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Protein

Ankyrin repeat domain-containing protein 17

Gene

ANKRD17

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Could play pivotal roles in cell cycle and DNA regulation (PubMed:19150984). Involved in innate immune defense against viruse by positively regulating the viral dsRNA receptors DDX58 and IFIH1 signaling pathways (PubMed:22328336). Involves in NOD2- and NOD1-mediated responses to bacteria suggesting a role in innate antibacterial immune pathways too (PubMed:23711367). Target of enterovirus 71 which is the major etiological agent of HFMD (hand, foot and mouth disease) (PubMed:17276651). Could play a central role for the formation and/or maintenance of the blood vessels of the circulation system (By similarity).By similarity4 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • chromatin binding Source: UniProtKB
  • RNA binding Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRNA-binding
Biological processHost-virus interaction, Immunity, Innate immunity

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ankyrin repeat domain-containing protein 17
Alternative name(s):
Gene trap ankyrin repeat protein
Serologically defined breast cancer antigen NY-BR-16
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ANKRD17
Synonyms:GTAR, KIAA0697
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000132466.17

Human Gene Nomenclature Database

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HGNCi
HGNC:23575 ANKRD17

Online Mendelian Inheritance in Man (OMIM)

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MIMi
615929 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O75179

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
26057

Open Targets

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OpenTargetsi
ENSG00000132466

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134943225

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ANKRD17

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003079171 – 2603Ankyrin repeat domain-containing protein 17Add BLAST2603

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1
Modified residuei19PhosphoserineCombined sources1
Modified residuei50PhosphoserineBy similarity1
Modified residuei156PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki318Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei803PhosphoserineCombined sources1
Modified residuei1457PhosphoserineCombined sources1
Modified residuei1635PhosphoserineCombined sources1
Modified residuei1639PhosphoserineCombined sources1
Modified residuei1696PhosphoserineCombined sources1
Modified residuei1700PhosphoserineCombined sources1
Modified residuei1709PhosphoserineCombined sources1
Modified residuei1874Asymmetric dimethylarginineBy similarity1
Modified residuei2042Phosphoserine1 Publication1
Modified residuei2044PhosphoserineBy similarity1
Modified residuei2045PhosphoserineCombined sources1 Publication1
Modified residuei2047PhosphoserineCombined sources1
Modified residuei2059PhosphoserineCombined sources1
Modified residuei2067PhosphoserineCombined sources1
Modified residuei2373PhosphoserineCombined sources1
Modified residuei2401PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated by CDK2.1 Publication

Keywords - PTMi

Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
O75179

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O75179

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O75179

PeptideAtlas

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PeptideAtlasi
O75179

PRoteomics IDEntifications database

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PRIDEi
O75179

ProteomicsDB human proteome resource

More...
ProteomicsDBi
49850
49851 [O75179-2]
49852 [O75179-3]
49853 [O75179-4]
49854 [O75179-5]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O75179

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
O75179

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitously expressed.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000132466 Expressed in 236 organ(s), highest expression level in secondary oocyte

CleanEx database of gene expression profiles

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CleanExi
HS_ANKRD17

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
O75179 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
O75179 HS

Organism-specific databases

Human Protein Atlas

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HPAi
HPA045024
HPA063731

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (via N-terminus) with NOD2. Interacts with CDK2, MCM3, MCM5, MCM7, CDC6 and PCNA. Interacts with MAVS and IFIH1. Interacts (via the second ankyrin repeat cluster) with DDX58.3 Publications
(Microbial infection) Interacts with enterovirus 71/EV71 capsid protein VP1.1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
117519, 50 interactors

Database of interacting proteins

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DIPi
DIP-47290N

Protein interaction database and analysis system

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IntActi
O75179, 19 interactors

Molecular INTeraction database

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MINTi
O75179

STRING: functional protein association networks

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STRINGi
9606.ENSP00000351416

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
O75179

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
O75179

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati233 – 262ANK 1Add BLAST30
Repeati266 – 295ANK 2Add BLAST30
Repeati300 – 329ANK 3Add BLAST30
Repeati333 – 362ANK 4Add BLAST30
Repeati366 – 395ANK 5Add BLAST30
Repeati400 – 429ANK 6Add BLAST30
Repeati433 – 462ANK 7Add BLAST30
Repeati466 – 495ANK 8Add BLAST30
Repeati499 – 528ANK 9Add BLAST30
Repeati533 – 562ANK 10Add BLAST30
Repeati563 – 592ANK 11Add BLAST30
Repeati596 – 625ANK 12Add BLAST30
Repeati629 – 658ANK 13Add BLAST30
Repeati663 – 692ANK 14Add BLAST30
Repeati696 – 725ANK 15Add BLAST30
Repeati1082 – 1111ANK 16Add BLAST30
Repeati1115 – 1144ANK 17Add BLAST30
Repeati1149 – 1178ANK 18Add BLAST30
Repeati1182 – 1211ANK 19Add BLAST30
Repeati1217 – 1246ANK 20Add BLAST30
Repeati1251 – 1280ANK 21Add BLAST30
Repeati1284 – 1313ANK 22Add BLAST30
Repeati1319 – 1348ANK 23Add BLAST30
Repeati1352 – 1381ANK 24Add BLAST30
Repeati1385 – 1414ANK 25Add BLAST30
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1725 – 1789KHPROSITE-ProRule annotationAdd BLAST65

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1442 – 1526Sequence analysisAdd BLAST85

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi96 – 110Gly-richAdd BLAST15
Compositional biasi858 – 1008Gln-richAdd BLAST151
Compositional biasi1603 – 1700Ser-richAdd BLAST98
Compositional biasi1950 – 2106Ser-richAdd BLAST157
Compositional biasi1966 – 2033Thr-richAdd BLAST68

Keywords - Domaini

ANK repeat, Coiled coil, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0504 Eukaryota
KOG4369 Eukaryota
COG0666 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000153768

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG071352

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
O75179

KEGG Orthology (KO)

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KOi
K16726

Identification of Orthologs from Complete Genome Data

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OMAi
DCGTASP

Database of Orthologous Groups

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OrthoDBi
EOG091G04SM

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O75179

TreeFam database of animal gene trees

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TreeFami
TF328552

Family and domain databases

Conserved Domains Database

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CDDi
cd00204 ANK, 7 hits

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.25.40.20, 8 hits
3.30.1370.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR004087 KH_dom
IPR004088 KH_dom_type_1
IPR036612 KH_dom_type_1_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00023 Ank, 2 hits
PF12796 Ank_2, 9 hits
PF00013 KH_1, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR01415 ANKYRIN

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00248 ANK, 25 hits
SM00322 KH, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF48403 SSF48403, 3 hits
SSF54791 SSF54791, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 20 hits
PS50084 KH_TYPE_1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (7+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 7 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 7 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O75179-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

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        10         20         30         40         50
MEKATVPVAA ATAAEGEGSP PAVAAVAGPP AAAEVGGGVG GSSRARSASS
60 70 80 90 100
PRGMVRVCDL LLKKKPPQQQ HHKAKRNRTC RPPSSSESSS DSDNSGGGGG
110 120 130 140 150
GGGGGGGGGG TSSNNSEEEE DDDDEEEEVS EVESFILDQD DLENPMLETA
160 170 180 190 200
SKLLLSGTAD GADLRTVDPE TQARLEALLE AAGIGKLSTA DGKAFADPEV
210 220 230 240 250
LRRLTSSVSC ALDEAAAALT RMRAESTANA GQSDNRSLAE ACSEGDVNAV
260 270 280 290 300
RKLLIEGRSV NEHTEEGESL LCLACSAGYY ELAQVLLAMH ANVEDRGIKG
310 320 330 340 350
DITPLMAAAN GGHVKIVKLL LAHKADVNAQ SSTGNTALTY ACAGGYVDVV
360 370 380 390 400
KVLLESGASI EDHNENGHTP LMEAGSAGHV EVARLLLENG AGINTHSNEF
410 420 430 440 450
KESALTLACY KGHLEMVRFL LEAGADQEHK TDEMHTALME ACMDGHVEVA
460 470 480 490 500
RLLLDSGAQV NMPADSFESP LTLAACGGHV ELAALLIERG ASLEEVNDEG
510 520 530 540 550
YTPLMEAARE GHEEMVALLL GQGANINAQT EETQETALTL ACCGGFLEVA
560 570 580 590 600
DFLIKAGADI ELGCSTPLME AAQEGHLELV KYLLAAGANV HATTATGDTA
610 620 630 640 650
LTYACENGHT DVADVLLQAG ADLEHESEGG RTPLMKAARA GHVCTVQFLI
660 670 680 690 700
SKGANVNRTT ANNDHTVLSL ACAGGHLAVV ELLLAHGADP THRLKDGSTM
710 720 730 740 750
LIEAAKGGHT SVVCYLLDYP NNLLSAPPPD VTQLTPPSHD LNRAPRVPVQ
760 770 780 790 800
ALPMVVPPQE PDKPPANVAT TLPIRNKAAS KQKSSSHLPA NSQDVQGYIT
810 820 830 840 850
NQSPESIVEE AQGKLTELEQ RIKEAIEKNA QLQSLELAHA DQLTKEKIEE
860 870 880 890 900
LNKTREEQIQ KKQKILEELQ KVERELQLKT QQQLKKQYLE VKAQRIQLQQ
910 920 930 940 950
QQQQSCQHLG LLTPVGVGEQ LSEGDYARLQ QVDPVLLKDE PQQTAAQMGF
960 970 980 990 1000
APIQPLAMPQ ALPLAAGPLP PGSIANLTEL QGVIVGQPVL GQAQLAGLGQ
1010 1020 1030 1040 1050
GILTETQQGL MVASPAQTLN DTLDDIMAAV SGRASAMSNT PTHSIAASIS
1060 1070 1080 1090 1100
QPQTPTPSPI ISPSAMLPIY PAIDIDAQTE SNHDTALTLA CAGGHEELVQ
1110 1120 1130 1140 1150
TLLERGASIE HRDKKGFTPL ILAATAGHVG VVEILLDNGA DIEAQSERTK
1160 1170 1180 1190 1200
DTPLSLACSG GRQEVVELLL ARGANKEHRN VSDYTPLSLA ASGGYVNIIK
1210 1220 1230 1240 1250
ILLNAGAEIN SRTGSKLGIS PLMLAAMNGH TAAVKLLLDM GSDINAQIET
1260 1270 1280 1290 1300
NRNTALTLAC FQGRTEVVSL LLDRKANVEH RAKTGLTPLM EAASGGYAEV
1310 1320 1330 1340 1350
GRVLLDKGAD VNAPPVPSSR DTALTIAADK GHYKFCELLI GRGAHIDVRN
1360 1370 1380 1390 1400
KKGNTPLWLA ANGGHLDVVQ LLVQAGADVD AADNRKITPL MAAFRKGHVK
1410 1420 1430 1440 1450
VVRYLVKEVN QFPSDSECMR YIATITDKEM LKKCHLCMES IVQAKDRQAA
1460 1470 1480 1490 1500
EANKNASILL EELDLEKLRE ESRRLALAAK REKRKEKRRK KKEEQRRKLE
1510 1520 1530 1540 1550
EIEAKNKENF ELQAAQEKEK LKVEDEPEVL TEPPSATTTT TIGISATWTT
1560 1570 1580 1590 1600
LAGSHGKRNN TITTTSSKRK NRKNKITPEN VQIIFDDPLP ISYSQPEKVN
1610 1620 1630 1640 1650
GESKSSSTSE SGDSDNMRIS SCSDESSNSN SSRKSDNHSP AVVTTTVSSK
1660 1670 1680 1690 1700
KQPSVLVTFP KEERKSVSGK ASIKLSETIS EGTSNSLSTC TKSGPSPLSS
1710 1720 1730 1740 1750
PNGKLTVASP KRGQKREEGW KEVVRRSKKV SVPSTVISRV IGRGGCNINA
1760 1770 1780 1790 1800
IREFTGAHID IDKQKDKTGD RIITIRGGTE STRQATQLIN ALIKDPDKEI
1810 1820 1830 1840 1850
DELIPKNRLK SSSANSKIGS SAPTTTAANT SLMGIKMTTV ALSSTSQTAT
1860 1870 1880 1890 1900
ALTVPAISSA STHKTIKNPV NNVRPGFPVS LPLAYPPPQF AHALLAAQTF
1910 1920 1930 1940 1950
QQIRPPRLPM THFGGTFPPA QSTWGPFPVR PLSPARATNS PKPHMVPRHS
1960 1970 1980 1990 2000
NQNSSGSQVN SAGSLTSSPT TTTSSSASTV PGTSTNGSPS SPSVRRQLFV
2010 2020 2030 2040 2050
TVVKTSNATT TTVTTTASNN NTAPTNATYP MPTAKEHYPV SSPSSPSPPA
2060 2070 2080 2090 2100
QPGGVSRNSP LDCGSASPNK VASSSEQEAG SPPVVETTNT RPPNSSSSSG
2110 2120 2130 2140 2150
SSSAHSNQQQ PPGSVSQEPR PPLQQSQVPP PEVRMTVPPL ATSSAPVAVP
2160 2170 2180 2190 2200
STAPVTYPMP QTPMGCPQPT PKMETPAIRP PPHGTTAPHK NSASVQNSSV
2210 2220 2230 2240 2250
AVLSVNHIKR PHSVPSSVQL PSTLSTQSAC QNSVHPANKP IAPNFSAPLP
2260 2270 2280 2290 2300
FGPFSTLFEN SPTSAHAFWG GSVVSSQSTP ESMLSGKSSY LPNSDPLHQS
2310 2320 2330 2340 2350
DTSKAPGFRP PLQRPAPSPS GIVNMDSPYG SVTPSSTHLG NFASNISGGQ
2360 2370 2380 2390 2400
MYGPGAPLGG APAAANFNRQ HFSPLSLLTP CSSASNDSSA QSVSSGVRAP
2410 2420 2430 2440 2450
SPAPSSVPLG SEKPSNVSQD RKVPVPIGTE RSARIRQTGT SAPSVIGSNL
2460 2470 2480 2490 2500
STSVGHSGIW SFEGIGGNQD KVDWCNPGMG NPMIHRPMSD PGVFSQHQAM
2510 2520 2530 2540 2550
ERDSTGIVTP SGTFHQHVPA GYMDFPKVGG MPFSVYGNAM IPPVAPIPDG
2560 2570 2580 2590 2600
AGGPIFNGPH AADPSWNSLI KMVSSSTENN GPQTVWTGPW APHMNSVHMN

QLG
Length:2,603
Mass (Da):274,258
Last modified:October 23, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBD2BF51889283483
GO
Isoform 2 (identifier: O75179-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1028-1028: Missing.

Show »
Length:2,602
Mass (Da):274,187
Checksum:iF446818E5B8ED6FB
GO
Isoform 3 (identifier: O75179-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1176-1187: KEHRNVSDYTPL → YRSTGMVLITHL
     1188-2603: Missing.

Note: No experimental confirmation available.
Show »
Length:1,187
Mass (Da):124,637
Checksum:iA0D3DD0135B33F07
GO
Isoform 4 (identifier: O75179-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     982-1010: GVIVGQPVLGQAQLAGLGQGILTETQQGL → VLSSLLQPCFLSTLPLILMHRLRVIMTRR
     1011-1603: Missing.

Note: No experimental confirmation available.
Show »
Length:2,010
Mass (Da):210,593
Checksum:iCAF01D3CC80C50E5
GO
Isoform 5 (identifier: O75179-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     742-751: NRAPRVPVQA → TDNIFPRLVC
     752-2603: Missing.

Note: No experimental confirmation available.
Show »
Length:751
Mass (Da):77,825
Checksum:i391CFA8C368A3895
GO
Isoform 6 (identifier: O75179-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     778-1028: Missing.

Note: Gene prediction based on EST data.
Show »
Length:2,352
Mass (Da):246,751
Checksum:i36D86547A481C76C
GO
Isoform 7 (identifier: O75179-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-130: MEKATVPVAA...DDDDEEEEVS → MVETAAEMEAYVLEDIL

Note: Gene prediction based on cDNA data.
Show »
Length:2,490
Mass (Da):263,556
Checksum:iC9D1FFCA1D5C4906
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YM23H0YM23_HUMAN
Ankyrin repeat domain-containing pr...
ANKRD17
2,487Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YLQ3H0YLQ3_HUMAN
Ankyrin repeat domain-containing pr...
ANKRD17
862Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1W2PQ15A0A1W2PQ15_HUMAN
Ankyrin repeat domain-containing pr...
ANKRD17
1,123Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAG48253 differs from that shown. Reason: Frameshift at several positions.Curated
The sequence AAH04173 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence BAB15260 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence BAB15260 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti304P → S in BAA31672 (PubMed:9734811).Curated1
Sequence conflicti705A → P in AAG48253 (PubMed:12747765).Curated1
Sequence conflicti713V → G in AAG48253 (PubMed:12747765).Curated1
Sequence conflicti1137D → G in BAB15260 (PubMed:14702039).Curated1
Sequence conflicti1163Q → P in AAG48253 (PubMed:12747765).Curated1
Sequence conflicti1391Missing in CAD38571 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0367112560H → Y. Corresponds to variant dbSNP:rs2306059Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0547571 – 130MEKAT…EEEVS → MVETAAEMEAYVLEDIL in isoform 7. CuratedAdd BLAST130
Alternative sequenceiVSP_028859742 – 751NRAPRVPVQA → TDNIFPRLVC in isoform 5. 1 Publication10
Alternative sequenceiVSP_028860752 – 2603Missing in isoform 5. 1 PublicationAdd BLAST1852
Alternative sequenceiVSP_047048778 – 1028Missing in isoform 6. CuratedAdd BLAST251
Alternative sequenceiVSP_028861982 – 1010GVIVG…TQQGL → VLSSLLQPCFLSTLPLILMH RLRVIMTRR in isoform 4. 1 PublicationAdd BLAST29
Alternative sequenceiVSP_0288621011 – 1603Missing in isoform 4. 1 PublicationAdd BLAST593
Alternative sequenceiVSP_0288631028Missing in isoform 2. 1 Publication1
Alternative sequenceiVSP_0288641176 – 1187KEHRN…DYTPL → YRSTGMVLITHL in isoform 3. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_0288651188 – 2603Missing in isoform 3. 1 PublicationAdd BLAST1416

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF308285 mRNA Translation: AAG48253.1 Frameshift.
AC053527 Genomic DNA No translation available.
AC095053 Genomic DNA No translation available.
AC105757 Genomic DNA No translation available.
CH471057 Genomic DNA Translation: EAX05655.1
BC004173 mRNA Translation: AAH04173.1 Sequence problems.
BC007747 mRNA Translation: AAH07747.2
BC019963 mRNA Translation: AAH19963.1
BC043394 mRNA Translation: AAH43394.1
AB014597 mRNA Translation: BAA31672.2
AL831903 mRNA Translation: CAD38571.2
AK025859 mRNA Translation: BAB15260.1 Sequence problems.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS34003.1 [O75179-6]
CCDS34004.1 [O75179-1]
CCDS68721.1 [O75179-7]

Protein sequence database of the Protein Information Resource

More...
PIRi
T00353

NCBI Reference Sequences

More...
RefSeqi
NP_001273700.1, NM_001286771.2 [O75179-7]
NP_056389.1, NM_015574.1 [O75179-2]
NP_115593.3, NM_032217.4 [O75179-1]
NP_942592.1, NM_198889.2 [O75179-6]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.601206
Hs.733994
Hs.743705

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000330838; ENSP00000332265; ENSG00000132466 [O75179-6]
ENST00000358602; ENSP00000351416; ENSG00000132466 [O75179-1]
ENST00000509867; ENSP00000427151; ENSG00000132466 [O75179-7]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
26057

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:26057

UCSC genome browser

More...
UCSCi
uc003hgo.5 human [O75179-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF308285 mRNA Translation: AAG48253.1 Frameshift.
AC053527 Genomic DNA No translation available.
AC095053 Genomic DNA No translation available.
AC105757 Genomic DNA No translation available.
CH471057 Genomic DNA Translation: EAX05655.1
BC004173 mRNA Translation: AAH04173.1 Sequence problems.
BC007747 mRNA Translation: AAH07747.2
BC019963 mRNA Translation: AAH19963.1
BC043394 mRNA Translation: AAH43394.1
AB014597 mRNA Translation: BAA31672.2
AL831903 mRNA Translation: CAD38571.2
AK025859 mRNA Translation: BAB15260.1 Sequence problems.
CCDSiCCDS34003.1 [O75179-6]
CCDS34004.1 [O75179-1]
CCDS68721.1 [O75179-7]
PIRiT00353
RefSeqiNP_001273700.1, NM_001286771.2 [O75179-7]
NP_056389.1, NM_015574.1 [O75179-2]
NP_115593.3, NM_032217.4 [O75179-1]
NP_942592.1, NM_198889.2 [O75179-6]
UniGeneiHs.601206
Hs.733994
Hs.743705

3D structure databases

ProteinModelPortaliO75179
SMRiO75179
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117519, 50 interactors
DIPiDIP-47290N
IntActiO75179, 19 interactors
MINTiO75179
STRINGi9606.ENSP00000351416

PTM databases

iPTMnetiO75179
PhosphoSitePlusiO75179

Polymorphism and mutation databases

BioMutaiANKRD17

Proteomic databases

EPDiO75179
MaxQBiO75179
PaxDbiO75179
PeptideAtlasiO75179
PRIDEiO75179
ProteomicsDBi49850
49851 [O75179-2]
49852 [O75179-3]
49853 [O75179-4]
49854 [O75179-5]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000330838; ENSP00000332265; ENSG00000132466 [O75179-6]
ENST00000358602; ENSP00000351416; ENSG00000132466 [O75179-1]
ENST00000509867; ENSP00000427151; ENSG00000132466 [O75179-7]
GeneIDi26057
KEGGihsa:26057
UCSCiuc003hgo.5 human [O75179-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
26057
DisGeNETi26057
EuPathDBiHostDB:ENSG00000132466.17

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ANKRD17
HGNCiHGNC:23575 ANKRD17
HPAiHPA045024
HPA063731
MIMi615929 gene
neXtProtiNX_O75179
OpenTargetsiENSG00000132466
PharmGKBiPA134943225

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0504 Eukaryota
KOG4369 Eukaryota
COG0666 LUCA
GeneTreeiENSGT00940000153768
HOVERGENiHBG071352
InParanoidiO75179
KOiK16726
OMAiDCGTASP
OrthoDBiEOG091G04SM
PhylomeDBiO75179
TreeFamiTF328552

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ANKRD17 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
ANKRD17

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
26057

Protein Ontology

More...
PROi
PR:O75179

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000132466 Expressed in 236 organ(s), highest expression level in secondary oocyte
CleanExiHS_ANKRD17
ExpressionAtlasiO75179 baseline and differential
GenevisibleiO75179 HS

Family and domain databases

CDDicd00204 ANK, 7 hits
Gene3Di1.25.40.20, 8 hits
3.30.1370.10, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR004087 KH_dom
IPR004088 KH_dom_type_1
IPR036612 KH_dom_type_1_sf
PfamiView protein in Pfam
PF00023 Ank, 2 hits
PF12796 Ank_2, 9 hits
PF00013 KH_1, 1 hit
PRINTSiPR01415 ANKYRIN
SMARTiView protein in SMART
SM00248 ANK, 25 hits
SM00322 KH, 1 hit
SUPFAMiSSF48403 SSF48403, 3 hits
SSF54791 SSF54791, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 20 hits
PS50084 KH_TYPE_1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiANR17_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O75179
Secondary accession number(s): E7EUV3
, G5E964, Q6PJ85, Q6PK85, Q6PKA2, Q86XI3, Q8NDR5, Q96I86, Q9H288, Q9H6J9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: October 23, 2007
Last modified: December 5, 2018
This is version 155 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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