UniProtKB - O75185 (AT2C2_HUMAN)
Protein
Calcium-transporting ATPase type 2C member 2
Gene
ATP2C2
Organism
Homo sapiens (Human)
Status
Functioni
This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.By similarity
Catalytic activityi
- EC:7.2.2.10
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 332 | Calcium 2; via carbonyl oxygenBy similarity | 1 | |
Metal bindingi | 333 | Calcium 2; via carbonyl oxygenBy similarity | 1 | |
Metal bindingi | 335 | Calcium 2; via carbonyl oxygenBy similarity | 1 | |
Metal bindingi | 337 | Calcium 2By similarity | 1 | |
Active sitei | 379 | 4-aspartylphosphate intermediateBy similarity | 1 | |
Metal bindingi | 674 | MagnesiumBy similarity | 1 | |
Metal bindingi | 678 | MagnesiumBy similarity | 1 | |
Metal bindingi | 768 | Calcium 2By similarity | 1 | |
Metal bindingi | 772 | Calcium 2By similarity | 1 |
GO - Molecular functioni
- ATPase activity Source: GO_Central
- ATP binding Source: UniProtKB-KW
- calcium transmembrane transporter activity, phosphorylative mechanism Source: GO_Central
- manganese transmembrane transporter activity, phosphorylative mechanism Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- proton-exporting ATPase activity, phosphorylative mechanism Source: GO_Central
GO - Biological processi
- calcium ion transmembrane transport Source: GO_Central
- cellular calcium ion homeostasis Source: GO_Central
- ion transmembrane transport Source: Reactome
- mammary gland epithelium development Source: Ensembl
- manganese ion transport Source: GO_Central
- positive regulation of calcium ion import Source: Ensembl
- protein localization to plasma membrane Source: Ensembl
Keywordsi
Molecular function | Translocase |
Biological process | Calcium transport, Ion transport, Transport |
Ligand | ATP-binding, Calcium, Magnesium, Metal-binding, Nucleotide-binding |
Enzyme and pathway databases
BRENDAi | 3.6.3.8, 2681 |
PathwayCommonsi | O75185 |
Reactomei | R-HSA-936837, Ion transport by P-type ATPases |
Protein family/group databases
TCDBi | 3.A.3.2.9, the p-type atpase (p-atpase) superfamily |
Names & Taxonomyi
Protein namesi | Recommended name: Calcium-transporting ATPase type 2C member 2Curated (EC:7.2.2.10)Short name: ATPase 2C2 Alternative name(s): Secretory pathway Ca(2+)-ATPase 2 |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:29103, ATP2C2 |
MIMi | 613082, gene |
neXtProti | NX_O75185 |
VEuPathDBi | HostDB:ENSG00000064270.12 |
Subcellular locationi
Other locations
- Membrane Curated; Multi-pass membrane protein Curated
Endoplasmic reticulum
- endoplasmic reticulum Source: GO_Central
Golgi apparatus
- Golgi membrane Source: GO_Central
Plasma Membrane
- cytoplasmic side of plasma membrane Source: Ensembl
- plasma membrane Source: GO_Central
Other locations
- cytoplasmic vesicle Source: Ensembl
- integral component of membrane Source: UniProtKB-KW
- perinuclear region of cytoplasm Source: Ensembl
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 106 | CytoplasmicSequence analysisAdd BLAST | 106 | |
Transmembranei | 107 – 127 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Topological domaini | 128 – 129 | ExtracellularSequence analysis | 2 | |
Transmembranei | 130 – 150 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 151 – 231 | CytoplasmicSequence analysisAdd BLAST | 81 | |
Transmembranei | 232 – 252 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Topological domaini | 253 – 293 | ExtracellularSequence analysisAdd BLAST | 41 | |
Transmembranei | 294 – 314 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 315 – 331 | CytoplasmicSequence analysisAdd BLAST | 17 | |
Transmembranei | 332 – 352 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Topological domaini | 353 – 750 | ExtracellularSequence analysisAdd BLAST | 398 | |
Transmembranei | 751 – 771 | Helical; Name=6Sequence analysisAdd BLAST | 21 | |
Topological domaini | 772 – 804 | CytoplasmicSequence analysisAdd BLAST | 33 | |
Transmembranei | 805 – 825 | Helical; Name=7Sequence analysisAdd BLAST | 21 | |
Topological domaini | 826 – 837 | ExtracellularSequence analysisAdd BLAST | 12 | |
Transmembranei | 838 – 855 | Helical; Name=8Sequence analysisAdd BLAST | 18 | |
Topological domaini | 856 – 874 | CytoplasmicSequence analysisAdd BLAST | 19 | |
Transmembranei | 875 – 895 | Helical; Name=9Sequence analysisAdd BLAST | 21 | |
Topological domaini | 896 – 905 | ExtracellularSequence analysis | 10 | |
Transmembranei | 906 – 926 | Helical; Name=10Sequence analysisAdd BLAST | 21 | |
Topological domaini | 927 – 946 | CytoplasmicSequence analysisAdd BLAST | 20 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 9914 |
OpenTargetsi | ENSG00000064270 |
PharmGKBi | PA162377204 |
Miscellaneous databases
Pharosi | O75185, Tbio |
Chemistry databases
DrugBanki | DB01189, Desflurane |
Genetic variation databases
BioMutai | ATP2C2 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000046207 | 1 – 946 | Calcium-transporting ATPase type 2C member 2Add BLAST | 946 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 264 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 267 | PhosphoserineCombined sources | 1 | |
Modified residuei | 268 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
jPOSTi | O75185 |
MassIVEi | O75185 |
PaxDbi | O75185 |
PeptideAtlasi | O75185 |
PRIDEi | O75185 |
ProteomicsDBi | 17939 49858 [O75185-1] 49859 [O75185-2] |
PTM databases
iPTMneti | O75185 |
PhosphoSitePlusi | O75185 |
Expressioni
Gene expression databases
Bgeei | ENSG00000064270, Expressed in rectum and 161 other tissues |
ExpressionAtlasi | O75185, baseline and differential |
Genevisiblei | O75185, HS |
Organism-specific databases
HPAi | ENSG00000064270, Tissue enhanced (intestine, salivary gland) |
Interactioni
Binary interactionsi
O75185
With | #Exp. | IntAct |
---|---|---|
ORAI1 [Q96D31] | 10 | EBI-2939806,EBI-2291476 |
Protein-protein interaction databases
BioGRIDi | 115243, 1 interactor |
IntActi | O75185, 2 interactors |
STRINGi | 9606.ENSP00000397925 |
Miscellaneous databases
RNActi | O75185, protein |
Family & Domainsi
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 114 – 119 | Poly-Leu | 6 |
Sequence similaritiesi
Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily. [View classification]Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0202, Eukaryota |
GeneTreei | ENSGT00940000160275 |
HOGENOMi | CLU_002360_3_1_1 |
InParanoidi | O75185 |
OMAi | IGWVQGK |
OrthoDBi | 100699at2759 |
PhylomeDBi | O75185 |
TreeFami | TF354251 |
Family and domain databases
Gene3Di | 3.40.1110.10, 1 hit 3.40.50.1000, 1 hit |
InterProi | View protein in InterPro IPR030334, ATP2C2 IPR006068, ATPase_P-typ_cation-transptr_C IPR004014, ATPase_P-typ_cation-transptr_N IPR023299, ATPase_P-typ_cyto_dom_N IPR018303, ATPase_P-typ_P_site IPR023298, ATPase_P-typ_TM_dom_sf IPR008250, ATPase_P-typ_transduc_dom_A_sf IPR036412, HAD-like_sf IPR023214, HAD_sf IPR006413, P-type_ATPase_IIA_PMR1 IPR001757, P_typ_ATPase |
PANTHERi | PTHR42861:SF23, PTHR42861:SF23, 1 hit |
Pfami | View protein in Pfam PF00689, Cation_ATPase_C, 1 hit PF00690, Cation_ATPase_N, 1 hit |
PRINTSi | PR00120, HATPASE |
SMARTi | View protein in SMART SM00831, Cation_ATPase_N, 1 hit |
SUPFAMi | SSF56784, SSF56784, 1 hit SSF81653, SSF81653, 1 hit SSF81660, SSF81660, 1 hit SSF81665, SSF81665, 1 hit |
TIGRFAMsi | TIGR01522, ATPase-IIA2_Ca, 1 hit TIGR01494, ATPase_P-type, 2 hits |
PROSITEi | View protein in PROSITE PS00154, ATPASE_E1_E2, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: O75185-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MVEGRVSEFL KKLGFSGGGR QYQALEKDEE EALIDEQSEL KAIEKEKKVT
60 70 80 90 100
ALPPKEACKC QKEDLARAFC VDLHTGLSEF SVTQRRLAHG WNEFVADNSE
110 120 130 140 150
PVWKKYLDQF KNPLILLLLG SALVSVLTKE YEDAVSIATA VLVVVTVAFI
160 170 180 190 200
QEYRSEKSLE ELTKLVPPEC NCLREGKLQH LLARELVPGD VVSLSIGDRI
210 220 230 240 250
PADIRLTEVT DLLVDESSFT GEAEPCSKTD SPLTGGGDLT TLSNIVFMGT
260 270 280 290 300
LVQYGRGQGV VIGTGESSQF GEVFKMMQAE ETPKTPLQKS MDRLGKQLTL
310 320 330 340 350
FSFGIIGLIM LIGWSQGKQL LSMFTIGVSL AVAAIPEGLP IVVMVTLVLG
360 370 380 390 400
VLRMAKKRVI VKKLPIVETL GCCSVLCSDK TGTLTANEMT VTQLVTSDGL
410 420 430 440 450
RAEVSGVGYD GQGTVCLLPS KEVIKEFSNV SVGKLVEAGC VANNAVIRKN
460 470 480 490 500
AVMGQPTEGA LMALAMKMDL SDIKNSYIRK KEIPFSSEQK WMAVKCSLKT
510 520 530 540 550
EDQEDIYFMK GALEEVIRYC TMYNNGGIPL PLTPQQRSFC LQEEKRMGSL
560 570 580 590 600
GLRVLALASG PELGRLTFLG LVGIIDPPRV GVKEAVQVLS ESGVSVKMIT
610 620 630 640 650
GDALETALAI GRNIGLCNGK LQAMSGEEVD SVEKGELADR VGKVSVFFRT
660 670 680 690 700
SPKHKLKIIK ALQESGAIVA MTGDGVNDAV ALKSADIGIA MGQTGTDVSK
710 720 730 740 750
EAANMILVDD DFSAIMNAVE EGKGIFYNIK NFVRFQLSTS ISALSLITLS
760 770 780 790 800
TVFNLPSPLN AMQILWINII MDGPPAQSLG VEPVDKDAFR QPPRSVRDTI
810 820 830 840 850
LSRALILKIL MSAAIIISGT LFIFWKEMPE DRASTPRTTT MTFTCFVFFD
860 870 880 890 900
LFNALTCRSQ TKLIFEIGFL RNHMFLYSVL GSILGQLAVI YIPPLQRVFQ
910 920 930 940
TENLGALDLL FLTGLASSVF ILSELLKLCE KYCCSPKRVQ MHPEDV
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketH3BS90 | H3BS90_HUMAN | Calcium-transporting ATPase type 2C... | ATP2C2 | 53 | Annotation score: |
Sequence cautioni
The sequence BAA31678 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Sequence conflicti | 171 | N → D in CAI46049 (PubMed:17974005).Curated | 1 | ||
Sequence conflicti | 361 | V → A in CAI46049 (PubMed:17974005).Curated | 1 | ||
Sequence conflicti | 880 | L → R in CAI46049 (PubMed:17974005).Curated | 1 | ||
Isoform 2 (identifier: O75185-2) | |||||
Sequence conflicti | 12 | R → I in BAA31678 (PubMed:9734811).Curated | 1 | ||
Isoform 3 (identifier: O75185-3) | |||||
Sequence conflicti | 789 | A → G in CAI46049 (PubMed:17974005).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_059137 | 165 | L → M1 PublicationCorresponds to variant dbSNP:rs247818Ensembl. | 1 | |
Natural variantiVAR_047935 | 411 | G → S. Corresponds to variant dbSNP:rs2303853Ensembl. | 1 | |
Natural variantiVAR_047936 | 466 | M → L1 PublicationCorresponds to variant dbSNP:rs247897Ensembl. | 1 | |
Natural variantiVAR_070929 | 604 | L → Q1 PublicationCorresponds to variant dbSNP:rs62640926Ensembl. | 1 | |
Natural variantiVAR_047937 | 907 | L → P. Corresponds to variant dbSNP:rs16973859EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_035989 | 1 – 70 | MVEGR…ARAFC → MLHFHLLKFKTRVVFSAVII MVTGLCLFLLSLPHLHGVFE QVPAPWWTSLCPWPIMEAAA FQSGSLYPVASFLAAPMSEL VPDLSFQ in isoform 2. 1 PublicationAdd BLAST | 70 | |
Alternative sequenceiVSP_054679 | 778 | S → RSSQKTEVCCTAVRLGVEGR GESTWAGRAG in isoform 3. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY791884 mRNA Translation: AAV54193.1 AB014603 mRNA Translation: BAA31678.2 Different initiation. AK300526 mRNA Translation: BAG62238.1 BX648333 mRNA Translation: CAI46049.1 CR749829 mRNA Translation: CAH18686.1 AC010551 Genomic DNA No translation available. AC022165 Genomic DNA No translation available. |
CCDSi | CCDS42207.1 [O75185-1] CCDS67088.1 [O75185-3] |
RefSeqi | NP_001273456.2, NM_001286527.2 [O75185-3] NP_001278383.1, NM_001291454.1 NP_055676.3, NM_014861.3 [O75185-1] |
Genome annotation databases
Ensembli | ENST00000262429; ENSP00000262429; ENSG00000064270 [O75185-1] ENST00000416219; ENSP00000397925; ENSG00000064270 [O75185-3] |
GeneIDi | 9914 |
KEGGi | hsa:9914 |
UCSCi | uc002fhx.4, human [O75185-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY791884 mRNA Translation: AAV54193.1 AB014603 mRNA Translation: BAA31678.2 Different initiation. AK300526 mRNA Translation: BAG62238.1 BX648333 mRNA Translation: CAI46049.1 CR749829 mRNA Translation: CAH18686.1 AC010551 Genomic DNA No translation available. AC022165 Genomic DNA No translation available. |
CCDSi | CCDS42207.1 [O75185-1] CCDS67088.1 [O75185-3] |
RefSeqi | NP_001273456.2, NM_001286527.2 [O75185-3] NP_001278383.1, NM_001291454.1 NP_055676.3, NM_014861.3 [O75185-1] |
3D structure databases
SMRi | O75185 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 115243, 1 interactor |
IntActi | O75185, 2 interactors |
STRINGi | 9606.ENSP00000397925 |
Chemistry databases
DrugBanki | DB01189, Desflurane |
Protein family/group databases
TCDBi | 3.A.3.2.9, the p-type atpase (p-atpase) superfamily |
PTM databases
iPTMneti | O75185 |
PhosphoSitePlusi | O75185 |
Genetic variation databases
BioMutai | ATP2C2 |
Proteomic databases
jPOSTi | O75185 |
MassIVEi | O75185 |
PaxDbi | O75185 |
PeptideAtlasi | O75185 |
PRIDEi | O75185 |
ProteomicsDBi | 17939 49858 [O75185-1] 49859 [O75185-2] |
Protocols and materials databases
Antibodypediai | 58367, 55 antibodies |
DNASUi | 9914 |
Genome annotation databases
Ensembli | ENST00000262429; ENSP00000262429; ENSG00000064270 [O75185-1] ENST00000416219; ENSP00000397925; ENSG00000064270 [O75185-3] |
GeneIDi | 9914 |
KEGGi | hsa:9914 |
UCSCi | uc002fhx.4, human [O75185-1] |
Organism-specific databases
CTDi | 9914 |
DisGeNETi | 9914 |
GeneCardsi | ATP2C2 |
HGNCi | HGNC:29103, ATP2C2 |
HPAi | ENSG00000064270, Tissue enhanced (intestine, salivary gland) |
MIMi | 613082, gene |
neXtProti | NX_O75185 |
OpenTargetsi | ENSG00000064270 |
PharmGKBi | PA162377204 |
VEuPathDBi | HostDB:ENSG00000064270.12 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0202, Eukaryota |
GeneTreei | ENSGT00940000160275 |
HOGENOMi | CLU_002360_3_1_1 |
InParanoidi | O75185 |
OMAi | IGWVQGK |
OrthoDBi | 100699at2759 |
PhylomeDBi | O75185 |
TreeFami | TF354251 |
Enzyme and pathway databases
BRENDAi | 3.6.3.8, 2681 |
PathwayCommonsi | O75185 |
Reactomei | R-HSA-936837, Ion transport by P-type ATPases |
Miscellaneous databases
BioGRID-ORCSi | 9914, 6 hits in 867 CRISPR screens |
ChiTaRSi | ATP2C2, human |
GenomeRNAii | 9914 |
Pharosi | O75185, Tbio |
PROi | PR:O75185 |
RNActi | O75185, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000064270, Expressed in rectum and 161 other tissues |
ExpressionAtlasi | O75185, baseline and differential |
Genevisiblei | O75185, HS |
Family and domain databases
Gene3Di | 3.40.1110.10, 1 hit 3.40.50.1000, 1 hit |
InterProi | View protein in InterPro IPR030334, ATP2C2 IPR006068, ATPase_P-typ_cation-transptr_C IPR004014, ATPase_P-typ_cation-transptr_N IPR023299, ATPase_P-typ_cyto_dom_N IPR018303, ATPase_P-typ_P_site IPR023298, ATPase_P-typ_TM_dom_sf IPR008250, ATPase_P-typ_transduc_dom_A_sf IPR036412, HAD-like_sf IPR023214, HAD_sf IPR006413, P-type_ATPase_IIA_PMR1 IPR001757, P_typ_ATPase |
PANTHERi | PTHR42861:SF23, PTHR42861:SF23, 1 hit |
Pfami | View protein in Pfam PF00689, Cation_ATPase_C, 1 hit PF00690, Cation_ATPase_N, 1 hit |
PRINTSi | PR00120, HATPASE |
SMARTi | View protein in SMART SM00831, Cation_ATPase_N, 1 hit |
SUPFAMi | SSF56784, SSF56784, 1 hit SSF81653, SSF81653, 1 hit SSF81660, SSF81660, 1 hit SSF81665, SSF81665, 1 hit |
TIGRFAMsi | TIGR01522, ATPase-IIA2_Ca, 1 hit TIGR01494, ATPase_P-type, 2 hits |
PROSITEi | View protein in PROSITE PS00154, ATPASE_E1_E2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | AT2C2_HUMAN | |
Accessioni | O75185Primary (citable) accession number: O75185 Secondary accession number(s): B4DU76 Q68CQ2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 18, 2001 |
Last sequence update: | September 12, 2018 | |
Last modified: | February 10, 2021 | |
This is version 178 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 16
Human chromosome 16: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants