP:rs3747631Ensembl.1
Natural variantiVAR_049899659V → A. Corresponds to variant dbSNP:rs34771052Ensembl.1
Natural variantiVAR_049900692P → S. Corresponds to variant dbSNP:rs11588857Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF030435 mRNA Translation: AAC39792.1
AY358290 mRNA Translation: AAQ88657.1
AK312408 mRNA Translation: BAG35321.1
AL512306 Genomic DNA No translation available.
CH471067 Genomic DNA Translation: EAW91520.1
BC034047 mRNA Translation: AAH34047.1
BC068541 mRNA Translation: AAH68541.1
CCDSiCCDS1448.1
RefSeqiNP_006329.2, NM_006338.2
NP_963924.1, NM_201630.1
XP_005244884.1, XM_005244827.3
XP_011507368.1, XM_011509066.2
XP_016855539.1, XM_017000050.1
UniGeneiHs.26312

Genome annotation databases

EnsembliENST00000367175; ENSP00000356143; ENSG00000170382
ENST00000367176; ENSP00000356144; ENSG00000170382
ENST00000367177; ENSP00000356145; ENSG00000170382
GeneIDi10446
KEGGihsa:10446
UCSCiuc001hbe.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiLRRN2_HUMAN
AccessioniPrimary (citable) accession number: O75325
Secondary accession number(s): B2R624
, Q5T0Y0, Q6UXM0, Q8N182
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: March 15, 2005
Last modified: June 20, 2018
This is version 166 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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