Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

UDP-glucuronosyltransferase 2B11

Gene

UGT2B11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.

Catalytic activityi

UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

GO - Molecular functioni

  • glucuronosyltransferase activity Source: UniProtKB
  • UDP-glycosyltransferase activity Source: GO_Central

GO - Biological processi

  • estrogen metabolic process Source: UniProtKB
  • xenobiotic glucuronidation Source: UniProtKB
  • xenobiotic metabolic process Source: ProtInc

Keywordsi

Molecular functionGlycosyltransferase, Transferase

Enzyme and pathway databases

BRENDAi2.4.1.17 2681
ReactomeiR-HSA-156588 Glucuronidation

Protein family/group databases

CAZyiGT1 Glycosyltransferase Family 1

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-glucuronosyltransferase 2B11 (EC:2.4.1.17)
Short name:
UDPGT 2B11
Gene namesi
Name:UGT2B11
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000213759.8
HGNCiHGNC:12545 UGT2B11
MIMi603064 gene
neXtProtiNX_O75310

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei493 – 513HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

Pathology & Biotechi

Organism-specific databases

DisGeNETi10720
OpenTargetsiENSG00000213759
PharmGKBiPA37187

Polymorphism and mutation databases

BioMutaiUGT2B11

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000003603522 – 529UDP-glucuronosyltransferase 2B11Add BLAST508

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei135N6-succinyllysineBy similarity1
Glycosylationi315N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiO75310
PeptideAtlasiO75310
PRIDEiO75310
ProteomicsDBi49886

PTM databases

iPTMnetiO75310
PhosphoSitePlusiO75310

Expressioni

Tissue specificityi

Widely expressed.

Gene expression databases

BgeeiENSG00000213759 Expressed in 36 organ(s), highest expression level in liver
CleanExiHS_UGT2B11
GenevisibleiO75310 HS

Organism-specific databases

HPAiHPA045108

Interactioni

Protein-protein interaction databases

IntActiO75310, 2 interactors
STRINGi9606.ENSP00000387683

Structurei

3D structure databases

ProteinModelPortaliO75310
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UDP-glycosyltransferase family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1192 Eukaryota
COG1819 LUCA
GeneTreeiENSGT00760000118949
HOGENOMiHOG000220831
HOVERGENiHBG004033
InParanoidiO75310
KOiK00699
OMAiISPCCEL
OrthoDBiEOG091G06JC
PhylomeDBiO75310
TreeFamiTF315472

Family and domain databases

InterProiView protein in InterPro
IPR002213 UDP_glucos_trans
IPR035595 UDP_glycos_trans_CS
PfamiView protein in Pfam
PF00201 UDPGT, 1 hit
PROSITEiView protein in PROSITE
PS00375 UDPGT, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O75310-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTLKWTSVLL LIHLSCYFSS GSCGKVLVWA AEYSHWMNMK TILKELVQRG
60 70 80 90 100
HEVTVLASSA SILFDPNDAS TLKFEVYPTS LTKTEFENII MQQVKRWSDI
110 120 130 140 150
RKDSFWLYFS QEQEILWELY DIFRNFCKDV VSNKKVMKKL QESRFDIVFA
160 170 180 190 200
DAVFPCGELL AALLNIRFVY SLRFTPGYTI ERHSGGLIFP PSYIPIVMSK
210 220 230 240 250
LSDQMTFMER VKNMIYVLYF DFWFQMSDMK KWDQFYSEVL GRPTTLFETM
260 270 280 290 300
GKADIWLMRN SWSFQFPHPF LPNVDFVGGF HCKPAKPLPK EMEEFVQSSG
310 320 330 340 350
ENGVVVFSLG SVISNMTAER ANVIATALAK IPQKVLWRFD GNKPDALGLN
360 370 380 390 400
TRLYKWIPQN DLLGHPKTRA FITHGGANGI YEAIYHGIPM VGIPLFFDQP
410 420 430 440 450
DNIAHMKAKG AAVRLDFNTM SSTDLLNALK TVINDPLYKE NIMKLSRIQH
460 470 480 490 500
DQPVKPLDRA VFWIEFVMPH KGAKHLRVAA HDLTWFQYHS LDVIGFLLAC
510 520
VATVIFIITK FCLFCFWKFA RKGKKGKRD
Length:529
Mass (Da):61,038
Last modified:November 1, 1998 - v1
Checksum:iCE4AC3C71CFC2AB4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF016492 mRNA Translation: AAC27891.1
BC069441 mRNA Translation: AAH69441.1
BC107059 mRNA Translation: AAI07060.1
BC107060 mRNA Translation: AAI07061.1
CCDSiCCDS3527.1
PIRiJE0200
RefSeqiNP_001064.1, NM_001073.2
UniGeneiHs.339811

Genome annotation databases

EnsembliENST00000446444; ENSP00000387683; ENSG00000213759
GeneIDi10720
KEGGihsa:10720
UCSCiuc003heh.5 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF016492 mRNA Translation: AAC27891.1
BC069441 mRNA Translation: AAH69441.1
BC107059 mRNA Translation: AAI07060.1
BC107060 mRNA Translation: AAI07061.1
CCDSiCCDS3527.1
PIRiJE0200
RefSeqiNP_001064.1, NM_001073.2
UniGeneiHs.339811

3D structure databases

ProteinModelPortaliO75310
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO75310, 2 interactors
STRINGi9606.ENSP00000387683

Protein family/group databases

CAZyiGT1 Glycosyltransferase Family 1

PTM databases

iPTMnetiO75310
PhosphoSitePlusiO75310

Polymorphism and mutation databases

BioMutaiUGT2B11

Proteomic databases

PaxDbiO75310
PeptideAtlasiO75310
PRIDEiO75310
ProteomicsDBi49886

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000446444; ENSP00000387683; ENSG00000213759
GeneIDi10720
KEGGihsa:10720
UCSCiuc003heh.5 human

Organism-specific databases

CTDi10720
DisGeNETi10720
EuPathDBiHostDB:ENSG00000213759.8
GeneCardsiUGT2B11
HGNCiHGNC:12545 UGT2B11
HPAiHPA045108
MIMi603064 gene
neXtProtiNX_O75310
OpenTargetsiENSG00000213759
PharmGKBiPA37187
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1192 Eukaryota
COG1819 LUCA
GeneTreeiENSGT00760000118949
HOGENOMiHOG000220831
HOVERGENiHBG004033
InParanoidiO75310
KOiK00699
OMAiISPCCEL
OrthoDBiEOG091G06JC
PhylomeDBiO75310
TreeFamiTF315472

Enzyme and pathway databases

BRENDAi2.4.1.17 2681
ReactomeiR-HSA-156588 Glucuronidation

Miscellaneous databases

ChiTaRSiUGT2B11 human
GenomeRNAii10720
PROiPR:O75310
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000213759 Expressed in 36 organ(s), highest expression level in liver
CleanExiHS_UGT2B11
GenevisibleiO75310 HS

Family and domain databases

InterProiView protein in InterPro
IPR002213 UDP_glucos_trans
IPR035595 UDP_glycos_trans_CS
PfamiView protein in Pfam
PF00201 UDPGT, 1 hit
PROSITEiView protein in PROSITE
PS00375 UDPGT, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiUDB11_HUMAN
AccessioniPrimary (citable) accession number: O75310
Secondary accession number(s): Q3KNV9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1998
Last modified: November 7, 2018
This is version 146 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again