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Protein

Cadherin-16

Gene

CDH16

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCell adhesion
LigandCalcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cadherin-16
Alternative name(s):
Kidney-specific cadherin
Short name:
Ksp-cadherin
Gene namesi
Name:CDH16
ORF Names:UNQ695/PRO1340
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000166589.12
HGNCiHGNC:1755 CDH16
MIMi603118 gene
neXtProtiNX_O75309

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini19 – 786ExtracellularSequence analysisAdd BLAST768
Transmembranei787 – 807HelicalSequence analysisAdd BLAST21
Topological domaini808 – 829CytoplasmicSequence analysisAdd BLAST22

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi1014
OpenTargetsiENSG00000166589
PharmGKBiPA26289

Polymorphism and mutation databases

BioMutaiCDH16

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000000380919 – 829Cadherin-16Add BLAST811

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi517N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi602N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi722N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei822PhosphoserineBy similarity1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiO75309
PeptideAtlasiO75309
PRIDEiO75309
ProteomicsDBi49884
49885 [O75309-2]

PTM databases

iPTMnetiO75309
PhosphoSitePlusiO75309

Expressioni

Tissue specificityi

Kidney specific.

Gene expression databases

BgeeiENSG00000166589 Expressed in 57 organ(s), highest expression level in adult mammalian kidney
CleanExiHS_CDH16
ExpressionAtlasiO75309 baseline and differential
GenevisibleiO75309 HS

Organism-specific databases

HPAiCAB013526
HPA036260

Interactioni

Protein-protein interaction databases

BioGridi107449, 3 interactors
IntActiO75309, 2 interactors
STRINGi9606.ENSP00000299752

Structurei

3D structure databases

ProteinModelPortaliO75309
SMRiO75309
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 126Cadherin 1PROSITE-ProRule annotationAdd BLAST102
Domaini131 – 235Cadherin 2PROSITE-ProRule annotationAdd BLAST105
Domaini242 – 336Cadherin 3PROSITE-ProRule annotationAdd BLAST95
Domaini341 – 449Cadherin 4PROSITE-ProRule annotationAdd BLAST109
Domaini455 – 564Cadherin 5PROSITE-ProRule annotationAdd BLAST110
Domaini569 – 665Cadherin 6PROSITE-ProRule annotationAdd BLAST97

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni666 – 786Ectodomain GAdd BLAST121

Domaini

Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.By similarity

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3594 Eukaryota
ENOG410XQHI LUCA
GeneTreeiENSGT00740000115559
HOGENOMiHOG000231613
HOVERGENiHBG050766
InParanoidiO75309
KOiK06810
OMAiHWVEPRE
OrthoDBiEOG091G03CL
PhylomeDBiO75309
TreeFamiTF316817

Family and domain databases

InterProiView protein in InterPro
IPR002126 Cadherin
IPR030721 Cadherin-16
IPR015919 Cadherin-like
IPR020894 Cadherin_CS
PANTHERiPTHR24028:SF1 PTHR24028:SF1, 1 hit
PfamiView protein in Pfam
PF00028 Cadherin, 4 hits
PRINTSiPR00205 CADHERIN
SMARTiView protein in SMART
SM00112 CA, 6 hits
SUPFAMiSSF49313 SSF49313, 6 hits
PROSITEiView protein in PROSITE
PS00232 CADHERIN_1, 2 hits
PS50268 CADHERIN_2, 5 hits

Sequences (4+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 5 potential isoforms that are computationally mapped.iShow all

Isoform 1 (identifier: O75309-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVPAWLWLLC VSVPQALPKA QPAELSVEVP ENYGGNFPLY LTKLPLPREG
60 70 80 90 100
AEGQIVLSGD SGKATEGPFA MDPDSGFLLV TRALDREEQA EYQLQVTLEM
110 120 130 140 150
QDGHVLWGPQ PVLVHVKDEN DQVPHFSQAI YRARLSRGTR PGIPFLFLEA
160 170 180 190 200
SDRDEPGTAN SDLRFHILSQ APAQPSPDMF QLEPRLGALA LSPKGSTSLD
210 220 230 240 250
HALERTYQLL VQVKDMGDQA SGHQATATVE VSIIESTWVS LEPIHLAENL
260 270 280 290 300
KVLYPHHMAQ VHWSGGDVHY HLESHPPGPF EVNAEGNLYV TRELDREAQA
310 320 330 340 350
EYLLQVRAQN SHGEDYAAPL ELHVLVMDEN DNVPICPPRD PTVSIPELSP
360 370 380 390 400
PGTEVTRLSA EDADAPGSPN SHVVYQLLSP EPEDGVEGRA FQVDPTSGSV
410 420 430 440 450
TLGVLPLRAG QNILLLVLAM DLAGAEGGFS STCEVEVAVT DINDHAPEFI
460 470 480 490 500
TSQIGPISLP EDVEPGTLVA MLTAIDADLE PAFRLMDFAI ERGDTEGTFG
510 520 530 540 550
LDWEPDSGHV RLRLCKNLSY EAAPSHEVVV VVQSVAKLVG PGPGPGATAT
560 570 580 590 600
VTVLVERVMP PPKLDQESYE ASVPISAPAG SFLLTIQPSD PISRTLRFSL
610 620 630 640 650
VNDSEGWLCI EKFSGEVHTA QSLQGAQPGD TYTVLVEAQD TDEPRLSASA
660 670 680 690 700
PLVIHFLKAP PAPALTLAPV PSQYLCTPRQ DHGLIVSGPS KDPDLASGHG
710 720 730 740 750
PYSFTLGPNP TVQRDWRLQT LNGSHAYLTL ALHWVEPREH IIPVVVSHNA
760 770 780 790 800
QMWQLLVRVI VCRCNVEGQC MRKVGRMKGM PTKLSAVGIL VGTLVAIGIF
810 820
LILIFTHWTM SRKKDPDQPA DSVPLKATV
Length:829
Mass (Da):89,923
Last modified:November 1, 1998 - v1
Checksum:i41966915E4BFC891
GO
Isoform 2 (identifier: O75309-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     642-663: Missing.

Note: No experimental confirmation available.
Show »
Length:807
Mass (Da):87,614
Checksum:iB41914FE7B643744
GO
Isoform 3 (identifier: O75309-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     121-217: Missing.

Note: No experimental confirmation available.
Show »
Length:732
Mass (Da):79,196
Checksum:i7A91F3743DD857BF
GO
Isoform 4 (identifier: O75309-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     642-680: Missing.

Note: No experimental confirmation available.
Show »
Length:790
Mass (Da):85,774
Checksum:iF4F26806CF6FE2EA
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BSG2H3BSG2_HUMAN
Cadherin-16
CDH16
749Annotation score:
H3BSV3H3BSV3_HUMAN
Cadherin-16
CDH16
248Annotation score:
A0A0B4J288A0A0B4J288_HUMAN
Cadherin-16
CDH16
175Annotation score:
I3L418I3L418_HUMAN
Cadherin-16
CDH16
238Annotation score:
J3QLA1J3QLA1_HUMAN
Cadherin-16
CDH16
124Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_021870191L → F. Corresponds to variant dbSNP:rs2271024Ensembl.1
Natural variantiVAR_021871257H → Y. Corresponds to variant dbSNP:rs2271023Ensembl.1
Natural variantiVAR_061058717R → H. Corresponds to variant dbSNP:rs34621310Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_046027121 – 217Missing in isoform 3. 1 PublicationAdd BLAST97
Alternative sequenceiVSP_046467642 – 680Missing in isoform 4. 1 PublicationAdd BLAST39
Alternative sequenceiVSP_013354642 – 663Missing in isoform 2. 1 PublicationAdd BLAST22

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF016272 mRNA Translation: AAC34255.1
AY358911 mRNA Translation: AAQ89270.1
AK225544 mRNA No translation available.
AK298255 mRNA Translation: BAG60520.1
AC009084 Genomic DNA No translation available.
BC027912 mRNA Translation: AAH27912.1
CCDSiCCDS10823.1 [O75309-1]
CCDS56002.1 [O75309-2]
CCDS58471.1 [O75309-4]
CCDS58472.1 [O75309-3]
RefSeqiNP_001191673.1, NM_001204744.1 [O75309-2]
NP_001191674.1, NM_001204745.1 [O75309-4]
NP_001191675.1, NM_001204746.1 [O75309-3]
NP_004053.1, NM_004062.3 [O75309-1]
UniGeneiHs.513660

Genome annotation databases

EnsembliENST00000299752; ENSP00000299752; ENSG00000166589 [O75309-1]
ENST00000394055; ENSP00000377619; ENSG00000166589 [O75309-2]
ENST00000565796; ENSP00000454784; ENSG00000166589 [O75309-4]
ENST00000568632; ENSP00000455263; ENSG00000166589 [O75309-3]
GeneIDi1014
KEGGihsa:1014
UCSCiuc002eql.3 human [O75309-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCAD16_HUMAN
AccessioniPrimary (citable) accession number: O75309
Secondary accession number(s): B4DPA8, H3BPD3, Q6UW93
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: November 1, 1998
Last modified: September 12, 2018
This is version 153 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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