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Protein

Stannin

Gene

SNN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in the toxic effects of organotins (PubMed:15269288). Plays a role in endosomal maturation (PubMed:27015288).2 Publications

GO - Molecular functioni

  • metal ion binding Source: CAFA

GO - Biological processi

  • response to toxic substance Source: CAFA

Names & Taxonomyi

Protein namesi
Recommended name:
Stannin
Alternative name(s):
AG8_1
Gene namesi
Name:SNN
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000184602.5
HGNCiHGNC:11149 SNN
MIMi603032 gene
neXtProtiNX_O75324

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 10Mitochondrial intermembrane1 Publication10
Transmembranei11 – 31HelicalSequence analysisAdd BLAST21
Topological domaini32 – 88Cytoplasmic1 PublicationAdd BLAST57

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000184602
PharmGKBiPA35991

Polymorphism and mutation databases

BioMutaiSNN

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000720141 – 88StanninAdd BLAST88

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei49PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO75324
PaxDbiO75324
PeptideAtlasiO75324
PRIDEiO75324
ProteomicsDBi49894

PTM databases

iPTMnetiO75324
PhosphoSitePlusiO75324

Expressioni

Gene expression databases

BgeeiENSG00000184602 Expressed in 227 organ(s), highest expression level in middle temporal gyrus
CleanExiHS_SNN
GenevisibleiO75324 HS

Organism-specific databases

HPAiHPA011055

Interactioni

Subunit structurei

Monomer.1 Publication

Protein-protein interaction databases

BioGridi113904, 6 interactors
STRINGi9606.ENSP00000329287

Structurei

Secondary structure

188
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

DisProtiDP00162
ProteinModelPortaliO75324
SMRiO75324
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO75324

Family & Domainsi

Sequence similaritiesi

Belongs to the stannin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IYFC Eukaryota
ENOG4111TD3 LUCA
GeneTreeiENSGT00390000009447
HOGENOMiHOG000261688
HOVERGENiHBG017824
InParanoidiO75324
OMAiYSARGPC
OrthoDBiEOG091G16Q5
PhylomeDBiO75324
TreeFamiTF336244

Family and domain databases

Gene3Di4.10.280.20, 1 hit
InterProiView protein in InterPro
IPR015137 SNN_cytoplasm
IPR015136 SNN_linker
IPR015135 SNN_transmemb
IPR038747 Stannin
IPR027435 Stannin_sf
PANTHERiPTHR28564 PTHR28564, 1 hit
PfamiView protein in Pfam
PF09051 SNN_cytoplasm, 1 hit
PF09050 SNN_linker, 1 hit
PF09049 SNN_transmemb, 1 hit

Sequencei

Sequence statusi: Complete.

O75324-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSIMDHSPTT GVVTVIVILI AIAALGALIL GCWCYLRLQR ISQSEDEESI
60 70 80
VGDGETKEPF LLVQYSAKGP CVERKAKLMT PNGPEVHG
Length:88
Mass (Da):9,497
Last modified:November 1, 1998 - v1
Checksum:i1E8DA73323C5D6DF
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01884217V → I1 PublicationCorresponds to variant dbSNP:rs8191328Ensembl.1
Natural variantiVAR_01884388G → S1 PublicationCorresponds to variant dbSNP:rs8191329Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF030196 mRNA Translation: AAC28427.1
AF070673 mRNA Translation: AAC83231.1
AL161976 mRNA Translation: CAB82314.1
AY325800 Genomic DNA Translation: AAP78484.1
CR542127 mRNA Translation: CAG46924.1
CR542138 mRNA Translation: CAG46935.1
CH471112 Genomic DNA Translation: EAW85146.1
CH471112 Genomic DNA Translation: EAW85147.1
BC036100 mRNA Translation: AAH36100.1
BC036443 mRNA Translation: AAH36443.1
CCDSiCCDS10549.1
PIRiT47139
RefSeqiNP_003489.1, NM_003498.5
XP_016879231.1, XM_017023742.1
UniGeneiHs.618526

Genome annotation databases

EnsembliENST00000329565; ENSP00000329287; ENSG00000184602
GeneIDi8303
KEGGihsa:8303
UCSCiuc002dbf.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF030196 mRNA Translation: AAC28427.1
AF070673 mRNA Translation: AAC83231.1
AL161976 mRNA Translation: CAB82314.1
AY325800 Genomic DNA Translation: AAP78484.1
CR542127 mRNA Translation: CAG46924.1
CR542138 mRNA Translation: CAG46935.1
CH471112 Genomic DNA Translation: EAW85146.1
CH471112 Genomic DNA Translation: EAW85147.1
BC036100 mRNA Translation: AAH36100.1
BC036443 mRNA Translation: AAH36443.1
CCDSiCCDS10549.1
PIRiT47139
RefSeqiNP_003489.1, NM_003498.5
XP_016879231.1, XM_017023742.1
UniGeneiHs.618526

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ZZANMR-A1-88[»]
DisProtiDP00162
ProteinModelPortaliO75324
SMRiO75324
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113904, 6 interactors
STRINGi9606.ENSP00000329287

PTM databases

iPTMnetiO75324
PhosphoSitePlusiO75324

Polymorphism and mutation databases

BioMutaiSNN

Proteomic databases

EPDiO75324
PaxDbiO75324
PeptideAtlasiO75324
PRIDEiO75324
ProteomicsDBi49894

Protocols and materials databases

DNASUi8303
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000329565; ENSP00000329287; ENSG00000184602
GeneIDi8303
KEGGihsa:8303
UCSCiuc002dbf.5 human

Organism-specific databases

CTDi8303
EuPathDBiHostDB:ENSG00000184602.5
GeneCardsiSNN
HGNCiHGNC:11149 SNN
HPAiHPA011055
MIMi603032 gene
neXtProtiNX_O75324
OpenTargetsiENSG00000184602
PharmGKBiPA35991
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IYFC Eukaryota
ENOG4111TD3 LUCA
GeneTreeiENSGT00390000009447
HOGENOMiHOG000261688
HOVERGENiHBG017824
InParanoidiO75324
OMAiYSARGPC
OrthoDBiEOG091G16Q5
PhylomeDBiO75324
TreeFamiTF336244

Miscellaneous databases

ChiTaRSiSNN human
EvolutionaryTraceiO75324
GeneWikiiSNN_(gene)
GenomeRNAii8303
PROiPR:O75324
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000184602 Expressed in 227 organ(s), highest expression level in middle temporal gyrus
CleanExiHS_SNN
GenevisibleiO75324 HS

Family and domain databases

Gene3Di4.10.280.20, 1 hit
InterProiView protein in InterPro
IPR015137 SNN_cytoplasm
IPR015136 SNN_linker
IPR015135 SNN_transmemb
IPR038747 Stannin
IPR027435 Stannin_sf
PANTHERiPTHR28564 PTHR28564, 1 hit
PfamiView protein in Pfam
PF09051 SNN_cytoplasm, 1 hit
PF09050 SNN_linker, 1 hit
PF09049 SNN_transmemb, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSNN_HUMAN
AccessioniPrimary (citable) accession number: O75324
Secondary accession number(s): D3DUG4, Q6FGI0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1998
Last modified: September 12, 2018
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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