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Protein

Leucine-rich repeat neuronal protein 2

Gene

LRRN2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • signaling receptor activity Source: ProtInc

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Leucine-rich repeat neuronal protein 2
Alternative name(s):
Glioma amplified on chromosome 1 protein
Leucine-rich repeat neuronal protein 5
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LRRN2
Synonyms:GAC1, LRRN5
ORF Names:UNQ256/PRO293
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000170382.11

Human Gene Nomenclature Database

More...
HGNCi
HGNC:16914 LRRN2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
605492 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O75325

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini19 – 630ExtracellularSequence analysisAdd BLAST612
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei631 – 651HelicalSequence analysisAdd BLAST21
Topological domaini652 – 713CytoplasmicSequence analysisAdd BLAST62

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
10446

Open Targets

More...
OpenTargetsi
ENSG00000170382

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162394661

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
LRRN2

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 18Sequence analysisAdd BLAST18
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001484919 – 713Leucine-rich repeat neuronal protein 2Add BLAST695

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi94N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi381N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi445 ↔ 497PROSITE-ProRule annotation
Glycosylationi555N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi583N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O75325

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O75325

PeptideAtlas

More...
PeptideAtlasi
O75325

PRoteomics IDEntifications database

More...
PRIDEi
O75325

ProteomicsDB human proteome resource

More...
ProteomicsDBi
49895

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O75325

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O75325

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Overamplified in malignant gliomas.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000170382 Expressed in 138 organ(s), highest expression level in anterior cingulate cortex

CleanEx database of gene expression profiles

More...
CleanExi
HS_LRRN2

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
O75325 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O75325 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA029124

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
115711, 18 interactors

Protein interaction database and analysis system

More...
IntActi
O75325, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000356143

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
O75325

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini20 – 69LRRNTAdd BLAST50
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati70 – 91LRR 1Add BLAST22
Repeati94 – 115LRR 2Add BLAST22
Repeati118 – 139LRR 3Add BLAST22
Repeati142 – 163LRR 4Add BLAST22
Repeati166 – 187LRR 5Add BLAST22
Repeati190 – 211LRR 6Add BLAST22
Repeati214 – 235LRR 7Add BLAST22
Repeati238 – 259LRR 8Add BLAST22
Repeati262 – 283LRR 9Add BLAST22
Repeati286 – 305LRR 10Add BLAST20
Repeati311 – 333LRR 11Add BLAST23
Repeati336 – 357LRR 12Add BLAST22
Domaini369 – 422LRRCTAdd BLAST54
Domaini422 – 511Ig-like C2-typeAdd BLAST90

Keywords - Domaini

Immunoglobulin domain, Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0619 Eukaryota
COG4886 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000161204

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000252914

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG052361

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O75325

Identification of Orthologs from Complete Genome Data

More...
OMAi
TEYWACL

Database of Orthologous Groups

More...
OrthoDBi
EOG091G066E

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O75325

TreeFam database of animal gene trees

More...
TreeFami
TF334360

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 1 hit
3.80.10.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000483 Cys-rich_flank_reg_C
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07679 I-set, 1 hit
PF13855 LRR_8, 3 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00409 IG, 1 hit
SM00408 IGc2, 1 hit
SM00369 LRR_TYP, 10 hits
SM00082 LRRCT, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48726 SSF48726, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS51450 LRR, 9 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

O75325-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRLLVAPLLL AWVAGATAAV PVVPWHVPCP PQCACQIRPW YTPRSSYREA
60 70 80 90 100
TTVDCNDLFL TAVPPALPAG TQTLLLQSNS IVRVDQSELG YLANLTELDL
110 120 130 140 150
SQNSFSDARD CDFHALPQLL SLHLEENQLT RLEDHSFAGL ASLQELYLNH
160 170 180 190 200
NQLYRIAPRA FSGLSNLLRL HLNSNLLRAI DSRWFEMLPN LEILMIGGNK
210 220 230 240 250
VDAILDMNFR PLANLRSLVL AGMNLREISD YALEGLQSLE SLSFYDNQLA
260 270 280 290 300
RVPRRALEQV PGLKFLDLNK NPLQRVGPGD FANMLHLKEL GLNNMEELVS
310 320 330 340 350
IDKFALVNLP ELTKLDITNN PRLSFIHPRA FHHLPQMETL MLNNNALSAL
360 370 380 390 400
HQQTVESLPN LQEVGLHGNP IRCDCVIRWA NATGTRVRFI EPQSTLCAEP
410 420 430 440 450
PDLQRLPVRE VPFREMTDHC LPLISPRSFP PSLQVASGES MVLHCRALAE
460 470 480 490 500
PEPEIYWVTP AGLRLTPAHA GRRYRVYPEG TLELRRVTAE EAGLYTCVAQ
510 520 530 540 550
NLVGADTKTV SVVVGRALLQ PGRDEGQGLE LRVQETHPYH ILLSWVTPPN
560 570 580 590 600
TVSTNLTWSS ASSLRGQGAT ALARLPRGTH SYNITRLLQA TEYWACLQVA
610 620 630 640 650
FADAHTQLAC VWARTKEATS CHRALGDRPG LIAILALAVL LLAAGLAAHL
660 670 680 690 700
GTGQPRKGVG GRRPLPPAWA FWGWSAPSVR VVSAPLVLPW NPGRKLPRSS
710
EGETLLPPLS QNS
Length:713
Mass (Da):78,859
Last modified:March 15, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8B97B131FF61254A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti355V → A in AAH34047 (PubMed:15489334).Curated1
Sequence conflicti355V → A in AAH68541 (PubMed:15489334).Curated1
Sequence conflicti474Y → C in AAC39792 (PubMed:9662332).Curated1
Sequence conflicti676A → P in AAH34047 (PubMed:15489334).Curated1
Sequence conflicti676A → P in AAH68541 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0219217P → L. Corresponds to variant dbSNP:rs3789044Ensembl.1
Natural variantiVAR_04989819A → T1 PublicationCorresponds to variant dbSNP:rs36012907Ensembl.1
Natural variantiVAR_021922518L → V. Corresponds to variant dbSNP:rs3747631Ensembl.1
Natural variantiVAR_049899659V → A. Corresponds to variant dbSNP:rs34771052Ensembl.1
Natural variantiVAR_049900692P → S. Corresponds to variant dbSNP:rs11588857Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF030435 mRNA Translation: AAC39792.1
AY358290 mRNA Translation: AAQ88657.1
AK312408 mRNA Translation: BAG35321.1
AL512306 Genomic DNA No translation available.
CH471067 Genomic DNA Translation: EAW91520.1
BC034047 mRNA Translation: AAH34047.1
BC068541 mRNA Translation: AAH68541.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS1448.1

NCBI Reference Sequences

More...
RefSeqi
NP_006329.2, NM_006338.2
NP_963924.1, NM_201630.1
XP_005244884.1, XM_005244827.3
XP_011507368.1, XM_011509066.2
XP_016855539.1, XM_017000050.1

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.26312

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000367175; ENSP00000356143; ENSG00000170382
ENST00000367176; ENSP00000356144; ENSG00000170382
ENST00000367177; ENSP00000356145; ENSG00000170382

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
10446

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:10446

UCSC genome browser

More...
UCSCi
uc001hbe.3 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF030435 mRNA Translation: AAC39792.1
AY358290 mRNA Translation: AAQ88657.1
AK312408 mRNA Translation: BAG35321.1
AL512306 Genomic DNA No translation available.
CH471067 Genomic DNA Translation: EAW91520.1
BC034047 mRNA Translation: AAH34047.1
BC068541 mRNA Translation: AAH68541.1
CCDSiCCDS1448.1
RefSeqiNP_006329.2, NM_006338.2
NP_963924.1, NM_201630.1
XP_005244884.1, XM_005244827.3
XP_011507368.1, XM_011509066.2
XP_016855539.1, XM_017000050.1
UniGeneiHs.26312

3D structure databases

ProteinModelPortaliO75325
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115711, 18 interactors
IntActiO75325, 1 interactor
STRINGi9606.ENSP00000356143

PTM databases

iPTMnetiO75325
PhosphoSitePlusiO75325

Polymorphism and mutation databases

BioMutaiLRRN2

Proteomic databases

MaxQBiO75325
PaxDbiO75325
PeptideAtlasiO75325
PRIDEiO75325
ProteomicsDBi49895

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
10446
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000367175; ENSP00000356143; ENSG00000170382
ENST00000367176; ENSP00000356144; ENSG00000170382
ENST00000367177; ENSP00000356145; ENSG00000170382
GeneIDi10446
KEGGihsa:10446
UCSCiuc001hbe.3 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
10446
DisGeNETi10446
EuPathDBiHostDB:ENSG00000170382.11

GeneCards: human genes, protein and diseases

More...
GeneCardsi
LRRN2

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0001502
HGNCiHGNC:16914 LRRN2
HPAiHPA029124
MIMi605492 gene
neXtProtiNX_O75325
OpenTargetsiENSG00000170382
PharmGKBiPA162394661

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0619 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00940000161204
HOGENOMiHOG000252914
HOVERGENiHBG052361
InParanoidiO75325
OMAiTEYWACL
OrthoDBiEOG091G066E
PhylomeDBiO75325
TreeFamiTF334360

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
LRRN2 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
LRRN2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
10446

Protein Ontology

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PROi
PR:O75325

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000170382 Expressed in 138 organ(s), highest expression level in anterior cingulate cortex
CleanExiHS_LRRN2
ExpressionAtlasiO75325 baseline and differential
GenevisibleiO75325 HS

Family and domain databases

Gene3Di2.60.40.10, 1 hit
3.80.10.10, 2 hits
InterProiView protein in InterPro
IPR000483 Cys-rich_flank_reg_C
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
PfamiView protein in Pfam
PF07679 I-set, 1 hit
PF13855 LRR_8, 3 hits
SMARTiView protein in SMART
SM00409 IG, 1 hit
SM00408 IGc2, 1 hit
SM00369 LRR_TYP, 10 hits
SM00082 LRRCT, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS51450 LRR, 9 hits

ProtoNet; Automatic hierarchical classification of proteins

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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLRRN2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O75325
Secondary accession number(s): B2R624
, Q5T0Y0, Q6UXM0, Q8N182
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: March 15, 2005
Last modified: December 5, 2018
This is version 169 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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