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Protein

Growth arrest and DNA damage-inducible protein GADD45 beta

Gene

GADD45B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the regulation of growth and apoptosis. Mediates activation of stress-responsive MTK1/MEKK4 MAPKKK.

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
Biological processApoptosis, Differentiation

Enzyme and pathway databases

SignaLinkiO75293
SIGNORiO75293

Names & Taxonomyi

Protein namesi
Recommended name:
Growth arrest and DNA damage-inducible protein GADD45 beta
Alternative name(s):
Myeloid differentiation primary response protein MyD118
Negative growth regulatory protein MyD118
Gene namesi
Name:GADD45B
Synonyms:MYD118
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000099860.8
HGNCiHGNC:4096 GADD45B
MIMi604948 gene
neXtProtiNX_O75293

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi4616
OpenTargetsiENSG00000099860
PharmGKBiPA28511

Polymorphism and mutation databases

BioMutaiGADD45B

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001483341 – 160Growth arrest and DNA damage-inducible protein GADD45 betaAdd BLAST160

Proteomic databases

PaxDbiO75293
PeptideAtlasiO75293
PRIDEiO75293
ProteomicsDBi49878

PTM databases

iPTMnetiO75293
PhosphoSitePlusiO75293

Expressioni

Gene expression databases

BgeeiENSG00000099860 Expressed in 234 organ(s), highest expression level in tibial artery
CleanExiHS_GADD45B
ExpressionAtlasiO75293 baseline and differential
GenevisibleiO75293 HS

Organism-specific databases

HPAiHPA029816

Interactioni

Subunit structurei

Interacts with GADD45GIP1.1 Publication

Binary interactionsi

Protein-protein interaction databases

BioGridi110701, 22 interactors
CORUMiO75293
DIPiDIP-24219N
IntActiO75293, 5 interactors
MINTiO75293
STRINGi9606.ENSP00000215631

Structurei

3D structure databases

ProteinModelPortaliO75293
SMRiO75293
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GADD45 family.Curated

Phylogenomic databases

eggNOGiENOG410IH6M Eukaryota
ENOG4111K8B LUCA
GeneTreeiENSGT00390000016506
HOGENOMiHOG000013221
HOVERGENiHBG051684
InParanoidiO75293
KOiK04402
OMAiAQRQDCL
PhylomeDBiO75293
TreeFamiTF300196

Family and domain databases

Gene3Di3.30.1330.30, 1 hit
InterProiView protein in InterPro
IPR024824 GADD45
IPR029064 L30e-like
IPR004038 Ribosomal_L7Ae/L30e/S12e/Gad45
PANTHERiPTHR10411 PTHR10411, 1 hit
PfamiView protein in Pfam
PF01248 Ribosomal_L7Ae, 1 hit
SUPFAMiSSF55315 SSF55315, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

O75293-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTLEELVACD NAAQKMQTVT AAVEELLVAA QRQDRLTVGV YESAKLMNVD
60 70 80 90 100
PDSVVLCLLA IDEEEEDDIA LQIHFTLIQS FCCDNDINIV RVSGMQRLAQ
110 120 130 140 150
LLGEPAETQG TTEARDLHCL LVTNPHTDAW KSHGLVEVAS YCEESRGNNQ
160
WVPYISLQER
Length:160
Mass (Da):17,818
Last modified:November 1, 1998 - v1
Checksum:i52712E307B322D46
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7EPQ8K7EPQ8_HUMAN
Growth arrest and DNA damage-induci...
GADD45B
176Annotation score:
Q6IX74Q6IX74_HUMAN
Growth arrest and DNA damage-induci...
GADD45B
66Annotation score:
K7EM97K7EM97_HUMAN
Growth arrest and DNA damage-induci...
GADD45B
60Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti95 – 96MQ → NA in AAC36361 (Ref. 1) Curated2
Sequence conflicti121 – 123LVT → PFLQ in AAC36361 (Ref. 1) Curated3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF090950 mRNA Translation: AAC36361.1
AF078077 mRNA Translation: AAC83328.1
AF087853 mRNA Translation: AAG48366.1
AF533019 Genomic DNA Translation: AAM92794.1
AK293087 mRNA Translation: BAF85776.1
AC005624 Genomic DNA Translation: AAC34572.1
CH471139 Genomic DNA Translation: EAW69376.1
BC113466 mRNA Translation: AAI13467.1
BC117469 mRNA Translation: AAI17470.1
CCDSiCCDS32868.1
RefSeqiNP_056490.2, NM_015675.3
UniGeneiHs.110571

Genome annotation databases

EnsembliENST00000215631; ENSP00000215631; ENSG00000099860
GeneIDi4616
KEGGihsa:4616
UCSCiuc002lwb.3 human

Similar proteinsi

Cross-referencesi

Web resourcesi

NIEHS-SNPs
Wikipedia

GADD45B entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF090950 mRNA Translation: AAC36361.1
AF078077 mRNA Translation: AAC83328.1
AF087853 mRNA Translation: AAG48366.1
AF533019 Genomic DNA Translation: AAM92794.1
AK293087 mRNA Translation: BAF85776.1
AC005624 Genomic DNA Translation: AAC34572.1
CH471139 Genomic DNA Translation: EAW69376.1
BC113466 mRNA Translation: AAI13467.1
BC117469 mRNA Translation: AAI17470.1
CCDSiCCDS32868.1
RefSeqiNP_056490.2, NM_015675.3
UniGeneiHs.110571

3D structure databases

ProteinModelPortaliO75293
SMRiO75293
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110701, 22 interactors
CORUMiO75293
DIPiDIP-24219N
IntActiO75293, 5 interactors
MINTiO75293
STRINGi9606.ENSP00000215631

PTM databases

iPTMnetiO75293
PhosphoSitePlusiO75293

Polymorphism and mutation databases

BioMutaiGADD45B

Proteomic databases

PaxDbiO75293
PeptideAtlasiO75293
PRIDEiO75293
ProteomicsDBi49878

Protocols and materials databases

DNASUi4616
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000215631; ENSP00000215631; ENSG00000099860
GeneIDi4616
KEGGihsa:4616
UCSCiuc002lwb.3 human

Organism-specific databases

CTDi4616
DisGeNETi4616
EuPathDBiHostDB:ENSG00000099860.8
GeneCardsiGADD45B
H-InvDBiHIX0174390
HGNCiHGNC:4096 GADD45B
HPAiHPA029816
MIMi604948 gene
neXtProtiNX_O75293
OpenTargetsiENSG00000099860
PharmGKBiPA28511
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IH6M Eukaryota
ENOG4111K8B LUCA
GeneTreeiENSGT00390000016506
HOGENOMiHOG000013221
HOVERGENiHBG051684
InParanoidiO75293
KOiK04402
OMAiAQRQDCL
PhylomeDBiO75293
TreeFamiTF300196

Enzyme and pathway databases

SignaLinkiO75293
SIGNORiO75293

Miscellaneous databases

GeneWikiiGADD45B
GenomeRNAii4616
PROiPR:O75293
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000099860 Expressed in 234 organ(s), highest expression level in tibial artery
CleanExiHS_GADD45B
ExpressionAtlasiO75293 baseline and differential
GenevisibleiO75293 HS

Family and domain databases

Gene3Di3.30.1330.30, 1 hit
InterProiView protein in InterPro
IPR024824 GADD45
IPR029064 L30e-like
IPR004038 Ribosomal_L7Ae/L30e/S12e/Gad45
PANTHERiPTHR10411 PTHR10411, 1 hit
PfamiView protein in Pfam
PF01248 Ribosomal_L7Ae, 1 hit
SUPFAMiSSF55315 SSF55315, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGA45B_HUMAN
AccessioniPrimary (citable) accession number: O75293
Secondary accession number(s): A8KAM2, O75960, Q17R46
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1998
Last modified: November 7, 2018
This is version 137 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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