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Entry version 160 (18 Sep 2019)
Sequence version 2 (28 Mar 2018)
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Protein

RNA/RNP complex-1-interacting phosphatase

Gene

DUSP11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Possesses RNA 5'-triphosphatase and diphosphatase activities, but displays a poor protein-tyrosine phosphatase activity. In addition, has phosphatase activity with ATP, ADP and O-methylfluorescein phosphate (in vitro). Binds to RNA. May participate in nuclear mRNA metabolism.3 Publications

Caution

It is uncertain whether Met-1 or Met-48 is the initiator.Curated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei199Phosphocysteine intermediatePROSITE-ProRule annotation1 Publication1 Publication1
Active sitei205Proton donor/acceptorSequence analysis1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, RNA-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
RNA/RNP complex-1-interacting phosphatase (EC:3.1.3.-)
Alternative name(s):
Dual specificity protein phosphatase 11
Phosphatase that interacts with RNA/RNP complex 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DUSP11
Synonyms:PIR1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:3066 DUSP11

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
603092 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O75319

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi166H → G: No effect on phosphatase activity with ATP and ADP. 1 Publication1
Mutagenesisi199C → S: Loss of activity. No effect in RNA-binding. 3 Publications1
Mutagenesisi201H → A: Strongly decreases phosphatase activity with ATP and ADP. 1 Publication1
Mutagenesisi204N → A: Strongly decreases phosphatase activity with ATP and ADP. 1 Publication1
Mutagenesisi239R → K: Slightly decreases phosphatase activity with ATP. Strongly decreases phosphatase activity with ADP. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
8446

Open Targets

More...
OpenTargetsi
ENSG00000144048

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA27521

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
DUSP11

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000948161 – 377RNA/RNP complex-1-interacting phosphataseAdd BLAST377

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
O75319

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
O75319

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
O75319

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O75319

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O75319

PeptideAtlas

More...
PeptideAtlasi
O75319

PRoteomics IDEntifications database

More...
PRIDEi
O75319

ProteomicsDB human proteome resource

More...
ProteomicsDBi
12230
49891 [O75319-1]
49892 [O75319-2]

PTM databases

DEPOD human dephosphorylation database

More...
DEPODi
O75319

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O75319

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O75319

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000144048 Expressed in 228 organ(s), highest expression level in fallopian tube

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
O75319 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O75319 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA021052

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer (PubMed:24531476). May interact with SFRS7 and SFRS9/SRP30C (PubMed:24447265).

2 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
114024, 54 interactors

Protein interaction database and analysis system

More...
IntActi
O75319, 16 interactors

Molecular INTeraction database

More...
MINTi
O75319

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000272444

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1377
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O75319

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini175 – 244Tyrosine-protein phosphataseAdd BLAST70

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni200 – 205Substrate binding1 Publication6

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2386 Eukaryota
COG5226 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155847

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000112295

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O75319

KEGG Orthology (KO)

More...
KOi
K14165

Identification of Orthologs from Complete Genome Data

More...
OMAi
RCRGHCI

Database of Orthologous Groups

More...
OrthoDBi
1544021at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O75319

TreeFam database of animal gene trees

More...
TreeFami
TF105124

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.90.190.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000340 Dual-sp_phosphatase_cat-dom
IPR029021 Prot-tyrosine_phosphatase-like
IPR016130 Tyr_Pase_AS
IPR000387 TYR_PHOSPHATASE_dom
IPR020422 TYR_PHOSPHATASE_DUAL_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00782 DSPc, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00195 DSPc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52799 SSF52799, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00383 TYR_PHOSPHATASE_1, 1 hit
PS50056 TYR_PHOSPHATASE_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: O75319-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRNSETLERG VGGCRVFSCL GSYPGIEGAG LALLADLALG GRLLGTHMSQ
60 70 80 90 100
WHHPRSGWGR RRDFSGRSSA KKKGGNHIPE RWKDYLPVGQ RMPGTRFIAF
110 120 130 140 150
KVPLQKSFEK KLAPEECFSP LDLFNKIREQ NEELGLIIDL TYTQRYYKPE
160 170 180 190 200
DLPETVPYLK IFTVGHQVPD DETIFKFKHA VNGFLKENKD NDKLIGVHCT
210 220 230 240 250
HGLNRTGYLI CRYLIDVEGV RPDDAIELFN RCRGHCLERQ NYIEDLQNGP
260 270 280 290 300
IRKNWNSSVP RSSDFEDSAH LMQPVHNKPV KQGPRYNLHQ IQGHSAPRHF
310 320 330 340 350
HTQTQSLQQS VRKFSENPHV YQRHHLPPPG PPGEDYSHRR YSWNVKPNAS
360 370
RAAQDRRRWY PYNYSRLSYP ACWEWTQ
Length:377
Mass (Da):43,710
Last modified:March 28, 2018 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i61002BD1E2B06A5D
GO
Isoform 2 (identifier: O75319-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     213-273: YLIDVEGVRP...DFEDSAHLMQ → RSLALSPRLE...IFSRDVVSPC
     274-377: Missing.

Show »
Length:273
Mass (Da):30,590
Checksum:i373A30BA85C828F2
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7C0E6H7C0E6_HUMAN
RNA/RNP complex-1-interacting phosp...
DUSP11
150Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAC39925 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAH00346 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAG37685 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti7L → W in AAC39925 (PubMed:9685386).Curated1
Sequence conflicti36D → G in CAH10467 (PubMed:17974005).Curated1
Sequence conflicti36D → G in AAC39925 (PubMed:9685386).Curated1
Sequence conflicti36D → G in BAG37685 (PubMed:14702039).Curated1
Sequence conflicti36D → G in AAH00346 (PubMed:15489334).Curated1
Sequence conflicti212R → I in AAH00346 (PubMed:15489334).Curated1
Isoform 2 (identifier: O75319-2)
Sequence conflicti215L → R in CAH10467 (PubMed:17974005).1
Sequence conflicti237G → S in CAH10467 (PubMed:17974005).1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_014136213 – 273YLIDV…AHLMQ → RSLALSPRLECSGTISTHSK FCFPGSRRSPASASQVAGTT GARHHARLIFCIFSRDVVSP C in isoform 2. 1 PublicationAdd BLAST61
Alternative sequenceiVSP_014137274 – 377Missing in isoform 2. 1 PublicationAdd BLAST104

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CR627368 mRNA Translation: CAH10467.1
AC092653 Genomic DNA No translation available.
AF023917 mRNA Translation: AAC39925.1 Different initiation.
AK315271 mRNA Translation: BAG37685.1 Different initiation.
BC000346 mRNA Translation: AAH00346.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS1928.2 [O75319-1]

NCBI Reference Sequences

More...
RefSeqi
NP_003575.2, NM_003584.2 [O75319-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000272444; ENSP00000272444; ENSG00000144048 [O75319-1]
ENST00000443070; ENSP00000413444; ENSG00000144048 [O75319-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
8446

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:8446

UCSC genome browser

More...
UCSCi
uc002sjp.4 human [O75319-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR627368 mRNA Translation: CAH10467.1
AC092653 Genomic DNA No translation available.
AF023917 mRNA Translation: AAC39925.1 Different initiation.
AK315271 mRNA Translation: BAG37685.1 Different initiation.
BC000346 mRNA Translation: AAH00346.1 Different initiation.
CCDSiCCDS1928.2 [O75319-1]
RefSeqiNP_003575.2, NM_003584.2 [O75319-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4JMJX-ray2.38A75-255[»]
4MBBX-ray1.85A76-254[»]
4NYHX-ray1.20A/B/C76-252[»]
SMRiO75319
ModBaseiSearch...

Protein-protein interaction databases

BioGridi114024, 54 interactors
IntActiO75319, 16 interactors
MINTiO75319
STRINGi9606.ENSP00000272444

PTM databases

DEPODiO75319
iPTMnetiO75319
PhosphoSitePlusiO75319

Polymorphism and mutation databases

BioMutaiDUSP11

Proteomic databases

EPDiO75319
jPOSTiO75319
MassIVEiO75319
MaxQBiO75319
PaxDbiO75319
PeptideAtlasiO75319
PRIDEiO75319
ProteomicsDBi12230
49891 [O75319-1]
49892 [O75319-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
8446
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000272444; ENSP00000272444; ENSG00000144048 [O75319-1]
ENST00000443070; ENSP00000413444; ENSG00000144048 [O75319-2]
GeneIDi8446
KEGGihsa:8446
UCSCiuc002sjp.4 human [O75319-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
8446
DisGeNETi8446

GeneCards: human genes, protein and diseases

More...
GeneCardsi
DUSP11
HGNCiHGNC:3066 DUSP11
HPAiHPA021052
MIMi603092 gene
neXtProtiNX_O75319
OpenTargetsiENSG00000144048
PharmGKBiPA27521

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2386 Eukaryota
COG5226 LUCA
GeneTreeiENSGT00940000155847
HOGENOMiHOG000112295
InParanoidiO75319
KOiK14165
OMAiRCRGHCI
OrthoDBi1544021at2759
PhylomeDBiO75319
TreeFamiTF105124

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
DUSP11 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
8446

Pharos

More...
Pharosi
O75319

Protein Ontology

More...
PROi
PR:O75319

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000144048 Expressed in 228 organ(s), highest expression level in fallopian tube
ExpressionAtlasiO75319 baseline and differential
GenevisibleiO75319 HS

Family and domain databases

Gene3Di3.90.190.10, 1 hit
InterProiView protein in InterPro
IPR000340 Dual-sp_phosphatase_cat-dom
IPR029021 Prot-tyrosine_phosphatase-like
IPR016130 Tyr_Pase_AS
IPR000387 TYR_PHOSPHATASE_dom
IPR020422 TYR_PHOSPHATASE_DUAL_dom
PfamiView protein in Pfam
PF00782 DSPc, 1 hit
SMARTiView protein in SMART
SM00195 DSPc, 1 hit
SUPFAMiSSF52799 SSF52799, 1 hit
PROSITEiView protein in PROSITE
PS00383 TYR_PHOSPHATASE_1, 1 hit
PS50056 TYR_PHOSPHATASE_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDUS11_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O75319
Secondary accession number(s): B2RCT8
, C9JYA6, Q6AI47, Q9BWE3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: March 28, 2018
Last modified: September 18, 2019
This is version 160 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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