UniProtKB - O75179 (ANR17_HUMAN)

>sp|O75179|ANR17_HUMAN Ankyrin repeat domain-containing protein 17 OS=Homo sapiens OX=9606 GN=ANKRD17 PE=1 SV=3
MEKATVPVAAATAAEGEGSPPAVAAVAGPPAAAEVGGGVGGSSRARSASSPRGMVRVCDL
LLKKKPPQQQHHKAKRNRTCRPPSSSESSSDSDNSGGGGGGGGGGGGGGGTSSNNSEEEE
DDDDEEEEVSEVESFILDQDDLENPMLETASKLLLSGTADGADLRTVDPETQARLEALLE
AAGIGKLSTADGKAFADPEVLRRLTSSVSCALDEAAAALTRMRAESTANAGQSDNRSLAE
ACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKG
DITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASI
EDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFL
LEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHV
ELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTL
ACCGGFLEVADFLIKAGADIELGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTA
LTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTT
ANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDYP
NNLLSAPPPDVTQLTPPSHDLNRAPRVPVQALPMVVPPQEPDKPPANVATTLPIRNKAAS
KQKSSSHLPANSQDVQGYITNQSPESIVEEAQGKLTELEQRIKEAIEKNAQLQSLELAHA
DQLTKEKIEELNKTREEQIQKKQKILEELQKVERELQLKTQQQLKKQYLEVKAQRIQLQQ
QQQQSCQHLGLLTPVGVGEQLSEGDYARLQQVDPVLLKDEPQQTAAQMGFAPIQPLAMPQ
ALPLAAGPLPPGSIANLTELQGVIVGQPVLGQAQLAGLGQGILTETQQGLMVASPAQTLN
DTLDDIMAAVSGRASAMSNTPTHSIAASISQPQTPTPSPIISPSAMLPIYPAIDIDAQTE
SNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGA
DIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIK
ILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLAC
FQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSR
DTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVD
AADNRKITPLMAAFRKGHVKVVRYLVKEVNQFPSDSECMRYIATITDKEMLKKCHLCMES
IVQAKDRQAAEANKNASILLEELDLEKLREESRRLALAAKREKRKEKRRKKKEEQRRKLE
EIEAKNKENFELQAAQEKEKLKVEDEPEVLTEPPSATTTTTIGISATWTTLAGSHGKRNN
TITTTSSKRKNRKNKITPENVQIIFDDPLPISYSQPEKVNGESKSSSTSESGDSDNMRIS
SCSDESSNSNSSRKSDNHSPAVVTTTVSSKKQPSVLVTFPKEERKSVSGKASIKLSETIS
EGTSNSLSTCTKSGPSPLSSPNGKLTVASPKRGQKREEGWKEVVRRSKKVSVPSTVISRV
IGRGGCNINAIREFTGAHIDIDKQKDKTGDRIITIRGGTESTRQATQLINALIKDPDKEI
DELIPKNRLKSSSANSKIGSSAPTTTAANTSLMGIKMTTVALSSTSQTATALTVPAISSA
STHKTIKNPVNNVRPGFPVSLPLAYPPPQFAHALLAAQTFQQIRPPRLPMTHFGGTFPPA
QSTWGPFPVRPLSPARATNSPKPHMVPRHSNQNSSGSQVNSAGSLTSSPTTTTSSSASTV
PGTSTNGSPSSPSVRRQLFVTVVKTSNATTTTVTTTASNNNTAPTNATYPMPTAKEHYPV
SSPSSPSPPAQPGGVSRNSPLDCGSASPNKVASSSEQEAGSPPVVETTNTRPPNSSSSSG
SSSAHSNQQQPPGSVSQEPRPPLQQSQVPPPEVRMTVPPLATSSAPVAVPSTAPVTYPMP
QTPMGCPQPTPKMETPAIRPPPHGTTAPHKNSASVQNSSVAVLSVNHIKRPHSVPSSVQL
PSTLSTQSACQNSVHPANKPIAPNFSAPLPFGPFSTLFENSPTSAHAFWGGSVVSSQSTP
ESMLSGKSSYLPNSDPLHQSDTSKAPGFRPPLQRPAPSPSGIVNMDSPYGSVTPSSTHLG
NFASNISGGQMYGPGAPLGGAPAAANFNRQHFSPLSLLTPCSSASNDSSAQSVSSGVRAP
SPAPSSVPLGSEKPSNVSQDRKVPVPIGTERSARIRQTGTSAPSVIGSNLSTSVGHSGIW
SFEGIGGNQDKVDWCNPGMGNPMIHRPMSDPGVFSQHQAMERDSTGIVTPSGTFHQHVPA
GYMDFPKVGGMPFSVYGNAMIPPVAPIPDGAGGPIFNGPHAADPSWNSLIKMVSSSTENN
GPQTVWTGPWAPHMNSVHMNQLG

Entry version 169 (07 Oct 2020)
Sequence version 3 (23 Oct 2007)
Previous versions | rss

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Protein

Ankyrin repeat domain-containing protein 17

Gene

ANKRD17

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Could play pivotal roles in cell cycle and DNA regulation (PubMed:19150984). Involved in innate immune defense against viruse by positively regulating the viral dsRNA receptors DDX58 and IFIH1 signaling pathways (PubMed:22328336). Involves in NOD2- and NOD1-mediated responses to bacteria suggesting a role in innate antibacterial immune pathways too (PubMed:23711367). Target of enterovirus 71 which is the major etiological agent of HFMD (hand, foot and mouth disease) (PubMed:17276651). Could play a central role for the formation and/or maintenance of the blood vessels of the circulation system (By similarity).By similarity4 Publications

GO - Molecular functionⁱ

Complete GO annotation on QuickGO ...

GO - Biological processⁱ

Complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	RNA-binding
Biological process	Host-virus interaction, Immunity, Innate immunity

Enzyme and pathway databases

PathwayCommonsⁱ	O75179

PathwayCommonsⁱ

O75179

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Ankyrin repeat domain-containing protein 17 Alternative name(s): Gene trap ankyrin repeat protein Serologically defined breast cancer antigen NY-BR-16
Gene namesⁱ	Name:ANKRD17 Synonyms:GTAR, KIAA0697
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 4

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000132466.17
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:23575, ANKRD17
MIMⁱ	615929, gene
neXtProtⁱ	NX_O75179

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	26057
Open Targets More...OpenTargetsⁱ	ENSG00000132466
PharmGKBⁱ	PA134943225

Miscellaneous databases

Pharosⁱ	O75179, Tbio

Pharosⁱ

O75179, Tbio

Polymorphism and mutation databases

BioMutaⁱ	ANKRD17

BioMutaⁱ

ANKRD17

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000307917	1 – 2603	Ankyrin repeat domain-containing protein 17Add BLAST		2603

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	1	N-acetylmethionineCombined sources	1
Modified residueⁱ	19	PhosphoserineCombined sources	1
Modified residueⁱ	50	PhosphoserineBy similarity	1
Modified residueⁱ	156	PhosphoserineCombined sources	1
Cross-linkⁱ	318	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	803	PhosphoserineCombined sources	1
Modified residueⁱ	1457	PhosphoserineCombined sources	1
Modified residueⁱ	1635	PhosphoserineCombined sources	1
Modified residueⁱ	1639	PhosphoserineCombined sources	1
Modified residueⁱ	1696	PhosphoserineCombined sources	1
Modified residueⁱ	1700	PhosphoserineCombined sources	1
Modified residueⁱ	1709	PhosphoserineCombined sources	1
Modified residueⁱ	1874	Asymmetric dimethylarginineBy similarity	1
Modified residueⁱ	2042	Phosphoserine1 Publication	1
Modified residueⁱ	2044	PhosphoserineBy similarity	1
Modified residueⁱ	2045	PhosphoserineCombined sources1 Publication	1
Modified residueⁱ	2047	PhosphoserineCombined sources	1
Modified residueⁱ	2059	PhosphoserineCombined sources	1
Modified residueⁱ	2067	PhosphoserineCombined sources	1
Modified residueⁱ	2373	PhosphoserineCombined sources	1
Modified residueⁱ	2401	PhosphoserineCombined sources	1

Post-translational modificationⁱ

Phosphorylated by CDK2.1 Publication

Keywords - PTMⁱ

Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	O75179
jPOSTⁱ	O75179
MassIVEⁱ	O75179
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	O75179
PaxDbⁱ	O75179
PeptideAtlas More...PeptideAtlasⁱ	O75179
PRIDEⁱ	O75179
ProteomicsDBⁱ	18505 33844 49850 [O75179-1] 49851 [O75179-2] 49852 [O75179-3] 49853 [O75179-4] 49854 [O75179-5]

PTM databases

GlyGenⁱ	O75179, 3 sites, 1 O-linked glycan (3 sites)
iPTMnetⁱ	O75179
MetOSiteⁱ	O75179
PhosphoSitePlusⁱ	O75179
SwissPalmⁱ	O75179

Expressionⁱ

Tissue specificityⁱ

Ubiquitously expressed.2 Publications

Gene expression databases

Bgeeⁱ	ENSG00000132466, Expressed in sural nerve and 247 other tissues
ExpressionAtlasⁱ	O75179, baseline and differential
Genevisibleⁱ	O75179, HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	ENSG00000132466, Low tissue specificity

HPAⁱ

ENSG00000132466, Low tissue specificity

Interactionⁱ

Subunit structureⁱ

Interacts (via N-terminus) with NOD2.

Interacts with CDK2, MCM3, MCM5, MCM7, CDC6 and PCNA.

Interacts with MAVS and IFIH1.

Interacts (via the second ankyrin repeat cluster) with DDX58.

3 Publications

(Microbial infection) Interacts with enterovirus 71/EV71 capsid protein VP1.

1 Publication

Protein-protein interaction databases

BioGRIDⁱ	117519, 65 interactors
Database of interacting proteins More...DIPⁱ	DIP-47290N
IntActⁱ	O75179, 41 interactors
Molecular INTeraction database More...MINTⁱ	O75179
STRINGⁱ	9606.ENSP00000351416

Miscellaneous databases

RNActⁱ	O75179, protein

RNActⁱ

O75179, protein

Structureⁱ

3D structure databases

SMRⁱ	O75179
ModBaseⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Repeatⁱ	233 – 262	ANK 1Add BLAST	30
Repeatⁱ	266 – 295	ANK 2Add BLAST	30
Repeatⁱ	300 – 329	ANK 3Add BLAST	30
Repeatⁱ	333 – 362	ANK 4Add BLAST	30
Repeatⁱ	366 – 395	ANK 5Add BLAST	30
Repeatⁱ	400 – 429	ANK 6Add BLAST	30
Repeatⁱ	433 – 462	ANK 7Add BLAST	30
Repeatⁱ	466 – 495	ANK 8Add BLAST	30
Repeatⁱ	499 – 528	ANK 9Add BLAST	30
Repeatⁱ	533 – 562	ANK 10Add BLAST	30
Repeatⁱ	563 – 592	ANK 11Add BLAST	30
Repeatⁱ	596 – 625	ANK 12Add BLAST	30
Repeatⁱ	629 – 658	ANK 13Add BLAST	30
Repeatⁱ	663 – 692	ANK 14Add BLAST	30
Repeatⁱ	696 – 725	ANK 15Add BLAST	30
Repeatⁱ	1082 – 1111	ANK 16Add BLAST	30
Repeatⁱ	1115 – 1144	ANK 17Add BLAST	30
Repeatⁱ	1149 – 1178	ANK 18Add BLAST	30
Repeatⁱ	1182 – 1211	ANK 19Add BLAST	30
Repeatⁱ	1217 – 1246	ANK 20Add BLAST	30
Repeatⁱ	1251 – 1280	ANK 21Add BLAST	30
Repeatⁱ	1284 – 1313	ANK 22Add BLAST	30
Repeatⁱ	1319 – 1348	ANK 23Add BLAST	30
Repeatⁱ	1352 – 1381	ANK 24Add BLAST	30
Repeatⁱ	1385 – 1414	ANK 25Add BLAST	30
Domainⁱ	1725 – 1789	KHPROSITE-ProRule annotationAdd BLAST	65

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	1442 – 1526	Sequence analysisAdd BLAST		85

Compositional bias

Feature key	Position(s)	DescriptionActions	Length
Compositional biasⁱ	96 – 110	Gly-richAdd BLAST	15
Compositional biasⁱ	858 – 1008	Gln-richAdd BLAST	151
Compositional biasⁱ	1603 – 1700	Ser-richAdd BLAST	98
Compositional biasⁱ	1950 – 2106	Ser-richAdd BLAST	157
Compositional biasⁱ	1966 – 2033	Thr-richAdd BLAST	68

Keywords - Domainⁱ

ANK repeat, Coiled coil, Repeat

Phylogenomic databases

eggNOGⁱ	KOG0504, Eukaryota KOG4369, Eukaryota
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00940000153768
HOGENOMⁱ	CLU_000590_0_1_1
InParanoidⁱ	O75179
KEGG Orthology (KO) More...KOⁱ	K16726
OMAⁱ	FGANIDH
Database of Orthologous Groups More...OrthoDBⁱ	1115202at2759
PhylomeDBⁱ	O75179
TreeFamⁱ	TF328552

Family and domain databases

Gene3Dⁱ	1.25.40.20, 8 hits 3.30.1370.10, 1 hit
InterProⁱ	View protein in InterPro IPR002110, Ankyrin_rpt IPR020683, Ankyrin_rpt-contain_dom IPR036770, Ankyrin_rpt-contain_sf IPR004087, KH_dom IPR004088, KH_dom_type_1 IPR036612, KH_dom_type_1_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00023, Ank, 2 hits PF12796, Ank_2, 9 hits PF00013, KH_1, 1 hit
PRINTSⁱ	PR01415, ANKYRIN
SMARTⁱ	View protein in SMART SM00248, ANK, 25 hits SM00322, KH, 1 hit
SUPFAMⁱ	SSF48403, SSF48403, 3 hits SSF54791, SSF54791, 1 hit
PROSITEⁱ	View protein in PROSITE PS50297, ANK_REP_REGION, 1 hit PS50088, ANK_REPEAT, 20 hits PS50084, KH_TYPE_1, 1 hit

Sequences (7+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 7 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 7 described isoforms and 3 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: O75179-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the canonicalⁱ sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

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        10         20         30         40         50
MEKATVPVAA ATAAEGEGSP PAVAAVAGPP AAAEVGGGVG GSSRARSASS 
        60         70         80         90        100
PRGMVRVCDL LLKKKPPQQQ HHKAKRNRTC RPPSSSESSS DSDNSGGGGG 
       110        120        130        140        150
GGGGGGGGGG TSSNNSEEEE DDDDEEEEVS EVESFILDQD DLENPMLETA 
       160        170        180        190        200
SKLLLSGTAD GADLRTVDPE TQARLEALLE AAGIGKLSTA DGKAFADPEV 
       210        220        230        240        250
LRRLTSSVSC ALDEAAAALT RMRAESTANA GQSDNRSLAE ACSEGDVNAV 
       260        270        280        290        300
RKLLIEGRSV NEHTEEGESL LCLACSAGYY ELAQVLLAMH ANVEDRGIKG 
       310        320        330        340        350
DITPLMAAAN GGHVKIVKLL LAHKADVNAQ SSTGNTALTY ACAGGYVDVV 
       360        370        380        390        400
KVLLESGASI EDHNENGHTP LMEAGSAGHV EVARLLLENG AGINTHSNEF 
       410        420        430        440        450
KESALTLACY KGHLEMVRFL LEAGADQEHK TDEMHTALME ACMDGHVEVA 
       460        470        480        490        500
RLLLDSGAQV NMPADSFESP LTLAACGGHV ELAALLIERG ASLEEVNDEG 
       510        520        530        540        550
YTPLMEAARE GHEEMVALLL GQGANINAQT EETQETALTL ACCGGFLEVA 
       560        570        580        590        600
DFLIKAGADI ELGCSTPLME AAQEGHLELV KYLLAAGANV HATTATGDTA 
       610        620        630        640        650
LTYACENGHT DVADVLLQAG ADLEHESEGG RTPLMKAARA GHVCTVQFLI 
       660        670        680        690        700
SKGANVNRTT ANNDHTVLSL ACAGGHLAVV ELLLAHGADP THRLKDGSTM 
       710        720        730        740        750
LIEAAKGGHT SVVCYLLDYP NNLLSAPPPD VTQLTPPSHD LNRAPRVPVQ 
       760        770        780        790        800
ALPMVVPPQE PDKPPANVAT TLPIRNKAAS KQKSSSHLPA NSQDVQGYIT 
       810        820        830        840        850
NQSPESIVEE AQGKLTELEQ RIKEAIEKNA QLQSLELAHA DQLTKEKIEE 
       860        870        880        890        900
LNKTREEQIQ KKQKILEELQ KVERELQLKT QQQLKKQYLE VKAQRIQLQQ 
       910        920        930        940        950
QQQQSCQHLG LLTPVGVGEQ LSEGDYARLQ QVDPVLLKDE PQQTAAQMGF 
       960        970        980        990       1000
APIQPLAMPQ ALPLAAGPLP PGSIANLTEL QGVIVGQPVL GQAQLAGLGQ 
      1010       1020       1030       1040       1050
GILTETQQGL MVASPAQTLN DTLDDIMAAV SGRASAMSNT PTHSIAASIS 
      1060       1070       1080       1090       1100
QPQTPTPSPI ISPSAMLPIY PAIDIDAQTE SNHDTALTLA CAGGHEELVQ 
      1110       1120       1130       1140       1150
TLLERGASIE HRDKKGFTPL ILAATAGHVG VVEILLDNGA DIEAQSERTK 
      1160       1170       1180       1190       1200
DTPLSLACSG GRQEVVELLL ARGANKEHRN VSDYTPLSLA ASGGYVNIIK 
      1210       1220       1230       1240       1250
ILLNAGAEIN SRTGSKLGIS PLMLAAMNGH TAAVKLLLDM GSDINAQIET 
      1260       1270       1280       1290       1300
NRNTALTLAC FQGRTEVVSL LLDRKANVEH RAKTGLTPLM EAASGGYAEV 
      1310       1320       1330       1340       1350
GRVLLDKGAD VNAPPVPSSR DTALTIAADK GHYKFCELLI GRGAHIDVRN 
      1360       1370       1380       1390       1400
KKGNTPLWLA ANGGHLDVVQ LLVQAGADVD AADNRKITPL MAAFRKGHVK 
      1410       1420       1430       1440       1450
VVRYLVKEVN QFPSDSECMR YIATITDKEM LKKCHLCMES IVQAKDRQAA 
      1460       1470       1480       1490       1500
EANKNASILL EELDLEKLRE ESRRLALAAK REKRKEKRRK KKEEQRRKLE 
      1510       1520       1530       1540       1550
EIEAKNKENF ELQAAQEKEK LKVEDEPEVL TEPPSATTTT TIGISATWTT 
      1560       1570       1580       1590       1600
LAGSHGKRNN TITTTSSKRK NRKNKITPEN VQIIFDDPLP ISYSQPEKVN 
      1610       1620       1630       1640       1650
GESKSSSTSE SGDSDNMRIS SCSDESSNSN SSRKSDNHSP AVVTTTVSSK 
      1660       1670       1680       1690       1700
KQPSVLVTFP KEERKSVSGK ASIKLSETIS EGTSNSLSTC TKSGPSPLSS 
      1710       1720       1730       1740       1750
PNGKLTVASP KRGQKREEGW KEVVRRSKKV SVPSTVISRV IGRGGCNINA 
      1760       1770       1780       1790       1800
IREFTGAHID IDKQKDKTGD RIITIRGGTE STRQATQLIN ALIKDPDKEI 
      1810       1820       1830       1840       1850
DELIPKNRLK SSSANSKIGS SAPTTTAANT SLMGIKMTTV ALSSTSQTAT 
      1860       1870       1880       1890       1900
ALTVPAISSA STHKTIKNPV NNVRPGFPVS LPLAYPPPQF AHALLAAQTF 
      1910       1920       1930       1940       1950
QQIRPPRLPM THFGGTFPPA QSTWGPFPVR PLSPARATNS PKPHMVPRHS 
      1960       1970       1980       1990       2000
NQNSSGSQVN SAGSLTSSPT TTTSSSASTV PGTSTNGSPS SPSVRRQLFV 
      2010       2020       2030       2040       2050
TVVKTSNATT TTVTTTASNN NTAPTNATYP MPTAKEHYPV SSPSSPSPPA 
      2060       2070       2080       2090       2100
QPGGVSRNSP LDCGSASPNK VASSSEQEAG SPPVVETTNT RPPNSSSSSG 
      2110       2120       2130       2140       2150
SSSAHSNQQQ PPGSVSQEPR PPLQQSQVPP PEVRMTVPPL ATSSAPVAVP 
      2160       2170       2180       2190       2200
STAPVTYPMP QTPMGCPQPT PKMETPAIRP PPHGTTAPHK NSASVQNSSV 
      2210       2220       2230       2240       2250
AVLSVNHIKR PHSVPSSVQL PSTLSTQSAC QNSVHPANKP IAPNFSAPLP 
      2260       2270       2280       2290       2300
FGPFSTLFEN SPTSAHAFWG GSVVSSQSTP ESMLSGKSSY LPNSDPLHQS 
      2310       2320       2330       2340       2350
DTSKAPGFRP PLQRPAPSPS GIVNMDSPYG SVTPSSTHLG NFASNISGGQ 
      2360       2370       2380       2390       2400
MYGPGAPLGG APAAANFNRQ HFSPLSLLTP CSSASNDSSA QSVSSGVRAP 
      2410       2420       2430       2440       2450
SPAPSSVPLG SEKPSNVSQD RKVPVPIGTE RSARIRQTGT SAPSVIGSNL 
      2460       2470       2480       2490       2500
STSVGHSGIW SFEGIGGNQD KVDWCNPGMG NPMIHRPMSD PGVFSQHQAM 
      2510       2520       2530       2540       2550
ERDSTGIVTP SGTFHQHVPA GYMDFPKVGG MPFSVYGNAM IPPVAPIPDG 
      2560       2570       2580       2590       2600
AGGPIFNGPH AADPSWNSLI KMVSSSTENN GPQTVWTGPW APHMNSVHMN 

QLG

Length:2,603

Mass (Da):274,258

Last modified:October 23, 2007 - v3

Checksum:ⁱBD2BF51889283483

Isoform 2 (identifier: O75179-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1028-1028: Missing.

« Hide

        10         20         30         40         50
MEKATVPVAA ATAAEGEGSP PAVAAVAGPP AAAEVGGGVG GSSRARSASS 
        60         70         80         90        100
PRGMVRVCDL LLKKKPPQQQ HHKAKRNRTC RPPSSSESSS DSDNSGGGGG 
       110        120        130        140        150
GGGGGGGGGG TSSNNSEEEE DDDDEEEEVS EVESFILDQD DLENPMLETA 
       160        170        180        190        200
SKLLLSGTAD GADLRTVDPE TQARLEALLE AAGIGKLSTA DGKAFADPEV 
       210        220        230        240        250
LRRLTSSVSC ALDEAAAALT RMRAESTANA GQSDNRSLAE ACSEGDVNAV 
       260        270        280        290        300
RKLLIEGRSV NEHTEEGESL LCLACSAGYY ELAQVLLAMH ANVEDRGIKG 
       310        320        330        340        350
DITPLMAAAN GGHVKIVKLL LAHKADVNAQ SSTGNTALTY ACAGGYVDVV 
       360        370        380        390        400
KVLLESGASI EDHNENGHTP LMEAGSAGHV EVARLLLENG AGINTHSNEF 
       410        420        430        440        450
KESALTLACY KGHLEMVRFL LEAGADQEHK TDEMHTALME ACMDGHVEVA 
       460        470        480        490        500
RLLLDSGAQV NMPADSFESP LTLAACGGHV ELAALLIERG ASLEEVNDEG 
       510        520        530        540        550
YTPLMEAARE GHEEMVALLL GQGANINAQT EETQETALTL ACCGGFLEVA 
       560        570        580        590        600
DFLIKAGADI ELGCSTPLME AAQEGHLELV KYLLAAGANV HATTATGDTA 
       610        620        630        640        650
LTYACENGHT DVADVLLQAG ADLEHESEGG RTPLMKAARA GHVCTVQFLI 
       660        670        680        690        700
SKGANVNRTT ANNDHTVLSL ACAGGHLAVV ELLLAHGADP THRLKDGSTM 
       710        720        730        740        750
LIEAAKGGHT SVVCYLLDYP NNLLSAPPPD VTQLTPPSHD LNRAPRVPVQ 
       760        770        780        790        800
ALPMVVPPQE PDKPPANVAT TLPIRNKAAS KQKSSSHLPA NSQDVQGYIT 
       810        820        830        840        850
NQSPESIVEE AQGKLTELEQ RIKEAIEKNA QLQSLELAHA DQLTKEKIEE 
       860        870        880        890        900
LNKTREEQIQ KKQKILEELQ KVERELQLKT QQQLKKQYLE VKAQRIQLQQ 
       910        920        930        940        950
QQQQSCQHLG LLTPVGVGEQ LSEGDYARLQ QVDPVLLKDE PQQTAAQMGF 
       960        970        980        990       1000
APIQPLAMPQ ALPLAAGPLP PGSIANLTEL QGVIVGQPVL GQAQLAGLGQ 
      1010       1020       1030       1040       1050
GILTETQQGL MVASPAQTLN DTLDDIMAVS GRASAMSNTP THSIAASISQ 
      1060       1070       1080       1090       1100
PQTPTPSPII SPSAMLPIYP AIDIDAQTES NHDTALTLAC AGGHEELVQT 
      1110       1120       1130       1140       1150
LLERGASIEH RDKKGFTPLI LAATAGHVGV VEILLDNGAD IEAQSERTKD 
      1160       1170       1180       1190       1200
TPLSLACSGG RQEVVELLLA RGANKEHRNV SDYTPLSLAA SGGYVNIIKI 
      1210       1220       1230       1240       1250
LLNAGAEINS RTGSKLGISP LMLAAMNGHT AAVKLLLDMG SDINAQIETN 
      1260       1270       1280       1290       1300
RNTALTLACF QGRTEVVSLL LDRKANVEHR AKTGLTPLME AASGGYAEVG 
      1310       1320       1330       1340       1350
RVLLDKGADV NAPPVPSSRD TALTIAADKG HYKFCELLIG RGAHIDVRNK 
      1360       1370       1380       1390       1400
KGNTPLWLAA NGGHLDVVQL LVQAGADVDA ADNRKITPLM AAFRKGHVKV 
      1410       1420       1430       1440       1450
VRYLVKEVNQ FPSDSECMRY IATITDKEML KKCHLCMESI VQAKDRQAAE 
      1460       1470       1480       1490       1500
ANKNASILLE ELDLEKLREE SRRLALAAKR EKRKEKRRKK KEEQRRKLEE 
      1510       1520       1530       1540       1550
IEAKNKENFE LQAAQEKEKL KVEDEPEVLT EPPSATTTTT IGISATWTTL 
      1560       1570       1580       1590       1600
AGSHGKRNNT ITTTSSKRKN RKNKITPENV QIIFDDPLPI SYSQPEKVNG 
      1610       1620       1630       1640       1650
ESKSSSTSES GDSDNMRISS CSDESSNSNS SRKSDNHSPA VVTTTVSSKK 
      1660       1670       1680       1690       1700
QPSVLVTFPK EERKSVSGKA SIKLSETISE GTSNSLSTCT KSGPSPLSSP 
      1710       1720       1730       1740       1750
NGKLTVASPK RGQKREEGWK EVVRRSKKVS VPSTVISRVI GRGGCNINAI 
      1760       1770       1780       1790       1800
REFTGAHIDI DKQKDKTGDR IITIRGGTES TRQATQLINA LIKDPDKEID 
      1810       1820       1830       1840       1850
ELIPKNRLKS SSANSKIGSS APTTTAANTS LMGIKMTTVA LSSTSQTATA 
      1860       1870       1880       1890       1900
LTVPAISSAS THKTIKNPVN NVRPGFPVSL PLAYPPPQFA HALLAAQTFQ 
      1910       1920       1930       1940       1950
QIRPPRLPMT HFGGTFPPAQ STWGPFPVRP LSPARATNSP KPHMVPRHSN 
      1960       1970       1980       1990       2000
QNSSGSQVNS AGSLTSSPTT TTSSSASTVP GTSTNGSPSS PSVRRQLFVT 
      2010       2020       2030       2040       2050
VVKTSNATTT TVTTTASNNN TAPTNATYPM PTAKEHYPVS SPSSPSPPAQ 
      2060       2070       2080       2090       2100
PGGVSRNSPL DCGSASPNKV ASSSEQEAGS PPVVETTNTR PPNSSSSSGS 
      2110       2120       2130       2140       2150
SSAHSNQQQP PGSVSQEPRP PLQQSQVPPP EVRMTVPPLA TSSAPVAVPS 
      2160       2170       2180       2190       2200
TAPVTYPMPQ TPMGCPQPTP KMETPAIRPP PHGTTAPHKN SASVQNSSVA 
      2210       2220       2230       2240       2250
VLSVNHIKRP HSVPSSVQLP STLSTQSACQ NSVHPANKPI APNFSAPLPF 
      2260       2270       2280       2290       2300
GPFSTLFENS PTSAHAFWGG SVVSSQSTPE SMLSGKSSYL PNSDPLHQSD 
      2310       2320       2330       2340       2350
TSKAPGFRPP LQRPAPSPSG IVNMDSPYGS VTPSSTHLGN FASNISGGQM 
      2360       2370       2380       2390       2400
YGPGAPLGGA PAAANFNRQH FSPLSLLTPC SSASNDSSAQ SVSSGVRAPS 
      2410       2420       2430       2440       2450
PAPSSVPLGS EKPSNVSQDR KVPVPIGTER SARIRQTGTS APSVIGSNLS 
      2460       2470       2480       2490       2500
TSVGHSGIWS FEGIGGNQDK VDWCNPGMGN PMIHRPMSDP GVFSQHQAME 
      2510       2520       2530       2540       2550
RDSTGIVTPS GTFHQHVPAG YMDFPKVGGM PFSVYGNAMI PPVAPIPDGA 
      2560       2570       2580       2590       2600
GGPIFNGPHA ADPSWNSLIK MVSSSTENNG PQTVWTGPWA PHMNSVHMNQ 

LG

Show »

Length:2,602

Mass (Da):274,187

Checksum:ⁱF446818E5B8ED6FB

Isoform 3 (identifier: O75179-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1176-1187: KEHRNVSDYTPL → YRSTGMVLITHL
1188-2603: Missing.

« Hide

        10         20         30         40         50
MEKATVPVAA ATAAEGEGSP PAVAAVAGPP AAAEVGGGVG GSSRARSASS 
        60         70         80         90        100
PRGMVRVCDL LLKKKPPQQQ HHKAKRNRTC RPPSSSESSS DSDNSGGGGG 
       110        120        130        140        150
GGGGGGGGGG TSSNNSEEEE DDDDEEEEVS EVESFILDQD DLENPMLETA 
       160        170        180        190        200
SKLLLSGTAD GADLRTVDPE TQARLEALLE AAGIGKLSTA DGKAFADPEV 
       210        220        230        240        250
LRRLTSSVSC ALDEAAAALT RMRAESTANA GQSDNRSLAE ACSEGDVNAV 
       260        270        280        290        300
RKLLIEGRSV NEHTEEGESL LCLACSAGYY ELAQVLLAMH ANVEDRGIKG 
       310        320        330        340        350
DITPLMAAAN GGHVKIVKLL LAHKADVNAQ SSTGNTALTY ACAGGYVDVV 
       360        370        380        390        400
KVLLESGASI EDHNENGHTP LMEAGSAGHV EVARLLLENG AGINTHSNEF 
       410        420        430        440        450
KESALTLACY KGHLEMVRFL LEAGADQEHK TDEMHTALME ACMDGHVEVA 
       460        470        480        490        500
RLLLDSGAQV NMPADSFESP LTLAACGGHV ELAALLIERG ASLEEVNDEG 
       510        520        530        540        550
YTPLMEAARE GHEEMVALLL GQGANINAQT EETQETALTL ACCGGFLEVA 
       560        570        580        590        600
DFLIKAGADI ELGCSTPLME AAQEGHLELV KYLLAAGANV HATTATGDTA 
       610        620        630        640        650
LTYACENGHT DVADVLLQAG ADLEHESEGG RTPLMKAARA GHVCTVQFLI 
       660        670        680        690        700
SKGANVNRTT ANNDHTVLSL ACAGGHLAVV ELLLAHGADP THRLKDGSTM 
       710        720        730        740        750
LIEAAKGGHT SVVCYLLDYP NNLLSAPPPD VTQLTPPSHD LNRAPRVPVQ 
       760        770        780        790        800
ALPMVVPPQE PDKPPANVAT TLPIRNKAAS KQKSSSHLPA NSQDVQGYIT 
       810        820        830        840        850
NQSPESIVEE AQGKLTELEQ RIKEAIEKNA QLQSLELAHA DQLTKEKIEE 
       860        870        880        890        900
LNKTREEQIQ KKQKILEELQ KVERELQLKT QQQLKKQYLE VKAQRIQLQQ 
       910        920        930        940        950
QQQQSCQHLG LLTPVGVGEQ LSEGDYARLQ QVDPVLLKDE PQQTAAQMGF 
       960        970        980        990       1000
APIQPLAMPQ ALPLAAGPLP PGSIANLTEL QGVIVGQPVL GQAQLAGLGQ 
      1010       1020       1030       1040       1050
GILTETQQGL MVASPAQTLN DTLDDIMAAV SGRASAMSNT PTHSIAASIS 
      1060       1070       1080       1090       1100
QPQTPTPSPI ISPSAMLPIY PAIDIDAQTE SNHDTALTLA CAGGHEELVQ 
      1110       1120       1130       1140       1150
TLLERGASIE HRDKKGFTPL ILAATAGHVG VVEILLDNGA DIEAQSERTK 
      1160       1170       1180 
DTPLSLACSG GRQEVVELLL ARGANYRSTG MVLITHL

Show »

Length:1,187

Mass (Da):124,637

Checksum:ⁱA0D3DD0135B33F07

Isoform 4 (identifier: O75179-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
982-1010: GVIVGQPVLGQAQLAGLGQGILTETQQGL → VLSSLLQPCFLSTLPLILMHRLRVIMTRR
1011-1603: Missing.

« Hide

        10         20         30         40         50
MEKATVPVAA ATAAEGEGSP PAVAAVAGPP AAAEVGGGVG GSSRARSASS 
        60         70         80         90        100
PRGMVRVCDL LLKKKPPQQQ HHKAKRNRTC RPPSSSESSS DSDNSGGGGG 
       110        120        130        140        150
GGGGGGGGGG TSSNNSEEEE DDDDEEEEVS EVESFILDQD DLENPMLETA 
       160        170        180        190        200
SKLLLSGTAD GADLRTVDPE TQARLEALLE AAGIGKLSTA DGKAFADPEV 
       210        220        230        240        250
LRRLTSSVSC ALDEAAAALT RMRAESTANA GQSDNRSLAE ACSEGDVNAV 
       260        270        280        290        300
RKLLIEGRSV NEHTEEGESL LCLACSAGYY ELAQVLLAMH ANVEDRGIKG 
       310        320        330        340        350
DITPLMAAAN GGHVKIVKLL LAHKADVNAQ SSTGNTALTY ACAGGYVDVV 
       360        370        380        390        400
KVLLESGASI EDHNENGHTP LMEAGSAGHV EVARLLLENG AGINTHSNEF 
       410        420        430        440        450
KESALTLACY KGHLEMVRFL LEAGADQEHK TDEMHTALME ACMDGHVEVA 
       460        470        480        490        500
RLLLDSGAQV NMPADSFESP LTLAACGGHV ELAALLIERG ASLEEVNDEG 
       510        520        530        540        550
YTPLMEAARE GHEEMVALLL GQGANINAQT EETQETALTL ACCGGFLEVA 
       560        570        580        590        600
DFLIKAGADI ELGCSTPLME AAQEGHLELV KYLLAAGANV HATTATGDTA 
       610        620        630        640        650
LTYACENGHT DVADVLLQAG ADLEHESEGG RTPLMKAARA GHVCTVQFLI 
       660        670        680        690        700
SKGANVNRTT ANNDHTVLSL ACAGGHLAVV ELLLAHGADP THRLKDGSTM 
       710        720        730        740        750
LIEAAKGGHT SVVCYLLDYP NNLLSAPPPD VTQLTPPSHD LNRAPRVPVQ 
       760        770        780        790        800
ALPMVVPPQE PDKPPANVAT TLPIRNKAAS KQKSSSHLPA NSQDVQGYIT 
       810        820        830        840        850
NQSPESIVEE AQGKLTELEQ RIKEAIEKNA QLQSLELAHA DQLTKEKIEE 
       860        870        880        890        900
LNKTREEQIQ KKQKILEELQ KVERELQLKT QQQLKKQYLE VKAQRIQLQQ 
       910        920        930        940        950
QQQQSCQHLG LLTPVGVGEQ LSEGDYARLQ QVDPVLLKDE PQQTAAQMGF 
       960        970        980        990       1000
APIQPLAMPQ ALPLAAGPLP PGSIANLTEL QVLSSLLQPC FLSTLPLILM 
      1010       1020       1030       1040       1050
HRLRVIMTRR KSSSTSESGD SDNMRISSCS DESSNSNSSR KSDNHSPAVV 
      1060       1070       1080       1090       1100
TTTVSSKKQP SVLVTFPKEE RKSVSGKASI KLSETISEGT SNSLSTCTKS 
      1110       1120       1130       1140       1150
GPSPLSSPNG KLTVASPKRG QKREEGWKEV VRRSKKVSVP STVISRVIGR 
      1160       1170       1180       1190       1200
GGCNINAIRE FTGAHIDIDK QKDKTGDRII TIRGGTESTR QATQLINALI 
      1210       1220       1230       1240       1250
KDPDKEIDEL IPKNRLKSSS ANSKIGSSAP TTTAANTSLM GIKMTTVALS 
      1260       1270       1280       1290       1300
STSQTATALT VPAISSASTH KTIKNPVNNV RPGFPVSLPL AYPPPQFAHA 
      1310       1320       1330       1340       1350
LLAAQTFQQI RPPRLPMTHF GGTFPPAQST WGPFPVRPLS PARATNSPKP 
      1360       1370       1380       1390       1400
HMVPRHSNQN SSGSQVNSAG SLTSSPTTTT SSSASTVPGT STNGSPSSPS 
      1410       1420       1430       1440       1450
VRRQLFVTVV KTSNATTTTV TTTASNNNTA PTNATYPMPT AKEHYPVSSP 
      1460       1470       1480       1490       1500
SSPSPPAQPG GVSRNSPLDC GSASPNKVAS SSEQEAGSPP VVETTNTRPP 
      1510       1520       1530       1540       1550
NSSSSSGSSS AHSNQQQPPG SVSQEPRPPL QQSQVPPPEV RMTVPPLATS 
      1560       1570       1580       1590       1600
SAPVAVPSTA PVTYPMPQTP MGCPQPTPKM ETPAIRPPPH GTTAPHKNSA 
      1610       1620       1630       1640       1650
SVQNSSVAVL SVNHIKRPHS VPSSVQLPST LSTQSACQNS VHPANKPIAP 
      1660       1670       1680       1690       1700
NFSAPLPFGP FSTLFENSPT SAHAFWGGSV VSSQSTPESM LSGKSSYLPN 
      1710       1720       1730       1740       1750
SDPLHQSDTS KAPGFRPPLQ RPAPSPSGIV NMDSPYGSVT PSSTHLGNFA 
      1760       1770       1780       1790       1800
SNISGGQMYG PGAPLGGAPA AANFNRQHFS PLSLLTPCSS ASNDSSAQSV 
      1810       1820       1830       1840       1850
SSGVRAPSPA PSSVPLGSEK PSNVSQDRKV PVPIGTERSA RIRQTGTSAP 
      1860       1870       1880       1890       1900
SVIGSNLSTS VGHSGIWSFE GIGGNQDKVD WCNPGMGNPM IHRPMSDPGV 
      1910       1920       1930       1940       1950
FSQHQAMERD STGIVTPSGT FHQHVPAGYM DFPKVGGMPF SVYGNAMIPP 
      1960       1970       1980       1990       2000
VAPIPDGAGG PIFNGPHAAD PSWNSLIKMV SSSTENNGPQ TVWTGPWAPH 
      2010
MNSVHMNQLG

Show »

Length:2,010

Mass (Da):210,593

Checksum:ⁱCAF01D3CC80C50E5

Isoform 5 (identifier: O75179-5) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
742-751: NRAPRVPVQA → TDNIFPRLVC
752-2603: Missing.

« Hide

        10         20         30         40         50
MEKATVPVAA ATAAEGEGSP PAVAAVAGPP AAAEVGGGVG GSSRARSASS 
        60         70         80         90        100
PRGMVRVCDL LLKKKPPQQQ HHKAKRNRTC RPPSSSESSS DSDNSGGGGG 
       110        120        130        140        150
GGGGGGGGGG TSSNNSEEEE DDDDEEEEVS EVESFILDQD DLENPMLETA 
       160        170        180        190        200
SKLLLSGTAD GADLRTVDPE TQARLEALLE AAGIGKLSTA DGKAFADPEV 
       210        220        230        240        250
LRRLTSSVSC ALDEAAAALT RMRAESTANA GQSDNRSLAE ACSEGDVNAV 
       260        270        280        290        300
RKLLIEGRSV NEHTEEGESL LCLACSAGYY ELAQVLLAMH ANVEDRGIKG 
       310        320        330        340        350
DITPLMAAAN GGHVKIVKLL LAHKADVNAQ SSTGNTALTY ACAGGYVDVV 
       360        370        380        390        400
KVLLESGASI EDHNENGHTP LMEAGSAGHV EVARLLLENG AGINTHSNEF 
       410        420        430        440        450
KESALTLACY KGHLEMVRFL LEAGADQEHK TDEMHTALME ACMDGHVEVA 
       460        470        480        490        500
RLLLDSGAQV NMPADSFESP LTLAACGGHV ELAALLIERG ASLEEVNDEG 
       510        520        530        540        550
YTPLMEAARE GHEEMVALLL GQGANINAQT EETQETALTL ACCGGFLEVA 
       560        570        580        590        600
DFLIKAGADI ELGCSTPLME AAQEGHLELV KYLLAAGANV HATTATGDTA 
       610        620        630        640        650
LTYACENGHT DVADVLLQAG ADLEHESEGG RTPLMKAARA GHVCTVQFLI 
       660        670        680        690        700
SKGANVNRTT ANNDHTVLSL ACAGGHLAVV ELLLAHGADP THRLKDGSTM 
       710        720        730        740        750
LIEAAKGGHT SVVCYLLDYP NNLLSAPPPD VTQLTPPSHD LTDNIFPRLV 

C

Show »

Length:751

Mass (Da):77,825

Checksum:ⁱ391CFA8C368A3895

Isoform 6 (identifier: O75179-6) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
778-1028: Missing.

« Hide

        10         20         30         40         50
MEKATVPVAA ATAAEGEGSP PAVAAVAGPP AAAEVGGGVG GSSRARSASS 
        60         70         80         90        100
PRGMVRVCDL LLKKKPPQQQ HHKAKRNRTC RPPSSSESSS DSDNSGGGGG 
       110        120        130        140        150
GGGGGGGGGG TSSNNSEEEE DDDDEEEEVS EVESFILDQD DLENPMLETA 
       160        170        180        190        200
SKLLLSGTAD GADLRTVDPE TQARLEALLE AAGIGKLSTA DGKAFADPEV 
       210        220        230        240        250
LRRLTSSVSC ALDEAAAALT RMRAESTANA GQSDNRSLAE ACSEGDVNAV 
       260        270        280        290        300
RKLLIEGRSV NEHTEEGESL LCLACSAGYY ELAQVLLAMH ANVEDRGIKG 
       310        320        330        340        350
DITPLMAAAN GGHVKIVKLL LAHKADVNAQ SSTGNTALTY ACAGGYVDVV 
       360        370        380        390        400
KVLLESGASI EDHNENGHTP LMEAGSAGHV EVARLLLENG AGINTHSNEF 
       410        420        430        440        450
KESALTLACY KGHLEMVRFL LEAGADQEHK TDEMHTALME ACMDGHVEVA 
       460        470        480        490        500
RLLLDSGAQV NMPADSFESP LTLAACGGHV ELAALLIERG ASLEEVNDEG 
       510        520        530        540        550
YTPLMEAARE GHEEMVALLL GQGANINAQT EETQETALTL ACCGGFLEVA 
       560        570        580        590        600
DFLIKAGADI ELGCSTPLME AAQEGHLELV KYLLAAGANV HATTATGDTA 
       610        620        630        640        650
LTYACENGHT DVADVLLQAG ADLEHESEGG RTPLMKAARA GHVCTVQFLI 
       660        670        680        690        700
SKGANVNRTT ANNDHTVLSL ACAGGHLAVV ELLLAHGADP THRLKDGSTM 
       710        720        730        740        750
LIEAAKGGHT SVVCYLLDYP NNLLSAPPPD VTQLTPPSHD LNRAPRVPVQ 
       760        770        780        790        800
ALPMVVPPQE PDKPPANVAT TLPIRNKAVS GRASAMSNTP THSIAASISQ 
       810        820        830        840        850
PQTPTPSPII SPSAMLPIYP AIDIDAQTES NHDTALTLAC AGGHEELVQT 
       860        870        880        890        900
LLERGASIEH RDKKGFTPLI LAATAGHVGV VEILLDNGAD IEAQSERTKD 
       910        920        930        940        950
TPLSLACSGG RQEVVELLLA RGANKEHRNV SDYTPLSLAA SGGYVNIIKI 
       960        970        980        990       1000
LLNAGAEINS RTGSKLGISP LMLAAMNGHT AAVKLLLDMG SDINAQIETN 
      1010       1020       1030       1040       1050
RNTALTLACF QGRTEVVSLL LDRKANVEHR AKTGLTPLME AASGGYAEVG 
      1060       1070       1080       1090       1100
RVLLDKGADV NAPPVPSSRD TALTIAADKG HYKFCELLIG RGAHIDVRNK 
      1110       1120       1130       1140       1150
KGNTPLWLAA NGGHLDVVQL LVQAGADVDA ADNRKITPLM AAFRKGHVKV 
      1160       1170       1180       1190       1200
VRYLVKEVNQ FPSDSECMRY IATITDKEML KKCHLCMESI VQAKDRQAAE 
      1210       1220       1230       1240       1250
ANKNASILLE ELDLEKLREE SRRLALAAKR EKRKEKRRKK KEEQRRKLEE 
      1260       1270       1280       1290       1300
IEAKNKENFE LQAAQEKEKL KVEDEPEVLT EPPSATTTTT IGISATWTTL 
      1310       1320       1330       1340       1350
AGSHGKRNNT ITTTSSKRKN RKNKITPENV QIIFDDPLPI SYSQPEKVNG 
      1360       1370       1380       1390       1400
ESKSSSTSES GDSDNMRISS CSDESSNSNS SRKSDNHSPA VVTTTVSSKK 
      1410       1420       1430       1440       1450
QPSVLVTFPK EERKSVSGKA SIKLSETISE GTSNSLSTCT KSGPSPLSSP 
      1460       1470       1480       1490       1500
NGKLTVASPK RGQKREEGWK EVVRRSKKVS VPSTVISRVI GRGGCNINAI 
      1510       1520       1530       1540       1550
REFTGAHIDI DKQKDKTGDR IITIRGGTES TRQATQLINA LIKDPDKEID 
      1560       1570       1580       1590       1600
ELIPKNRLKS SSANSKIGSS APTTTAANTS LMGIKMTTVA LSSTSQTATA 
      1610       1620       1630       1640       1650
LTVPAISSAS THKTIKNPVN NVRPGFPVSL PLAYPPPQFA HALLAAQTFQ 
      1660       1670       1680       1690       1700
QIRPPRLPMT HFGGTFPPAQ STWGPFPVRP LSPARATNSP KPHMVPRHSN 
      1710       1720       1730       1740       1750
QNSSGSQVNS AGSLTSSPTT TTSSSASTVP GTSTNGSPSS PSVRRQLFVT 
      1760       1770       1780       1790       1800
VVKTSNATTT TVTTTASNNN TAPTNATYPM PTAKEHYPVS SPSSPSPPAQ 
      1810       1820       1830       1840       1850
PGGVSRNSPL DCGSASPNKV ASSSEQEAGS PPVVETTNTR PPNSSSSSGS 
      1860       1870       1880       1890       1900
SSAHSNQQQP PGSVSQEPRP PLQQSQVPPP EVRMTVPPLA TSSAPVAVPS 
      1910       1920       1930       1940       1950
TAPVTYPMPQ TPMGCPQPTP KMETPAIRPP PHGTTAPHKN SASVQNSSVA 
      1960       1970       1980       1990       2000
VLSVNHIKRP HSVPSSVQLP STLSTQSACQ NSVHPANKPI APNFSAPLPF 
      2010       2020       2030       2040       2050
GPFSTLFENS PTSAHAFWGG SVVSSQSTPE SMLSGKSSYL PNSDPLHQSD 
      2060       2070       2080       2090       2100
TSKAPGFRPP LQRPAPSPSG IVNMDSPYGS VTPSSTHLGN FASNISGGQM 
      2110       2120       2130       2140       2150
YGPGAPLGGA PAAANFNRQH FSPLSLLTPC SSASNDSSAQ SVSSGVRAPS 
      2160       2170       2180       2190       2200
PAPSSVPLGS EKPSNVSQDR KVPVPIGTER SARIRQTGTS APSVIGSNLS 
      2210       2220       2230       2240       2250
TSVGHSGIWS FEGIGGNQDK VDWCNPGMGN PMIHRPMSDP GVFSQHQAME 
      2260       2270       2280       2290       2300
RDSTGIVTPS GTFHQHVPAG YMDFPKVGGM PFSVYGNAMI PPVAPIPDGA 
      2310       2320       2330       2340       2350
GGPIFNGPHA ADPSWNSLIK MVSSSTENNG PQTVWTGPWA PHMNSVHMNQ 

LG

Show »

Length:2,352

Mass (Da):246,751

Checksum:ⁱ36D86547A481C76C

Isoform 7 (identifier: O75179-7) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-130: MEKATVPVAA...DDDDEEEEVS → MVETAAEMEAYVLEDIL

« Hide

        10         20         30         40         50
MVETAAEMEA YVLEDILEVE SFILDQDDLE NPMLETASKL LLSGTADGAD 
        60         70         80         90        100
LRTVDPETQA RLEALLEAAG IGKLSTADGK AFADPEVLRR LTSSVSCALD 
       110        120        130        140        150
EAAAALTRMR AESTANAGQS DNRSLAEACS EGDVNAVRKL LIEGRSVNEH 
       160        170        180        190        200
TEEGESLLCL ACSAGYYELA QVLLAMHANV EDRGIKGDIT PLMAAANGGH 
       210        220        230        240        250
VKIVKLLLAH KADVNAQSST GNTALTYACA GGYVDVVKVL LESGASIEDH 
       260        270        280        290        300
NENGHTPLME AGSAGHVEVA RLLLENGAGI NTHSNEFKES ALTLACYKGH 
       310        320        330        340        350
LEMVRFLLEA GADQEHKTDE MHTALMEACM DGHVEVARLL LDSGAQVNMP 
       360        370        380        390        400
ADSFESPLTL AACGGHVELA ALLIERGASL EEVNDEGYTP LMEAAREGHE 
       410        420        430        440        450
EMVALLLGQG ANINAQTEET QETALTLACC GGFLEVADFL IKAGADIELG 
       460        470        480        490        500
CSTPLMEAAQ EGHLELVKYL LAAGANVHAT TATGDTALTY ACENGHTDVA 
       510        520        530        540        550
DVLLQAGADL EHESEGGRTP LMKAARAGHV CTVQFLISKG ANVNRTTANN 
       560        570        580        590        600
DHTVLSLACA GGHLAVVELL LAHGADPTHR LKDGSTMLIE AAKGGHTSVV 
       610        620        630        640        650
CYLLDYPNNL LSAPPPDVTQ LTPPSHDLNR APRVPVQALP MVVPPQEPDK 
       660        670        680        690        700
PPANVATTLP IRNKAASKQK SSSHLPANSQ DVQGYITNQS PESIVEEAQG 
       710        720        730        740        750
KLTELEQRIK EAIEKNAQLQ SLELAHADQL TKEKIEELNK TREEQIQKKQ 
       760        770        780        790        800
KILEELQKVE RELQLKTQQQ LKKQYLEVKA QRIQLQQQQQ QSCQHLGLLT 
       810        820        830        840        850
PVGVGEQLSE GDYARLQQVD PVLLKDEPQQ TAAQMGFAPI QPLAMPQALP 
       860        870        880        890        900
LAAGPLPPGS IANLTELQGV IVGQPVLGQA QLAGLGQGIL TETQQGLMVA 
       910        920        930        940        950
SPAQTLNDTL DDIMAAVSGR ASAMSNTPTH SIAASISQPQ TPTPSPIISP 
       960        970        980        990       1000
SAMLPIYPAI DIDAQTESNH DTALTLACAG GHEELVQTLL ERGASIEHRD 
      1010       1020       1030       1040       1050
KKGFTPLILA ATAGHVGVVE ILLDNGADIE AQSERTKDTP LSLACSGGRQ 
      1060       1070       1080       1090       1100
EVVELLLARG ANKEHRNVSD YTPLSLAASG GYVNIIKILL NAGAEINSRT 
      1110       1120       1130       1140       1150
GSKLGISPLM LAAMNGHTAA VKLLLDMGSD INAQIETNRN TALTLACFQG 
      1160       1170       1180       1190       1200
RTEVVSLLLD RKANVEHRAK TGLTPLMEAA SGGYAEVGRV LLDKGADVNA 
      1210       1220       1230       1240       1250
PPVPSSRDTA LTIAADKGHY KFCELLIGRG AHIDVRNKKG NTPLWLAANG 
      1260       1270       1280       1290       1300
GHLDVVQLLV QAGADVDAAD NRKITPLMAA FRKGHVKVVR YLVKEVNQFP 
      1310       1320       1330       1340       1350
SDSECMRYIA TITDKEMLKK CHLCMESIVQ AKDRQAAEAN KNASILLEEL 
      1360       1370       1380       1390       1400
DLEKLREESR RLALAAKREK RKEKRRKKKE EQRRKLEEIE AKNKENFELQ 
      1410       1420       1430       1440       1450
AAQEKEKLKV EDEPEVLTEP PSATTTTTIG ISATWTTLAG SHGKRNNTIT 
      1460       1470       1480       1490       1500
TTSSKRKNRK NKITPENVQI IFDDPLPISY SQPEKVNGES KSSSTSESGD 
      1510       1520       1530       1540       1550
SDNMRISSCS DESSNSNSSR KSDNHSPAVV TTTVSSKKQP SVLVTFPKEE 
      1560       1570       1580       1590       1600
RKSVSGKASI KLSETISEGT SNSLSTCTKS GPSPLSSPNG KLTVASPKRG 
      1610       1620       1630       1640       1650
QKREEGWKEV VRRSKKVSVP STVISRVIGR GGCNINAIRE FTGAHIDIDK 
      1660       1670       1680       1690       1700
QKDKTGDRII TIRGGTESTR QATQLINALI KDPDKEIDEL IPKNRLKSSS 
      1710       1720       1730       1740       1750
ANSKIGSSAP TTTAANTSLM GIKMTTVALS STSQTATALT VPAISSASTH 
      1760       1770       1780       1790       1800
KTIKNPVNNV RPGFPVSLPL AYPPPQFAHA LLAAQTFQQI RPPRLPMTHF 
      1810       1820       1830       1840       1850
GGTFPPAQST WGPFPVRPLS PARATNSPKP HMVPRHSNQN SSGSQVNSAG 
      1860       1870       1880       1890       1900
SLTSSPTTTT SSSASTVPGT STNGSPSSPS VRRQLFVTVV KTSNATTTTV 
      1910       1920       1930       1940       1950
TTTASNNNTA PTNATYPMPT AKEHYPVSSP SSPSPPAQPG GVSRNSPLDC 
      1960       1970       1980       1990       2000
GSASPNKVAS SSEQEAGSPP VVETTNTRPP NSSSSSGSSS AHSNQQQPPG 
      2010       2020       2030       2040       2050
SVSQEPRPPL QQSQVPPPEV RMTVPPLATS SAPVAVPSTA PVTYPMPQTP 
      2060       2070       2080       2090       2100
MGCPQPTPKM ETPAIRPPPH GTTAPHKNSA SVQNSSVAVL SVNHIKRPHS 
      2110       2120       2130       2140       2150
VPSSVQLPST LSTQSACQNS VHPANKPIAP NFSAPLPFGP FSTLFENSPT 
      2160       2170       2180       2190       2200
SAHAFWGGSV VSSQSTPESM LSGKSSYLPN SDPLHQSDTS KAPGFRPPLQ 
      2210       2220       2230       2240       2250
RPAPSPSGIV NMDSPYGSVT PSSTHLGNFA SNISGGQMYG PGAPLGGAPA 
      2260       2270       2280       2290       2300
AANFNRQHFS PLSLLTPCSS ASNDSSAQSV SSGVRAPSPA PSSVPLGSEK 
      2310       2320       2330       2340       2350
PSNVSQDRKV PVPIGTERSA RIRQTGTSAP SVIGSNLSTS VGHSGIWSFE 
      2360       2370       2380       2390       2400
GIGGNQDKVD WCNPGMGNPM IHRPMSDPGV FSQHQAMERD STGIVTPSGT 
      2410       2420       2430       2440       2450
FHQHVPAGYM DFPKVGGMPF SVYGNAMIPP VAPIPDGAGG PIFNGPHAAD 
      2460       2470       2480       2490
PSWNSLIKMV SSSTENNGPQ TVWTGPWAPH MNSVHMNQLG

Show »

Length:2,490

Mass (Da):263,556

Checksum:ⁱC9D1FFCA1D5C4906

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

H0YM23	H0YM23_HUMAN	Ankyrin repeat domain-containing pr... Ankyrin repeat domain-containing protein 17	ANKRD17	2,487	Annotation score:
H0YLQ3	H0YLQ3_HUMAN	Ankyrin repeat domain-containing pr... Ankyrin repeat domain-containing protein 17	ANKRD17	862	Annotation score:
A0A1W2PQ15	A0A1W2PQ15_HUMAN	Ankyrin repeat domain-containing pr... Ankyrin repeat domain-containing protein 17	ANKRD17	1,123	Annotation score:

Sequence cautionⁱ

The sequence AAG48253 differs from that shown. Reason: Frameshift.Curated

The sequence AAH04173 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated

The sequence BAB15260 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated

The sequence BAB15260 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	304	P → S in BAA31672 (PubMed:9734811).Curated	1
Sequence conflictⁱ	705	A → P in AAG48253 (PubMed:12747765).Curated	1
Sequence conflictⁱ	713	V → G in AAG48253 (PubMed:12747765).Curated	1
Sequence conflictⁱ	1137	D → G in BAB15260 (PubMed:14702039).Curated	1
Sequence conflictⁱ	1163	Q → P in AAG48253 (PubMed:12747765).Curated	1
Sequence conflictⁱ	1391	Missing in CAD38571 (PubMed:17974005).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_036711	2560	H → Y. Corresponds to variant dbSNP:rs2306059Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_054757	1 – 130	MEKAT…EEEVS → MVETAAEMEAYVLEDIL in isoform 7. CuratedAdd BLAST	130
Alternative sequenceⁱVSP_028859	742 – 751	NRAPRVPVQA → TDNIFPRLVC in isoform 5. 1 Publication	10
Alternative sequenceⁱVSP_028860	752 – 2603	Missing in isoform 5. 1 PublicationAdd BLAST	1852
Alternative sequenceⁱVSP_047048	778 – 1028	Missing in isoform 6. CuratedAdd BLAST	251
Alternative sequenceⁱVSP_028861	982 – 1010	GVIVG…TQQGL → VLSSLLQPCFLSTLPLILMH RLRVIMTRR in isoform 4. 1 PublicationAdd BLAST	29
Alternative sequenceⁱVSP_028862	1011 – 1603	Missing in isoform 4. 1 PublicationAdd BLAST	593
Alternative sequenceⁱVSP_028863	1028	Missing in isoform 2. 1 Publication	1
Alternative sequenceⁱVSP_028864	1176 – 1187	KEHRN…DYTPL → YRSTGMVLITHL in isoform 3. 1 PublicationAdd BLAST	12
Alternative sequenceⁱVSP_028865	1188 – 2603	Missing in isoform 3. 1 PublicationAdd BLAST	1416

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF308285 mRNA Translation: AAG48253.1 Frameshift. AC053527 Genomic DNA No translation available. AC095053 Genomic DNA No translation available. AC105757 Genomic DNA No translation available. CH471057 Genomic DNA Translation: EAX05655.1 BC004173 mRNA Translation: AAH04173.1 Sequence problems. BC007747 mRNA Translation: AAH07747.2 BC019963 mRNA Translation: AAH19963.1 BC043394 mRNA Translation: AAH43394.1 AB014597 mRNA Translation: BAA31672.2 AL831903 mRNA Translation: CAD38571.2 AK025859 mRNA Translation: BAB15260.1 Sequence problems.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS34003.1 [O75179-6] CCDS34004.1 [O75179-1] CCDS68721.1 [O75179-7]
PIRⁱ	T00353
NCBI Reference Sequences More...RefSeqⁱ	NP_001273700.1, NM_001286771.2 [O75179-7] NP_056389.1, NM_015574.1 [O75179-2] NP_115593.3, NM_032217.4 [O75179-1] NP_942592.1, NM_198889.2 [O75179-6]

Genome annotation databases

Ensemblⁱ	ENST00000330838; ENSP00000332265; ENSG00000132466 [O75179-6] ENST00000358602; ENSP00000351416; ENSG00000132466 [O75179-1] ENST00000509867; ENSP00000427151; ENSG00000132466 [O75179-7]
GeneIDⁱ	26057
KEGGⁱ	hsa:26057
UCSC genome browser More...UCSCⁱ	uc003hgo.5, human [O75179-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O75179-2	ANKRD17 isoform 2 (Fragment)		PANTR		2486	UniRef100_O75179-2
O75179-7	ANKRD17 isoform 4		PANTR		2490	UniRef100_A0A6D2X5D9
Ankyrin repeat domain 17		GORGO		2490
Ankyrin repeat domain 17		PANTR		2490

Protein	Similar proteins		Species	Score	Length	Source
O75179	ankyrin repeat domain-containing protein 17 isoform X1		SAPAP		2609	UniRef90_O75179
ANK_REP_REGION domain-containing protein		Cebus capucinus imitator		2607
ANK_REP_REGION domain-containing protein		MANLE		2603
Ankyrin repeat domain 17		MACMU		2603
Ankyrin repeat domain 17		PANTR		2603
+104
O75179-2	ANKRD17 isoform 2 (Fragment)		PANTR		2486	UniRef90_O75179-2
ankyrin repeat domain-containing protein 17 isoform X2		Odocoileus virginianus texanus		2619
ankyrin repeat domain-containing protein 17 isoform X2		PHYMC		2617
ankyrin repeat domain-containing protein 17 isoform X2		DELLE		2617
ankyrin repeat domain-containing protein 17 isoform X2		TURTR		2614
+224
O75179-3	ANKRD17		CEREH		1387	UniRef90_O75179-3

Protein	Similar proteins		Species	Score	Length	Source
O75179	ankyrin repeat domain-containing protein 17 isoform X1		SAPAP		2609	UniRef50_O75179
ANK_REP_REGION domain-containing protein		Cebus capucinus imitator		2607
ANK_REP_REGION domain-containing protein		CERAT		2603
ANKRD17 isoform 1		PONAB		2603
ANK_REP_REGION domain-containing protein		NOMLE		2603
+1147
O75179-2	Ankyrin repeat domain-containing protein 17		MOUSE		2603	UniRef50_O75179-2
ANKRD17 isoform 2 (Fragment)		PANTR		2486
ankyrin repeat domain-containing protein 17 isoform X2		Odocoileus virginianus texanus		2619
ankyrin repeat domain-containing protein 17 isoform X2		DELLE		2617
ankyrin repeat domain-containing protein 17 isoform X2		PHYMC		2617
+637
O75179-3	ANKRD17		CEREH		1387	UniRef50_O75179-3
Ankyrin repeat domain-containing protein 17 (Fragment)		SCHGA		1663
Ankyrin repeat domain-containing protein 17 (Fragment)		yellow sugarcane aphid		1437
Ankyrin repeat domain-containing protein 17 (Fragment)		yellow sugarcane aphid		1149
O75179-4	Ankyrin repeat domain 17		PSETE		2205	UniRef50_O75179-4
Ankyrin repeat domain-containing protein 17		TUPCH		2321
ANK_REP_REGION domain-containing protein		CALMI		2381
Ankyrin repeat domain 17		URSAM		2061
ANK_REP_REGION domain-containing protein		STRHB		2384
+73
O75179-5	ANKH1 (Fragment)		blackstripe livebearer		611	UniRef50_O75179-5
ANK_REP_REGION domain-containing protein		LYNCA		620
ankyrin repeat and KH domain-containing protein 1 isoform X11		VICPA		632
ANK_REP_REGION domain-containing protein		PIG		622
ankyrin repeat and KH domain-containing protein 1 isoform X3		Ursus arctos horribilis		622
+112

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF308285 mRNA Translation: AAG48253.1 Frameshift. AC053527 Genomic DNA No translation available. AC095053 Genomic DNA No translation available. AC105757 Genomic DNA No translation available. CH471057 Genomic DNA Translation: EAX05655.1 BC004173 mRNA Translation: AAH04173.1 Sequence problems. BC007747 mRNA Translation: AAH07747.2 BC019963 mRNA Translation: AAH19963.1 BC043394 mRNA Translation: AAH43394.1 AB014597 mRNA Translation: BAA31672.2 AL831903 mRNA Translation: CAD38571.2 AK025859 mRNA Translation: BAB15260.1 Sequence problems.
CCDSⁱ	CCDS34003.1 [O75179-6] CCDS34004.1 [O75179-1] CCDS68721.1 [O75179-7]
PIRⁱ	T00353
RefSeqⁱ	NP_001273700.1, NM_001286771.2 [O75179-7] NP_056389.1, NM_015574.1 [O75179-2] NP_115593.3, NM_032217.4 [O75179-1] NP_942592.1, NM_198889.2 [O75179-6]

3D structure databases

SMRⁱ	O75179
ModBaseⁱ	Search...

Protein-protein interaction databases

BioGRIDⁱ	117519, 65 interactors
DIPⁱ	DIP-47290N
IntActⁱ	O75179, 41 interactors
MINTⁱ	O75179
STRINGⁱ	9606.ENSP00000351416

PTM databases

GlyGenⁱ	O75179, 3 sites, 1 O-linked glycan (3 sites)
iPTMnetⁱ	O75179
MetOSiteⁱ	O75179
PhosphoSitePlusⁱ	O75179
SwissPalmⁱ	O75179

Polymorphism and mutation databases

BioMutaⁱ	ANKRD17

BioMutaⁱ

ANKRD17

Proteomic databases

EPDⁱ	O75179
jPOSTⁱ	O75179
MassIVEⁱ	O75179
MaxQBⁱ	O75179
PaxDbⁱ	O75179
PeptideAtlasⁱ	O75179
PRIDEⁱ	O75179
ProteomicsDBⁱ	18505 33844 49850 [O75179-1] 49851 [O75179-2] 49852 [O75179-3] 49853 [O75179-4] 49854 [O75179-5]

Protocols and materials databases

Antibodypediaⁱ	24452, 137 antibodies

Antibodypediaⁱ

24452, 137 antibodies

Genome annotation databases

Ensemblⁱ	ENST00000330838; ENSP00000332265; ENSG00000132466 [O75179-6] ENST00000358602; ENSP00000351416; ENSG00000132466 [O75179-1] ENST00000509867; ENSP00000427151; ENSG00000132466 [O75179-7]
GeneIDⁱ	26057
KEGGⁱ	hsa:26057
UCSCⁱ	uc003hgo.5, human [O75179-1]

Organism-specific databases

CTDⁱ	26057
DisGeNETⁱ	26057
EuPathDBⁱ	HostDB:ENSG00000132466.17
GeneCardsⁱ	ANKRD17
HGNCⁱ	HGNC:23575, ANKRD17
HPAⁱ	ENSG00000132466, Low tissue specificity
MIMⁱ	615929, gene
neXtProtⁱ	NX_O75179
OpenTargetsⁱ	ENSG00000132466
PharmGKBⁱ	PA134943225
HUGEⁱ	Search...
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0504, Eukaryota KOG4369, Eukaryota
GeneTreeⁱ	ENSGT00940000153768
HOGENOMⁱ	CLU_000590_0_1_1
InParanoidⁱ	O75179
KOⁱ	K16726
OMAⁱ	FGANIDH
OrthoDBⁱ	1115202at2759
PhylomeDBⁱ	O75179
TreeFamⁱ	TF328552

Enzyme and pathway databases

PathwayCommonsⁱ	O75179

PathwayCommonsⁱ

O75179

Miscellaneous databases

BioGRID-ORCSⁱ	26057, 88 hits in 878 CRISPR screens
ChiTaRSⁱ	ANKRD17, human
GeneWikiⁱ	ANKRD17
GenomeRNAiⁱ	26057
Pharosⁱ	O75179, Tbio
Protein Ontology More...PROⁱ	PR:O75179
RNActⁱ	O75179, protein
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000132466, Expressed in sural nerve and 247 other tissues
ExpressionAtlasⁱ	O75179, baseline and differential
Genevisibleⁱ	O75179, HS

Family and domain databases

Gene3Dⁱ	1.25.40.20, 8 hits 3.30.1370.10, 1 hit
InterProⁱ	View protein in InterPro IPR002110, Ankyrin_rpt IPR020683, Ankyrin_rpt-contain_dom IPR036770, Ankyrin_rpt-contain_sf IPR004087, KH_dom IPR004088, KH_dom_type_1 IPR036612, KH_dom_type_1_sf
Pfamⁱ	View protein in Pfam PF00023, Ank, 2 hits PF12796, Ank_2, 9 hits PF00013, KH_1, 1 hit
PRINTSⁱ	PR01415, ANKYRIN
SMARTⁱ	View protein in SMART SM00248, ANK, 25 hits SM00322, KH, 1 hit
SUPFAMⁱ	SSF48403, SSF48403, 3 hits SSF54791, SSF54791, 1 hit
PROSITEⁱ	View protein in PROSITE PS50297, ANK_REP_REGION, 1 hit PS50088, ANK_REPEAT, 20 hits PS50084, KH_TYPE_1, 1 hit
ProtoNetⁱ	Search...
MobiDBⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ANR17_HUMAN
Accessionⁱ	O75179Primary (citable) accession number: O75179 Secondary accession number(s): E7EUV3 Q9H6J9
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 23, 2007
	Last sequence update:	October 23, 2007
	Last modified:	October 7, 2020
	This is version 169 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Reference proteome

Documents

Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 4
Human chromosome 4: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations

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UniProtKB - O75179 (ANR17_HUMAN)

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Ankyrin repeat domain-containing protein 17

ANKRD17

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Miscellaneous databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Coiled coil

Compositional bias

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ