Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Calcium-responsive transactivator

Gene

SS18L1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, Chromatin regulator
Biological processTranscription, Transcription regulation
LigandCalcium

Enzyme and pathway databases

SIGNOR Signaling Network Open Resource

More...
SIGNORi
O75177

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Calcium-responsive transactivator
Alternative name(s):
SS18-like protein 1
SYT homolog 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SS18L1
Synonyms:CREST, KIAA0693
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 20

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000184402.14

Human Gene Nomenclature Database

More...
HGNCi
HGNC:15592 SS18L1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
606472 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O75177

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Centromere, Chromosome, Kinetochore, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
26039

Open Targets

More...
OpenTargetsi
ENSG00000184402

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA37989

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SS18L1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001818251 – 396Calcium-responsive transactivatorAdd BLAST396

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
O75177

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
O75177

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O75177

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O75177

PeptideAtlas

More...
PeptideAtlasi
O75177

PRoteomics IDEntifications database

More...
PRIDEi
O75177

ProteomicsDB human proteome resource

More...
ProteomicsDBi
49845
49846 [O75177-2]
49847 [O75177-3]
49848 [O75177-4]
49849 [O75177-5]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O75177

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O75177

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous; with lowest levels in spleen.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000184402 Expressed in 233 organ(s), highest expression level in forebrain

CleanEx database of gene expression profiles

More...
CleanExi
HS_SS18L1

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
O75177 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O75177 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB011827
HPA059046

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer. Dimerization may be necessary for its function in neuronal dendritic development. Interacts (via C-terminus) with CREBBP (via N-terminus), EP300 and SMARCA4/BRG1. Interacts with the nBAF complex. Association with CREBBP facilitates transcription while the association with SMARCA4/BRG1 suppresses CREST-mediated transcription in resting neurons (By similarity).By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
117505, 42 interactors

Protein interaction database and analysis system

More...
IntActi
O75177, 27 interactors

Molecular INTeraction database

More...
MINTi
O75177

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000333012

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
O75177

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 148N-terminal auto-inhibitory domain; necessary for interaction with SMARCA4/BRG1By similarityAdd BLAST148
Regioni149 – 232Methionine-rich intra-molecular domainBy similarityAdd BLAST84
Regioni246 – 317MFD domainBy similarityAdd BLAST72
Regioni334 – 396Necessary for nuclear localizationBy similarityAdd BLAST63
Regioni387 – 396Necessary for interaction with CREBBP and for the recruitment of CREBBP to the nuclear bodiesBy similarity10

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi50 – 53SH2-bindingSequence analysis4
Motifi353 – 356SH2-bindingSequence analysis4
Motifi371 – 379SH3-bindingSequence analysis9
Motifi391 – 394SH2-bindingSequence analysis4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi190 – 396Gln-richAdd BLAST207

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The MFD (multi-functional domain) domain is involved in transcription transactivation, nuclear body targeting and dimerization.By similarity

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SS18 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3227 Eukaryota
ENOG41128HA LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159853

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG003892

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O75177

Identification of Orthologs from Complete Genome Data

More...
OMAi
QYMGQEE

Database of Orthologous Groups

More...
OrthoDBi
1442230at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O75177

TreeFam database of animal gene trees

More...
TreeFami
TF330999

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007726 SS18_fam

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05030 SSXT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O75177-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSVAFASARP RGKGEVTQQT IQKMLDENHH LIQCILEYQS KGKTAECTQY
60 70 80 90 100
QQILHRNLVY LATIADSNQN MQSLLPAPPT QNMNLGPGAL TQSGSSQGLH
110 120 130 140 150
SQGSLSDAIS TGLPPSSLLQ GQIGNGPSHV SMQQTAPNTL PTTSMSISGP
160 170 180 190 200
GYSHAGPASQ GVPMQGQGTI GNYVSRTNIN MQSNPVSMMQ QQAATSHYSS
210 220 230 240 250
AQGGSQHYQG QSSIAMMGQG SQGSSMMGQR PMAPYRPSQQ GSSQQYLGQE
260 270 280 290 300
EYYGEQYSHS QGAAEPMGQQ YYPDGHGDYA YQQSSYTEQS YDRSFEESTQ
310 320 330 340 350
HYYEGGNSQY SQQQAGYQQG AAQQQTYSQQ QYPSQQSYPG QQQGYGSAQG
360 370 380 390
APSQYPGYQQ GQGQQYGSYR APQTAPSAQQ QRPYGYEQGQ YGNYQQ
Length:396
Mass (Da):42,990
Last modified:January 31, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB76B7D61C7DF5592
GO
Isoform 2 (identifier: O75177-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-23: MSVAFASARPRGKGEVTQQTIQK → M

Show »
Length:374
Mass (Da):40,649
Checksum:i365CA60BB485F174
GO
Isoform 3 (identifier: O75177-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-82: Missing.

Show »
Length:314
Mass (Da):33,767
Checksum:iC39CE9C4D11202ED
GO
Isoform 4 (identifier: O75177-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-131: Missing.

Show »
Length:265
Mass (Da):29,056
Checksum:iD35D21D42D2235A9
GO
Isoform 5 (identifier: O75177-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-49: MSVAFASARP...SKGKTAECTQ → MQSLSTEARY...ICPRSPPARR

Show »
Length:399
Mass (Da):43,408
Checksum:i1136A7C72AE9C53F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9BR54Q9BR54_HUMAN
Calcium-responsive transactivator
SS18L1
128Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YDW4H0YDW4_HUMAN
Calcium-responsive transactivator
SS18L1
211Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA31668 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti128S → G in CAE45918 (PubMed:11230166).Curated1
Sequence conflicti139T → S in BAF84174 (PubMed:14702039).Curated1
Sequence conflicti143T → A in BAG54230 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_062534189M → I1 PublicationCorresponds to variant dbSNP:rs17853304Ensembl.1
Natural variantiVAR_053691321A → T. Corresponds to variant dbSNP:rs36106901Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0386971 – 131Missing in isoform 4. 1 PublicationAdd BLAST131
Alternative sequenceiVSP_0386981 – 82Missing in isoform 3. 1 PublicationAdd BLAST82
Alternative sequenceiVSP_0386991 – 49MSVAF…AECTQ → MQSLSTEARYVPRVPQHRDQ ISPRSPQHGGQICPRSPLHR GQICPRSPPARR in isoform 5. 1 PublicationAdd BLAST49
Alternative sequenceiVSP_0387001 – 23MSVAF…QTIQK → M in isoform 2. 1 PublicationAdd BLAST23

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB014593 mRNA Translation: BAA31668.1 Different initiation.
BX640848 mRNA Translation: CAE45918.1
AY203931 mRNA Translation: AAP34454.1
AK125656 mRNA Translation: BAG54230.1
AK291485 mRNA Translation: BAF84174.1
AL078633 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW75393.1
CH471077 Genomic DNA Translation: EAW75392.1
CH471077 Genomic DNA Translation: EAW75395.1
BC034494 mRNA Translation: AAH34494.1
BC068993 mRNA Translation: AAH68993.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS13491.1 [O75177-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001288707.1, NM_001301778.1 [O75177-4]
NP_945173.1, NM_198935.2 [O75177-1]
XP_005260448.1, XM_005260391.1 [O75177-2]
XP_011527066.1, XM_011528764.2 [O75177-2]
XP_011527069.1, XM_011528767.1 [O75177-5]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.154429

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000331758; ENSP00000333012; ENSG00000184402 [O75177-1]
ENST00000370848; ENSP00000359885; ENSG00000184402 [O75177-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
26039

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:26039

UCSC genome browser

More...
UCSCi
uc002ycb.4 human [O75177-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB014593 mRNA Translation: BAA31668.1 Different initiation.
BX640848 mRNA Translation: CAE45918.1
AY203931 mRNA Translation: AAP34454.1
AK125656 mRNA Translation: BAG54230.1
AK291485 mRNA Translation: BAF84174.1
AL078633 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW75393.1
CH471077 Genomic DNA Translation: EAW75392.1
CH471077 Genomic DNA Translation: EAW75395.1
BC034494 mRNA Translation: AAH34494.1
BC068993 mRNA Translation: AAH68993.1
CCDSiCCDS13491.1 [O75177-1]
RefSeqiNP_001288707.1, NM_001301778.1 [O75177-4]
NP_945173.1, NM_198935.2 [O75177-1]
XP_005260448.1, XM_005260391.1 [O75177-2]
XP_011527066.1, XM_011528764.2 [O75177-2]
XP_011527069.1, XM_011528767.1 [O75177-5]
UniGeneiHs.154429

3D structure databases

ProteinModelPortaliO75177
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117505, 42 interactors
IntActiO75177, 27 interactors
MINTiO75177
STRINGi9606.ENSP00000333012

PTM databases

iPTMnetiO75177
PhosphoSitePlusiO75177

Polymorphism and mutation databases

BioMutaiSS18L1

Proteomic databases

EPDiO75177
jPOSTiO75177
MaxQBiO75177
PaxDbiO75177
PeptideAtlasiO75177
PRIDEiO75177
ProteomicsDBi49845
49846 [O75177-2]
49847 [O75177-3]
49848 [O75177-4]
49849 [O75177-5]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
26039
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000331758; ENSP00000333012; ENSG00000184402 [O75177-1]
ENST00000370848; ENSP00000359885; ENSG00000184402 [O75177-3]
GeneIDi26039
KEGGihsa:26039
UCSCiuc002ycb.4 human [O75177-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
26039
DisGeNETi26039
EuPathDBiHostDB:ENSG00000184402.14

GeneCards: human genes, protein and diseases

More...
GeneCardsi
SS18L1
HGNCiHGNC:15592 SS18L1
HPAiCAB011827
HPA059046
MIMi606472 gene
neXtProtiNX_O75177
OpenTargetsiENSG00000184402
PharmGKBiPA37989

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3227 Eukaryota
ENOG41128HA LUCA
GeneTreeiENSGT00940000159853
HOVERGENiHBG003892
InParanoidiO75177
OMAiQYMGQEE
OrthoDBi1442230at2759
PhylomeDBiO75177
TreeFamiTF330999

Enzyme and pathway databases

SIGNORiO75177

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
SS18L1 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
SS18L1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
26039

Protein Ontology

More...
PROi
PR:O75177

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000184402 Expressed in 233 organ(s), highest expression level in forebrain
CleanExiHS_SS18L1
ExpressionAtlasiO75177 baseline and differential
GenevisibleiO75177 HS

Family and domain databases

InterProiView protein in InterPro
IPR007726 SS18_fam
PfamiView protein in Pfam
PF05030 SSXT, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCREST_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O75177
Secondary accession number(s): A6NNE3
, A8K620, B3KWR8, E1P5H7, Q5JXJ3, Q6MZV9, Q6NTH3, Q6XYD9, Q8NE69, Q9BR55, Q9H4K6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: January 31, 2002
Last modified: January 16, 2019
This is version 147 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again