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UniProtKB - O75208 (COQ9_HUMAN)

Protein

Ubiquinone biosynthesis protein COQ9, mitochondrial

Gene

COQ9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Lipid-binding protein involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration. Binds a phospholipid of at least 10 carbons in each acyl group. May be required to present its bound-lipid to COQ7.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: ubiquinone biosynthesis

This protein is involved in the pathway ubiquinone biosynthesis, which is part of Cofactor biosynthesis.By similarity
View all proteins of this organism that are known to be involved in the pathway ubiquinone biosynthesis and in Cofactor biosynthesis.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • lipid binding Source: UniProtKB
  • protein homodimerization activity Source: UniProtKB
View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processUbiquinone biosynthesis
LigandLipid-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-2142789 Ubiquinol biosynthesis

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...UniPathwayi
UPA00232

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ubiquinone biosynthesis protein COQ9, mitochondrial
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:COQ9
Synonyms:C16orf49
ORF Names:HSPC326, PSEC0129
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000088682.13

Human Gene Nomenclature Database

More...HGNCi		HGNC:25302 COQ9

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		612837 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_O75208

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Coenzyme Q10 deficiency, primary, 5 (COQ10D5)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of coenzyme Q10 deficiency, an autosomal recessive disorder with variable manifestations consistent with 5 major phenotypes. The phenotypes include an encephalomyopathic form with seizures and ataxia; a multisystem infantile form with encephalopathy, cardiomyopathy and renal failure; a predominantly cerebellar form with ataxia and cerebellar atrophy; Leigh syndrome with growth retardation; and an isolated myopathic form.
See also OMIM:614654

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi190L → E: Impairs interaction with COQ7. 1 Publication1
Mutagenesisi227M → E: Impairs interaction with COQ7. 1 Publication1
Mutagenesisi237D → K: Impairs interaction with COQ7. 1 Publication1
Mutagenesisi240W → D or K: Abolishes interaction with COQ7. 1 Publication1
Mutagenesisi241Y → D or K: Abolishes interaction with COQ7. 1 Publication1
Mutagenesisi256L → K: Impairs interaction with COQ7. 1 Publication1

Keywords - Diseasei

Primary mitochondrial disease

Organism-specific databases

DisGeNET

More...DisGeNETi		57017

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...GeneReviewsi		COQ9

MalaCards human disease database

More...MalaCardsi		COQ9
MIMi614654 phenotype

Open Targets

More...OpenTargetsi		ENSG00000088682

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		319678 Encephalopathy-hypertrophic cardiomyopathy-renal tubular disease syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA142672085

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		COQ9

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a transit peptide.<p><a href='/help/transit' target='_top'>More...</a></p>Transit peptidei1 – 44MitochondrionSequence analysisAdd BLAST44
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000022863745 – 318Ubiquinone biosynthesis protein COQ9, mitochondrialAdd BLAST274

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei175N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		O75208

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		O75208

MaxQB - The MaxQuant DataBase

More...MaxQBi		O75208

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O75208

PeptideAtlas

More...PeptideAtlasi		O75208

PRoteomics IDEntifications database

More...PRIDEi		O75208

ProteomicsDB human proteome resource

More...ProteomicsDBi		49869
49870 [O75208-2]

Consortium for Top Down Proteomics

More...TopDownProteomicsi		O75208-1 [O75208-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		O75208

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		O75208

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000088682 Expressed in 169 organ(s), highest expression level in apex of heart

CleanEx database of gene expression profiles

More...CleanExi		HS_COQ9

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		O75208 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		O75208 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		HPA040918

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer. Interacts with COQ7.1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		121326, 180 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-3642 CoQ biosynthetic complex

Protein interaction database and analysis system

More...IntActi		O75208, 56 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000262507

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1318
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4RHPX-ray2.39A/B84-318[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...ProteinModelPortali		O75208

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		O75208

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni241 – 244Lipid bindingCombined sources1 Publication4

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Structurally similar to the bacterial FadR protein (fatty acid metabolism regulator protein).1 Publication

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the COQ9 family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2969 Eukaryota
COG5590 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00390000009328

The HOVERGEN Database of Homologous Vertebrate Genes

More...HOVERGENi		HBG079760

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O75208

KEGG Orthology (KO)

More...KOi		K18587

Identification of Orthologs from Complete Genome Data

More...OMAi		DPSWYTK

Database of Orthologous Groups

More...OrthoDBi		1304924at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		O75208

TreeFam database of animal gene trees

More...TreeFami		TF324653

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR013718 COQ9
IPR012762 Ubiq_biosynth_COQ9

The PANTHER Classification System

More...PANTHERi		PTHR21427 PTHR21427, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF08511 COQ9, 1 hit

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR02396 diverge_rpsU, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O75208-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAAAVSGAL GRAGWRLLQL RCLPVARCRQ ALVPRAFHAS AVGLRSSDEQ 
        60         70         80         90        100
KQQPPNSFSQ QHSETQGAEK PDPESSHSPP RYTDQGGEEE EDYESEEQLQ 
       110        120        130        140        150
HRILTAALEF VPAHGWTAEA IAEGAQSLGL SSAAASMFGK DGSELILHFV 
       160        170        180        190        200
TQCNTRLTRV LEEEQKLVQL GQAEKRKTDQ FLRDAVETRL RMLIPYIEHW 
       210        220        230        240        250
PRALSILMLP HNIPSSLSLL TSMVDDMWHY AGDQSTDFNW YTRRAMLAAI 
       260        270        280        290        300
YNTTELVMMQ DSSPDFEDTW RFLENRVNDA MNMGHTAKQV KSTGEALVQG 
       310 
LMGAAVTLKN LTGLNQRR
Length:318
Mass (Da):35,509
Last modified:November 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF648B4B409E749DA
GO
Isoform 2 (identifier: O75208-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     127-135: SLGLSSAAA → VCIGEGGAT
     136-318: Missing.

Note: No experimental confirmation available.
Show »
Length:135
Mass (Da):14,505
Checksum:i9C945AE4C90B6CC1
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BRC0H3BRC0_HUMAN
Ubiquinone biosynthesis protein COQ...
COQ9
207Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BPC6H3BPC6_HUMAN
Ubiquinone biosynthesis protein COQ...
COQ9
188Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BVA5H3BVA5_HUMAN
Ubiquinone biosynthesis protein COQ...
COQ9
172Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BNT2H3BNT2_HUMAN
Ubiquinone biosynthesis protein COQ...
COQ9
303Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BSJ5H3BSJ5_HUMAN
Ubiquinone biosynthesis protein COQ...
COQ9
283Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BPY0H3BPY0_HUMAN
Ubiquinone biosynthesis protein COQ...
COQ9
89Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BPW3H3BPW3_HUMAN
Ubiquinone biosynthesis protein COQ...
COQ9
102Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAF29004 differs from that shown. Reason: Frameshift at positions 26, 133, 138 and 141.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_017683127 – 135SLGLSSAAA → VCIGEGGAT in isoform 2. 1 Publication9
Alternative sequenceiVSP_017684136 – 318Missing in isoform 2. 1 PublicationAdd BLAST183

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF161444 mRNA Translation: AAF29004.1 Frameshift.
AK075438 mRNA Translation: BAC11621.1
AK290627 mRNA Translation: BAF83316.1
AC004382 Genomic DNA Translation: AAC24313.1
CH471092 Genomic DNA Translation: EAW82928.1
BC001478 mRNA Translation: AAH01478.2
BC054340 mRNA Translation: AAH54340.2
BC064946 mRNA Translation: AAH64946.1
AL136884 mRNA Translation: CAB66818.2

The Consensus CDS (CCDS) project

More...CCDSi		CCDS32459.1 [O75208-1]

Protein sequence database of the Protein Information Resource

More...PIRi		T46490

NCBI Reference Sequences

More...RefSeqi		NP_064708.1, NM_020312.3 [O75208-1]

UniGene gene-oriented nucleotide sequence clusters

More...UniGenei		Hs.513632

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000262507; ENSP00000262507; ENSG00000088682 [O75208-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		57017

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:57017

UCSC genome browser

More...UCSCi		uc002elq.4 human [O75208-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF161444 mRNA Translation: AAF29004.1 Frameshift.
AK075438 mRNA Translation: BAC11621.1
AK290627 mRNA Translation: BAF83316.1
AC004382 Genomic DNA Translation: AAC24313.1
CH471092 Genomic DNA Translation: EAW82928.1
BC001478 mRNA Translation: AAH01478.2
BC054340 mRNA Translation: AAH54340.2
BC064946 mRNA Translation: AAH64946.1
AL136884 mRNA Translation: CAB66818.2
CCDSiCCDS32459.1 [O75208-1]
PIRiT46490
RefSeqiNP_064708.1, NM_020312.3 [O75208-1]
UniGeneiHs.513632

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4RHPX-ray2.39A/B84-318[»]
ProteinModelPortaliO75208
SMRiO75208
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121326, 180 interactors
ComplexPortaliCPX-3642 CoQ biosynthetic complex
IntActiO75208, 56 interactors
STRINGi9606.ENSP00000262507

PTM databases

iPTMnetiO75208
PhosphoSitePlusiO75208

Polymorphism and mutation databases

BioMutaiCOQ9

Proteomic databases

EPDiO75208
jPOSTiO75208
MaxQBiO75208
PaxDbiO75208
PeptideAtlasiO75208
PRIDEiO75208
ProteomicsDBi49869
49870 [O75208-2]
TopDownProteomicsiO75208-1 [O75208-1]

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		57017
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000262507; ENSP00000262507; ENSG00000088682 [O75208-1]
GeneIDi57017
KEGGihsa:57017
UCSCiuc002elq.4 human [O75208-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		57017
DisGeNETi57017
EuPathDBiHostDB:ENSG00000088682.13

GeneCards: human genes, protein and diseases

More...GeneCardsi		COQ9
GeneReviewsiCOQ9
HGNCiHGNC:25302 COQ9
HPAiHPA040918
MalaCardsiCOQ9
MIMi612837 gene
614654 phenotype
neXtProtiNX_O75208
OpenTargetsiENSG00000088682
Orphaneti319678 Encephalopathy-hypertrophic cardiomyopathy-renal tubular disease syndrome
PharmGKBiPA142672085

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG2969 Eukaryota
COG5590 LUCA
GeneTreeiENSGT00390000009328
HOVERGENiHBG079760
InParanoidiO75208
KOiK18587
OMAiDPSWYTK
OrthoDBi1304924at2759
PhylomeDBiO75208
TreeFamiTF324653

Enzyme and pathway databases

UniPathwayi
UPA00232

ReactomeiR-HSA-2142789 Ubiquinol biosynthesis

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		COQ9 human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		COQ9

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		57017

Protein Ontology

More...PROi		PR:O75208

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000088682 Expressed in 169 organ(s), highest expression level in apex of heart
CleanExiHS_COQ9
ExpressionAtlasiO75208 baseline and differential
GenevisibleiO75208 HS

Family and domain databases

InterProiView protein in InterPro
IPR013718 COQ9
IPR012762 Ubiq_biosynth_COQ9
PANTHERiPTHR21427 PTHR21427, 1 hit
PfamiView protein in Pfam
PF08511 COQ9, 1 hit
TIGRFAMsiTIGR02396 diverge_rpsU, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCOQ9_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O75208
Secondary accession number(s): A8K3L2
, Q7L5V7, Q7Z5T6, Q8NBL4, Q9NTJ2, Q9P056
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: November 1, 1998
Last modified: January 16, 2019
This is version 143 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
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