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Protein

Zinc finger protein 780A

Gene

ZNF780A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in transcriptional regulation.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri165 – 187C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri193 – 215C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri221 – 243C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri249 – 271C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri277 – 299C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri305 – 327C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri333 – 355C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri361 – 383C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri389 – 411C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri417 – 439C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri445 – 467C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri473 – 495C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri501 – 523C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri529 – 551C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri557 – 579C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri585 – 607C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri613 – 635C2H2-type 17PROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein 780A
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZNF780A
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000197782.14

Human Gene Nomenclature Database

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HGNCi
HGNC:27603 ZNF780A

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O75290

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

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OpenTargetsi
ENSG00000197782

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162410417

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ZNF780A

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002636901 – 641Zinc finger protein 780AAdd BLAST641

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
O75290

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O75290

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O75290

PeptideAtlas

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PeptideAtlasi
O75290

PRoteomics IDEntifications database

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PRIDEi
O75290

ProteomicsDB human proteome resource

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ProteomicsDBi
49876
49877 [O75290-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
O75290

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
O75290

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000197782 Expressed in 142 organ(s), highest expression level in leukocyte

CleanEx database of gene expression profiles

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CleanExi
HS_ZNF780A

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
O75290 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O75290 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA003311

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
129827, 3 interactors

Protein interaction database and analysis system

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IntActi
O75290, 2 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000400997

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
O75290

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
O75290

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini6 – 77KRABPROSITE-ProRule annotationAdd BLAST72

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri165 – 187C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri193 – 215C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri221 – 243C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri249 – 271C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri277 – 299C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri305 – 327C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri333 – 355C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri361 – 383C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri389 – 411C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri417 – 439C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri445 – 467C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri473 – 495C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri501 – 523C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri529 – 551C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri557 – 579C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri585 – 607C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri613 – 635C2H2-type 17PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1721 Eukaryota
COG5048 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000162062

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000234617

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG018163

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
O75290

KEGG Orthology (KO)

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KOi
K09228

Identification of Orthologs from Complete Genome Data

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OMAi
CNTHKPY

Database of Orthologous Groups

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OrthoDBi
1318335at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
O75290

TreeFam database of animal gene trees

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TreeFami
TF341817

Family and domain databases

Conserved Domains Database

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CDDi
cd07765 KRAB_A-box, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 14 hits

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 17 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 9 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 17 hits
PS50157 ZINC_FINGER_C2H2_2, 17 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O75290-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVHGSVTFRD VAIDFSQEEW ECLQPDQRTL YRDVMLENYS HLISLGSSIS
60 70 80 90 100
KPDVITLLEQ EKEPWMVVRK ETSRRYPDLE LKYGPEKVSP ENDTSEVNLP
110 120 130 140 150
KQVIKQISTT LGIEAFYFRN DSEYRQFEGL QGYQEGNINQ KMISYEKLPT
160 170 180 190 200
HTPHASLICN THKPYECKEC GKYFSRSANL IQHQSIHTGE KPFECKECGK
210 220 230 240 250
AFRLHIQFTR HQKFHTGEKP FECNECGKAF SLLTLLNRHK NIHTGEKLFE
260 270 280 290 300
CKECGKSFNR SSNLVQHQSI HSGVKPYECK ECGKGFNRGA HLIQHQKIHS
310 320 330 340 350
NEKPFVCKEC GMAFRYHYQL IEHCQIHTGE KPFECKECGK AFTLLTKLVR
360 370 380 390 400
HQKIHTGEKP FECRECGKAF SLLNQLNRHK NIHTGEKPFE CKECGKSFNR
410 420 430 440 450
SSNLVQHQSI HAGIKPYECK ECGKGFNRGA HLIQHQKIHS NEKPFVCREC
460 470 480 490 500
EMAFRYHCQL IEHSRIHTGD KPFECQDCGK AFNRGSSLVQ HQSIHTGEKP
510 520 530 540 550
YECKECGKAF RLYLQLSQHQ KTHTGEKPFE CKECGKFFRR GSNLNQHRSI
560 570 580 590 600
HTGKKPFECK ECGKAFRLHM HLIRHQKLHT GEKPFECKEC GKAFRLHMQL
610 620 630 640
IRHQKLHTGE KPFECKECGK VFSLPTQLNR HKNIHTGEKA S
Length:641
Mass (Da):74,531
Last modified:December 16, 2008 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFE92AF740839A86D
GO
Isoform 2 (identifier: O75290-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MGRSPRKIDQFCNSSNM
     103-141: VIKQISTTLG...GYQEGNINQK → ISSLASKPSF...SLVYCSLEIL
     142-641: Missing.

Note: No experimental confirmation available.
Show »
Length:158
Mass (Da):18,256
Checksum:iE8DF8674C3FE501B
GO
Isoform 3 (identifier: O75290-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     45-45: L → LA

Note: No experimental confirmation available. Gene prediction based on EST data.
Show »
Length:642
Mass (Da):74,602
Checksum:i84DEFC8DEBD6C736
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0C4DG08A0A0C4DG08_HUMAN
Zinc finger protein 780A
ZNF780A
607Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QXV4M0QXV4_HUMAN
Zinc finger protein 780A
ZNF780A
156Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QYL2M0QYL2_HUMAN
Zinc finger protein 780A
ZNF780A
90Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A075B7B0A0A075B7B0_HUMAN
Zinc finger protein 780A
ZNF780A
106Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A075B796A0A075B796_HUMAN
Zinc finger protein 780A
ZNF780A
110Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A075B791A0A075B791_HUMAN
Zinc finger protein 780A
ZNF780A
109Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAC34327 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti104I → L in AK091274 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0377181M → MGRSPRKIDQFCNSSNM in isoform 2. 1 Publication1
Alternative sequenceiVSP_04646545L → LA in isoform 3. Curated1
Alternative sequenceiVSP_037719103 – 141VIKQI…NINQK → ISSLASKPSFTAIHIQRRIH CRICIAFGYLSLVYCSLEIL in isoform 2. 1 PublicationAdd BLAST39
Alternative sequenceiVSP_037720142 – 641Missing in isoform 2. 1 PublicationAdd BLAST500

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AK091274 mRNA No translation available.
AK131328 mRNA Translation: BAD18488.1
AC005614 Genomic DNA Translation: AAC34327.1 Sequence problems.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS33026.2 [O75290-1]
CCDS46078.1 [O75290-2]
CCDS46079.1 [O75290-3]

NCBI Reference Sequences

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RefSeqi
NP_001010880.2, NM_001010880.2 [O75290-1]
NP_001136050.1, NM_001142578.1 [O75290-1]
NP_001136051.1, NM_001142579.1 [O75290-2]
XP_005258830.1, XM_005258773.2 [O75290-3]
XP_006723213.1, XM_006723150.3 [O75290-3]
XP_011525073.1, XM_011526771.2 [O75290-3]
XP_011525074.1, XM_011526772.2 [O75290-3]
XP_016882106.1, XM_017026617.1
XP_016882107.1, XM_017026618.1 [O75290-1]
XP_016882108.1, XM_017026619.1 [O75290-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.115140

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000340963; ENSP00000341507; ENSG00000197782 [O75290-1]
ENST00000414720; ENSP00000416294; ENSG00000197782 [O75290-2]
ENST00000455521; ENSP00000400997; ENSG00000197782 [O75290-3]
ENST00000594395; ENSP00000469786; ENSG00000197782 [O75290-3]
ENST00000595687; ENSP00000472189; ENSG00000197782 [O75290-1]
ENST00000626168; ENSP00000487366; ENSG00000280568 [O75290-3]
ENST00000626829; ENSP00000487177; ENSG00000280568 [O75290-1]
ENST00000628273; ENSP00000487520; ENSG00000280568 [O75290-1]
ENST00000630440; ENSP00000486672; ENSG00000280568 [O75290-2]
ENST00000630528; ENSP00000486345; ENSG00000280568 [O75290-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
284323

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:284323

UCSC genome browser

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UCSCi
uc002omw.5 human [O75290-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK091274 mRNA No translation available.
AK131328 mRNA Translation: BAD18488.1
AC005614 Genomic DNA Translation: AAC34327.1 Sequence problems.
CCDSiCCDS33026.2 [O75290-1]
CCDS46078.1 [O75290-2]
CCDS46079.1 [O75290-3]
RefSeqiNP_001010880.2, NM_001010880.2 [O75290-1]
NP_001136050.1, NM_001142578.1 [O75290-1]
NP_001136051.1, NM_001142579.1 [O75290-2]
XP_005258830.1, XM_005258773.2 [O75290-3]
XP_006723213.1, XM_006723150.3 [O75290-3]
XP_011525073.1, XM_011526771.2 [O75290-3]
XP_011525074.1, XM_011526772.2 [O75290-3]
XP_016882106.1, XM_017026617.1
XP_016882107.1, XM_017026618.1 [O75290-1]
XP_016882108.1, XM_017026619.1 [O75290-1]
UniGeneiHs.115140

3D structure databases

ProteinModelPortaliO75290
SMRiO75290
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129827, 3 interactors
IntActiO75290, 2 interactors
STRINGi9606.ENSP00000400997

PTM databases

iPTMnetiO75290
PhosphoSitePlusiO75290

Polymorphism and mutation databases

BioMutaiZNF780A

Proteomic databases

jPOSTiO75290
MaxQBiO75290
PaxDbiO75290
PeptideAtlasiO75290
PRIDEiO75290
ProteomicsDBi49876
49877 [O75290-2]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
284323
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000340963; ENSP00000341507; ENSG00000197782 [O75290-1]
ENST00000414720; ENSP00000416294; ENSG00000197782 [O75290-2]
ENST00000455521; ENSP00000400997; ENSG00000197782 [O75290-3]
ENST00000594395; ENSP00000469786; ENSG00000197782 [O75290-3]
ENST00000595687; ENSP00000472189; ENSG00000197782 [O75290-1]
ENST00000626168; ENSP00000487366; ENSG00000280568 [O75290-3]
ENST00000626829; ENSP00000487177; ENSG00000280568 [O75290-1]
ENST00000628273; ENSP00000487520; ENSG00000280568 [O75290-1]
ENST00000630440; ENSP00000486672; ENSG00000280568 [O75290-2]
ENST00000630528; ENSP00000486345; ENSG00000280568 [O75290-3]
GeneIDi284323
KEGGihsa:284323
UCSCiuc002omw.5 human [O75290-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
284323
EuPathDBiHostDB:ENSG00000197782.14

GeneCards: human genes, protein and diseases

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GeneCardsi
ZNF780A
HGNCiHGNC:27603 ZNF780A
HPAiHPA003311
neXtProtiNX_O75290
OpenTargetsiENSG00000197782
PharmGKBiPA162410417

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00940000162062
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiO75290
KOiK09228
OMAiCNTHKPY
OrthoDBi1318335at2759
PhylomeDBiO75290
TreeFamiTF341817

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
284323

Protein Ontology

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PROi
PR:O75290

Gene expression databases

BgeeiENSG00000197782 Expressed in 142 organ(s), highest expression level in leukocyte
CleanExiHS_ZNF780A
ExpressionAtlasiO75290 baseline and differential
GenevisibleiO75290 HS

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 14 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 17 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 9 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 17 hits
PS50157 ZINC_FINGER_C2H2_2, 17 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZ780A_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O75290
Secondary accession number(s): E9PB48, Q6ZN87
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: December 16, 2008
Last modified: January 16, 2019
This is version 152 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
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