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Protein

Paired amphipathic helix protein Sin3b

Gene

SIN3B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as a transcriptional repressor. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Interacts with MAD-MAX heterodimers by binding to MAD. The heterodimer then represses transcription by tethering SIN3B to DNA. Also forms a complex with FOXK1 which represses transcription. With FOXK1, regulates cell cycle progression probably by repressing cell cycle inhibitor genes expression.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • chromatin binding Source: Ensembl
  • transcription corepressor activity Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRepressor
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-400206 Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
R-HSA-427413 NoRC negatively regulates rRNA expression
R-HSA-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Paired amphipathic helix protein Sin3b
Alternative name(s):
Histone deacetylase complex subunit Sin3b
Transcriptional corepressor Sin3b
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SIN3BImported
Synonyms:KIAA0700
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000127511.9

Human Gene Nomenclature Database

More...
HGNCi
HGNC:19354 SIN3B

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
607777 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O75182

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
23309

Open Targets

More...
OpenTargetsi
ENSG00000127511

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134909030

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SIN3B

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001215391 – 1162Paired amphipathic helix protein Sin3bAdd BLAST1162

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei709PhosphoserineBy similarity1
Modified residuei712PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Ubiquitinated by RNF220 that leads to proteasomal degradation.By similarity

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
O75182

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O75182

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O75182

PeptideAtlas

More...
PeptideAtlasi
O75182

PRoteomics IDEntifications database

More...
PRIDEi
O75182

ProteomicsDB human proteome resource

More...
ProteomicsDBi
49855
49856 [O75182-2]
49857 [O75182-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O75182

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O75182

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000127511 Expressed in 202 organ(s), highest expression level in left lobe of thyroid gland

CleanEx database of gene expression profiles

More...
CleanExi
HS_SIN3B

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
O75182 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O75182 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA050329

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with FOXK1/MNF, MXI, MAD, NCOR1 and SAP30. Interaction with SUDS3 enhances the interaction with HDAC1 to form a complex. Interacts with CRY1, HCFC1, MAD3, MAD4, MAEL, REST, RNF220 and SETDB1. Interacts with C6orf89 (PubMed:23460338). Interacts with MYT1L (By similarity).By similarity2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
MYCP011067EBI-540462,EBI-447544

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
116901, 67 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-3322 SIN3B histone deacetylase complex

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
O75182

Protein interaction database and analysis system

More...
IntActi
O75182, 28 interactors

Molecular INTeraction database

More...
MINTi
O75182

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000369131

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
O75182

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O75182

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini37 – 107PAH 1PROSITE-ProRule annotationAdd BLAST71
Domaini153 – 238PAH 2PROSITE-ProRule annotationAdd BLAST86
Domaini292 – 369PAH 3PROSITE-ProRule annotationAdd BLAST78

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 308Interaction with CRY1By similarityAdd BLAST308
Regioni59 – 105Interaction with RESTBy similarityAdd BLAST47
Regioni284 – 540Interaction with NCOR1By similarityAdd BLAST257
Regioni392 – 591Interaction with SUDS3 and HDAC1By similarityAdd BLAST200

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4204 Eukaryota
COG5602 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159560

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000230688

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG060425

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O75182

Identification of Orthologs from Complete Genome Data

More...
OMAi
CNVDCRF

Database of Orthologous Groups

More...
OrthoDBi
EOG091G03HY

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O75182

TreeFam database of animal gene trees

More...
TreeFami
TF106187

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013194 HDAC_interact_dom
IPR003822 PAH
IPR036600 PAH_sf
IPR039774 Sin3-like
IPR031693 Sin3_C

The PANTHER Classification System

More...
PANTHERi
PTHR12346 PTHR12346, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02671 PAH, 3 hits
PF08295 Sin3_corepress, 2 hits
PF16879 Sin3a_C, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00761 HDAC_interact, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47762 SSF47762, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51477 PAH, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O75182-1) [UniParc]FASTAAdd to basket
Also known as: Long

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAHAGGGSGG SGAGGPAGRG LSGARWGRSG SAGHEKLPVH VEDALTYLDQ
60 70 80 90 100
VKIRFGSDPA TYNGFLEIMK EFKSQSIDTP GVIRRVSQLF HEHPDLIVGF
110 120 130 140 150
NAFLPLGYRI DIPKNGKLNI QSPLTSQENS HNHGDGAEDF KQQVPYKEDK
160 170 180 190 200
PQVPLESDSV EFNNAISYVN KIKTRFLDHP EIYRSFLEIL HTYQKEQLNT
210 220 230 240 250
RGRPFRGMSE EEVFTEVANL FRGQEDLLSE FGQFLPEAKR SLFTGNGPCE
260 270 280 290 300
MHSVQKNEHD KTPEHSRKRS RPSLLRPVSA PAKKKMKLRG TKDLSIAAVG
310 320 330 340 350
KYGTLQEFSF FDKVRRVLKS QEVYENFLRC IALFNQELVS GSELLQLVSP
360 370 380 390 400
FLGKFPELFA QFKSFLGVKE LSFAPPMSDR SGDGISREID YASCKRIGSS
410 420 430 440 450
YRALPKTYQQ PKCSGRTAIC KELDHWTLLQ GSWTDDYCMS KFKNTCWIPG
460 470 480 490 500
YSAGVLNDTW VSFPSWSEDS TFVSSKKTPY EEQLHRCEDE RFELDVVLET
510 520 530 540 550
NLATIRVLES VQKKLSRMAP EDQEKFRLDD SLGGTSEVIQ RRAIYRIYGD
560 570 580 590 600
KAPEIIESLK KNPVTAVPVV LKRLKAKEEE WREAQQGFNK IWREQYEKAY
610 620 630 640 650
LKSLDHQAVN FKQNDTKALR SKSLLNEIES VYDEHQEQHS EGRSAPSSEP
660 670 680 690 700
HLIFVYEDRQ ILEDAAALIS YYVKRQPAIQ KEDQGTIHQL LHQFVPSLFF
710 720 730 740 750
SQQLDLGASE ESADEDRDSP QGQTTDPSER KKPAPGPHSS PPEEKGAFGD
760 770 780 790 800
APATEQPPLP PPAPHKPLDD VYSLFFANNN WYFFLRLHQT LCSRLLKIYR
810 820 830 840 850
QAQKQLLEYR TEKEREKLLC EGRREKGSDP AMELRLKQPS EVELEEYYPA
860 870 880 890 900
FLDMVRSLLE GSIDPTQYED TLREMFTIHA YVGFTMDKLV QNIARQLHHL
910 920 930 940 950
VSDDVCLKVV ELYLNEKKRG AAGGNLSSRC VRAARETSYQ WKAERCMADE
960 970 980 990 1000
NCFKVMFLQR KGQVIMTIEL LDTEEAQTED PVEVQHLARY VEQYVGTEGA
1010 1020 1030 1040 1050
SSSPTEGFLL KPVFLQRNLK KFRRRWQSEQ ARALRGEARS SWKRLVGVES
1060 1070 1080 1090 1100
ACDVDCRFKL STHKMVFIVN SEDYMYRRGT LCRAKQVQPL VLLRHHQHFE
1110 1120 1130 1140 1150
EWHSRWLEDN VTVEAASLVQ DWLMGEEDED MVPCKTLCET VHVHGLPVTR
1160
YRVQYSRRPA SP
Note: No experimental confirmation available.Curated
Length:1,162
Mass (Da):133,066
Last modified:June 21, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i03D3B24AF1CF40B6
GO
Isoform 21 Publication (identifier: O75182-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     423-454: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:1,130
Mass (Da):129,359
Checksum:iB767339317ECC96D
GO
Isoform 31 Publication (identifier: O75182-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     354-1162: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:353
Mass (Da):39,507
Checksum:i95056B3DCF6C0D53
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M0R271M0R271_HUMAN
Paired amphipathic helix protein Si...
SIN3B
309Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QYC5M0QYC5_HUMAN
Paired amphipathic helix protein Si...
SIN3B
720Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA31675 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_014185354 – 1162Missing in isoform 3. 1 PublicationAdd BLAST809
Alternative sequenceiVSP_014186423 – 454Missing in isoform 2. 1 PublicationAdd BLAST32

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY706204 mRNA Translation: AAU01916.1
AB014600 mRNA Translation: BAA31675.2 Different initiation.
CH471106 Genomic DNA Translation: EAW84565.1
BC005113 mRNA Translation: AAH05113.1
BC025026 mRNA Translation: AAH25026.1
BC063531 mRNA Translation: AAH63531.1
BC110821 mRNA Translation: AAI10822.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS32946.1 [O75182-1]
CCDS74308.1 [O75182-2]

NCBI Reference Sequences

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RefSeqi
NP_001284524.1, NM_001297595.1 [O75182-2]
NP_001284526.1, NM_001297597.1
NP_056075.1, NM_015260.3 [O75182-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.13999

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000248054; ENSP00000248054; ENSG00000127511 [O75182-2]
ENST00000379803; ENSP00000369131; ENSG00000127511 [O75182-1]
ENST00000596802; ENSP00000473039; ENSG00000127511 [O75182-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
23309

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:23309

UCSC genome browser

More...
UCSCi
uc002new.4 human [O75182-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY706204 mRNA Translation: AAU01916.1
AB014600 mRNA Translation: BAA31675.2 Different initiation.
CH471106 Genomic DNA Translation: EAW84565.1
BC005113 mRNA Translation: AAH05113.1
BC025026 mRNA Translation: AAH25026.1
BC063531 mRNA Translation: AAH63531.1
BC110821 mRNA Translation: AAI10822.1
CCDSiCCDS32946.1 [O75182-1]
CCDS74308.1 [O75182-2]
RefSeqiNP_001284524.1, NM_001297595.1 [O75182-2]
NP_001284526.1, NM_001297597.1
NP_056075.1, NM_015260.3 [O75182-1]
UniGeneiHs.13999

3D structure databases

ProteinModelPortaliO75182
SMRiO75182
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116901, 67 interactors
ComplexPortaliCPX-3322 SIN3B histone deacetylase complex
CORUMiO75182
IntActiO75182, 28 interactors
MINTiO75182
STRINGi9606.ENSP00000369131

PTM databases

iPTMnetiO75182
PhosphoSitePlusiO75182

Polymorphism and mutation databases

BioMutaiSIN3B

Proteomic databases

EPDiO75182
MaxQBiO75182
PaxDbiO75182
PeptideAtlasiO75182
PRIDEiO75182
ProteomicsDBi49855
49856 [O75182-2]
49857 [O75182-3]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
23309
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000248054; ENSP00000248054; ENSG00000127511 [O75182-2]
ENST00000379803; ENSP00000369131; ENSG00000127511 [O75182-1]
ENST00000596802; ENSP00000473039; ENSG00000127511 [O75182-3]
GeneIDi23309
KEGGihsa:23309
UCSCiuc002new.4 human [O75182-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
23309
DisGeNETi23309
EuPathDBiHostDB:ENSG00000127511.9

GeneCards: human genes, protein and diseases

More...
GeneCardsi
SIN3B
HGNCiHGNC:19354 SIN3B
HPAiHPA050329
MIMi607777 gene
neXtProtiNX_O75182
OpenTargetsiENSG00000127511
PharmGKBiPA134909030

Human Unidentified Gene-Encoded large proteins database

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HUGEi
Search...

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4204 Eukaryota
COG5602 LUCA
GeneTreeiENSGT00940000159560
HOGENOMiHOG000230688
HOVERGENiHBG060425
InParanoidiO75182
OMAiCNVDCRF
OrthoDBiEOG091G03HY
PhylomeDBiO75182
TreeFamiTF106187

Enzyme and pathway databases

ReactomeiR-HSA-400206 Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
R-HSA-427413 NoRC negatively regulates rRNA expression
R-HSA-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
SIN3B human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
SIN3B

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
23309

Protein Ontology

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PROi
PR:O75182

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000127511 Expressed in 202 organ(s), highest expression level in left lobe of thyroid gland
CleanExiHS_SIN3B
ExpressionAtlasiO75182 baseline and differential
GenevisibleiO75182 HS

Family and domain databases

InterProiView protein in InterPro
IPR013194 HDAC_interact_dom
IPR003822 PAH
IPR036600 PAH_sf
IPR039774 Sin3-like
IPR031693 Sin3_C
PANTHERiPTHR12346 PTHR12346, 1 hit
PfamiView protein in Pfam
PF02671 PAH, 3 hits
PF08295 Sin3_corepress, 2 hits
PF16879 Sin3a_C, 1 hit
SMARTiView protein in SMART
SM00761 HDAC_interact, 1 hit
SUPFAMiSSF47762 SSF47762, 3 hits
PROSITEiView protein in PROSITE
PS51477 PAH, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSIN3B_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O75182
Secondary accession number(s): Q2NL91
, Q68GC2, Q6P4B8, Q8TB34, Q9BSC8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 24, 2003
Last sequence update: June 21, 2005
Last modified: December 5, 2018
This is version 163 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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