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UniProtKB - O75185 (AT2C2_HUMAN)

Entry version 174 (22 Apr 2020)
Sequence version 3 (12 Sep 2018)
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Protein

Calcium-transporting ATPase type 2C member 2

Gene

ATP2C2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi332Calcium 2; via carbonyl oxygenBy similarity1
Metal bindingi333Calcium 2; via carbonyl oxygenBy similarity1
Metal bindingi335Calcium 2; via carbonyl oxygenBy similarity1
Metal bindingi337Calcium 2By similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei3794-aspartylphosphate intermediateBy similarity1
Metal bindingi674MagnesiumBy similarity1
Metal bindingi678MagnesiumBy similarity1
Metal bindingi768Calcium 2By similarity1
Metal bindingi772Calcium 2By similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTranslocase
Biological processCalcium transport, Ion transport, Transport
LigandATP-binding, Calcium, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		3.6.3.8 2681

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-936837 Ion transport by P-type ATPases

Protein family/group databases

Transport Classification Database

More...TCDBi		3.A.3.2.9 the p-type atpase (p-atpase) superfamily

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Calcium-transporting ATPase type 2C member 2Curated (EC:7.2.2.10)
Short name:
ATPase 2C2
Alternative name(s):
Secretory pathway Ca(2+)-ATPase 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ATP2C2Imported
Synonyms:KIAA0703, SPCA2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:29103 ATP2C2

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		613082 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_O75185

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 106CytoplasmicSequence analysisAdd BLAST106
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei107 – 127Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini128 – 129ExtracellularSequence analysis2
Transmembranei130 – 150Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini151 – 231CytoplasmicSequence analysisAdd BLAST81
Transmembranei232 – 252Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini253 – 293ExtracellularSequence analysisAdd BLAST41
Transmembranei294 – 314Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini315 – 331CytoplasmicSequence analysisAdd BLAST17
Transmembranei332 – 352Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini353 – 750ExtracellularSequence analysisAdd BLAST398
Transmembranei751 – 771Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini772 – 804CytoplasmicSequence analysisAdd BLAST33
Transmembranei805 – 825Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini826 – 837ExtracellularSequence analysisAdd BLAST12
Transmembranei838 – 855Helical; Name=8Sequence analysisAdd BLAST18
Topological domaini856 – 874CytoplasmicSequence analysisAdd BLAST19
Transmembranei875 – 895Helical; Name=9Sequence analysisAdd BLAST21
Topological domaini896 – 905ExtracellularSequence analysis10
Transmembranei906 – 926Helical; Name=10Sequence analysisAdd BLAST21
Topological domaini927 – 946CytoplasmicSequence analysisAdd BLAST20

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		9914

Open Targets

More...OpenTargetsi		ENSG00000064270

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA162377204

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		O75185 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ATP2C2

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000462071 – 946Calcium-transporting ATPase type 2C member 2Add BLAST946

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei264PhosphothreonineCombined sources1
Modified residuei267PhosphoserineCombined sources1
Modified residuei268PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		O75185

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		O75185

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O75185

PeptideAtlas

More...PeptideAtlasi		O75185

PRoteomics IDEntifications database

More...PRIDEi		O75185

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		17939
49858 [O75185-1]
49859 [O75185-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		O75185

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		O75185

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000064270 Expressed in transverse colon and 148 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		O75185 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		O75185 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000064270 Tissue enhanced (intestine, salivary gland)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

Protein interaction database and analysis system

More...IntActi		O75185, 2 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000397925

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		O75185 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		O75185

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi114 – 119Poly-Leu6

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily. [View classification]Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0202 Eukaryota
COG0474 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000160275

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_002360_3_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O75185

KEGG Orthology (KO)

More...KOi		K01537

Identification of Orthologs from Complete Genome Data

More...OMAi		ALAMKME

Database of Orthologous Groups

More...OrthoDBi		100699at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		O75185

TreeFam database of animal gene trees

More...TreeFami		TF354251

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.40.1110.10, 1 hit
3.40.50.1000, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR030334 ATP2C2
IPR006068 ATPase_P-typ_cation-transptr_C
IPR004014 ATPase_P-typ_cation-transptr_N
IPR023299 ATPase_P-typ_cyto_dom_N
IPR018303 ATPase_P-typ_P_site
IPR023298 ATPase_P-typ_TM_dom_sf
IPR008250 ATPase_P-typ_transduc_dom_A_sf
IPR036412 HAD-like_sf
IPR023214 HAD_sf
IPR006413 P-type_ATPase_IIA_PMR1
IPR001757 P_typ_ATPase

The PANTHER Classification System

More...PANTHERi		PTHR42861:SF23 PTHR42861:SF23, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00689 Cation_ATPase_C, 1 hit
PF00690 Cation_ATPase_N, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00120 HATPASE

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00831 Cation_ATPase_N, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF56784 SSF56784, 1 hit
SSF81653 SSF81653, 1 hit
SSF81660 SSF81660, 1 hit
SSF81665 SSF81665, 1 hit

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR01522 ATPase-IIA2_Ca, 1 hit
TIGR01494 ATPase_P-type, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00154 ATPASE_E1_E2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: O75185-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVEGRVSEFL KKLGFSGGGR QYQALEKDEE EALIDEQSEL KAIEKEKKVT 
        60         70         80         90        100
ALPPKEACKC QKEDLARAFC VDLHTGLSEF SVTQRRLAHG WNEFVADNSE 
       110        120        130        140        150
PVWKKYLDQF KNPLILLLLG SALVSVLTKE YEDAVSIATA VLVVVTVAFI 
       160        170        180        190        200
QEYRSEKSLE ELTKLVPPEC NCLREGKLQH LLARELVPGD VVSLSIGDRI 
       210        220        230        240        250
PADIRLTEVT DLLVDESSFT GEAEPCSKTD SPLTGGGDLT TLSNIVFMGT 
       260        270        280        290        300
LVQYGRGQGV VIGTGESSQF GEVFKMMQAE ETPKTPLQKS MDRLGKQLTL 
       310        320        330        340        350
FSFGIIGLIM LIGWSQGKQL LSMFTIGVSL AVAAIPEGLP IVVMVTLVLG 
       360        370        380        390        400
VLRMAKKRVI VKKLPIVETL GCCSVLCSDK TGTLTANEMT VTQLVTSDGL 
       410        420        430        440        450
RAEVSGVGYD GQGTVCLLPS KEVIKEFSNV SVGKLVEAGC VANNAVIRKN 
       460        470        480        490        500
AVMGQPTEGA LMALAMKMDL SDIKNSYIRK KEIPFSSEQK WMAVKCSLKT 
       510        520        530        540        550
EDQEDIYFMK GALEEVIRYC TMYNNGGIPL PLTPQQRSFC LQEEKRMGSL 
       560        570        580        590        600
GLRVLALASG PELGRLTFLG LVGIIDPPRV GVKEAVQVLS ESGVSVKMIT 
       610        620        630        640        650
GDALETALAI GRNIGLCNGK LQAMSGEEVD SVEKGELADR VGKVSVFFRT 
       660        670        680        690        700
SPKHKLKIIK ALQESGAIVA MTGDGVNDAV ALKSADIGIA MGQTGTDVSK 
       710        720        730        740        750
EAANMILVDD DFSAIMNAVE EGKGIFYNIK NFVRFQLSTS ISALSLITLS 
       760        770        780        790        800
TVFNLPSPLN AMQILWINII MDGPPAQSLG VEPVDKDAFR QPPRSVRDTI 
       810        820        830        840        850
LSRALILKIL MSAAIIISGT LFIFWKEMPE DRASTPRTTT MTFTCFVFFD 
       860        870        880        890        900
LFNALTCRSQ TKLIFEIGFL RNHMFLYSVL GSILGQLAVI YIPPLQRVFQ 
       910        920        930        940 
TENLGALDLL FLTGLASSVF ILSELLKLCE KYCCSPKRVQ MHPEDV
Length:946
Mass (Da):103,169
Last modified:September 12, 2018 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE270F10EAAD185E3
GO
Isoform 2 (identifier: O75185-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-70: MVEGRVSEFL...QKEDLARAFC → MLHFHLLKFK...SELVPDLSFQ

Show »
Length:963
Mass (Da):105,023
Checksum:iE4EE385F968777B2
GO
Isoform 3 (identifier: O75185-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     778-778: S → RSSQKTEVCCTAVRLGVEGRGESTWAGRAG

Show »
Length:975
Mass (Da):106,217
Checksum:i6E1DBC61CC542971
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BS90H3BS90_HUMAN
Calcium-transporting ATPase type 2C...
ATP2C2
53Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA31678 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti171N → D in CAI46049 (PubMed:17974005).Curated1
Sequence conflicti361V → A in CAI46049 (PubMed:17974005).Curated1
Sequence conflicti880L → R in CAI46049 (PubMed:17974005).Curated1
Isoform 2 (identifier: O75185-2)
Sequence conflicti12R → I in BAA31678 (PubMed:9734811).Curated1
Isoform 3 (identifier: O75185-3)
Sequence conflicti789A → G in CAI46049 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_059137165L → M1 PublicationCorresponds to variant dbSNP:rs247818Ensembl.1
Natural variantiVAR_047935411G → S. Corresponds to variant dbSNP:rs2303853Ensembl.1
Natural variantiVAR_047936466M → L1 PublicationCorresponds to variant dbSNP:rs247897Ensembl.1
Natural variantiVAR_070929604L → Q1 PublicationCorresponds to variant dbSNP:rs62640926Ensembl.1
Natural variantiVAR_047937907L → P. Corresponds to variant dbSNP:rs16973859Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0359891 – 70MVEGR…ARAFC → MLHFHLLKFKTRVVFSAVII MVTGLCLFLLSLPHLHGVFE QVPAPWWTSLCPWPIMEAAA FQSGSLYPVASFLAAPMSEL VPDLSFQ in isoform 2. 1 PublicationAdd BLAST70
Alternative sequenceiVSP_054679778S → RSSQKTEVCCTAVRLGVEGR GESTWAGRAG in isoform 3. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AY791884 mRNA Translation: AAV54193.1
AB014603 mRNA Translation: BAA31678.2 Different initiation.
AK300526 mRNA Translation: BAG62238.1
BX648333 mRNA Translation: CAI46049.1
CR749829 mRNA Translation: CAH18686.1
AC010551 Genomic DNA No translation available.
AC022165 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS42207.1 [O75185-1]
CCDS67088.1 [O75185-3]

NCBI Reference Sequences

More...RefSeqi		NP_001273456.2, NM_001286527.2 [O75185-3]
NP_001278383.1, NM_001291454.1
NP_055676.3, NM_014861.3 [O75185-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000262429; ENSP00000262429; ENSG00000064270 [O75185-1]
ENST00000416219; ENSP00000397925; ENSG00000064270 [O75185-3]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		9914

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:9914

UCSC genome browser

More...UCSCi		uc002fhx.4 human [O75185-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY791884 mRNA Translation: AAV54193.1
AB014603 mRNA Translation: BAA31678.2 Different initiation.
AK300526 mRNA Translation: BAG62238.1
BX648333 mRNA Translation: CAI46049.1
CR749829 mRNA Translation: CAH18686.1
AC010551 Genomic DNA No translation available.
AC022165 Genomic DNA No translation available.
CCDSiCCDS42207.1 [O75185-1]
CCDS67088.1 [O75185-3]
RefSeqiNP_001273456.2, NM_001286527.2 [O75185-3]
NP_001278383.1, NM_001291454.1
NP_055676.3, NM_014861.3 [O75185-1]

3D structure databases

SMRiO75185
ModBaseiSearch...

Protein-protein interaction databases

IntActiO75185, 2 interactors
STRINGi9606.ENSP00000397925

Protein family/group databases

TCDBi3.A.3.2.9 the p-type atpase (p-atpase) superfamily

PTM databases

iPTMnetiO75185
PhosphoSitePlusiO75185

Polymorphism and mutation databases

BioMutaiATP2C2

Proteomic databases

jPOSTiO75185
MassIVEiO75185
PaxDbiO75185
PeptideAtlasiO75185
PRIDEiO75185
ProteomicsDBi17939
49858 [O75185-1]
49859 [O75185-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		58367 53 antibodies

The DNASU plasmid repository

More...DNASUi		9914

Genome annotation databases

EnsembliENST00000262429; ENSP00000262429; ENSG00000064270 [O75185-1]
ENST00000416219; ENSP00000397925; ENSG00000064270 [O75185-3]
GeneIDi9914
KEGGihsa:9914
UCSCiuc002fhx.4 human [O75185-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		9914
DisGeNETi9914

GeneCards: human genes, protein and diseases

More...GeneCardsi		ATP2C2
HGNCiHGNC:29103 ATP2C2
HPAiENSG00000064270 Tissue enhanced (intestine, salivary gland)
MIMi613082 gene
neXtProtiNX_O75185
OpenTargetsiENSG00000064270
PharmGKBiPA162377204

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0202 Eukaryota
COG0474 LUCA
GeneTreeiENSGT00940000160275
HOGENOMiCLU_002360_3_1_1
InParanoidiO75185
KOiK01537
OMAiALAMKME
OrthoDBi100699at2759
PhylomeDBiO75185
TreeFamiTF354251

Enzyme and pathway databases

BRENDAi3.6.3.8 2681
ReactomeiR-HSA-936837 Ion transport by P-type ATPases

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ATP2C2 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		9914
PharosiO75185 Tbio

Protein Ontology

More...PROi		PR:O75185
RNActiO75185 protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000064270 Expressed in transverse colon and 148 other tissues
ExpressionAtlasiO75185 baseline and differential
GenevisibleiO75185 HS

Family and domain databases

Gene3Di3.40.1110.10, 1 hit
3.40.50.1000, 1 hit
InterProiView protein in InterPro
IPR030334 ATP2C2
IPR006068 ATPase_P-typ_cation-transptr_C
IPR004014 ATPase_P-typ_cation-transptr_N
IPR023299 ATPase_P-typ_cyto_dom_N
IPR018303 ATPase_P-typ_P_site
IPR023298 ATPase_P-typ_TM_dom_sf
IPR008250 ATPase_P-typ_transduc_dom_A_sf
IPR036412 HAD-like_sf
IPR023214 HAD_sf
IPR006413 P-type_ATPase_IIA_PMR1
IPR001757 P_typ_ATPase
PANTHERiPTHR42861:SF23 PTHR42861:SF23, 1 hit
PfamiView protein in Pfam
PF00689 Cation_ATPase_C, 1 hit
PF00690 Cation_ATPase_N, 1 hit
PRINTSiPR00120 HATPASE
SMARTiView protein in SMART
SM00831 Cation_ATPase_N, 1 hit
SUPFAMiSSF56784 SSF56784, 1 hit
SSF81653 SSF81653, 1 hit
SSF81660 SSF81660, 1 hit
SSF81665 SSF81665, 1 hit
TIGRFAMsiTIGR01522 ATPase-IIA2_Ca, 1 hit
TIGR01494 ATPase_P-type, 2 hits
PROSITEiView protein in PROSITE
PS00154 ATPASE_E1_E2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAT2C2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O75185
Secondary accession number(s): B4DU76
, E7ES94, Q5HYC3, Q5S053, Q68CQ2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: September 12, 2018
Last modified: April 22, 2020
This is version 174 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
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