DNAJB6

Functionⁱ

Plays an indispensable role in the organization of KRT8/KRT18 filaments. Acts as an endogenous molecular chaperone for neuronal proteins including huntingtin. Suppresses aggregation and toxicity of polyglutamine-containing, aggregation-prone proteins. Isoform B but not isoform A inhibits huntingtin aggregation. Has a stimulatory effect on the ATPase activity of HSP70 in a dose-dependent and time-dependent manner and hence acts as a co-chaperone of HSP70. Also reduces cellular toxicity and caspase-3 activity.5 Publications

GO - Molecular functionⁱ

ATPase activator activity
Source: UniProtKB
Inferred from direct assayⁱ
- 11896048
chaperone binding
Source: UniProtKB
Inferred from direct assayⁱ
- 11896048
DNA binding Source: Ensembl
heat shock protein binding
Source: UniProtKB
Inferred from direct assayⁱ
- 10954706
identical protein binding
Source: IntAct
Inferred from physical interactionⁱ
- 22366786
unfolded protein binding
Source: UniProtKB
Inferred from direct assayⁱ
- 21231916

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

actin cytoskeleton organization Source: Ensembl
chorio-allantoic fusion Source: Ensembl
chorion development Source: Ensembl
extracellular matrix organization Source: Ensembl
intermediate filament organization
Source: UniProtKB
Inferred from direct assayⁱ
- 10954706
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
Source: UniProtKB
Inferred from direct assayⁱ
- 11896048
negative regulation of inclusion body assembly
Source: UniProtKB
Inferred from direct assayⁱ
- 21231916
negative regulation of transcription, DNA-templated Source: Ensembl
protein folding
Source: UniProtKB
Inferred from direct assayⁱ
- 11896048
protein localization to nucleus Source: Ensembl
regulation of cellular response to heat Source: Reactome
regulation of protein localization
Source: ParkinsonsUK-UCL
Inferred from mutant phenotypeⁱ
- 20889486
syncytiotrophoblast cell differentiation involved in labyrinthine layer development Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Chaperone

Molecular function

Chaperone

Enzyme and pathway databases

Reactomeⁱ	R-HSA-3371453 Regulation of HSF1-mediated heat shock response

Reactomeⁱ

R-HSA-3371453 Regulation of HSF1-mediated heat shock response

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: DnaJ homolog subfamily B member 6 Alternative name(s): HHDJ1 Heat shock protein J2 Short name: HSJ-2 MRJ MSJ-1
Gene namesⁱ	Name:DNAJB6 Synonyms:HSJ2, MRJ, MSJ1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 7

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000105993.14
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:14888 DNAJB6
MIMⁱ	611332 gene
neXtProtⁱ	NX_O75190

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Limb-girdle muscular dystrophy 1E (LGMD1E)2 Publications

The disease is caused by mutations affecting the gene represented in this entry. There is evidence that LGMD1E is caused by dysfunction of isoform B (PubMed:22366786).1 Publication

Disease descriptionAn autosomal dominant myopathy characterized by adult onset of proximal muscle weakness, beginning in the hip girdle region and later progressing to the shoulder girdle region.

Keywords - Diseaseⁱ

Disease mutation, Limb-girdle muscular dystrophy

Organism-specific databases

DisGeNET More...DisGeNETⁱ	10049
GeneReviewsⁱ	DNAJB6
MalaCards human disease database More...MalaCardsⁱ	DNAJB6
MIMⁱ	603511 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000105993
Orphanetⁱ	34516 Autosomal dominant limb-girdle muscular dystrophy type 1D
PharmGKBⁱ	PA27418

Polymorphism and mutation databases

BioMutaⁱ	DNAJB6

BioMutaⁱ

DNAJB6

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		Removed1 Publication
ChainⁱPRO_0000071025	2 – 326	DnaJ homolog subfamily B member 6Add BLAST		325

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	135	Omega-N-methylarginineBy similarity		1
Modified residueⁱ	277	PhosphoserineCombined sources		1

Keywords - PTMⁱ

Methylation, Phosphoprotein

Proteomic databases

EPDⁱ	O75190
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	O75190
PaxDbⁱ	O75190
PeptideAtlas More...PeptideAtlasⁱ	O75190
PRIDEⁱ	O75190
ProteomicsDBⁱ	49860 49861 [O75190-2] 49862 [O75190-3]
TopDownProteomicsⁱ	O75190-1 [O75190-1]

PTM databases

iPTMnetⁱ	O75190
PhosphoSitePlusⁱ	O75190
SwissPalmⁱ	O75190

Expressionⁱ

Tissue specificityⁱ

Widely expressed. Highest levels in testis and brain, and lower levels in heart, spleen, intestine, ovary, placenta, lung, kidney, pancreas, thymus, prostate, skeletal muscle, liver and leukocytes. In testis, expressed in germ cells in the earlier stages of differentiation pathway as well as in spermatids. In brain, expressed at a higher level in hippocampus and thalamus and a lower level in amygdala, substantia nigra, corpus callosum and caudate nucleus.4 Publications

Gene expression databases

Bgeeⁱ	ENSG00000105993 Expressed in 218 organ(s), highest expression level in cerebellar hemisphere
CleanExⁱ	HS_DNAJB6
ExpressionAtlasⁱ	O75190 baseline and differential
Genevisibleⁱ	O75190 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB004670 HPA024258 HPA058593

HPAⁱ

CAB004670
HPA024258
HPA058593

Interactionⁱ

Subunit structureⁱ

Homooligomer. Interacts with BAG3, HSPB8 and STUB1. Interacts with ALKBH1 (By similarity). Interacts with HSP70, KRT18 and PTTG. Isoform B interacts with histone deacetylases HDAC4, HDAC6, and SIRT2, HDAC activity is required for antiaggregation.By similarity3 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
BRMS1	Q9HCU9	2	EBI-1053164,EBI-714781
DYSF	O75923	2	EBI-1053164,EBI-2799016
KRT18	P05783	6	EBI-1053164,EBI-297888
MLF1	P58340	2	EBI-1053164,EBI-721328
MLF2	Q15773	3	EBI-1053164,EBI-1051875
SGCG	Q13326	2	EBI-1053164,EBI-5357343

GO - Molecular functionⁱ

chaperone binding
Source: UniProtKB
Inferred from direct assayⁱ
- 11896048
heat shock protein binding
Source: UniProtKB
Inferred from direct assayⁱ
- 10954706
identical protein binding
Source: IntAct
Inferred from physical interactionⁱ
- 22366786
unfolded protein binding
Source: UniProtKB
Inferred from direct assayⁱ
- 21231916

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	115360, 60 interactors
IntActⁱ	O75190, 68 interactors
Molecular INTeraction database More...MINTⁱ	O75190
STRINGⁱ	9606.ENSP00000262177

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	O75190
SMRⁱ	O75190
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	2 – 69	JPROSITE-ProRule annotationAdd BLAST		68

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	2 – 146	Interaction with HSP701 PublicationAdd BLAST		145
Regionⁱ	119 – 242	Interaction with KRT181 PublicationAdd BLAST		124

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	83 – 172	Gly/Phe-richAdd BLAST		90
Compositional biasⁱ	155 – 194	Ser-richAdd BLAST		40

Domainⁱ

The antiaggregation activity of isoform B resides in the serine-rich region and the C-terminus.

Phylogenomic databases

eggNOGⁱ	KOG0714 Eukaryota COG0484 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118947
HOVERGENⁱ	HBG066998
InParanoidⁱ	O75190
KEGG Orthology (KO) More...KOⁱ	K09512
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G152F
PhylomeDBⁱ	O75190
TreeFamⁱ	TF105142

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd06257 DnaJ, 1 hit
Gene3Dⁱ	1.10.287.110, 1 hit
InterProⁱ	View protein in InterPro IPR001623 DnaJ_domain IPR018253 DnaJ_domain_CS IPR036869 J_dom_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00226 DnaJ, 1 hit
PRINTSⁱ	PR00625 JDOMAIN
SMARTⁱ	View protein in SMART SM00271 DnaJ, 1 hit
SUPFAMⁱ	SSF46565 SSF46565, 1 hit
PROSITEⁱ	View protein in PROSITE PS00636 DNAJ_1, 1 hit PS50076 DNAJ_2, 1 hit

Sequences (4+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 4 described isoforms and 9 potential isoforms that are computationally mapped.Show all Align All

Isoform A (identifier: O75190-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVDYYEVLGV QRHASPEDIK KAYRKLALKW HPDKNPENKE EAERKFKQVA 
        60         70         80         90        100
EAYEVLSDAK KRDIYDKYGK EGLNGGGGGG SHFDSPFEFG FTFRNPDDVF 
       110        120        130        140        150
REFFGGRDPF SFDFFEDPFE DFFGNRRGPR GSRSRGTGSF FSAFSGFPSF 
       160        170        180        190        200
GSGFSSFDTG FTSFGSLGHG GLTSFSSTSF GGSGMGNFKS ISTSTKMVNG 
       210        220        230        240        250
RKITTKRIVE NGQERVEVEE DGQLKSLTIN GVADDDALAE ERMRRGQNAL 
       260        270        280        290        300
PAQPAGLRPP KPPRPASLLR HAPHCLSEEE GEQDRPRAPG PWDPLASAAG 
       310        320 
LKEGGKRKKQ KQREESKKKK STKGNH

Length:326

Mass (Da):36,087

Last modified:October 18, 2001 - v2

Checksum:ⁱECF1628BF7A524F3

GO

Isoform B (identifier: O75190-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
232-241: VADDDALAEE → KEQLLRLDNK
242-326: Missing.

« Hide

        10         20         30         40         50
MVDYYEVLGV QRHASPEDIK KAYRKLALKW HPDKNPENKE EAERKFKQVA 
        60         70         80         90        100
EAYEVLSDAK KRDIYDKYGK EGLNGGGGGG SHFDSPFEFG FTFRNPDDVF 
       110        120        130        140        150
REFFGGRDPF SFDFFEDPFE DFFGNRRGPR GSRSRGTGSF FSAFSGFPSF 
       160        170        180        190        200
GSGFSSFDTG FTSFGSLGHG GLTSFSSTSF GGSGMGNFKS ISTSTKMVNG 
       210        220        230        240 
RKITTKRIVE NGQERVEVEE DGQLKSLTIN GKEQLLRLDN K

Show »

Length:241

Mass (Da):26,900

Checksum:ⁱCD5A49CAB66C2E16

GO

Isoform C (identifier: O75190-3) [UniParc]FASTA Add to basket

Also known as: a

The sequence of this isoform differs from the canonical sequence as follows:
301-326: LKEGGKRKKQKQREESKKKKSTKGNH → VQREAAVEQAQSETSLGARGQRGHK

« Hide

        10         20         30         40         50
MVDYYEVLGV QRHASPEDIK KAYRKLALKW HPDKNPENKE EAERKFKQVA 
        60         70         80         90        100
EAYEVLSDAK KRDIYDKYGK EGLNGGGGGG SHFDSPFEFG FTFRNPDDVF 
       110        120        130        140        150
REFFGGRDPF SFDFFEDPFE DFFGNRRGPR GSRSRGTGSF FSAFSGFPSF 
       160        170        180        190        200
GSGFSSFDTG FTSFGSLGHG GLTSFSSTSF GGSGMGNFKS ISTSTKMVNG 
       210        220        230        240        250
RKITTKRIVE NGQERVEVEE DGQLKSLTIN GVADDDALAE ERMRRGQNAL 
       260        270        280        290        300
PAQPAGLRPP KPPRPASLLR HAPHCLSEEE GEQDRPRAPG PWDPLASAAG 
       310        320 
VQREAAVEQA QSETSLGARG QRGHK

Note: No experimental confirmation available.

Show »

Length:325

Mass (Da):35,714

Checksum:ⁱ01F47DA9A87EBC74

GO

Isoform D (identifier: O75190-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-59: MVDYYEVLGVQRHASPEDIKKAYRKLALKWHPDKNPENKEEAERKFKQVAEAYEVLSDA → MPHPRILKRP

« Hide

        10         20         30         40         50
MPHPRILKRP KKRDIYDKYG KEGLNGGGGG GSHFDSPFEF GFTFRNPDDV 
        60         70         80         90        100
FREFFGGRDP FSFDFFEDPF EDFFGNRRGP RGSRSRGTGS FFSAFSGFPS 
       110        120        130        140        150
FGSGFSSFDT GFTSFGSLGH GGLTSFSSTS FGGSGMGNFK SISTSTKMVN 
       160        170        180        190        200
GRKITTKRIV ENGQERVEVE EDGQLKSLTI NGVADDDALA EERMRRGQNA 
       210        220        230        240        250
LPAQPAGLRP PKPPRPASLL RHAPHCLSEE EGEQDRPRAP GPWDPLASAA 
       260        270 
GLKEGGKRKK QKQREESKKK KSTKGNH

Note: No experimental confirmation available.

Show »

Length:277

Mass (Da):30,369

Checksum:ⁱ97C70A8C1DF2CACC

GO

Computationally mapped potential isoform sequencesⁱ

There are 9 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

E9PH18	E9PH18_HUMAN	DnaJ homolog subfamily B member 6 DnaJ homolog subfamily B member 6	DNAJB6	211	Annotation score:
A0A0J9YX62	A0A0J9YX62_HUMAN	DnaJ homolog subfamily B member 6 DnaJ homolog subfamily B member 6	DNAJB6	334	Annotation score:
C9J2C4	C9J2C4_HUMAN	DnaJ homolog subfamily B member 6 DnaJ homolog subfamily B member 6	DNAJB6	228	Annotation score:
C9JDX6	C9JDX6_HUMAN	DnaJ homolog subfamily B member 6 DnaJ homolog subfamily B member 6	DNAJB6	125	Annotation score:
C9JDR7	C9JDR7_HUMAN	DnaJ homolog subfamily B member 6 DnaJ homolog subfamily B member 6	DNAJB6	98	Annotation score:
C9JB42	C9JB42_HUMAN	DnaJ homolog subfamily B member 6 DnaJ homolog subfamily B member 6	DNAJB6	66	Annotation score:
F8WCZ4	F8WCZ4_HUMAN	DnaJ homolog subfamily B member 6 DnaJ homolog subfamily B member 6	DNAJB6	129	Annotation score:
C9J2P2	C9J2P2_HUMAN	DnaJ homolog subfamily B member 6 DnaJ homolog subfamily B member 6	DNAJB6	145	Annotation score:
C9JN01	C9JN01_HUMAN	DnaJ homolog subfamily B member 6 DnaJ homolog subfamily B member 6	DNAJB6	45	Annotation score:

Sequence cautionⁱ

The sequence AAD16010 differs from that shown. Reason: Frameshift at position 197.Curated

The sequence BAD93096 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	128	G → S in BAD97321 (Ref. 9) Curated		1
Sequence conflictⁱ	303	E → G in BAF85714 (PubMed:14702039).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_067833	89	F → I in LGMD1E; the mutation results in inefficient inhibition of protein aggregation by isoform B. 1 PublicationCorresponds to variant dbSNP:rs387907150EnsemblClinVar.	1
Natural variantⁱVAR_067834	93	F → L in LGMD1E; the mutation results in inefficient inhibition of protein aggregation by isoform B. 2 PublicationsCorresponds to variant dbSNP:rs387907046EnsemblClinVar.	1
Natural variantⁱVAR_079428	96	P → L Found in a family with autosomal-dominantly inherited distal-onset myopathy; significant loss of its ability to suppress aggregation of polyglutamine-containing proteins. 1 Publication	1
Natural variantⁱVAR_067835	96	P → R in LGMD1E. 1 PublicationCorresponds to variant dbSNP:rs387907047EnsemblClinVar.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_053894	1 – 59	MVDYY…VLSDA → MPHPRILKRP in isoform D. CuratedAdd BLAST	59
Alternative sequenceⁱVSP_001289	232 – 241	VADDDALAEE → KEQLLRLDNK in isoform B. 10 Publications	10
Alternative sequenceⁱVSP_001290	242 – 326	Missing in isoform B. 10 PublicationsAdd BLAST	85
Alternative sequenceⁱVSP_026180	301 – 326	LKEGG…TKGNH → VQREAAVEQAQSETSLGARG QRGHK in isoform C. 4 PublicationsAdd BLAST	26

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF080569 mRNA Translation: AAD16010.1 Frameshift. AB015798 mRNA Translation: BAA88769.1 AB015799 mRNA Translation: BAA88770.1 AF060703 mRNA Translation: AAF21257.1 AB014888 mRNA Translation: BAA32209.1 AF075601 mRNA Translation: AAD43194.1 CR533498 mRNA Translation: CAG38529.1 AB209859 mRNA Translation: BAD93096.1 Different initiation. AK223601 mRNA Translation: BAD97321.1 AK291953 mRNA Translation: BAF84642.1 AK293025 mRNA Translation: BAF85714.1 AK297796 mRNA Translation: BAG60135.1 AL136707 mRNA Translation: CAB66642.1 AC006372 Genomic DNA No translation available. AC079306 Genomic DNA Translation: AAS07392.1 AC079306 Genomic DNA Translation: AAS07393.1 CH236954 Genomic DNA Translation: EAL23923.1 CH236954 Genomic DNA Translation: EAL23924.1 CH471149 Genomic DNA Translation: EAX04570.1 BC000177 mRNA Translation: AAH00177.1 BC002446 mRNA Translation: AAH02446.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS47755.1 [O75190-2] CCDS5946.1 [O75190-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_005485.1, NM_005494.2 [O75190-2] NP_490647.1, NM_058246.3 [O75190-1]
UniGeneⁱ	Hs.188591 Hs.490745

Genome annotation databases

Ensemblⁱ	ENST00000262177; ENSP00000262177; ENSG00000105993 [O75190-1] ENST00000429029; ENSP00000397556; ENSG00000105993 [O75190-2]
GeneIDⁱ	10049
KEGGⁱ	hsa:10049
UCSC genome browser More...UCSCⁱ	uc003wnj.4 human [O75190-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O75190	Uncharacterized protein DNAJB6 (Fragment)		HUMAN		95	UniRef100_O75190
O75190-2	DNAJB6 isoform 3		PANTR		241	UniRef100_O75190-2
DNAJB6 isoform 3		PONAB		241
O75190-3	DnaJ homolog subfamily B member 6		HUMAN		334	UniRef100_A0A0J9YX62
DNAJB6 isoform 13 (Fragment)		PONAB		159
DNAJB6 isoform 11 (Fragment)		PANTR		125
DnaJ homolog subfamily B member 6 (Fragment)		HUMAN		125
DNAJB6 isoform 11 (Fragment)		PONAB		125
+6

Protein	Similar proteins		Species	Score	Length	Source
O75190	DnaJ homolog subfamily B member 6		PONAB		326	UniRef90_O75190
Uncharacterized protein DNAJB6 (Fragment)		HUMAN		95
Uncharacterized protein		MACNE		326
Uncharacterized protein		COLAP		326
Uncharacterized protein		MANLE		326
+17
O75190-2	DNAJB6 isoform 3		PANTR		241	UniRef90_O75190-2
DNAJB6 isoform 3		PONAB		241
Uncharacterized protein		HORSE		241
dnaJ homolog subfamily B member 6 isoform X4		DELLE		240
UPI00072E3DA1		ACIJB		282
+13
O75190-3	DnaJ homolog subfamily B member 6		MACFA		334	UniRef90_A0A2K5W2A5
Uncharacterized protein		RHIRO		335
Uncharacterized protein		RHIBE		335
DnaJ homolog subfamily B member 6 (Fragment)		HUMAN		98
DNAJB6 isoform 12 (Fragment)		PONAB		98
+22
O75190-4	cDNA FLJ51007, highly similar to DnaJ homolog subfamily B member 6		HUMAN		294	UniRef90_O75190-4
UPI00020AF131		NOMLE		277
UPI000DC19393		THEGE		277

Protein	Similar proteins		Species	Score	Length	Source
O75190	DnaJ homolog subfamily B member 6		PONAB		326	UniRef50_O75190
DnaJ homolog subfamily B member 6		MOUSE		365
DnaJ homolog subfamily B member 6		RAT		357
Uncharacterized protein DNAJB6 (Fragment)		HUMAN		95
Uncharacterized protein		MACNE		326
+68
O75190-2	DNAJB6 isoform 3		PANTR		241	UniRef50_O75190-2
DNAJB6 isoform 3		PONAB		241
Uncharacterized protein		HORSE		241
dnaJ homolog subfamily B member 6 isoform X4		DELLE		240
Uncharacterized protein		TAEGU		243
+53
O75190-3	DnaJ homolog subfamily B member 6		MACFA		334	UniRef50_A0A2K5W2A5
Uncharacterized protein		RHIRO		335
Uncharacterized protein		RHIBE		335
DnaJ homolog subfamily B member 6 (Fragment)		HUMAN		98
DNAJB6 isoform 12 (Fragment)		PONAB		98
+102
O75190-4	cDNA FLJ51007, highly similar to DnaJ homolog subfamily B member 6		HUMAN		294	UniRef50_O75190-4
DnaJ-like protein subfamily B member 6		HETGA		326
Uncharacterized protein		MONDO		291
Uncharacterized protein		PELSI		323
dnaJ homolog subfamily B member 6 isoform X1		DIPOR		319
+31

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF080569 mRNA Translation: AAD16010.1 Frameshift. AB015798 mRNA Translation: BAA88769.1 AB015799 mRNA Translation: BAA88770.1 AF060703 mRNA Translation: AAF21257.1 AB014888 mRNA Translation: BAA32209.1 AF075601 mRNA Translation: AAD43194.1 CR533498 mRNA Translation: CAG38529.1 AB209859 mRNA Translation: BAD93096.1 Different initiation. AK223601 mRNA Translation: BAD97321.1 AK291953 mRNA Translation: BAF84642.1 AK293025 mRNA Translation: BAF85714.1 AK297796 mRNA Translation: BAG60135.1 AL136707 mRNA Translation: CAB66642.1 AC006372 Genomic DNA No translation available. AC079306 Genomic DNA Translation: AAS07392.1 AC079306 Genomic DNA Translation: AAS07393.1 CH236954 Genomic DNA Translation: EAL23923.1 CH236954 Genomic DNA Translation: EAL23924.1 CH471149 Genomic DNA Translation: EAX04570.1 BC000177 mRNA Translation: AAH00177.1 BC002446 mRNA Translation: AAH02446.1
CCDSⁱ	CCDS47755.1 [O75190-2] CCDS5946.1 [O75190-1]
RefSeqⁱ	NP_005485.1, NM_005494.2 [O75190-2] NP_490647.1, NM_058246.3 [O75190-1]
UniGeneⁱ	Hs.188591 Hs.490745

3D structure databases

ProteinModelPortalⁱ	O75190
SMRⁱ	O75190
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	115360, 60 interactors
IntActⁱ	O75190, 68 interactors
MINTⁱ	O75190
STRINGⁱ	9606.ENSP00000262177

PTM databases

iPTMnetⁱ	O75190
PhosphoSitePlusⁱ	O75190
SwissPalmⁱ	O75190

Polymorphism and mutation databases

BioMutaⁱ	DNAJB6

BioMutaⁱ

DNAJB6

Proteomic databases

EPDⁱ	O75190
MaxQBⁱ	O75190
PaxDbⁱ	O75190
PeptideAtlasⁱ	O75190
PRIDEⁱ	O75190
ProteomicsDBⁱ	49860 49861 [O75190-2] 49862 [O75190-3]
TopDownProteomicsⁱ	O75190-1 [O75190-1]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	10049
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000262177; ENSP00000262177; ENSG00000105993 [O75190-1] ENST00000429029; ENSP00000397556; ENSG00000105993 [O75190-2]
GeneIDⁱ	10049
KEGGⁱ	hsa:10049
UCSCⁱ	uc003wnj.4 human [O75190-1]

Organism-specific databases

CTDⁱ	10049
DisGeNETⁱ	10049
EuPathDBⁱ	HostDB:ENSG00000105993.14
GeneCardsⁱ	DNAJB6
GeneReviewsⁱ	DNAJB6
HGNCⁱ	HGNC:14888 DNAJB6
HPAⁱ	CAB004670 HPA024258 HPA058593
MalaCardsⁱ	DNAJB6
MIMⁱ	603511 phenotype 611332 gene
neXtProtⁱ	NX_O75190
OpenTargetsⁱ	ENSG00000105993
Orphanetⁱ	34516 Autosomal dominant limb-girdle muscular dystrophy type 1D
PharmGKBⁱ	PA27418
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0714 Eukaryota COG0484 LUCA
GeneTreeⁱ	ENSGT00760000118947
HOVERGENⁱ	HBG066998
InParanoidⁱ	O75190
KOⁱ	K09512
OrthoDBⁱ	EOG091G152F
PhylomeDBⁱ	O75190
TreeFamⁱ	TF105142

Enzyme and pathway databases

Reactomeⁱ	R-HSA-3371453 Regulation of HSF1-mediated heat shock response

Reactomeⁱ

R-HSA-3371453 Regulation of HSF1-mediated heat shock response

Miscellaneous databases

ChiTaRSⁱ	DNAJB6 human
GeneWikiⁱ	DNAJB6
GenomeRNAiⁱ	10049
Protein Ontology More...PROⁱ	PR:O75190
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000105993 Expressed in 218 organ(s), highest expression level in cerebellar hemisphere
CleanExⁱ	HS_DNAJB6
ExpressionAtlasⁱ	O75190 baseline and differential
Genevisibleⁱ	O75190 HS

Family and domain databases

CDDⁱ	cd06257 DnaJ, 1 hit
Gene3Dⁱ	1.10.287.110, 1 hit
InterProⁱ	View protein in InterPro IPR001623 DnaJ_domain IPR018253 DnaJ_domain_CS IPR036869 J_dom_sf
Pfamⁱ	View protein in Pfam PF00226 DnaJ, 1 hit
PRINTSⁱ	PR00625 JDOMAIN
SMARTⁱ	View protein in SMART SM00271 DnaJ, 1 hit
SUPFAMⁱ	SSF46565 SSF46565, 1 hit
PROSITEⁱ	View protein in PROSITE PS00636 DNAJ_1, 1 hit PS50076 DNAJ_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	DNJB6_HUMAN
Accessionⁱ	O75190Primary (citable) accession number: O75190 Secondary accession number(s): A4D232 Q9UIK6
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
	Last sequence update:	October 18, 2001
	Last modified:	October 10, 2018
	This is version 183 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Direct protein sequencing, Reference proteome

Documents

Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM

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UniProtKB - O75190 (DNJB6_HUMAN)

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DnaJ homolog subfamily B member 6

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

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GO - Molecular functionⁱ

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Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

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Keywords - Technical termⁱ