UniProtKB - O75177 (CREST_HUMAN)
Calcium-responsive transactivator
SS18L1
Functioni
GO - Molecular functioni
- transcription coactivator activity Source: InterPro
GO - Biological processi
- chromatin organization Source: UniProtKB-KW
- dendrite development Source: Ensembl
- positive regulation of dendrite morphogenesis Source: GO_Central
- positive regulation of transcription, DNA-templated Source: UniProtKB
- positive regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | Activator, Chromatin regulator |
Biological process | Transcription, Transcription regulation |
Ligand | Calcium |
Enzyme and pathway databases
PathwayCommonsi | O75177 |
SIGNORi | O75177 |
Names & Taxonomyi
Protein namesi | Recommended name: Calcium-responsive transactivatorAlternative name(s): SS18-like protein 1 SYT homolog 1 |
Gene namesi | Name:SS18L1 Synonyms:CREST, KIAA0693 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:15592, SS18L1 |
MIMi | 606472, gene |
neXtProti | NX_O75177 |
VEuPathDBi | HostDB:ENSG00000184402.14 |
Subcellular locationi
Nucleus
- Nucleus By similarity
Other locations
- kinetochore By similarity
Note: Localizes to nuclear bodies. Colocalizes with SGO1 at kinetochore (By similarity).By similarity
Cytosol
- cytosol Source: HPA
Nucleus
- nBAF complex Source: Ensembl
- nuclear body Source: Ensembl
- nucleoplasm Source: HPA
- nucleus Source: UniProtKB
Other locations
- condensed chromosome kinetochore Source: UniProtKB-SubCell
- kinetochore Source: MGI
Keywords - Cellular componenti
Centromere, Chromosome, Kinetochore, NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 26039 |
OpenTargetsi | ENSG00000184402 |
PharmGKBi | PA37989 |
Miscellaneous databases
Pharosi | O75177, Tbio |
Genetic variation databases
BioMutai | SS18L1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000181825 | 1 – 396 | Calcium-responsive transactivatorAdd BLAST | 396 |
Proteomic databases
EPDi | O75177 |
jPOSTi | O75177 |
MassIVEi | O75177 |
MaxQBi | O75177 |
PaxDbi | O75177 |
PeptideAtlasi | O75177 |
PRIDEi | O75177 |
ProteomicsDBi | 49845 [O75177-1] 49846 [O75177-2] 49847 [O75177-3] 49848 [O75177-4] 49849 [O75177-5] |
PTM databases
iPTMneti | O75177 |
PhosphoSitePlusi | O75177 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000184402, Expressed in forebrain and 245 other tissues |
ExpressionAtlasi | O75177, baseline and differential |
Genevisiblei | O75177, HS |
Organism-specific databases
HPAi | ENSG00000184402, Low tissue specificity |
Interactioni
Subunit structurei
Homodimer. Dimerization may be necessary for its function in neuronal dendritic development.
Interacts (via C-terminus) with CREBBP (via N-terminus), EP300 and SMARCA4/BRG1.
Interacts with the nBAF complex. Association with CREBBP facilitates transcription while the association with SMARCA4/BRG1 suppresses CREST-mediated transcription in resting neurons (By similarity).
By similarityBinary interactionsi
Hide detailsO75177
Isoform 5 [O75177-5]
Protein-protein interaction databases
BioGRIDi | 117505, 60 interactors |
IntActi | O75177, 37 interactors |
MINTi | O75177 |
STRINGi | 9606.ENSP00000333012 |
Miscellaneous databases
RNActi | O75177, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 148 | N-terminal auto-inhibitory domain; necessary for interaction with SMARCA4/BRG1By similarityAdd BLAST | 148 | |
Regioni | 149 – 232 | Methionine-rich intra-molecular domainBy similarityAdd BLAST | 84 | |
Regioni | 246 – 317 | MFD domainBy similarityAdd BLAST | 72 | |
Regioni | 334 – 396 | Necessary for nuclear localizationBy similarityAdd BLAST | 63 | |
Regioni | 387 – 396 | Necessary for interaction with CREBBP and for the recruitment of CREBBP to the nuclear bodiesBy similarity | 10 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 50 – 53 | SH2-bindingSequence analysis | 4 | |
Motifi | 353 – 356 | SH2-bindingSequence analysis | 4 | |
Motifi | 371 – 379 | SH3-bindingSequence analysis | 9 | |
Motifi | 391 – 394 | SH2-bindingSequence analysis | 4 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 190 – 396 | Gln-richAdd BLAST | 207 |
Domaini
Sequence similaritiesi
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG3227, Eukaryota |
GeneTreei | ENSGT00940000159853 |
HOGENOMi | CLU_054580_1_0_1 |
InParanoidi | O75177 |
OMAi | DDSTQHY |
PhylomeDBi | O75177 |
TreeFami | TF330999 |
Family and domain databases
InterProi | View protein in InterPro IPR007726, SS18_fam |
Pfami | View protein in Pfam PF05030, SSXT, 1 hit |
s (5+)i Sequence
Sequence statusi: Complete.
This entry describes 5 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 5 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSVAFASARP RGKGEVTQQT IQKMLDENHH LIQCILEYQS KGKTAECTQY
60 70 80 90 100
QQILHRNLVY LATIADSNQN MQSLLPAPPT QNMNLGPGAL TQSGSSQGLH
110 120 130 140 150
SQGSLSDAIS TGLPPSSLLQ GQIGNGPSHV SMQQTAPNTL PTTSMSISGP
160 170 180 190 200
GYSHAGPASQ GVPMQGQGTI GNYVSRTNIN MQSNPVSMMQ QQAATSHYSS
210 220 230 240 250
AQGGSQHYQG QSSIAMMGQG SQGSSMMGQR PMAPYRPSQQ GSSQQYLGQE
260 270 280 290 300
EYYGEQYSHS QGAAEPMGQQ YYPDGHGDYA YQQSSYTEQS YDRSFEESTQ
310 320 330 340 350
HYYEGGNSQY SQQQAGYQQG AAQQQTYSQQ QYPSQQSYPG QQQGYGSAQG
360 370 380 390
APSQYPGYQQ GQGQQYGSYR APQTAPSAQQ QRPYGYEQGQ YGNYQQ
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ9BR54 | Q9BR54_HUMAN | Calcium-responsive transactivator | SS18L1 | 128 | Annotation score: | ||
H0YDW4 | H0YDW4_HUMAN | Calcium-responsive transactivator | SS18L1 | 211 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 128 | S → G in CAE45918 (PubMed:11230166).Curated | 1 | |
Sequence conflicti | 139 | T → S in BAF84174 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 143 | T → A in BAG54230 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_062534 | 189 | M → I1 PublicationCorresponds to variant dbSNP:rs17853304Ensembl. | 1 | |
Natural variantiVAR_053691 | 321 | A → T. Corresponds to variant dbSNP:rs36106901Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_038697 | 1 – 131 | Missing in isoform 4. 1 PublicationAdd BLAST | 131 | |
Alternative sequenceiVSP_038698 | 1 – 82 | Missing in isoform 3. 1 PublicationAdd BLAST | 82 | |
Alternative sequenceiVSP_038699 | 1 – 49 | MSVAF…AECTQ → MQSLSTEARYVPRVPQHRDQ ISPRSPQHGGQICPRSPLHR GQICPRSPPARR in isoform 5. 1 PublicationAdd BLAST | 49 | |
Alternative sequenceiVSP_038700 | 1 – 23 | MSVAF…QTIQK → M in isoform 2. 1 PublicationAdd BLAST | 23 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB014593 mRNA Translation: BAA31668.1 Different initiation. BX640848 mRNA Translation: CAE45918.1 AY203931 mRNA Translation: AAP34454.1 AK125656 mRNA Translation: BAG54230.1 AK291485 mRNA Translation: BAF84174.1 AL078633 Genomic DNA No translation available. CH471077 Genomic DNA Translation: EAW75393.1 CH471077 Genomic DNA Translation: EAW75392.1 CH471077 Genomic DNA Translation: EAW75395.1 BC034494 mRNA Translation: AAH34494.1 BC068993 mRNA Translation: AAH68993.1 |
CCDSi | CCDS13491.1 [O75177-1] |
RefSeqi | NP_001288707.1, NM_001301778.1 [O75177-4] NP_945173.1, NM_198935.2 [O75177-1] XP_005260448.1, XM_005260391.1 [O75177-2] XP_011527066.1, XM_011528764.2 [O75177-2] XP_011527069.1, XM_011528767.1 [O75177-5] |
Genome annotation databases
Ensembli | ENST00000331758; ENSP00000333012; ENSG00000184402 [O75177-1] ENST00000370848; ENSP00000359885; ENSG00000184402 [O75177-3] |
GeneIDi | 26039 |
KEGGi | hsa:26039 |
UCSCi | uc002ycb.4, human [O75177-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB014593 mRNA Translation: BAA31668.1 Different initiation. BX640848 mRNA Translation: CAE45918.1 AY203931 mRNA Translation: AAP34454.1 AK125656 mRNA Translation: BAG54230.1 AK291485 mRNA Translation: BAF84174.1 AL078633 Genomic DNA No translation available. CH471077 Genomic DNA Translation: EAW75393.1 CH471077 Genomic DNA Translation: EAW75392.1 CH471077 Genomic DNA Translation: EAW75395.1 BC034494 mRNA Translation: AAH34494.1 BC068993 mRNA Translation: AAH68993.1 |
CCDSi | CCDS13491.1 [O75177-1] |
RefSeqi | NP_001288707.1, NM_001301778.1 [O75177-4] NP_945173.1, NM_198935.2 [O75177-1] XP_005260448.1, XM_005260391.1 [O75177-2] XP_011527066.1, XM_011528764.2 [O75177-2] XP_011527069.1, XM_011528767.1 [O75177-5] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 117505, 60 interactors |
IntActi | O75177, 37 interactors |
MINTi | O75177 |
STRINGi | 9606.ENSP00000333012 |
PTM databases
iPTMneti | O75177 |
PhosphoSitePlusi | O75177 |
Genetic variation databases
BioMutai | SS18L1 |
Proteomic databases
EPDi | O75177 |
jPOSTi | O75177 |
MassIVEi | O75177 |
MaxQBi | O75177 |
PaxDbi | O75177 |
PeptideAtlasi | O75177 |
PRIDEi | O75177 |
ProteomicsDBi | 49845 [O75177-1] 49846 [O75177-2] 49847 [O75177-3] 49848 [O75177-4] 49849 [O75177-5] |
Protocols and materials databases
Antibodypediai | 44341, 143 antibodies |
DNASUi | 26039 |
Genome annotation databases
Ensembli | ENST00000331758; ENSP00000333012; ENSG00000184402 [O75177-1] ENST00000370848; ENSP00000359885; ENSG00000184402 [O75177-3] |
GeneIDi | 26039 |
KEGGi | hsa:26039 |
UCSCi | uc002ycb.4, human [O75177-1] |
Organism-specific databases
CTDi | 26039 |
DisGeNETi | 26039 |
GeneCardsi | SS18L1 |
HGNCi | HGNC:15592, SS18L1 |
HPAi | ENSG00000184402, Low tissue specificity |
MIMi | 606472, gene |
neXtProti | NX_O75177 |
OpenTargetsi | ENSG00000184402 |
PharmGKBi | PA37989 |
VEuPathDBi | HostDB:ENSG00000184402.14 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3227, Eukaryota |
GeneTreei | ENSGT00940000159853 |
HOGENOMi | CLU_054580_1_0_1 |
InParanoidi | O75177 |
OMAi | DDSTQHY |
PhylomeDBi | O75177 |
TreeFami | TF330999 |
Enzyme and pathway databases
PathwayCommonsi | O75177 |
SIGNORi | O75177 |
Miscellaneous databases
BioGRID-ORCSi | 26039, 7 hits in 997 CRISPR screens |
ChiTaRSi | SS18L1, human |
GeneWikii | SS18L1 |
GenomeRNAii | 26039 |
Pharosi | O75177, Tbio |
PROi | PR:O75177 |
RNActi | O75177, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000184402, Expressed in forebrain and 245 other tissues |
ExpressionAtlasi | O75177, baseline and differential |
Genevisiblei | O75177, HS |
Family and domain databases
InterProi | View protein in InterPro IPR007726, SS18_fam |
Pfami | View protein in Pfam PF05030, SSXT, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CREST_HUMAN | |
Accessioni | O75177Primary (citable) accession number: O75177 Secondary accession number(s): A6NNE3 Q9H4K6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 31, 2002 |
Last sequence update: | January 31, 2002 | |
Last modified: | April 7, 2021 | |
This is version 163 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 20
Human chromosome 20: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families