UniProtKB - O75191 (XYLB_HUMAN)
Protein
Xylulose kinase
Gene
XYLB
Organism
Homo sapiens (Human)
Status
Functioni
Phosphorylates D-xylulose to produce D-xylulose 5-phosphate, a molecule that may play an important role in the regulation of glucose metabolism and lipogenesis.1 Publication
Catalytic activityi
- EC:2.7.1.171 Publication
Kineticsi
- KM=24 µM for D-xylulose1 Publication
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 99 | Substrate | 1 | |
Binding sitei | 170 | Substrate | 1 | |
Binding sitei | 280 | Substrate | 1 | |
Binding sitei | 281 | Substrate | 1 | |
Binding sitei | 355 | ATP | 1 | |
Binding sitei | 445 | ATP | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 441 – 442 | ATP | 2 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- xylulokinase activity Source: UniProtKB
GO - Biological processi
- carbohydrate metabolic process Source: ProtInc
- D-xylose metabolic process Source: UniProtKB-KW
- generation of precursor metabolites and energy Source: ProtInc
- glucuronate catabolic process to xylulose 5-phosphate Source: Reactome
- phosphorylation Source: GO_Central
- xylulose catabolic process Source: BHF-UCL
- xylulose metabolic process Source: UniProtKB
Keywordsi
Molecular function | Kinase, Transferase |
Biological process | Carbohydrate metabolism, Xylose metabolism |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
BRENDAi | 2.7.1.17 2681 |
Reactomei | R-HSA-5661270 Formation of xylulose-5-phosphate |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:XYLB |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000093217.9 |
HGNCi | HGNC:12839 XYLB |
MIMi | 604049 gene |
neXtProti | NX_O75191 |
Subcellular locationi
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 9942 |
OpenTargetsi | ENSG00000093217 |
PharmGKBi | PA37430 |
Polymorphism and mutation databases
BioMutai | XYLB |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000230985 | 1 – 536 | Xylulose kinaseAdd BLAST | 536 |
Proteomic databases
EPDi | O75191 |
jPOSTi | O75191 |
MaxQBi | O75191 |
PaxDbi | O75191 |
PeptideAtlasi | O75191 |
PRIDEi | O75191 |
ProteomicsDBi | 49863 |
PTM databases
iPTMneti | O75191 |
PhosphoSitePlusi | O75191 |
Expressioni
Gene expression databases
Bgeei | ENSG00000093217 Expressed in 145 organ(s), highest expression level in right lobe of liver |
ExpressionAtlasi | O75191 baseline and differential |
Genevisiblei | O75191 HS |
Organism-specific databases
HPAi | HPA037863 HPA038415 |
Interactioni
Subunit structurei
Monomer.1 Publication
Protein-protein interaction databases
BioGridi | 115268, 6 interactors |
STRINGi | 9606.ENSP00000207870 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4BC2 | X-ray | 1.97 | A/B/C | 1-536 | [»] | |
4BC3 | X-ray | 1.68 | A/B/C | 1-536 | [»] | |
4BC4 | X-ray | 1.79 | A/B/C | 1-536 | [»] | |
4BC5 | X-ray | 1.98 | A/B/C | 1-536 | [»] | |
ProteinModelPortali | O75191 | |||||
SMRi | O75191 | |||||
ModBasei | Search... | |||||
MobiDBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the FGGY kinase family.Curated
Phylogenomic databases
eggNOGi | KOG2531 Eukaryota COG1070 LUCA |
GeneTreei | ENSGT00390000010821 |
HOGENOMi | HOG000174850 |
HOVERGENi | HBG053124 |
InParanoidi | O75191 |
KOi | K00854 |
OMAi | YGFPPGC |
OrthoDBi | 592116at2759 |
PhylomeDBi | O75191 |
TreeFami | TF313643 |
Family and domain databases
InterProi | View protein in InterPro IPR000577 Carb_kinase_FGGY IPR018485 Carb_kinase_FGGY_C IPR018484 Carb_kinase_FGGY_N |
Pfami | View protein in Pfam PF02782 FGGY_C, 1 hit PF00370 FGGY_N, 1 hit |
PIRSFi | PIRSF000538 GlpK, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: O75191-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
10 20 30 40 50
MAEHAPRRCC LGWDFSTQQV KVVAVDAELN VFYEESVHFD RDLPEFGTQG
60 70 80 90 100
GVHVHKDGLT VTSPVLMWVQ ALDIILEKMK ASGFDFSQVL ALSGAGQQHG
110 120 130 140 150
SIYWKAGAQQ ALTSLSPDLR LHQQLQDCFS ISDCPVWMDS STTAQCRQLE
160 170 180 190 200
AAVGGAQALS CLTGSRAYER FTGNQIAKIY QQNPEAYSHT ERISLVSSFA
210 220 230 240 250
ASLFLGSYSP IDYSDGSGMN LLQIQDKVWS QACLGACAPH LEEKLSPPVP
260 270 280 290 300
SCSVVGAISS YYVQRYGFPP GCKVVAFTGD NPASLAGMRL EEGDIAVSLG
310 320 330 340 350
TSDTLFLWLQ EPMPALEGHI FCNPVDSQHY MALLCFKNGS LMREKIRNES
360 370 380 390 400
VSRSWSDFSK ALQSTEMGNG GNLGFYFDVM EITPEIIGRH RFNTENHKVA
410 420 430 440 450
AFPGDVEVRA LIEGQFMAKR IHAEGLGYRV MSKTKILATG GASHNREILQ
460 470 480 490 500
VLADVFDAPV YVIDTANSAC VGSAYRAFHG LAGGTDVPFS EVVKLAPNPR
510 520 530
LAATPSPGAS QVYEALLPQY AKLEQRILSQ TRGPPE
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A3B3IRM4 | A0A3B3IRM4_HUMAN | Xylulose kinase | XYLB | 555 | Annotation score: | ||
A0A3B3IS07 | A0A3B3IS07_HUMAN | Xylulose kinase | XYLB | 309 | Annotation score: | ||
F8WBF6 | F8WBF6_HUMAN | Xylulose kinase | XYLB | 61 | Annotation score: | ||
C9J0N9 | C9J0N9_HUMAN | Xylulose kinase | XYLB | 66 | Annotation score: |
Sequence cautioni
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_055151 | 85 | D → E3 PublicationsCorresponds to variant dbSNP:rs17118Ensembl. | 1 | |
Natural variantiVAR_055152 | 133 | D → N. Corresponds to variant dbSNP:rs2234610Ensembl. | 1 | |
Natural variantiVAR_055153 | 139 | D → E. Corresponds to variant dbSNP:rs151611Ensembl. | 1 | |
Natural variantiVAR_055154 | 262 | Y → N1 PublicationCorresponds to variant dbSNP:rs196380Ensembl. | 1 | |
Natural variantiVAR_055155 | 348 | N → D. Corresponds to variant dbSNP:rs2234622Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_055522 | 1 – 137 | Missing in isoform 2. 1 PublicationAdd BLAST | 137 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK293325 mRNA Translation: BAG56843.1 AK314386 mRNA Translation: BAG37011.1 AP006191 Genomic DNA No translation available. AP006193 Genomic DNA No translation available. CH471055 Genomic DNA Translation: EAW64532.1 BC137076 mRNA Translation: AAI37077.1 BC137080 mRNA Translation: AAI37081.1 AB015046 mRNA Translation: BAA31527.1 Sequence problems. |
CCDSi | CCDS2678.1 [O75191-1] |
RefSeqi | NP_005099.2, NM_005108.3 [O75191-1] |
UniGenei | Hs.659985 |
Genome annotation databases
Ensembli | ENST00000207870; ENSP00000207870; ENSG00000093217 [O75191-1] |
GeneIDi | 9942 |
KEGGi | hsa:9942 |
UCSCi | uc003cic.3 human [O75191-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK293325 mRNA Translation: BAG56843.1 AK314386 mRNA Translation: BAG37011.1 AP006191 Genomic DNA No translation available. AP006193 Genomic DNA No translation available. CH471055 Genomic DNA Translation: EAW64532.1 BC137076 mRNA Translation: AAI37077.1 BC137080 mRNA Translation: AAI37081.1 AB015046 mRNA Translation: BAA31527.1 Sequence problems. |
CCDSi | CCDS2678.1 [O75191-1] |
RefSeqi | NP_005099.2, NM_005108.3 [O75191-1] |
UniGenei | Hs.659985 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4BC2 | X-ray | 1.97 | A/B/C | 1-536 | [»] | |
4BC3 | X-ray | 1.68 | A/B/C | 1-536 | [»] | |
4BC4 | X-ray | 1.79 | A/B/C | 1-536 | [»] | |
4BC5 | X-ray | 1.98 | A/B/C | 1-536 | [»] | |
ProteinModelPortali | O75191 | |||||
SMRi | O75191 | |||||
ModBasei | Search... | |||||
MobiDBi | Search... |
Protein-protein interaction databases
BioGridi | 115268, 6 interactors |
STRINGi | 9606.ENSP00000207870 |
PTM databases
iPTMneti | O75191 |
PhosphoSitePlusi | O75191 |
Polymorphism and mutation databases
BioMutai | XYLB |
Proteomic databases
EPDi | O75191 |
jPOSTi | O75191 |
MaxQBi | O75191 |
PaxDbi | O75191 |
PeptideAtlasi | O75191 |
PRIDEi | O75191 |
ProteomicsDBi | 49863 |
Protocols and materials databases
DNASUi | 9942 |
Structural Biology Knowledgebase | Search... |
Genome annotation databases
Ensembli | ENST00000207870; ENSP00000207870; ENSG00000093217 [O75191-1] |
GeneIDi | 9942 |
KEGGi | hsa:9942 |
UCSCi | uc003cic.3 human [O75191-1] |
Organism-specific databases
CTDi | 9942 |
DisGeNETi | 9942 |
EuPathDBi | HostDB:ENSG00000093217.9 |
GeneCardsi | XYLB |
H-InvDBi | HIX0003180 |
HGNCi | HGNC:12839 XYLB |
HPAi | HPA037863 HPA038415 |
MIMi | 604049 gene |
neXtProti | NX_O75191 |
OpenTargetsi | ENSG00000093217 |
PharmGKBi | PA37430 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2531 Eukaryota COG1070 LUCA |
GeneTreei | ENSGT00390000010821 |
HOGENOMi | HOG000174850 |
HOVERGENi | HBG053124 |
InParanoidi | O75191 |
KOi | K00854 |
OMAi | YGFPPGC |
OrthoDBi | 592116at2759 |
PhylomeDBi | O75191 |
TreeFami | TF313643 |
Enzyme and pathway databases
BRENDAi | 2.7.1.17 2681 |
Reactomei | R-HSA-5661270 Formation of xylulose-5-phosphate |
Miscellaneous databases
ChiTaRSi | XYLB human |
GenomeRNAii | 9942 |
PROi | PR:O75191 |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000093217 Expressed in 145 organ(s), highest expression level in right lobe of liver |
ExpressionAtlasi | O75191 baseline and differential |
Genevisiblei | O75191 HS |
Family and domain databases
InterProi | View protein in InterPro IPR000577 Carb_kinase_FGGY IPR018485 Carb_kinase_FGGY_C IPR018484 Carb_kinase_FGGY_N |
Pfami | View protein in Pfam PF02782 FGGY_C, 1 hit PF00370 FGGY_N, 1 hit |
PIRSFi | PIRSF000538 GlpK, 1 hit |
ProtoNeti | Search... |
Entry informationi
Entry namei | XYLB_HUMAN | |
Accessioni | O75191Primary (citable) accession number: O75191 Secondary accession number(s): B2RAW4, B4DDT2, B9EH64 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 4, 2006 |
Last sequence update: | May 5, 2009 | |
Last modified: | February 13, 2019 | |
This is version 127 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Complete proteome, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations